Personkort bilde
Photo: UiT
Professor

Hanna-Kirsti Schrøder Leiros

Professor, Biomolecular and Structural Chemistry, Norstruct Department of Chemistry
Norwegian flag icon Sami flag icon

Antibiotic resistance, β-lactams, Metallo-β-lactamases, Serine-β-lactamases, Enzymology, Fragment screening, Surface plasmon resonance (SPR), Biophysical characterization, Enzyme inhibitor design, Drug design, Protein crystallography.

I am part of the research group Structural Chemistry.

I am one group leader in Centre for New Antibacterial Strategies (CANS) at UiT.

Is groupleader in LacZymes.

 

Crystallization of proteins, structure determination, structure activity relationships (SAR), drug design, inhibitor.

Supervision of students.  

  • Frøhlich, Christopher; Gama, João Alves; Harms, Klaus; Hirvonen, Viivi H. A.; Lund, Bjarte Aarmo; van der Kamp, Marc W.; Johnsen, Pål Jarle; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Cryptic β-Lactamase Evolution Is Driven by Low β-Lactam Concentrations. mSphere 2021. ISSN 2379-5042.s doi: 10.1128/mSphere.00108-21.

  • Pan, Jolyn; Lian, Kjersti; Sarre, Aili; Leiros, Hanna-Kirsti Schrøder; Williamson, Adele Kim. Bacteriophage origin of some minimal ATP-dependent DNA ligases: a new structure from Burkholderia pseudomallei with striking similarity to Chlorella virus ligase. Scientific Reports 2021; Volum 11. ISSN 2045-2322.s 1 - 14.s doi: 10.1038/s41598-021-98155-w.

  • Lund, Bjarte Aarmo; Thomassen, Ane Molden; Carlsen, Trine Josefine Warg; Leiros, Hanna-Kirsti Schrøder. Biochemical and biophysical characterization of the OXA-48-like carbapenemase OXA-436. Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2021; Volum 77 (9). ISSN 1744-3091.s 312 - 318.s doi: 10.1107/S2053230X21008645.

  • Silk, Mitchell; Price, Jason R.; Mohanty, Biswaranjan; Leiros, Hanna-Kirsti Schrøder; Lund, Bjarte Aarmo; Thompson, Phillip E.; Chalmers, David. Side-Chain Interactions in d/l Peptide Nanotubes: Studies by Crystallography, NMR Spectroscopy and Molecular Dynamics. Chemistry - A European Journal 2021. ISSN 0947-6539.s doi: 10.1002/chem.202102106.

  • Samuelsen, Ørjan; Åstrand, Ove Alexander Høgmoen; Frøhlich, Christopher; Heikal, Adam; Skagseth, Susann; Carlsen, Trine Josefine Olsen; Leiros, Hanna-Kirsti S.; Bayer, Annette; Schnaars, Christian; Kildahl-Andersen, Geir; Lauksund, Silje; Finke, Sarah; Huber, Sandra; Gjøen, Tor; Andresen, Adriana Magalhaes Santos; Økstad, Ole Andreas; Rongved, Pål. ZN148 Is a Modular Synthetic Metallo-beta-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens In Vivo. (https://aac.asm.org/content/early/2020/03/11/AAC.02415-19.long) Antimicrobial Agents and Chemotherapy 2020; Volum 64 (6). ISSN 0066-4804.s doi: 10.1128/AAC.02415-19.

  • Frøhlich, Christopher; Sørum, Vidar; Huber, Sandra; Samuelsen, Ørjan; Berglund, Fanny; Kristiansson, Erik; Kotsakis, Stathis D.; Marathe, Nachiket; Larsson, DG Joakim; Leiros, Hanna-Kirsti Schrøder. Structural and biochemical characterization of the environmental MBLs MYO-1, ECV-1 and SHD-1. Journal of Antimicrobial Chemotherapy 2020; Volum 75. ISSN 0305-7453.s 2554 - 2563.s doi: 10.1093/jac/dkaa175.

  • Williamson, Adele Kim; Leiros, Hanna-Kirsti S.. Structural insight into DNA joining: from conserved mechanisms to diverse scaffolds. Nucleic Acids Research (NAR) 2020; Volum 48 (15). ISSN 0305-1048.s 8225 - 8242.s doi: 10.1093/nar/gkaa307.

  • Leiros, Hanna-Kirsti S.; Thomassen, Ane Molden; Samuelsen, Ørjan; Flach, Carl-Fredrik; Kotsakis, Stathis D.; Larsson, Joakim. Structural insights into the enhanced carbapenemase efficiency of OXA-655 compared to OXA-10. (Fulltekst: https://febs.onlinelibrary.wiley.com/doi/full/10.1002/2211-5463.12935 FEBS Open Bio 2020; Volum 10 (9). ISSN 2211-5463.s 1821 - 1832.s doi: 10.1002/2211-5463.12935.

  • Muhammad, Zeeshan; Skagseth, Susann; Boomgaren, Marc; Akhter, Sundus; Frøhlich, Christopher; Ismael, Aya; Christopeit, Tony; Bayer, Annette; Leiros, Hanna-Kirsti S.. Structural studies of triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-β-lactamases. Bioorganic & Medicinal Chemistry 2020; Volum 28 (15). ISSN 0968-0896.s doi: 10.1016/j.bmc.2020.115598.

  • Prandina, Anthony; Radix, Sylvie; Le Borgne, Marc; Jordheim, Lars Petter; Bousfiha, Zineb; Fröhlich, Christopher; Leiros, Hanna-Kirsti S.; Samuelsen, Ørjan; Frøvold, Espen; Rongved, Pål; Åstrand, Ove Alexander Høgmoen. Synthesis and biological evaluation of new dipicolylamine zinc chelators as metallo-β-lactamase inhibitors. Tetrahedron 2019; Volum 75 (11). ISSN 0040-4020.s 1525 - 1540.s doi: 10.1016/j.tet.2019.02.004.

  • Williamson, Adele Kim; Leiros, Hanna-Kirsti S.. Structural intermediates of a DNA-ligase complex illuminate the role of the catalytic metal ion and mechanism of phosphodiester bond formation. (https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkz596) (Fulltekst: https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkz596 Nucleic Acids Research (NAR) 2019; Volum 47 (14). ISSN 0305-1048.s 7147 - 7162.s doi: 10.1093/nar/gkz596.

  • Frøhlich, Christopher; Sørum, Vidar; Thomassen, Ane Molden; Johnsen, Pål Jarle; Leiros, Hanna-Kirsti S.; Samuelsen, Ørjan. OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs. mSphere 2019; Volum 4 (2). ISSN 2379-5042.s doi: 10.1128/mSphere.00024-19.

  • Ahkter, Sundus; Lund, Bjarte Aarmo; Ismael, Aya; Langer, Manuel; Isaksson, Johan; Christopeit, Tony; Leiros, Hanna-Kirsti S.; Bayer, Annette. A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design. European Journal of Medicinal Chemistry 2018; Volum 145. ISSN 0223-5234.s 634 - 648.s doi: 10.1016/j.ejmech.2017.12.085.

  • Williamson, Adele Kim; Grgic, Miriam; Leiros, Hanna-Kirsti S.. DNA binding with a minimal scaffold: structure-function analysis of Lig E DNA ligases. Nucleic Acids Research (NAR) 2018; Volum 46 (16). ISSN 0305-1048.s 8616 - 8629.s doi: 10.1093/nar/gky622.

  • Lund, Bjarte Aarmo; Thomassen, Ane Molden; Nesheim, Birgit Helene Berg; Carlsen, Trine Josefine Olsen; Isaksson, Johan; Christopeit, Tony; Leiros, Hanna-Kirsti S.. The biological assembly of OXA‐48 reveals a dimer interface with high charge complementarity and very high affinity. The FEBS Journal 2018; Volum 285 (22). ISSN 1742-464X.s 4214 - 4228.s doi: 10.1111/febs.14643.

