Photo: Bjørn-Kåre Iversen
Ole Petter Rekvig
Professor emeritus
Ole Petter Rekvig
:
The greatest contribution to medical science is the transformation from studying symptoms to studying their causes—the unrelenting legacy of Robert Koch and Louis Pasteur—and a causality perspective to approach a definition of SLE
Frontiers in Immunology 2024 DOI
Ole Petter Rekvig
:
SLE classification criteria: Is “The causality principle” integrated and operative – and do the molecular and genetical network, on which criteria depend on, support the definition of SLE as “a one disease entity” – A theoretical discussion
Ole Petter Rekvig
:
SLE classification criteria: Science-based icons or algorithmic distractions – an intellectually demanding dilemma
Ole Petter Rekvig
:
The Anti-DNA Antibodies: Their Specificities for Unique DNA Structures and Their Unresolved Clinical Impact—A System Criticism and a Hypothesis
Ole Petter Rekvig
:
Autoimmunity and SLE: Factual and Semantic Evidence-Based Critical Analyses of Definitions, Etiology, and Pathogenesis
Ole Petter Rekvig
:
The dsDNA, Anti-dsDNA Antibody, and Lupus Nephritis: What We Agree on, What Must Be Done, and What the Best Strategy Forward Could Be
Unni Igesund,
Grete Overvåg,
Guri Rasmussen,
Ole Petter Rekvig
:
Kartlegging av prosedyrer for oppdekking av instrumentbord ved kirurgiske inngrep
Dhivya Thiyagarajan,
Hege Lynum Pedersen,
Natalya Seredkina,
Kjersti Daae Horvei,
Lorena Arranz,
Ramon Sonneveld
et al.:
IL-1β Promotes a New Function of DNase I as a Transcription Factor for the Fas Receptor Gene
Hege Lynum Pedersen,
Kjersti Daae Horvei,
Dhivya Thiyagarajan,
Gudrun Norby,
Natalya Seredkina,
Gabriella Moroni
et al.:
Lupus nephritis: low urinary DNase I levels reflect loss of
renal DNase I and may be utilized as a biomarker of
disease progression
Ole Petter Rekvig
:
Systemic lupus erythematosus: Definitions, contexts, conflicts, enigmas
Ronald Van Vollenhoven,
Alexandre Voskuyl,
George Bertsias,
Cynthia Aranow,
Martin Aringer,
Laurent Arnaud
et al.:
A framework for remission in SLE: Consensus findings from a large international task force on definitions of remission in SLE (DORIS)
Annals of the Rheumatic Diseases 2017 DOI
Kjersti Daae Horvei,
Hege Lynum Pedersen,
Silje Fismen,
Dhivya Thiyagarajan,
Andrea Schneider,
Ole Petter Rekvig
et al.:
Lupus nephritis progression in FcγRIIB-/-yaa mice is associated with early development of glomerular electron dense deposits and loss of renal DNase I in severe disease.
Nishant Dwivedi,
Annica Hedberg,
Ying Yi Zheng,
Indira Neeli,
Minoru Satoh,
Laurence Morel
et al.:
B Cell Tolerance to Deiminated Histones in BALB/c, C57BL/6, and Autoimmune-Prone Mouse Strains
Harri Itkonen,
Michael Brown,
Alfonso Urbanucci,
Gregory Tredwell,
Chung Ho Lau,
Stefan Jörg Barfeld
et al.:
Lipid degradation promotes prostate cancer cell survival
OncoTarget 2017 DOI
Ole Petter Rekvig,
Dhivya Thiyagarajan,
Hege Lynum Pedersen,
Kjersti Daae Horvei,
Natalya Seredkina
:
Future perspectives on pathogenesis of Lupus Nephritis: facts, problems, and potential causal therapy modalities
American Journal of Pathology 2016 DOI
Christoffer Tandrup Nielsen,
Ole Østergaard,
Ole Petter Rekvig,
Gunnar Sturfelt,
Saren Jacobsen,
Niels Henrik Helweg Heegaard
:
Galectin-3 binding protein links circulating microparticles with electron dense glomerular deposits in lupus nephritis
Lupus 2015 DOI
Dhivya Thiyagarajan,
Ole Petter Rekvig,
Natalya Seredkina
:
TNFα amplifies DNaseI expression in renal tubular cells while IL-1β promotes nuclear DNaseI translocation in an endonuclease-inactive form
Ole Petter Rekvig
:
The anti-DNA antibody: Origin and impact, dogmas and controversies
Nature Reviews Rheumatology 2015 DOI
Ole Petter Rekvig
:
Anti-dsDNA antibodies as a classification criterion and a diagnostic marker for systemic lupus erythematosus: Critical remarks
Clinical and Experimental Immunology 2015 DOI
Hege Lynum Pedersen,
Kjersti Daae Horvei,
Dhivya Thiyagarajan,
Natalya Seredkina,
Ole Petter Rekvig
:
Murine and human lupus nephritis: pathogenic mechanisms and theoretical strategies for therapy
Seminars in Nephrology 2015 DOI
Ole Petter Rekvig,
Johan van der Vlag,
Natalya Seredkina
:
Review: Antinucleosome antibodies: A critical reflection on their specificities and diagnostic impact
Arthritis and Rheumatism 2014 DOI
Michele Compagno,
Ole Petter Rekvig,
Anders Bengtsson,
Gunnar Sturfeld,
Niels H. H. Heegaard,
Andreas Jönsen
et al.:
Clinical phenotype associations with various types of anti-dsDNA antibodies in patients with recent onset of rheumatic symptoms. Results from a multicentre observational study
Michele Compagno,
S. Jacobsen,
Ole Petter Rekvig,
L. Truedsson,
Niels H. H. Heegaard,
Johannes C Nossent
et al.:
Low diagnostic and predictive value of anti-dsDNA antibodies in unselected patients with recent onset of rheumatic symptoms: results from a long-term follow-up Scandinavian multicentre study
Scandinavian Journal of Rheumatology 2013 DOI
Natalya Seredkina,
Johan van der Vlag,
Jo Berden,
Elin Synnøve Mortensen,
Ole Petter Rekvig
:
Lupus Nephritis: Enigmas, Conflicting Models and an Emerging Concept
Silje Fismen,
Dhivya Thiyagarajan,
Natalya Seredkina,
Henrik Nielsen,
Søren Jacobsen,
Thomas Elung-Jensen
et al.:
Impact of the Tumor Necrosis Factor Receptor-Associated Protein 1 (Trap1) on Renal DNaseI Shutdown and on Progression of Murine and Human Lupus Nephritis
American Journal of Pathology 2013 DOI
Annica Hedberg,
Premasany Kanapathippillai,
Ole Petter Rekvig,
Kristin Andreassen Fenton
:
LMW Heparin Prevents Increased Kidney Expression of Proinflammatory Mediators in (NZBxNZW)F1 Mice
Ole Petter Rekvig,
Chaim Putterman,
Cinzia Casu,
Hua-Xin Gao,
Anna Ghirardello,
Elin Synnøve Mortensen
et al.:
Autoantibodies in lupus: Culprits or passive bystanders?
Autoimmunity Reviews 2012 DOI
Dhivya Thiyagarajan,
Silje Fismen,
Natalya Seredkina,
Søren Jacobsen,
Thomas Elung-Jensen,
Anne-Lise Kamper
et al.:
Silencing of Renal DNaseI in Murine Lupus Nephritis Imposes Exposure of Large Chromatin Fragments and Activation of Toll Like Receptors and the Clec4e
Franz Gruber,
Tuija Lundan,
Rasmus Goll,
Aleksandra Silye,
Ingvild Mikkola,
Ole Petter Rekvig
et al.:
BCR-ABL isoforms associated with intrinsic or acquired resistance to imatinib: more heterogeneous than just ABL kinase domain point mutations?
Medical Oncology (MO) 2012 DOI
Ole Petter Rekvig,
Elin Synnøve Mortensen
:
Immunity and autoimmunity to dsDNA and chromatin - the role of immunogenic DNA-binding proteins and nuclease deficiencies
Autoimmunity 2012 DOI
Marko Radic,
Martin Herrmann,
Johan van der Vlag,
Ole Petter Rekvig
:
Regulatory and pathogenetic mechanisms of autoantibodies in SLE
Autoimmunity 2011 DOI
Janne erikke Mjelle,
Ole Petter Rekvig,
Johan van der Vlag,
Kristin Andreassen Fenton
:
Nephritogenic antibodies bind in glomeruli through interaction with exposed chromatin fragments and not with renal cross-reactive antigens
Autoimmunity 2011 DOI
Annica Hedberg,
Elin Mortensen,
Ole Petter Rekvig
:
Chromatin as a target antigen in human and murine lupus nephritis
Arthritis Research & Therapy 2011 DOI
Annica Hedberg,
Silje Fismen,
Kristin Andreassen Fenton,
Christopher Graham Fenton,
Bjarne Østerud,
Elin Mortensen
et al.:
Heparin Exerts a Dual Effect on Murine Lupus Nephritis by Enhancing Enzymatic Chromatin Degradation and Preventing Chromatin Binding in Glomerular Membranes
Arthritis and Rheumatism 2011 DOI
Mariann Hellvik Jørgensen,
Ole Petter Rekvig,
