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  3. Elin Moe
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Photo: Ukjent
Ansatte-IK---Elin-Moe.jpg
Department of Chemistry elin.moe@uit.no Tromsø

Elin Moe

Associate Professor II, Biomolecular and Structural Chemistry

  • Fernandes, A.; Piotrowski, Yvonne; Williamson, Adele Kim; Frade, K.; Moe, Elin. Studies of multifunctional DNA polymerase I from the extremely radiation resistant Deinococcus radiodurans: Recombinant expression, purification and characterization of the full-length protein and its large fragment. Protein Expression and Purification 2021; Volum 187. ISSN 1046-5928.s doi: 10.1016/j.pep.2021.105925.
  • Sarre, Aili; Stelter, Meike; Rollo, Filipe; De Bonis, Salvatore; Seck, Anna; Hognon, Cecilia; Ravanat, Jean-Luc; Monari, Antonio; Dehez, Francois; Moe, Elin; Timmins, Joanna. The three Endonuclease III variants of Deinococcus radiodurans possess distinct and complementary DNA repair activities. DNA Repair 2019; Volum 78. ISSN 1568-7864.s 45 - 59.s doi: 10.1016/j.dnarep.2019.03.014.
  • Timmins, Joanna; Moe, Elin. A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans: Major Findings, Functional and Mechanistic Insight and Challenges. Computational and Structural Biotechnology Journal 2016; Volum 14. ISSN 2001-0370.s 168 - 176.s doi: 10.1016/j.csbj.2016.04.001.
  • Lian, Kjersti; Leiros, Hanna-Kirsti S.; Moe, Elin. MutT from the fish pathogen Aliivibrio salmonicida is a cold-active nucleotide-pool sanitization enzyme with unexpectedly high thermostability. FEBS Open Bio 2015; Volum 5. ISSN 2211-5463.s 107 - 116.s doi: 10.1016/j.fob.2015.01.006.
  • Niiranen, Laila; Lian, Kjersti; Johnson, Kenneth A; Moe, Elin. Crystal structure of the DNA polymerase III β subunit (β-clamp) from the extremophile Deinococcus radiodurans. BMC Structural Biology 2015; Volum 15 (5). ISSN 1472-6807.s doi: 10.1186/s12900-015-0032-6.
  • Pedersen, Hege Lynum; Johnson, Kenneth; McVey, Colin; Leiros, Ingar; Moe, Elin. Structure determination of uracil-DNA N-glycosylase from Deinococcus radiodurans in complex with DNA. Acta Crystallographica Section D: Biological Crystallography 2015; Volum 71. ISSN 0907-4449.s 2137 - 2149.s doi: 10.1107/S1399004715014157.
  • Sarre, Aili; Ökvist, Mats; Klar, Tobias; Hall, David; Smalås, Arne O.; McSweeney, Sean; Timmins, Joanna; Moe, Elin. Structural and functional characterization of two unusual endonuclease III enzymes from Deinococcus radiodurans. Journal of Structural Biology 2015; Volum 191 (2). ISSN 1047-8477.s 87 - 99.s doi: 10.1016/j.jsb.2015.05.009.
  • Moe, Elin; Assefa, Netsanet Gizaw; Leiros, Ingar; Torseth, Kathrin; Smalås, Arne O.; Willassen, Nils Peder. Reduced Hydrophobicity of the Minor Groove Intercalation Loop is Critical for Efficient Catalysis by Cold Adapted Uracil-DNA N-Glycosylase from Atlantic Cod. Journal of Thermodynamics & Catalysis 2015; Volum 6 (3). ISSN 2157-7544.s doi: 10.4172/2157-7544.1000155.
  • Moe, Elin; Sezer, Murat; Hildebrandt, Peter; Todorovic, Smilja. Surface enhanced vibrational spectroscopic evidence for an alternative DNA-independent redox activation of endonuclease III. Chemical Communications 2015; Volum 51. ISSN 1359-7345.s 3255 - 3257.s doi: 10.1039/C4CC09498K.
  • Sarre, Aili; Ökvist, Mats; Klar, Tobias; Moe, Elin; Timmins, Joanna. Expression, purification and crystallization of two endonuclease III enzymes from Deinococcus radiodurans. Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2014; Volum 70 (12). ISSN 1744-3091.s 1688 - 1692.s doi: 10.1107/S2053230X14024935.