  • Samuelsen, Ørjan; Hansen, Frank; Aasnæs, Bettina; Hasman, Henrik; Lund, Bjarte Aarmo; Leiros, Hanna-Kirsti S.; Lilje, Berit; James Peter, Jessin Janice; Jakobsen, Lotte; Littauer, Pia; Søes, Lillian M; Holzknecht, Barbara J.; Andersen, Leif P; Stegger, Marc; Andersen, Paal S.; Hammerum, Anette M.. Dissemination and Characteristics of a Novel Plasmid-Encoded Carbapenem-Hydrolyzing Class D β-Lactamase, OXA-436, Found in Isolates from Four Patients at Six Different Hospitals in Denmark. Antimicrobial Agents and Chemotherapy 2018; Volum 62 (1). ISSN 0066-4804.s doi: 10.1128/AAC.01260-17.

  • Marcoccia, Francesca; Leiros, Hanna-Kirsti S.; Aschi, Massimiliano; Amicosante, Gianfranco; Perilli, Mariagrazia. Exploring the role of L209 residue in the active site of NDM-1 a metallo-β-lactamase. PLOS ONE 2018; Volum 13 (1). ISSN 1932-6203.s doi: 10.1371/journal.pone.0189686.

  • Lund, Bjarte Aarmo; Thomassen, Ane Molden; Carlsen, Trine Josefine Olsen; Leiros, Hanna-Kirsti S.. Structure, activity and thermostability investigations of OXA-163, OXA-181 and OXA-245 using biochemical analysis, crystal structures and differential scanning calorimetry analysis. Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2017; Volum 73 (10). ISSN 1744-3091.s 579 - 587.s doi: 10.1107/S2053230X17013838.

  • Skagseth, Susann; Christopeit, Tony; Akhter, Sundus; Bayer, Annette; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Structural insights into TMB-1 and the role of residues 119 and 228 in substrate and inhibitor binding. Antimicrobial Agents and Chemotherapy 2017; Volum 61:e02602-16 (8). ISSN 0066-4804.s 1 - 19.s doi: 10.1128/AAC.02602-16.

  • Skagseth, Susann; Akhter, Sundus; Paulsen, Marianne H.; Zeeshan, Muhammad; Lauksund, Silje; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.; Bayer, Annette. Metallo-β-lactamase inhibitors by bioisosteric replacement: preparation, activity and binding. European Journal of Medicinal Chemistry 2017; Volum 135. ISSN 0223-5234.s 159 - 173.s doi: 10.1016/j.ejmech.2017.04.035.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Bjerga, Gro Elin Kjæreng; Spencer, James; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Role of residues W228 and Y233 in the structure and activity of metallo-β-lactamase GIM-1. Antimicrobial Agents and Chemotherapy 2016; Volum 60 (2). ISSN 0066-4804.s 990 - 1002.s doi: 10.1128/AAC.02017-15.

  • Christopeit, Tony; Yang, Ke-Wu; Yang, Shao-Kang; Leiros, Hanna-Kirsti S.. The structure of the metallo-β-lactamase VIM-2 in complex with a triazolylthioacetamide inhibitor. Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2016; Volum 72 (11). ISSN 1744-3091.s 813 - 819.s doi: 10.1107/S2053230X16016113.

  • Christopeit, Tony; Leiros, Hanna-Kirsti S.. Fragment-based discovery of inhibitor scaffolds targeting the metallo-β-lactamases NDM-1 and VIM-2. Bioorganic & Medicinal Chemistry Letters 2016; Volum 26 (8). ISSN 0960-894X.s 1973 - 1977.s doi: 10.1016/j.bmcl.2016.03.004.

  • De Santi, Concetta; Leiros, Hanna-Kirsti S.; Di Scala, Alessia; de Pascale, Donatella; Altermark, Bjørn; Willassen, Nils Peder. Biochemical characterization and structural analysis of a new cold-active and salt-tolerant esterase from the marine bacterium Thalassospira sp.. Extremophiles 2016; Volum 20 (3). ISSN 1431-0651.s 323 - 336.s doi: 10.1007/s00792-016-0824-z.

  • Christopeit, Tony; Albert, Anastasia; Leiros, Hanna-Kirsti S.. Discovery of a novel covalent non-β-lactam inhibitor of the metallo-β-lactamase NDM-1. Bioorganic & Medicinal Chemistry 2016; Volum 24 (13). ISSN 0968-0896.s 2947 - 2953.s doi: 10.1016/j.bmc.2016.04.064.

  • Lund, Bjarte Aarmo; Christopeit, Tony; Guttormsen, Yngve; Bayer, Annette; Leiros, Hanna-Kirsti S.. Screening and Design of Inhibitor Scaffolds for the Antibiotic Resistance Oxacillinase-48 (OXA-48) through Surface Plasmon Resonance Screening. Journal of Medicinal Chemistry 2016; Volum 59 (11). ISSN 0022-2623.s 5542 - 5554.s doi: 10.1021/acs.jmedchem.6b00660.

  • Leiros, Hanna-Kirsti S.; Edvardsen, Kine Susann Waade; Bjerga, Gro Elin Kjæreng; Samuelsen, Ørjan. Structural and biochemical characterization of VIM-26 shows that Leu224 has implications for the substrate specificity of VIM metallo-β-lactamases. The FEBS Journal 2015; Volum 282 (6). ISSN 1742-464X.s 1031 - 1042.s doi: 10.1111/febs.13200.

  • Hansen, Hilde; Johansen, Jostein a; Leiros, Hanna-Kirsti S.; Purohit, Amit Anand; Willassen, Nils Peder; Bjelland, Ane Mohn; Kellermann, Stefanie J.. The autoinducer synthases LuxI and AinS are responsible for temperature-dependent AHL production in the fish pathogen Aliivibrio salmonicida. BMC Microbiology 2015. ISSN 1471-2180.s doi: 10.1186/s12866-015-0402-z.

  • Christopeit, Tony; Carlsen, Trine Josefine Olsen; Helland, Ronny; Leiros, Hanna-Kirsti S.. Discovery of novel inhibitor scaffolds against the metallo-β-lactamase VIM-2 by surface plasmon resonance (SPR) based fragment screening. Journal of Medicinal Chemistry 2015; Volum 58 (21). ISSN 0022-2623.s 8671 - 8682.s doi: 10.1021/acs.jmedchem.5b01289.

  • Aubi Catevilla, Oscar; Flydal, Marte Innselset; Zheng, Huaixin; Skjærven, Lars; Rekand, Illimar; Leiros, Hanna-Kirsti S.; Haug, Bengt Erik; Cianciotto, Nicholas P.; Martinez, Aurora; Underhaug, Jarl. Discovery of a Specific Inhibitor of Pyomelanin Synthesis in Legionella pneumophila. Journal of Medicinal Chemistry 2015; Volum 58 (21). ISSN 0022-2623.s 8402 - 8412.s doi: 10.1021/acs.jmedchem.5b01589.

  • Hansen, Hilde; Purohit, Amit Anand; Leiros, Hanna-Kirsti S.; Johansen, Jostein; Kellermann, Stefanie J.; Bjelland, Ane Mohn; Willassen, Nils Peder. The autoinducer synthases LuxI and AinS are responsible for temperature-dependent AHL production in the fish pathogen Aliivibrio salmonicida. BMC Microbiology 2015; Volum 15 (69). ISSN 1471-2180.s doi: 10.1186/s12866-015-0402-z.

  • Lian, Kjersti; Leiros, Hanna-Kirsti S.; Moe, Elin. MutT from the fish pathogen Aliivibrio salmonicida is a cold-active nucleotide-pool sanitization enzyme with unexpectedly high thermostability. FEBS Open Bio 2015; Volum 5. ISSN 2211-5463.s 107 - 116.s doi: 10.1016/j.fob.2015.01.006.

  • Williamson, Adele Kim; Rothweiler, Ulli; Leiros, Hanna-Kirsti S.. Enzyme-adenylate structure of a bacterial ATP-dependent DNA ligase with a minimized DNA-binding surface. Acta Crystallographica Section D: Biological Crystallography 2014; Volum 70 (11). ISSN 0907-4449.s 3043 - 3056.s doi: 10.1107/S1399004714021099.

