Personkort bilde
Researcher

Piotrowski, Yvonne

Research Scientist, Biomolecular and Structural Chemistry, Norstruct Department of Chemistry
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Biotechnology

Enzyme engineering

Innovation research

Protein crystallography

Synthetic biology

Outreach activities (Science Days, recruitment)

since 09/2009 - Researcher at NorStruct, Department of Chemistry, UiT - The Arctic University of Norway, Norway

ChimPol – Chimeric DNA polymerases as enzymatic drivers for single cell genomics (Mabit program, March 2019 - March 2020)

MarSynth – Marine DNA modifying enzymes for synthetic biology (NRC, BIOTEK2021, July 2017 - July 2020)

Marine DNA polymerases as engines for single cell genomics (Mabit program, Febr. 2017 - Febr. 2018)

MDxPol – Marine DNA polymerases as tools for next generation molecular diagnostics solution (NRC, FORNY2020, Oct. 2016 - October 2018)

Optimization and application of marine cold-adapted DNA polymerases (NRC, BIOTEK2021, Oct. 2013 - Oct. 2016)

MabCent – Enzyme discovery in the Centre for research-based Innovation on marine bioactives and drug discovery (NRC, Aug. 2009 - Oct. 2013)

 

09/2004 - 01/2010

Doctoral research study at the University of Lübeck, Germany, Institute of Biochemistry, Germany, PhD thesis: "The coronavirus X-domain - Crystallographic and biochemical analysis of viral homologues of macro domain proteins", supervisor: Prof. Dr. R. Hilgenfeld

 

10/1999 - 08/2004

Study of biochemistry at Greifswald University, Germany, Dept. of Biotechnology & Enzyme Catalysis, Institute of Biochemistry, diploma thesis: "Developing a method for the in vivo-evolution of esterases", supervisor: Prof. Dr. U.T. Bornscheuer

  • Piotrowski, Yvonne; Gurung, Man Kumari; Larsen, Atle Noralf. Characterization and engineering of a DNA polymerase reveals a single amino-acid substitution in the fingers subdomain to increase strand-displacement activity of A-family prokaryotic DNA polymerases. BMC Molecular and Cell Biology 2019; Volum 20:31. ISSN 2661-8850.s 1 - 11.s doi: 10.1186/s12860-019-0216-1.

  • Piotrowski, Yvonne; Berg, Kristel; Klebl, David P.; Leiros, Ingar; Larsen, Atle Noralf. Characterization of an intertidal zone metagenome oligoribonuclease and the role of the intermolecular disulfide bond for homodimer formation and nuclease activity. FEBS Open Bio 2019; Volum 9 (10). ISSN 2211-5463.s 1674 - 1688.s doi: 10.1002/2211-5463.12720.

  • Piotrowski, Yvonne; Assefa, Netsanet Gizaw; Helland, Ronny; Johannessen, Kirsti Merete; Willassen, Nils Peder; Larsen, Atle Noralf. Enzymes from the Arctic - The cold gold. BioProsp 2015 2015-02-18 - 2015-02-20 2015.

  • Piotrowski, Yvonne; Assefa, Netsanet Gizaw; Helland, Ronny; Johannessen, Kirsti Merete; Landfald, Bjarne; Smalås, Arne O.; Jørgensen, Trond Ø.; Willassen, Nils Peder; Larsen, Atle Noralf. Enzymes from the Arctic - The cold gold. DNA polymerases: Biology, Diseases and Biomedical Applications 2014-08-31 - 2014-09-04 2014.

  • Piotrowski, Yvonne; Johannessen, Kirsti Merete; Assefa, Netsanet Gizaw; Landfald, Bjarne; Smalås, Arne O.; Jørgensen, Trond Ø.; Willassen, Nils Peder; Larsen, Atle Noralf. MabCent - Discovery of arctic marine enzymes. NBS kontaktmøte 2012 2012-01-19 - 2012-01-22 2012.

  • Piotrowski, Yvonne; Assefa, Netsanet Gizaw; Helland, Ronny; Johannessen, Kirsti Merete; Willassen, Nils Peder; Larsen, Atle Noralf. Enzymes from the Arctic - The cold gold. BioProsp 2015 2015-02-18 - 2015-02-20 2015.

  • Piotrowski, Yvonne; Assefa, Netsanet Gizaw; Helland, Ronny; Johannessen, Kirsti Merete; Landfald, Bjarne; Smalås, Arne O.; Jørgensen, Trond Ø.; Willassen, Nils Peder; Larsen, Atle Noralf. Enzymes from the Arctic - The cold gold. DNA polymerases: Biology, Diseases and Biomedical Applications 2014-08-31 - 2014-09-04 2014.

  • Piotrowski, Yvonne; Johannessen, Kirsti Merete; Assefa, Netsanet Gizaw; Landfald, Bjarne; Smalås, Arne O.; Jørgensen, Trond Ø.; Willassen, Nils Peder; Larsen, Atle Noralf. MabCent - Discovery of arctic marine enzymes. NBS kontaktmøte 2012 2012-01-19 - 2012-01-22 2012.

  • Patents

    Larsen A.N., Piotrowski Y., “Position based increase in application relevant properties”. Patent application filed in UK December 2017

    Larsen A.N., Piotrowski Y., Assefa N.G., Lanes O. ”Marine DNA polymerase”. Patent application filed in UK March 2016, Patent Application No. 1604876.1

    Larsen A.N., Piotrowski Y., Willassen N.P., Lanes O., Lorentzen M.S., Solstad T., Andreassen E., Elde M. ”Heat Labile Exonucleases” International Patent Application, PCT/EP2015/001703

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    Member of research group