  • Assefa, Netsanet Gizaw; Niiranen, Laila; Johnson, Kenneth; Leiros, Hanna-Kirsti S.; Smalås, Arne O.; Willassen, Nils Peder; Moe, Elin. Structural and biophysical analysis of interactions between cod and human uracil-DNA N-glycosylase (UNG) and UNG inhibitor (Ugi). Acta Crystallographica Section D: Biological Crystallography 2014; Volum 70 (8). ISSN 0907-4449.s 2093 - 2100.s doi: 10.1107/S1399004714011699.
  • Assefa, Netsanet Gizaw; Niiranen, Laila; Willassen, Nils P; Smalås, Arne O.; Moe, Elin. Thermal unfolding studies of cold adapted uracil-DNA N-glycosylase (UNG) from Atlantic cod (Gadus morhua). A comparative study with human UNG. Comparative Biochemistry and Physiology - Part B: Biochemistry & Molecular Biology 2012; Volum 161 (1). ISSN 1096-4959.s 60 - 68.s doi: 10.1016/j.cbpb.2011.09.007.
  • Moe, Elin; Hall, D R; Leiros, Ingar; Monsen, Vivi Talstad; Timmins, Joanna; McSweeney, Sean. Structure-function studies of an unusual 3-methyladenine DNA glycosylase II (AlkA) from Deinococcus radiodurans. Acta Crystallographica Section D: Biological Crystallography 2012; Volum 68. ISSN 0907-4449.s 703 - 712.s doi: 10.1107/S090744491200947X.
  • Ræder, Inger Lin Uttakleiv; Moe, Elin; Willassen, Nils Peder; Smalås, Arne Oskar; Leiros, Ingar. Structure of uracil-DNA N-glycosylase (UNG) from Vibrio cholerae: mapping temperature adaptation through structural and mutational analysis. Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2010; Volum 66. ISSN 1744-3091.s 130 - 136.s doi: 10.1107/S1744309109052063.
  • Altermark, Bjørn; Helland, Ronny; Moe, Elin; Willassen, Nils Peder; Smalås, Arne Oskar. Structural adaptation of endonuclease I from the cold-adapted and halophilic bacterium Vibrio salmonicida. Acta Crystallographica Section D: Biological Crystallography 2008; Volum 64. ISSN 0907-4449.s 368 - 376.s doi: 10.1107/S0907444908000097.
  • Ræder, Inger Lin Uttakleiv; Leiros, Ingar; Willassen, Nils Peder; Smalås, Arne Oskar; Moe, Elin. Uracil-DNA N-glycosylase (UNG) from the marine, psychrophilic bacterium Vibrio salmonicida shows cold adapted features A comparative analysis to Vibrio cholerae uracil-DNA N-glycosylase. Enzyme and Microbial Technology 2008; Volum 42 (7). ISSN 0141-0229.s 594 - 600.s doi: 10.1016/j.enzmictec.2008.02.005.
  • Altermark, Bjørn; Helland, Ronny; Moe, Elin; Willassen, Nils Peder; Smalås, Arne Oskar. Environmental adaptation of endonuclease I from Vibrio salmonicida. Acta Crystallographica Section D: Biological Crystallography 2008; Volum 64. ISSN 0907-4449.s 368 - 376.
  • Leiros, Ingar; Nabong, Marivi P.; Grøsvik, Kristin; Ringvoll, Jeanette; Haugland, GT; Uldal, Lene; Reite, Karen; Olsbu, Inger K.; Knævelsrud, I.; Moe, Elin; Andersen, Ole A.; Birkeland, Nils-Kåre; Ruoff, Peter; Klungland, Arne; Bjelland, Svein. Structural basis for enzymatic excision of N-1-methyladenine and N-3-methylcytosine from DNA. EMBO Journal 2007; Volum 26. ISSN 0261-4189.
  • Leiros, Hanna-Kirsti S.; Pey, AL; Innselset, M; Innselset, Marte; Moe, Elin; Leiros, Ingar; Steen, IH; Martinez, A. Structure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H, a monomeric cold active enzyme with local flexibility around the active site and high overall stability. Journal of Biological Chemistry 2007; Volum 282. ISSN 0021-9258.s doi: 10.1074/jbc.M610174200.
  • Leiros, Ingar; Nabong, Marivi; Nabong, MP; Grosvik, K; Grøsvik, Kristin; Ringvoll, J; Ringvoll, Jeanette; Haugland, GT; Uldal, Lene; Uldal, L; Reite, K; Olsbu, IK; Knævelsrud, Ingeborg; Knaevelsrud, I; Moe, Elin; Andersen, Ole Andreas; Birkeland, NK; Ruoff, P; Klungland, A; Bjelland, S. Structural basis for enzymatic excision of N-1-methyladenine and N-3-methylcytosine from DNA. EMBO Journal 2007; Volum 26. ISSN 0261-4189.s doi: 10.1038/sj.emboj.7601662.