  • Assefa, Netsanet Gizaw; Niiranen, Laila; Johnson, Kenneth; Leiros, Hanna-Kirsti S.; Smalås, Arne O.; Willassen, Nils Peder; Moe, Elin. Structural and biophysical analysis of interactions between cod and human uracil-DNA N-glycosylase (UNG) and UNG inhibitor (Ugi). Acta Crystallographica Section D: Biological Crystallography 2014; Volum 70 (8). ISSN 0907-4449.s 2093 - 2100.s doi: 10.1107/S1399004714011699.

  • Leiros, Hanna-Kirsti S.; Skagseth, Susann; Edvardsen, Kine Susann Waade; Lorentzen, Marit Sjo; Bjerga, Gro Elin Kjæreng; Leiros, Ingar; Samuelsen, Ørjan. His224 alters the R2 drug binding site and Phe218 influences the catalytic efficiency of the metallo-β-lactamase VIM-7. Antimicrobial Agents and Chemotherapy 2014; Volum 58 (8). ISSN 0066-4804.s 4826 - 4836.s doi: 10.1128/AAC.02735-13.

  • Lund, Bjarte Aarmo; Leiros, Hanna-Kirsti S.; Bjerga, Gro Elin Kjæreng. A high-throughput, restriction-free cloning and screening strategy based on ccdB-gene replacement. Microbial Cell Factories 2014; Volum 13:38. ISSN 1475-2859.s doi: 10.1186/1475-2859-13-38.

  • Sivertsen, Annfrid; Isaksson, Johan; Leiros, Hanna-Kirsti S.; Svenson, Johan; Svendsen, John Sigurd; Brandsdal, Bjørn Olav. Synthetic cationic antimicrobial peptides bind with their hydrophobic parts to drug site II of human serum albumin. BMC Structural Biology 2014; Volum 14:4. ISSN 1472-6807.s doi: 10.1186/1472-6807-14-4.

  • Fu, Juan; Leiros, Hanna-Kirsti S.; De pascale, Donatella; Johnson, Kenneth; Blencke, Hans-Matti; Landfald, Bjarne. Functional and structural studies of a novel cold-adapted esterase from an Arctic intertidal metagenomic library. Applied Microbiology and Biotechnology 2013; Volum 97. ISSN 0175-7598.s 3965 - 3978.s doi: 10.1007/s00253-012-4276-9.

  • Leiros, Hanna-Kirsti S.; Flydal, Marte Innselset; Martinez, Aurora. Structural and thermodynamic insight into phenylalanine hydroxylase from the human pathogen Legionella pneumophila. FEBS Open Bio 2013; Volum 3. ISSN 2211-5463.s 370 - 378.s doi: 10.1016/j.fob.2013.08.006.

  • Purohit, Amit Anand; Johansen, Jostein a; Hansen, Hilde; Leiros, Hanna-Kirsti S.; Kashulin, Alexander; Karlsen, Christian; Smalås, Arne O.; Haugen, Peik; Willassen, Nils Peder. Presence of acyl-homoserine lactones in 57 members of the Vibrionaceae family. Journal of Applied Microbiology 2013; Volum 115 (3). ISSN 1364-5072.s 835 - 847.s doi: 10.1111/jam.12264.

  • Borra, Naga Pardha Saradhi; Samuelsen, Ørjan; Spencer, James; Walsh, Timothy R.; Lorentzen, marit sjo; Leiros, Hanna-Kirsti S.. Crystal Structures of Pseudomonas aeruginosa GIM-1: Active-Site Plasticity in Metallo-beta-Lactamases. Antimicrobial Agents and Chemotherapy 2013; Volum 57 (2). ISSN 0066-4804.s 848 - 854.s doi: 10.1128/AAC.02227-12.

  • Leiros, Hanna-Kirsti S.; Borra, Naga Pardha Saradhi; Brandsdal, Bjørn Olav; Edvardsen, Kine Susann Waade; Spencer, James; Walsh, Timothy R.; Samuelsen, Ørjan. Crystal Structure of the Mobile Metallo-beta-Lactamase AIM-1 from Pseudomonas aeruginosa: Insights into Antibiotic Binding and the Role of Gln157. Antimicrobial Agents and Chemotherapy 2012; Volum 56 (8). ISSN 0066-4804.s 4341 - 4353.s doi: 10.1128/AAC.00448-12.

  • Leiros, Hanna-Kirsti S.; Fedøy, Anita-Elin; Leiros, Ingar; Steen, Ida Helene. The complex structures of isocitrate dehydrogenase from Clostridium thermocellum and Desulfotalea psychrophila support a new active site locking mechanism. FEBS Open Bio 2012. ISSN 2211-5463.s doi: 10.1016/j.fob.2012.06.003.

  • Saradhi, Pardha; Leiros, Hanna-Kirsti S.; Ahmad, Rafi; Spencer, James; Leiros, Ingar; Walsh, Timothy R.; Sundsfjord, Arnfinn; Samuelsen, Ørjan. Structural and Computational Investigations of VIM-7: Insights into the Substrate Specificity of VIM Metallo-beta-Lactamases. Journal of Molecular Biology (JMB) 2011; Volum 411 (1). ISSN 0022-2836.s 174 - 189.s doi: 10.1016/j.jmb.2011.05.035.

  • Pedersen, hege lynum; Ahmad, Rafi; Riise, EK; Leiros, Hanna-Kirsti S.; Hauglid, Stefan; Espelid, S; Brandsdal, Bjørn Olav; Leiros, Ingar; Willassen, Nils P; Haugen, Peik. Experimental and computational characterization of the ferric uptake regulator from Aliivibrio salmonicida (Vibrio salmonicida). Journal of Microbiology 2010; Volum 48 (2). ISSN 1225-8873.s 174 - 183.s doi: 10.1007/s12275-010-9199-5.

  • Leiros, Hanna-Kirsti S.; Brandsdal, Bjørn Olav; McSweeney, Seán M.. Biophysical characterization and mutational analysis of the antibiotic resistance protein NimA from Deinococcus radiodurans. Biochimica et Biophysica Acta - Proteins and Proteomics 2010; Volum 1804 (4). ISSN 1570-9639.s 967 - 976.s doi: 10.1016/j.bbapap.2010.01.010.

  • Niiranen, Laila Mirja; Altermark, Bjørn; Brandsdal, Bjørn Olav; Leiros, Hanna-Kirsti S.; Helland, Ronny; Smalås, Arne Oskar; Willassen, Nils Peder. Effects of salt on the kinetics and thermodynamic stability of endonuclease I from Vibrio salmonicida and Vibrio cholerae. The FEBS Journal 2008; Volum 275. ISSN 1742-464X.s 1593 - 1605.s doi: 10.1111/j.1742-4658.2008.06317.x.

  • Leiros, Hanna-Kirsti S.; Tedesco, Consiglia; McSweeney, Seán M.. High-resolution structure of the antibiotic resistance protein NimA from Deinococcus radiodurans. Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2008; Volum 64. ISSN 1744-3091.s 442 - 447.s doi: 10.1107/S1744309108009901.

  • Wang, Ellen; Koutsioulis, D.; Leiros, Hanna-Kirsti S.; Andersen, Ole Andreas; Bouriotis, V.; Hough, Edward; Heikinheimo, Pirkko a. Crystal structure of alkaline phosphatase from the Antarctic bacterium TAB5. Journal of Molecular Biology (JMB) 2007; Volum 366. ISSN 0022-2836.s doi: 10.1016/j.jmb.2006.11.079.

  • Riise, Ellen Kristin; Lorentzen, marit sjo; Helland, Ronny; Smalås, Arne Oskar; Leiros, Hanna-Kirsti S.; Willassen, Nils Peder. The first structure of a cold-active catalase from Vibrio salmonicida at 1.96 angstrom reveals structural aspects of cold adaptation. Acta Crystallographica Section D: Biological Crystallography 2007; Volum 63. ISSN 0907-4449.s 135 - 148.s doi: 10.1107/S0907444906043812.