Rasmus S. Jacobsen,
Søren Jacobsen,
Kristin Andreassen Fenton
:
Circulating levels of chromatin fragments are inversely correlated with anti-dsDNA antibody levels in human and murine systemic lupus erythematosus
Immunology Letters 2011 DOI
Natalya Seredkina,
Ole Petter Rekvig
:
Acquired loss of renal nuclease activity is restricted to DNaseI and is an organ-selective feature of murine lupus nephritis
American Journal of Pathology 2011 DOI
Anders Aune Tveita,
Ole Petter Rekvig
:
Alterations in Wnt Pathway Activity in Mouse Serum and Kidneys During Lupus Development
Arthritis and Rheumatism 2011 DOI
Silje Fismen,
Elin Mortensen,
Ole Petter Rekvig
:
Nuclease deficiencies promote end-stage lupus nephritis but not nephritogenic autoimmunity in (NZBxNZW) F1 mice
Immunology and Cell Biology 2011 DOI
Kristin Andreassen Fenton,
berit TØmmerÅs,
Tony Norman Marion,
Ole Petter Rekvik
:
Pure anti-dsDNA mAbs need chromatin structures to promote glomerular mesangial deposits in BALB/c mice
Autoimmunity 2010 DOI
Silje Fismen,
Elin Mortensen,
Ole Petter Rekvig
:
Nuclease deficiencies promote end-stage lupus nephritis but not nephritogenic autoimmunity in (NZB x NZW) F1 mice
Immunology and Cell Biology 2010 DOI
M Mosca,
C Tani,
M Aringer,
S Bombardieri,
D Boumpas,
R Brey
et al.:
European League Against Rheumatism recommendations for monitoring patients with systemic lupus erythematosus in clinical practice and in observational studies
Annals of the Rheumatic Diseases 2010 DOI
Annica Hedberg,
Silje Fismen,
Kristin Andreassen Fenton,
Elin Mortensen,
Ole Petter Rekvig
:
Deposition of chromatin-IgG complexes in skin of nephritic MRL-lpr/lpr mice is associated with increased local matrix metalloprotease activities
Experimental Dermatology 2010 DOI
Svetlana Zykova,
Anders Tveita,
Ole Petter Rekvik
:
Renal Dnase1 Enzyme Activity and Protein Expression Is Selectively Shut Down in Murine and Human Membranoproliferative Lupus Nephritis
Silje Fismen,
Annica Hedberg,
Kristin Andreassen Fenton,
S Jacobsen,
E Krarup,
AL Kamper
et al.:
Circulating chromatin-anti-chromatin antibody complexes bind with high affinity to dermo-epidermal structures in murine and human lupus nephritis
Lupus 2009 DOI
Janne erikke Mjelle,
manar Kalaaji,
Ole Petter Rekvik
:
Exposure of chromatin and not high affinity for dsDNA determines the nephritogenic impact of anti-dsDNA antibodies in (NZBNZW)F1 mice
Autoimmunity 2009 DOI
Hege Lynum Pedersen,
Kjersti Daae Horvei,
Dhivya Thiyagarajan,
Gudrun Norby,
Natalya Seredkina,
Gabriella Moroni
et al.:
LUPUS NEPHRITIS: SEVERELY REDUCED URINARY DNASE I LEVELS REFLECT LOSS OF RENAL DNASE I, DISEASE PROGRESSION AND MAY REDUCE THE NEED FOR RENAL BIOPSIES
2018
Ole Petter Rekvig,
Johan van der Vlag
:
The pathogenesis and diagnosis of systemic lupus erythematosus: Still not resolved
Seminars in Immunopathology 2014 DOI
michele compagno,
Søren Jacobsen,
Ole Petter Rekvig,
Lennart Truedsson,
Niels H. H. Heegaard,
Johannes C Nossent
et al.:
Diagnostic Accuracy of Anti-dsDNA Antibodies in Unselected Patients with Recent Onset of Rheumatic Symptoms
Arthritis and Rheumatism 2012
Steinar Daae Johansen,
morten Andreassen,
Igor Babiak,
Teshome Bizuayehu,
Dag-Hugo Coucheron,
M. Raafat El-Gewely
et al.:
Investigating miRNAs and transcriptomes at our local SOLiD sequencing facility
2011
Natalya Seredkina,
Ole Petter Rekvig
:
Acquired loss of renal Dnase1 is an organ specific feature for severe lupus nephritis
2010
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Research interests
Studies on the genesis of antibodies to dsDNA and to chromatin
Basic and clinical science on SLE and lupus nephritis
Transcriptomics in lupus nephritis
To understand the role of autoimmunity to chromatin in lupus nephritis