  • Altermark, Bjørn; Thorvaldsen, Steinar; Moe, Elin; Smalås, Arne Oskar; Willassen, Nils Peder. Sequence comparison and environmental adaptation of a bacterial endonuclease. Computational biology and chemistry 2007; Volum 31 (3). ISSN 1476-9271.s 163 - 172.s doi: 10.1016/j.compbiolchem.2007.03.003.
  • Altermark, Bjørn; Niiranen, Laila Mirja; Willassen, Nils Peder; Smalås, Arne Oskar; Moe, Elin. Comparative studies of endonuclease I from cold-adapted Vibrio salmonicida and mesophilic Vibrio cholerae. The FEBS Journal 2007; Volum 274. ISSN 1742-464X.s doi: 10.1111/j.1742-4658.2006.05580.x.
  • Dennis, RJ; Micossi, E.; McCarthy, J.J.; Moe, Elin; Gordon, E.; Kozielski-Stuhrmann, S.; Leonard, G.A; McSweeney, S.. Structure of the manganese superoxide dismutase from Deinococcus radiodurans in two crystal forms. Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2006; Volum 62. ISSN 1744-3091.
  • Lorentzen, Marit Sjo; Moe, Elin; Jouve, HM; Willassen, Nils Peder. Cold adapted features of Vibrio salmonicida catalase: characterisation and comparison to the mesophilic counterpart from Proteus mirabilis. Extremophiles 2006; Volum 10 (5). ISSN 1431-0651.s 427 - 440.
  • Larsen, Atle Noralf; Moe, Elin; Helland, Ronny; Gjellesvik, Dag Rune; Willassen, Nils Peder. Characterization of a recombinantly expressed proteinase K-like enzyme from a psychrotrophic Serratia sp. The FEBS Journal 2006; Volum 273 (1). ISSN 1742-464X.s 47 - 60.
  • Moe, Elin; Leiros, Ingar; Smalås, Arne Oskar; McSweeney, Sean. The crystal structure of mismatch-specific uracil-DNA glycosylase (MUG) from Deinococcus radiodurans reveals a novel catalytic residue and broad substrate specificity. Journal of Biological Chemistry 2006; Volum 281. ISSN 0021-9258.
  • Olufsen, Magne; Smalås, Arne Oskar; Moe, Elin; Brandsdal, Bjørn Olav. Increased flexibility as a strategy for cold adaptation - A comparative molecular dynamics study of cold- and warm-active uracil DNA glycosylase. Journal of Biological Chemistry 2005; Volum 280. ISSN 0021-9258.
  • Leiros, Ingar; Moe, Elin; Smalås, Arne Oskar; McSweeney, Sean. Structure of the uracil-DNA N-glycosylase (UNG) from Deinococcus radiodurans. Acta Crystallographica Section D: Biological Crystallography 2005; Volum 61. ISSN 0907-4449.
  • Moe, Elin; Leiros, Ingar; Riise, Ellen Kristin; Olufsen, Magne; Lanes, Olav; Smalås, Arne Oskar; Willassen, Nils Peder. Optimisation of the surface electrostatics as a strategy for cold adaptation of uracil-DNA N-glycosylase (UNG) from Atlantic cod (Gadus morhua). Journal of Molecular Biology (JMB) 2004; Volum 343. ISSN 0022-2836.s 1221 - 1230.
  • Moe, Elin; Leiros, Ingar; Riise, Ellen Kristin; Olufsen, Magne; Lanes, Olav; Smalås, Arne Oskar; Willassen, Nils Peder. Optimisation of the surface electrostatics as a strategy for cold adaptation of uracil-DNA N-glycosylase (UNG) from Atlantic cod (Gadus morhua). Journal of Molecular Biology (JMB) 2004; Volum 343 (5). ISSN 0022-2836.s 1221 - 1230.
  • Leiros, Ingar; Moe, Elin; Lanes, Olav; Smalås, Arne Oskar; Willassen, Nils Peder. The crystal structure of uracil-DNA-glycosylase from Atlantic cod (Gadus morhua) reveals cold-adaptation fetures. Acta Crystallographica Section D: Biological Crystallography 2003; Volum 59. ISSN 0907-4449.s 1357 - 1365.
  • Leiros, Ingar; Moe, Elin; Lanes, Olav; Smalås, Arne Oskar; Willassen, Nils Peder. The crystal structure of uracil-DNA-glycosylase from Atlantic cod (Gadus morhua) reveals cold-adaptation fetures. Acta Crystallographica Section D: Biological Crystallography 2003; Volum 59. ISSN 0907-4449.s 1357 - 1365.