  • Leiros, Hanna-Kirsti S.; Pey, AL; Innselset, M; Innselset, Marte; Moe, Elin; Leiros, Ingar; Steen, IH; Martinez, A. Structure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H, a monomeric cold active enzyme with local flexibility around the active site and high overall stability. Journal of Biological Chemistry 2007; Volum 282. ISSN 0021-9258.s doi: 10.1074/jbc.M610174200.

  • Fedøy, Anita-Elin; Fedoy, AE; Yang, Nannan; Martinez, A; Leiros, Hanna-Kirsti S.; Steen, IH. Structural and functional properties of isocitrate dehydrogenase from the psychrophilic bacterium Desulfotalea psychrophila reveal a cold-active enzyme with an unusual high thermal stability. Journal of Molecular Biology (JMB) 2007; Volum 372. ISSN 0022-2836.s 130 - 149.s doi: 10.1016/j.jmb.2007.06.040.

  • Leiros, Hanna-Kirsti S.; McSweeney, Sean. The crystal structure of DR2241 from Deinococcus radiodurans at 1.9 Å resolution reveals a multi-domain protein with structural similarity to chelatases but also with two additional novel domains. Journal of Structural Biology 2007; Volum 159. ISSN 1047-8477.s 92 - 102.

  • Leiros, Hanna-Kirsti S.; Timmins, J.; Ravelli, R.B.; McSweeney, Seán M.. Is radiation damage dependent on the dose rate used during macromolecular crystallography data collection?. Acta Crystallographica Section D: Biological Crystallography 2006; Volum 62. ISSN 0907-4449.s 125 - 132.

  • Timmins, Joanna; Leiros, Hanna-Kirsti S.; Leonard, Gordon; Leiros, Ingar; McSweeney, Sean. Crystal structure of maltooligosyltrehalose trehalohydrolase from Deinococcus radiodurans in complex with disaccharides. Journal of Molecular Biology (JMB) 2005; Volum 347 (5). ISSN 0022-2836.s 949 - 963.

  • Weik, M.; Schreurs, A.M.; Leiros, Hanna-Kirsti S.; Zaccai, G.; Ravelli, R.B.; Gros, P.. Supercooled liquid-like solvent in trypsin crystals: implications for crystal annealing and temperature-controlled X-ray radiation damage studies. Journal of Synchrotron Radiation 2005; Volum 12 (3). ISSN 0909-0495.s 310 - 317.

  • Leiros, Hanna-Kirsti S.; Kozielski-Stuhrmann, S.; Kapp, U; Terradot, L; Leonard, G.A; McSweeney, Seán M.. Structural basis of 5-nitroimidazole antibiotic resistance: The crystal structure of NimA from Deinococcus radiodurans. Journal of Biological Chemistry 2004; Volum 279 (53). ISSN 0021-9258.s 55840 - 55849.

  • Leiros, Hanna-Kirsti S.; Leiros, Hanna Kirsti Schrøder; Brandsdal, Bjørn Olav; Andersen, Ole Andreas; Os, vibeke; Leiros, Ingar; Leiros, Ingar; Helland, Ronny; Otlewski, J.; Otlewski, Jacek; Willassen, Nils Peder; Smalås, Arne Oskar. Trypsin specificity as elucidated by LIE calculations, X-ray structures, and association constant measurements. Protein Science 2004; Volum 13. ISSN 0961-8368.s 1056 - 1070.

  • Ravelli, R.G.B.; Leiros, Hanna-Kirsti S.; Pan, B.; Caffrey, M.; McSweeney, Seán M.. Specific radiation damage can be used to solve macromolecular crystal structures. Structure 2003; Volum 11 (2). ISSN 0969-2126.s 217 - 214.

  • Heikinheimo, Pirkko a; Helland, Ronny; Leiros, Hanna-Kirsti S.; Leiros, Ingar; Karlsen, Solveig; Evjen, gry; Ravelli, Raimond; Schoehn, Guy; Ruigrok, Rob; McSweeney, Sean; Hough, Edward. The structure of the bovine lysosomal a-mannosidase suggests a novel mechanism for low pH activation. Journal of Molecular Biology (JMB) 2003; Volum 327 (3). ISSN 0022-2836.s 631 - 644.

  • Leiros, Hanna-Kirsti S.; McSweeney, Seán M.; Smalås, Arne Oskar. Atomic resolution structures of trypsin provide insight into structural radiation damage. Acta Crystallographica Section D: Biological Crystallography 2001; Volum 57. ISSN 0907-4449.s 488 - 497.

  • Smalås, Arne Oskar; Leiros, Hanna-Kirsti S.; Os, V.; Willassen, Nils Peder. Cold adapted Enzymes. Biotechnology Annual Review 2000; Volum 6. ISSN 1387-2656.s 1 - 57.

  • Gorfe, A.A.; Brandsdal, Bjørn Olav; Leiros, Hanna-Kirsti S.; Helland, Ronny; Smalås, Arne Oskar. Electrostatics of mesophilic and psychrophilic trypsin isoenzymes: qualitative evaluation of electrostatic differences at the substrate binding site. Proteins: Structure, Function, and Bioinformatics 2000; Volum 40. ISSN 0887-3585.s 207 - 217.

  • Leiros, Hanna-Kirsti S.; Willassen, Nils Peder; Smalås, Arne Oskar. Residue determinants and sequence analysis of cold-adapted trypsins. Extremophiles 1999; Volum 3. ISSN 1431-0651.s 205 - 219.

  • Leiros, Hanna-Kirsti S.; Willassen, Nils Peder; Smalås, Arne Oskar. Structural comparison of psychrophilic and mesophilic trypsins. Elucidating the molecular basis of cold-adaptation. European Journal of Biochemistry (EJB) 1999; Volum 267. ISSN 0014-2956.s 1039 - 1049.

  • Steien, Tore Rasmussen; Leiros, Hanna-Kirsti S.. Kjemikerne prøver å stoppe kjeften på antibiotikadreperne. (https://www.farmatid.no/artikler/prover-stoppe-kjeften-pa-antibiotikadreperne) Norsk Farmaceutisk Tidsskrift 2020. ISSN 0029-1935.

  • Leiros, Hanna-Kirsti S.. Vil ha 40 prosent kvinner i toppstillingar. (http://kifinfo.no/nb/2020/09/vil-ha-40-prosent-kvinner-i-toppstillingar) 2020.

  • Leiros, Hanna-Kirsti S.. På Labben med Forskningsdagene 2020. På Institutt for kjemi, UiT. "Proteiner som gjør at bakterier er resistente mot antibiotika".. (https://www.youtube.com/watch?v=gCIVGW5FCKg) 2020.

  • Frøhlich, Christopher; Leiros, Hanna-Kirsti S.; Miton, Charlotte; Tokuriki, Nobuhiko. Ceftazidime drives the evolution of the carbapenemase OXA-48. GW4 Multidisciplinary Approaches to AMR: From Bench to Bedside and Beyond 2020 2020-12-01 - 2020-12-03 2020.

  • Leiros, Hanna-Kirsti S.. Fighting the antibiotic resistant serine-beta-lactamase OXA-48 - through altered ceftazidime activity or new inhibitors?. Gjesteforelesning ved Biomedical Sciences, University of Bristol 2019-12-04 - 2019-12-04 2019.

  • Leiros, Hanna-Kirsti S.. Antibiotika resistens er et globalt problem. Nye inhibitorer og velkjente antibiotika, kan de sammen bli ny behandlings metode?. NT-Fak administrasjonen 2019-03-19 - 2019-03-19 2019.

  • Leiros, Hanna-Kirsti S.. Inhibitor potential of Serine- and Metallo-beta-lactamase inhibitors, and Biochemical and Biophysical characterization. AROHP 2019 workshop on Antimicrobial resistance (AMR), March 2019 (https://en.uit.no/prosjekter/prosjektsub?p_document_id=467132&sub_id=625781) 2019-03-05 - 2019-03-11 2019.

