Ole K Greiner-Tollersrud

Biochemistry professor

  • Esther Llop, Ana Ardá, Elsa Zacco, Roisin O’Flaherty, María-Salud García-Ayllón, Massimo Aureli et al.:
    Proceedings of workshop: “Neuroglycoproteins in health and disease”, INNOGLY cost action
    Glycoconjugate Journal 2022 DOI
  • Xiaobo Song, ole kristian Tollersrud, Huimin Zhou :
    Oral Microbiota Variation: A Risk Factor for Development and Poor Prognosis of Esophageal Cancer
    Digestive Diseases and Sciences 2021 DOI
  • ole kristian Tollersrud :
    The non-classical N-glycan processing pathway of bovine brain ecto-nucleotide phosphodiesterase/pyrophosphatase 6 (eNPP6) is brain specific and not due to mannose-6-phosphorylation
    Neurochemical Research 2014 DOI
  • Linn Greiner-Tollersrud, Thomas Berg, Hilde Monica Frostad Riise Stensland, Gry Evjen, Ole Kristian Tollersrud :
    Bovine Brain Myelin Glycerophosphocholine Choline Phosphodiesterase is an Alkaline Lysosphingomyelinase of the eNPP-Family, Regulated by Lysosomal Sorting
    Neurochemical Research 2013 DOI
  • G Casteinovo, T Levade, hilde frostad riise Stensland, MJ Nonnon, MA Berges, ole kristian Tollersrud et al.:
    Adult leukoencephalopathy caused by alpha-mannosidosis deficiency
    Revue neurologique (Paris) 2007
  • V Faid, gry Evjen, ole kristian Tollersrud, JC Michalski, W Morelle :
    Site-specific glycosylation analysis of the bovine lysosomal alpha-mannosidase
    Glycobiology 2006
  • DP Roces, R Lullmann-Rauch, JH Peng, C Balducci, C Andersson, Ole K Greiner-Tollersrud et al.:
    Efficacy of enzyme replacement therapy in alpha-mannosidosis mice: a preclinical animal study
    Human Molecular Genetics 2004
  • Gaute Hansen, Thomas Berg, Hilde Riise Stensland, Pirkko A Heikinheimo, Helle Bagterp Klenow, Gry Evjen et al.:
    Intracellular transport of human lysosomal alpha-mannosidase and alpha-mannosidosis-related mutants
    Biochemical Journal 2004
  • Karen Kristine Sørensen, ole kristian Tollersrud, gry Evjen, Bård Smedsrød :
    Mannose-receptor-mediated clearance of lysosomal -mannosidase in scavenger endothelium of cod endocardium
    Comparative Biochemistry and Physiology - Part A: Comparative Physiology 2001
  • Thomas Berg, Barbara King, Peter Meikle, Øivind Nilssen, ole kristian Tollersrud, John Hopwood :
    Purification and Characterization of Recombinant Human Lysosomal alpha-Mannosidase
    Molecular Genetics and Metabolism 2001 DOI
  • Hilde Monica Frostad Riise, Gaute Hansen, ole kristian Tollersrud, Øivind Nilssen :
    Characterization of a novel alpha-mannosidosis-causing mutation and its use in leukocyte genotyping after bone marrow transplantation
    Human Genetics 1999
  • Thomas Berg, Gaute Hansen, Dag Malm, Lisbeth Tranebjærg, ole kristian Tollersrud, Øivind Nilssen :
    Spectrum of mutations in alpha-mannosidosis
    American Journal of Human Genetics 1999
  • Thomas Berg, Peter J Healy, ole kristian Tollersrud, Øivind Nilssen :
    Molecular heterogeneity for bovine alpha-mannosidosis: PCR based assays for breed-specific mutations
    Research in Veterinary Science 1997
  • Thomas Berg, ole kristian Tollersrud, Steven U. Walkley, Donald S. Siegel, Øivind Nilssen :
    Purification of feline lysosomal alpha-mannosidase, determination of its cDNA sequence and identification of a mutation causing alpha-mannosidosis i Persian cats
    Biochemical Journal 1997
  • Øivind Nilssen, Thomas Berg, Hilde Monica Frostad Riise, Umayal Ramachandran, gry Evjen, Gaute Hansen et al.:
    alpha-mannosidosis: functional cloning of the lysosomal alpha-mannosidase cDNA and identification of a mutation in two affected siblings
    Human Molecular Genetics 1997 DOI
  • ole kristian Tollersrud, Thomas Berg, Peter Healy, gry Evjen, Umayal Ramachandran, Øivind Nilssen :
    Purification of bovine lysosomal alpha-mannosidase, characterization of its gene and determination of two mutations that cause alpha-mannosidosis
    European Journal of Biochemistry (EJB) 1997 DOI
  • Hilde Monica Frostad Riise, Thomas Berg, Øivind Nilssen, Giovanno Romeo, ole kristian Tollersrud, Isabella Ceccherini :
    Genomic structure of the human lysosomal alpha-mannosidase gene (MAN2B1)
    Genomics 1997
  • P Saftig, ole kristian Tollersrud, T Berg :
    Lysosomal Storage Disorders (Review)
    Springer 2005
  • Ole Kristian Tollersrud :
    Varmt anbefalt for legestudenten
    Tidsskrift for Den norske legeforening 2020 DOI
  • ole kristian Tollersrud, gry Evjen, thomas Berg, hilde frostad riise Stensland :
    Characterisation of two new enzymes involved in lysosomal phospholipid degradation
    The FEBS Journal 2010
  • ole kristian Tollersrud :
    The mannose 6-phosphate dependent sorting of lysosomal proteins: Changing a dogma
  • Pirkko a Heikinheimo, Ronny Helland, Hanna-Kirsti S. Leiros, Ingar Leiros, Solveig Karlsen, gry Evjen et al.:
    Structure of the Bovine Lysosomal a-Mannosidase, the Enzyme Involved in the Lysosomal Storage Disease a-Mannosidosis
    ESRF Highlights 2002 2003

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    Research interests

    My research interest is concentrated in the proteins within the secretory room among eukaryotes, mainly humans.  I define the secretory room as all extracellular space in the organism, including the outer part of the cell membrane, and the lysosomes.  The secretory room can be divided into two major parts divided by the blood-brain barrier, the peripheral, including the vascular system,  and the central, which is the brain. 

    Nearly all of the proteins within the secretory room are N-glycosylated, and the N-glycans can possess a large array of different structures and functions.  We call this a glycan language.  Though my research I strive to translate the glycan-language.  Presently I concentrate on the three proteins lysosomal alpha-mannosidase, arylsulphatase B and eNPP6.


    Member of research group