  • Pierechod, Marcin Miroslaw; De Santi, Concetta; Whitaker, Ragnhild; Moe, Elin; Antti, Henrik; Almqvist, Fredrik; Willassen, Nils Peder; Haugen, Peik. MicroMBT: Microbial communities and moving bed technology as tools for conversion of Marine Biomass. Marine Biotechnology ERA-NET Final Conference 2017-11-20 - 2017-11-21 2017.
  • De Santi, Concetta; Whitaker, Ragnhild; Moe, Elin; Almqvist, Fredrik; Willassen, Nils Peder; Haugen, Peik. MicroMBT: Microbial communities and moving bed technology as tools for conversion of marine biomass. BIOPROSP_17 2017-03-08 - 2017-03-10 2017.
  • De Santi, Concetta; Dragøy Whitaker, Ragnhild; Moe, Elin; Almqvist, Fredrik; Willassen, Nils Peder; Haugen, Peik. MicroMBT: Microbial communities and moving bed technology as tools for conversion of marine biomass. MaCuMBA: International marine microbiome conference 2016-06-27 - 2016-06-30 2016.
  • Moe, Elin; Leiros, Ingar; Hall, David; Sarre, Aili; Smalås, Arne O.; McSweeney, Sean; Timmins, Joanna. Base Excision Repair (BER) in Deinococcus radiodurans. Tomas Lindahl Conference on DNA repair 2015-06-17 - 2015-06-21 2015.
  • Fonseca, Davi de Miranda; Baar, Cecilie Christensen; Assefa, Netsanet Gizaw; Moe, Elin; Liabakk, Nina-Beate; Leiros, Hanna-Kirsti S.; Aas, Per Arne; Skorpen, Frank; Krokan, Hans Einar. Thermo-sensitive human UNG-mutants. XII Annual SBDR Program Project Workshop 2013-04-11 - 2013-04-13 2013.
  • Fonseca, Davi de Miranda; Moe, Elin; Liabakk, Nina-Beate; Baar, Cecilie Christensen; Skorpen, Frank; Krokan, Hans Einar. Thermo-sensitive mutants of UNG protein studied by structural experiments – Perspectives. The 3rd Erling Seeberg Symposium on DNA Repair 2012-06-19 - 2012-06-24 2012.
  • Pedersen, Hege Lynum; Niiranen, Laila; Lian, Kjersti; Sarre, Aili; Timmins, Joanna; McSweeney, Sean; Smalås, Arne O.; Moe, Elin. Protein interaction studies of BER proteins from the extreme radiation resistant bacterium Deinococcus radiodurans. Biocrys 2010 Fundamentals of Modern Methods of Biocrystallography 2010-06-09 - 2010-06-16 2010.
  • Niiranen, Laila; Pedersen, Hege Lynum; Lien, Kjersti; Sarre, Aili; Timmins, Joanna; McSweeney, S; Moe, Elin. Identification of novel interaction partners for DNA glycosylases in the extreme radiation resistant bacterium Deinococcus radiodurans. Erling Seeberg Symposium of DNA Repair 2009-05-20 - 2009-05-25 2009.
  • Assefa, Netsanet Gizaw; Moe, Elin; Smalås, Arne Oskar; Willassen, Nils Peder. Thermodynamic characterization of uracil-DNA N-glycosylase (UNG) from Atlantic cod (Gadus morhua). The FEBS Journal 2008; Volum 275. ISSN 1742-464X.s 188 - 188.
  • Leiros, Hanna-Kirsti S.; Pey, Angel L.; Innselset, M; Moe, Elin; Leiros, Ingar; Steen, Ida Helene; Martinez, Aurora. Crystal Structure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H reveals a monomeric cold active enzyme with local flexibility around the active site and high overall stability. Norwegian Biochemical Society (NBS) contact meeting 2008 2008-01-17 - 2008-01-20 2008.
  • Moe, Elin; Leiros, Ingar; Hall, David Richard; Smalås, Arne Oskar; McSweeney, Sean. Structure/function studies of Base Excision Repair (BER) enzymes from the extreme radiation resistant bacterium Deinococcus radiodurans. The Norwegian Biochemical Society 44th Contact meeting 2008-01-17 - 2008-01-20 2008.