  • Frøhlich, Christopher; Leiros, Hanna-Kirsti S.; Johnsen, Pål Jarle; Samuelsen, Ørjan. Sub-inhibitory concentrations of ceftazidime drive evolution of the OXA-48 carbapenemase. ECCMID 2019 2019-04-13 - 2019-04-16 2019.

  • Frøhlich, Christopher; Sørum, Vidar; Leiros, Hanna-Kirsti S.; Johnsen, Pål Jarle; Samuelsen, Ørjan. Development of OXA-48 mediated ceftazidme-avibactam resistance is associated with an evolutionary trade-off. ECCMID 2018-04-24 - 2018.

  • Williamson, Adele Kim; Hjerde, Erik; Sarre, Aili; Leiros, Ingar; Berg, Kristel; Leiros, Hanna-Kirsti S.. Discovery and design of novel DNA ligases for biotechnology. 6th International Conference on Novel Enzymes 2018 2018-10-09 - 2018-10-12 2018.

  • Bayer, Annette; Leiros, Hanna-Kirsti S.; Akhter, Sundus; Lund, Bjarte Aarmo; Christopeit, Tony; Ismael, Aya. Towards Antibiotic Resistance Breakers: Fragment-Based Design of OXA- 48 Inhibitors. FRAGMENTS2017 2017-03-05 - 2017-03-07 2017.

  • Leiros, Hanna-Kirsti S.. Enzymer involvert i antibiotika resistens. (https://www.biokjemisk.no/nbs-nytt/se-nbs-nytt-online/) NBS-nytt 2017; Volum 4. ISSN 0801-3535.s 34 - 35.

  • Os, Vibeke; Skagseth, Susann; Leiros, Hanna-Kirsti S.. "Superbugs" skal ikke lengre få herje i fred, Vil gjenreise effekten av antibiotika.. (Fulltekst: https://uit.no/nyheter/artikkel?p_document_id=514293&p_dim=88131 2017.

  • Skagseth, Susann; Leiros, Hanna-Kirsti S.. Forskere vil gjenreise effekten av antibiotika. https://forskning.no/kortnytt/forskere-vil-gjenreise-effekten-av-antibiotika. (https://forskning.no/kortnytt/forskere-vil-gjenreise-effekten-av-antibiotika) 2017.

  • Leiros, Hanna-Kirsti S.. Kampen. Den livsfarlige resistensen.. (Fulltekst: https://www.youtube.com/watch?v=NT1ksFkPOHs&feature=youtu.be 2017.

  • Leiros, Hanna-Kirsti S.. Inhibitors can help fighting antibiotic resistance bacteria, but how do we find the best inhibitors?. 53rd NBS contact meeting 2017-01-19 - 2017-01-22 2017.

  • Leiros, Hanna-Kirsti S.. Aiming for inhibitors towards beta-lactamases involved in antibiotic resistance, but starting with fragment screening. How is the progress?. Nordic Chemical Biology Network, Workshop in fragment screening. 2017-06-01 - 2017-06-01 2017.

  • Leiros, Hanna-Kirsti S.. Fragment screening used successfully for detecting OXA, VIM or NDM inhibitors. 13th Beta-Lactamase Meeting 2017-06-16 - 2017.

  • Williamson, Adele Kim; Hjerde, Erik; Leiros, Hanna-Kirsti S.; Lian, Kjersti; Ramirez, Miguel A.; Patrick, Wayne M.. Beyond T4: discovery and design of DNA ligases for use in biotechnological applications. Cryo-EM Symposium 2017-07-06 - 2017-07-07 2017.

  • Lund, Bjarte Aarmo; Leiros, Hanna-Kirsti S.; Bayer, Annette; Samuelsen, Ørjan; Christopeit, Tony. The OXA-class of β-lactamases. A structural view on antibiotic resistance. 2017 ISBN 978-82-8236-269-6.

  • Leiros, Hanna-Kirsti S.. Searching for inhibitors towards beta-lactamases involved in antibiotic resistance, starting with fragment screening. Can we reach into the clinic?. Seminar serie 2016-10-05 - 2016.

  • Williamson, Adele Kim; Kahlke, Tim; Hjerde, Erik; Leiros, Hanna-Kirsti S.. Structural and Bioinformatic Studies of the ‘Lig E’Group of Bacterial ATP-Dependent DNA Ligases. The 52nd NBS contact meeting 2016-01-21 - 2016-01-24 2016.

  • Williamson, Adele Kim; Leiros, Hanna-Kirsti S.; Hjerde, Erik; Lian, Kjersti; Ramirez, Miguel A.; Patrick, Wayne M.. Beyond T4: discovery and design of DNA ligases for use in biotechnological applications. EMBO Conference Series: The biochemistry and chemistry of biocatalysis: From understanding to design 2016-06-12 - 2016-06-15 2016.

  • Lund, Bjarte Aarmo; Akhter, Sundus; Guttormsen, Yngve; Christopeit, Tony; Isaksson, Johan; Bayer, Annette; Leiros, Hanna-Kirsti S.. Structure-guided drug design for the antibiotic resistance enzyme OXA-48. 7th Annual BioStruct Conference 2016-08-25 - 2016-08-28 2016.

  • Ahkter, Sundus; Lund, Bjarte Aarmo; Guttormsen, Yngve; Christopeit, Tony; Bayer, Annette; Leiros, Hanna-Kirsti S.. Addressing Antibiotic Resistance: Fragment-Based Design of OXA-48 Inhibitors. 31. Organisk Kjemisk Vintermøte 2016-01-07 - 2016-01-10 2016.

  • Lund, Bjarte Aarmo; Christopeit, Tony; Ahkter, Sundus; Guttormsen, Yngve; Isaksson, Johan; Bayer, Annette; Leiros, Hanna-Kirsti S.. Structure-Guided Drug Design for the Antibiotic Resistance Enzyme OXA-48. ASM Microbe 2016 2016-06-16 - 2016-06-20 2016.

  • Christopeit, Tony; Carlsen, Trine Josefine Olsen; Albert, Anastasia; Skagseth, Susann; Leiros, Hanna-Kirsti S.. Discovery of a Novel Covalent Inhibitor of the Metallo-beta-lactamase NDM-1. 52nd Norwegian Biochemical Society Contact Meeting, Tromsø 2016-01-21 - 2016-01-24 2016.

  • Lund, Bjarte Aarmo; Ahkter, Sundus; Guttormsen, Yngve; Christopeit, Tony; Bayer, Annette; Leiros, Hanna-Kirsti S.. Structure-guided drug design for the antibiotic resistance enzyme OXA-48. 52nd Norwegian Biochemical Society Contact Meeting, Tromsø 2016-01-21 - 2016-01-24 2016.

  • Skagseth, Susann; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. The impact of residues 119 and 228 in the Tripoli metallo-beta-lactamase TMB-1 involved in resistance to beta-lactam antibiotics. 52nd Norwegian Biochemical Society Contact Meeting, Tromsø 2016-01-21 - 2016-01-24 2016.

  • Nesheim, Birgit Berg; Carlsen, Trine Josefine Olsen; Lund, Bjarte Aarmo; Leiros, Hanna-Kirsti S.. Residue profiling of antibiotic resistant OXA-beta-lactamases through mutagenesis, enzyme kinetics and 3D structures. 52nd Norwegian Biochemical Society Contact Meeting, Tromsø 2016-01-21 - 2016-01-24 2016.

  • Åstrand, Ove Alexander Høgmoen; Leiros, Hanna-Kirsti S.; Samuelsen, Ørjan; Bayer, Annette; Rongved, Pål. Overcoming b-lactam resistance - A potential solution to multi-drug resistant bacteria. Organisk Kjemisk Vintermøte 2015 2015-01-08 - 2015-01-11 2015.

  • Leiros, Hanna-Kirsti S.. Enzymatic characterization and structural insight into Metallo-beta-Lactamases (MBL) and Serine-beta-lactamases (SBL). Pre-Centre for Infection Prevention and Treatment (preCIPT) 2015-10-14 - 2015.