  • Leiros, Ingar; Nabong, Marivi P.; Haugland, Gyri Teien; Ringvoll, Jeanette; Grøsvik, Kristin; Moe, Elin; Knævelsrud, Ingeborg; Reite, Karen; Andersen, Ole Andreas; Birkeland, Nils-Kåre; Klungland, Arne; Bjelland, Svein. Excision of 1-methyladenine and 3-methylcytosine from DNA by AfAlkA of Archaeoglobus fulgidus.. Erling Seeberg symposium on DNA repair, 2006-05-28 - 2006-06-02 2006.
  • Altermark, Bjørn; Helland, Ronny; Niiranen, Laila Mirja; Moe, Elin; Brandsdal, Bjørn Olav; Smalås, Arne Oskar; Willassen, Nils Peder. Optimum enzymatic activity of endonuclease I from Vibrio salmonicida and Vibrio cholerae correlateswith the bacterial growth habitat. BIOPROSP 2006 2006-10-11 - 2006-10-12 2006.
  • Moe, Elin; Timmins, Joanna; Hall, David Richard; Leiros, Ingar; McSweeney, Sean. Structure-function studies of DNA repair proteins from Deinococcus radiodurans. International Conference on Structural Genomics 2006 2006-10-22 - 2006-10-26 2006.
  • Ræder, Inger Lin Uttakleiv; Leiros, Ingar; Willassen, Nils Peder; Smalås, Arne Oskar; Moe, Elin. Uracil-DNA N-glycosylase (UNG) from the marine psychrophilic bacterium Vibrio salmonicida shows cold adapted features. BIOPROSP 2006 2006-10-11 - 2006-10-12 2006.
  • Leiros, Ingar; Nabong, Marivi P.; Haugland, GT; Ringvoll, Jeanette; Grøsvik, K; Grøsvik, K; Moe, Elin; Knævelsrud, I.; Knævelsrud, I.; Reite, Karen; Andersen, Ole A.; Birkeland, Nils-Kåre; Klungland, Arne; Bjelland, Svein; Bjelland, Svein. Excision of 1-methyladenine and 3-methylcytosine from DNA by AfAlkA of Archaeoglobus fulgidus. Erling Seeberg symposium on DNA repair 2006-05-30 - 2006-06-05 2006.
  • Lorentzen, marit sjo; Moe, Elin; Willassen, Nils Peder. Vibrio salmonicida catalase shows cold-adapted features. . The Norwegian Biochemical Society 41st Contact meeting 2005-01-13 - 2005-01-16 2005.
  • Moe, Elin; Leiros, Ingar; Smalås, Arne Oskar; McSweeney, Sean. Crystallisation and structure determination of uracil-DNA glycosylases from Deinococcus radiodurans and Vibrio salmonicida. A Collaboration between ESRF and NorStruct. The 3rd Norwegian User Meeting - Application of Synchrotron radiation 2005-03-10 - 2005-03-11 2005.
  • Moe, Elin; Leiros, Ingar; Smalås, Arne Oskar; McSweeney, Sean. Crystallisation and structure determination of a mismatch specific DNA glycosylase (MUG) from Deinococcus radiodurans. Functional genomics in the Nordic Countries 2005-09-05 - 2005.
  • Olufsen, Magne; Brandsdal, Bjørn Olav; Moe, Elin; Smalås, Arne Oskar. Increased Molecular Flexibility Plays a Central Role in Cold-Adaptation of Uracil DNA Glycosylase. BIOPROSP: symposium marine bioprospecting 2004-10-13 - 2004-10-14 2004.
  • Moe, Elin; Leiros, Ingar; Smalås, Arne Oskar; McSweeney, Sean. Structure determination of mismatch specific uracil-DNA glycosylase (MUG) from the radiation resistant bacteria Deinococcus radiodurans. VI European Protein science meeting 2004-04-30 - 2005-05-04 2004.
  • Altermark, Bjørn; Moe, Elin; Smalås, Arne Oskar; Willassen, Nils Peder. Are Lysines important for cold adaptation of Vibrio salmonicida nuclease?. BIOPROSP 2004 2004-10-13 - 2004-10-14 2004.
  • Moe, Elin; Leiros, Ingar; Smalås, Arne Oskar; Willassen, Nils Peder. Screening for cold adapted enzymes. BIOPROSP 2004 2004-10-13 - 2004-10-14 2004.
  • Olufsen, Magne; Moe, Elin; Brandsdal, Bjørn Olav; Willassen, Nils Peder; Smalås, Arne Oskar. STRUCTURAL AND ENERGETIC ASPECTS OF PROTEIN DNA-RECOGNITION. hurtigrute seminar 2003-12-01 - 2003-12-02 2003.
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    Teaching

    Kje-3603 Protein production technology