  • Leiros, Hanna-Kirsti S.. Fighting Antibiotic Resistance Through Inhibitor Screening – Can Crystal Structures Help Out?. Norwegian Biochemical Society (NBS), avd Ås, Seminar serie 2015-06-23 - 2015-06-23 2015.

  • Leiros, Hanna-Kirsti S.. Can We Overcome beat-Lactamase-mediated Antibiotic Resistance Through Inhibitor Screening?. Norwegian Biochemical Society Contact Meeting 2015-02-09 - 2015-02-13 2015.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Akhter, Sundus; Zeeshan, Muhammad; Åstrand, Ove Alexander Høgmoen; Bayer, Annette; Rongved, Pål; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. The fight against metallo-beta-lactamases and antibiotic resistance. Annual BioStruct Conference, The National graduate school in structural biology 2015-09-27 - 2015-09-30 2015.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Akhter, Sundus; Zeeshan, Muhammad; Åstrand, Ove Alexander Høgmoen; Bayer, Annette; Rongved, Pål; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. The fight against metallo-beta-lactamases and antibiotic resistance. BioStruct Open Day 2015-03-20 - 2015-03-20 2015.

  • Christopeit, Tony; Carlsen, Trine Josefine Olsen; Skagseth, Susann; Lund, Bjarte Aarmo; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Using fragment screening to identify novel starting points for potent inhibitors of metallo-beta-lactamase VIM-2. Fragments 2015: Fifth RSC-BMCS Fragment-based Drug Discovery meeting 2015-03-22 - 2015-03-22 2015.

  • Christopeit, Tony; Lund, Bjarte Aarmo; Carlsen, Trine Josefine Olsen; Skagseth, Susann; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Using Fragment Screening to Identify Novel Starting Points for Potent Carbapenemase Inhibitors. Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC) 2015-09-17 - 2015-09-21 2015.

  • Lund, Bjarte Aarmo; Guttormsen, Yngve; Christopeit, Tony; Bayer, Annette; Leiros, Hanna-Kirsti S.. Design of OXA-48 class D beta-lactamase inhibitors by fragment-based drug design. Annual BioStruct Conference, The National graduate school in structural biology 2015-08-27 - 2015-08-30 2015.

  • Lund, Bjarte Aarmo; Christopeit, Tony; Bjerga, Gro Elin Kjæreng; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Combating antibiotic resistance: Fragment-based screening for class D β-lactamase inhibitors. BioStruct OpenDay 2015-03-20 - 2015-03-20 2015.

  • Lund, Bjarte Aarmo; Christopeit, Tony; Bjerga, Gro Elin Kjæreng; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Combating antibiotic resistance: Fragment-based screening for class D β-lactamase inhibitors.. Cambridge Healthtech Institute’s (CHI) Drug Discovery Chemistry conference. 2015-04-22 - 2015-04-23 2015.

  • Lund, Bjarte Aarmo; Bjerga, Gro Elin Kjæreng; Christopeit, Tony; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Fragment-based screening for class D β-lactamase inhibitors. Combating antibiotic resistance. 51st Norwegian Biochemical Society Contact Meeting, Svalbard 2015-02-09 - 2015-02-13 2015.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Christopeit, Tony; Akhter, Sundus; Zeeshan, Muhammad; Åstrand, Ove Alexander Høgmoen; Bayer, Annette; Rongved, Pål; Samulesen, Ørjan; Leiros, Hanna-Kirsti S.. The fight against metallo-beta-lactamases and antibiotic resistance. 51st Norwegian Biochemical Society Contact Meeting, Svalbard 2015-02-09 - 2015-02-13 2015.

  • Leiros, Hanna-Kirsti S.. Antibiotika resistens. Hvorfor virker ikke antibiotikaet når vi er syke? Hva gjør en kjemiker med det?. Kjemikonferansen 2015 2015-01-22 - 2015-01-22 2015.

  • Leiros, Hanna-Kirsti S.. On the Road Searching for Inhibitors against beta-Lactamases Involved in Antibiotic Resistance. The Norwegian Biochemical Society (NBS) Contact Meeting 2014 2014-01-23 - 2014-01-26 2014.

  • Leiros, Hanna-Kirsti S.; Beck, Ellen-Marie. 100 år med krystallografi, 100 years with crystallography.. Utstilling i glassmonter, 3.4x1 meter, Poster og gjenstander 2014-11-07 - 2015-04-07 2014.

  • Lund, Bjarte Aarmo; Bjerga, Gro Elin Kjæreng; Christopeit, Tony; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Structural view on antibiotic resistance. Fragment-based lead discovery for the inhibition of oxacillinases. 12th Beta-Lactamase Meeting 2014-06-28 - 2014-07-01 2014.

  • Lund, Bjarte Aarmo; Bjerga, Gro Elin Kjæreng; Christopeit, Tony; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Structural view on antibiotic resistance. Fragment-based lead discovery for the inhibition of oxacillinases. The 46th INTERNATIONAL SCHOOL OF CRYSTALLOGRAPHY 2014-05-30 - 2014-06-08 2014.

  • Christopeit, Tony; Carlsen, Trine Josefine Olsen; Skagseth, Susann; Lund, Bjarte Aarmo; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Characterization of substrate and inhibitor binding to different beta-lactamases using Surface Plasmon Resonance based biosensors. 12th Beta-Lactamase Meeting 2014-06-28 - 2014-07-01 2014.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Bjerga, Gro Elin Kjæreng; Bayer, Annette; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. The importance of residue Trp228 and Tyr233 in the metallo-beta-lactamase GIM-1. 12th Beta-Lactamase Meeting 2014-06-28 - 2014-07-01 2014.

  • Paulsen, Marianne H.; Engqvist, Stig Olov Magnus; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.; Skagseth, Susann; Leszczak, Kinga; Akhter, Sundus; Bayer, Annette. Synthesis of potential metallo-beta-lactamase inhibitors. Organisk kjemisk vintermøte OKV29 2014-01-09 - 2014-01-12 2014.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Bjerga, Gro Elin Kjæreng; Bayer, Annette; Samulesen, Ørjan; Leiros, Hanna-Kirsti S.. The importance of residue W228 and Y233 in the metallo-beta-lactamase GIM-1. The Norwegian Biochemical Society (NBS) Contact Meeting 2014 2014-01-23 - 2014-01-26 2014.

  • Skagseth, Susann; Edvardsen, Kine Susann Waade; Bjerga, Gro Elin Kjæreng; Lorentzen, marit sjo; Leiros, Ingar; Samulesen, Ørjan; Leiros, Hanna-Kirsti S.. Site-directed mutagenesis of metallo-beta-lactamase VIM-7 from the opportunistic human pathogenic bacteria Pseudomonas aeruginosa. NBS konferanse 2013-01-31 - 2013-02-03 2013.

  • Fonseca, Davi de Miranda; Baar, Cecilie Christensen; Assefa, Netsanet Gizaw; Moe, Elin; Liabakk, Nina-Beate; Leiros, Hanna-Kirsti S.; Aas, Per Arne; Skorpen, Frank; Krokan, Hans Einar. Thermo-sensitive human UNG-mutants. XII Annual SBDR Program Project Workshop 2013-04-11 - 2013-04-13 2013.

  • Leiros, Hanna-Kirsti S.. Metallo-beta-Lactamases Cause Clinical Problems due to Antibiotic Resistance. Can Crystal Structures Help Out?. Norsk Biokjemisk Selskap (NBS) 49th Contact Meeting 2013-01-31 - 2013-02-03 2013.

  • Leiros, Hanna-Kirsti S.. Radiation damage. BioStruct- Synchrotron Data Collection, ESRF 2013-09-09 - 2013-09-13 2013.

  • Fedøy, Anita-Elin; Leiros, Hanna-Kirsti S.; Steen, Ida Helene; Birkeland, Nils-Kåre. Bacterial subfamiliy II isocitrate dehydrogenase: adaptations to low and high temperatures. Extremophiles 2012 2012-09-10 - 2012-09-13 2012.

  • Leiros, Hanna-Kirsti S.. Antibiotikaresistent - hva nå. Science - who cares? 2010-09-02 - 2010.

  • Leiros, Hanna-Kirsti S.. Antibiotika resistens: en utfordring både for forskere og kliniske behandlere. Populærvitenskaplige fordragsserie (Fulltekst: http://webtv.uit.no/mediasite/SilverlightPlayer/Default.aspx?peid=dd381ad927fe4b859ab395f92994df25 2010-12-03 - 2010.

  • Leiros, Hanna-Kirsti S.; Pey, Angel L.; Innselset, M; Moe, Elin; Leiros, Ingar; Steen, Ida Helene; Martinez, Aurora. Crystal Structure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H reveals a monomeric cold active enzyme with local flexibility around the active site and high overall stability. Norwegian Biochemical Society (NBS) contact meeting 2008 2008-01-17 - 2008-01-20 2008.

  • Fedøy, Anita-Elin; Yang, Nannan; Martinez, Aurora; Leiros, Hanna-Kirsti S.; Steen, Ida Helene. A cold-active enzyme with an unusual high thermal stability: Isocitrate dehydrogenase from the psychrophilic bacterium Desulfotalea psychrophila. The Norwegian Biochemical Society 44th Contact Meeting 2008-01-17 - 2008-01-20 2008.

  • Fedøy, Anita-Elin; Yang, Nannan; Martinez, Aurora; Leiros, Hanna-kirsti S.; Steen, Ida Helene. A cold-active enzyme with an unusual high thermal stability: Isocitrate dehydrogenase from the psycrophilic bacterium Desulfotalea psycrophila. Extremophiles 2008 2008-09-07 - 2008-09-11 2008.

  • Leiros, Hanna-Kirsti S.. A structural view on antibiotic resistance: DrNimA (DR0842) from Deinococcus radiodurans. Combating Antibiotic Resistance-Development of Inhibitors against Antibiotic Resistance Enzymes. 2008-08-13 - 2008-08-13 2008.

  • Leiros, Hanna-Kirsti S.. Radiation Damage and Dose-Rate effects on heavy atoms. Guest lecture at Department of Chemistry, University of Oslo, Norway. 2007-10-19 - 2007-10-19 2007.

  • Leiros, Hanna-Kirsti S.. Crystal Structure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H - reveals a monomeric cold active enzyme with local flexibility around the active site and high overall stability. 9th International Conference on Biology and Synchrotron Radiation 2007-08-12 - 2007-08-17 2007.

  • Leiros, Hanna-Kirsti S.. Radiation damage: How to avid it while colleting X-ray data and how to use it solving new protein structures. 19th Nordic Structural Chemistry Meeting 2007-01-08 - 2007-01-11 2007.

  • Leiros, Hanna-Kirsti S.. Radiation damage: How to avoid it while collecting X-ray data and how to use it. 19th Nordic Structural Chemistry Meeting, NSM 19 2007-01-08 - 2007-01-11 2007.

  • Leiros, Hanna-Kirsti S.. Phenylalanine hydroxylase from the cold adapted bacterium Colwellia psychrerythraea 34: - Biochemical and structural properties. NorStruct seminar at Sommarøy, Norway 2006-12-07 - 2006-12-08 2006.

  • Fedøy, Anita-Elin; Yang, Nannan; Leiros, Hanna-Kirsti S.; Birkeland, Nils-Kåre; Steen, Ida Helene. Biochemical and structural basis of cold-adaptation in isocitrate dehydrogenase from Desulfotalea psychrophila. Extremophiles 2006 2006-09-17 - 2006-09-21 2006.

  • Steen, Ida Helene; Fedøy, Anita-Elin; Yang, Nannan; Leiros, Hanna-Kirsti S.; Karlström, Mikael; Ladenstein, Rudolf; Birkeland, Nils-Kåre. Biochemical characterization and structure analysis of extremophilic isocitrate dehydrogenase. From functional genomics to natural products of marine microorganisms 2006-06-21 - 2006-06-24 2006.

  • Timmins, Joanna; Leiros, Hanna-Kirsti S.; Leonard, Gordon; Leiros, Ingar; McSweeney, Sean. Crystal Structure of Maltooligosyltrehalose Trehalohydrolase from D. radiodurans. ESRF Highlights 2005 2006.s 68 - 70.

  • Leiros, Hanna-Kirsti schrøder; McSweeney, Seán M.. Radiation Damage and Dose-Rate effects on heavy atoms. Gjesteforelesning 2005-10-19 - 2005-10-19 2005.

  • Leiros, Hanna-Kirsti S.. Is the Deinococcus radiodurans protein DR2241 a chelatase? Inserting Fe or Co2+ into Hemes?. ESRF Macro Molecular science day, Col de Porte, Grenoble, France. 2005-06-14 - 2005-06-14 2005.

  • Hall, David Richard; Leiros, Ingar; Leiros, Hanna-Kirsti S.; Micossi, E.; Gordon, E.; Macedo, S.; Kapp, U.; Jamin, C.; Timmins, Joanna; Leonard, Gordon; McSweeney, Sean. Structural Genomics at the ESRF: Studying Deinococcus radiodurans. ESRF Highlights 2003 2004.s 29 - 29.

  • Heikinheimo, Pirkko a; Helland, Ronny; Leiros, Hanna-Kirsti S.; Leiros, Ingar; Karlsen, Solveig; Evjen, gry; Ravelli, Raimond; Schoehn, Guy; Ruigrok, Rob; Tollersrud, ole kristian; McSweeney, Sean; Hough, Edward. Structure of the Bovine Lysosomal a-Mannosidase, the Enzyme Involved in the Lysosomal Storage Disease a-Mannosidosis. ESRF Highlights 2002 2003.s 12 - 13.

  • Leiros, Hanna-Kirsti S.. Comparison of psychrophilic and mesophilic trypsins : elucidating the basis of cold-adaptation. 1999.

  • Helland, Ronny; Berglund, Gunnar; Hansen, Lars Kr; Heimstad, Eldbjørg S.; Hordvik, Asbjørn; Leiros, Ingar; Leiros, Hanna-Kirsti S.; Os, vibeke; Outzen, Heidi; Willassen, Nils Peder; Smalås, Arne Oskar. Structure-Function Relation Studies of Enzymes from Cold Adapted Species. Higher European Research Course for Users of Large Experimental Systems (HERCULES) 1995-02-26 - 1995-04-07 1995.

  • Leiros, Hanna-Kirsti S.. Crystallographic studies of cationic trypsin from the North Atlantic salmon (Salmo salar). 1995.

  • Steien, Tore Rasmussen; Leiros, Hanna-Kirsti S.. Kjemikerne prøver å stoppe kjeften på antibiotikadreperne. (https://www.farmatid.no/artikler/prover-stoppe-kjeften-pa-antibiotikadreperne) Norsk Farmaceutisk Tidsskrift 2020. ISSN 0029-1935.

  • Leiros, Hanna-Kirsti S.. Vil ha 40 prosent kvinner i toppstillingar. (http://kifinfo.no/nb/2020/09/vil-ha-40-prosent-kvinner-i-toppstillingar) 2020.

  • Leiros, Hanna-Kirsti S.. På Labben med Forskningsdagene 2020. På Institutt for kjemi, UiT. "Proteiner som gjør at bakterier er resistente mot antibiotika".. (https://www.youtube.com/watch?v=gCIVGW5FCKg) 2020.

  • Frøhlich, Christopher; Leiros, Hanna-Kirsti S.; Miton, Charlotte; Tokuriki, Nobuhiko. Ceftazidime drives the evolution of the carbapenemase OXA-48. GW4 Multidisciplinary Approaches to AMR: From Bench to Bedside and Beyond 2020 2020-12-01 - 2020-12-03 2020.

  • Leiros, Hanna-Kirsti S.. Fighting the antibiotic resistant serine-beta-lactamase OXA-48 - through altered ceftazidime activity or new inhibitors?. Gjesteforelesning ved Biomedical Sciences, University of Bristol 2019-12-04 - 2019-12-04 2019.

  • Leiros, Hanna-Kirsti S.. Antibiotika resistens er et globalt problem. Nye inhibitorer og velkjente antibiotika, kan de sammen bli ny behandlings metode?. NT-Fak administrasjonen 2019-03-19 - 2019-03-19 2019.

  • Leiros, Hanna-Kirsti S.. Inhibitor potential of Serine- and Metallo-beta-lactamase inhibitors, and Biochemical and Biophysical characterization. AROHP 2019 workshop on Antimicrobial resistance (AMR), March 2019 (https://en.uit.no/prosjekter/prosjektsub?p_document_id=467132&sub_id=625781) 2019-03-05 - 2019-03-11 2019.

  • Frøhlich, Christopher; Leiros, Hanna-Kirsti S.; Johnsen, Pål Jarle; Samuelsen, Ørjan. Sub-inhibitory concentrations of ceftazidime drive evolution of the OXA-48 carbapenemase. ECCMID 2019 2019-04-13 - 2019-04-16 2019.

  • Frøhlich, Christopher; Sørum, Vidar; Leiros, Hanna-Kirsti S.; Johnsen, Pål Jarle; Samuelsen, Ørjan. Development of OXA-48 mediated ceftazidme-avibactam resistance is associated with an evolutionary trade-off. ECCMID 2018-04-24 - 2018.

  • Williamson, Adele Kim; Hjerde, Erik; Sarre, Aili; Leiros, Ingar; Berg, Kristel; Leiros, Hanna-Kirsti S.. Discovery and design of novel DNA ligases for biotechnology. 6th International Conference on Novel Enzymes 2018 2018-10-09 - 2018-10-12 2018.

  • Bayer, Annette; Leiros, Hanna-Kirsti S.; Akhter, Sundus; Lund, Bjarte Aarmo; Christopeit, Tony; Ismael, Aya. Towards Antibiotic Resistance Breakers: Fragment-Based Design of OXA- 48 Inhibitors. FRAGMENTS2017 2017-03-05 - 2017-03-07 2017.

  • Leiros, Hanna-Kirsti S.. Enzymer involvert i antibiotika resistens. (https://www.biokjemisk.no/nbs-nytt/se-nbs-nytt-online/) NBS-nytt 2017; Volum 4. ISSN 0801-3535.s 34 - 35.

  • Os, Vibeke; Skagseth, Susann; Leiros, Hanna-Kirsti S.. "Superbugs" skal ikke lengre få herje i fred, Vil gjenreise effekten av antibiotika.. (Fulltekst: https://uit.no/nyheter/artikkel?p_document_id=514293&p_dim=88131 2017.

  • Skagseth, Susann; Leiros, Hanna-Kirsti S.. Forskere vil gjenreise effekten av antibiotika. https://forskning.no/kortnytt/forskere-vil-gjenreise-effekten-av-antibiotika. (https://forskning.no/kortnytt/forskere-vil-gjenreise-effekten-av-antibiotika) 2017.

  • Leiros, Hanna-Kirsti S.. Kampen. Den livsfarlige resistensen.. (Fulltekst: https://www.youtube.com/watch?v=NT1ksFkPOHs&feature=youtu.be 2017.

  • Leiros, Hanna-Kirsti S.. Inhibitors can help fighting antibiotic resistance bacteria, but how do we find the best inhibitors?. 53rd NBS contact meeting 2017-01-19 - 2017-01-22 2017.

  • Leiros, Hanna-Kirsti S.. Aiming for inhibitors towards beta-lactamases involved in antibiotic resistance, but starting with fragment screening. How is the progress?. Nordic Chemical Biology Network, Workshop in fragment screening. 2017-06-01 - 2017-06-01 2017.

  • Leiros, Hanna-Kirsti S.. Fragment screening used successfully for detecting OXA, VIM or NDM inhibitors. 13th Beta-Lactamase Meeting 2017-06-16 - 2017.

  • Williamson, Adele Kim; Hjerde, Erik; Leiros, Hanna-Kirsti S.; Lian, Kjersti; Ramirez, Miguel A.; Patrick, Wayne M.. Beyond T4: discovery and design of DNA ligases for use in biotechnological applications. Cryo-EM Symposium 2017-07-06 - 2017-07-07 2017.

  • Lund, Bjarte Aarmo; Leiros, Hanna-Kirsti S.; Bayer, Annette; Samuelsen, Ørjan; Christopeit, Tony. The OXA-class of β-lactamases. A structural view on antibiotic resistance. 2017 ISBN 978-82-8236-269-6.

  • Leiros, Hanna-Kirsti S.. Searching for inhibitors towards beta-lactamases involved in antibiotic resistance, starting with fragment screening. Can we reach into the clinic?. Seminar serie 2016-10-05 - 2016.

  • Williamson, Adele Kim; Kahlke, Tim; Hjerde, Erik; Leiros, Hanna-Kirsti S.. Structural and Bioinformatic Studies of the ‘Lig E’Group of Bacterial ATP-Dependent DNA Ligases. The 52nd NBS contact meeting 2016-01-21 - 2016-01-24 2016.

  • Williamson, Adele Kim; Leiros, Hanna-Kirsti S.; Hjerde, Erik; Lian, Kjersti; Ramirez, Miguel A.; Patrick, Wayne M.. Beyond T4: discovery and design of DNA ligases for use in biotechnological applications. EMBO Conference Series: The biochemistry and chemistry of biocatalysis: From understanding to design 2016-06-12 - 2016-06-15 2016.

  • Lund, Bjarte Aarmo; Akhter, Sundus; Guttormsen, Yngve; Christopeit, Tony; Isaksson, Johan; Bayer, Annette; Leiros, Hanna-Kirsti S.. Structure-guided drug design for the antibiotic resistance enzyme OXA-48. 7th Annual BioStruct Conference 2016-08-25 - 2016-08-28 2016.

  • Ahkter, Sundus; Lund, Bjarte Aarmo; Guttormsen, Yngve; Christopeit, Tony; Bayer, Annette; Leiros, Hanna-Kirsti S.. Addressing Antibiotic Resistance: Fragment-Based Design of OXA-48 Inhibitors. 31. Organisk Kjemisk Vintermøte 2016-01-07 - 2016-01-10 2016.

  • Lund, Bjarte Aarmo; Christopeit, Tony; Ahkter, Sundus; Guttormsen, Yngve; Isaksson, Johan; Bayer, Annette; Leiros, Hanna-Kirsti S.. Structure-Guided Drug Design for the Antibiotic Resistance Enzyme OXA-48. ASM Microbe 2016 2016-06-16 - 2016-06-20 2016.

  • Christopeit, Tony; Carlsen, Trine Josefine Olsen; Albert, Anastasia; Skagseth, Susann; Leiros, Hanna-Kirsti S.. Discovery of a Novel Covalent Inhibitor of the Metallo-beta-lactamase NDM-1. 52nd Norwegian Biochemical Society Contact Meeting, Tromsø 2016-01-21 - 2016-01-24 2016.

  • Lund, Bjarte Aarmo; Ahkter, Sundus; Guttormsen, Yngve; Christopeit, Tony; Bayer, Annette; Leiros, Hanna-Kirsti S.. Structure-guided drug design for the antibiotic resistance enzyme OXA-48. 52nd Norwegian Biochemical Society Contact Meeting, Tromsø 2016-01-21 - 2016-01-24 2016.

  • Skagseth, Susann; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. The impact of residues 119 and 228 in the Tripoli metallo-beta-lactamase TMB-1 involved in resistance to beta-lactam antibiotics. 52nd Norwegian Biochemical Society Contact Meeting, Tromsø 2016-01-21 - 2016-01-24 2016.

  • Nesheim, Birgit Berg; Carlsen, Trine Josefine Olsen; Lund, Bjarte Aarmo; Leiros, Hanna-Kirsti S.. Residue profiling of antibiotic resistant OXA-beta-lactamases through mutagenesis, enzyme kinetics and 3D structures. 52nd Norwegian Biochemical Society Contact Meeting, Tromsø 2016-01-21 - 2016-01-24 2016.

  • Åstrand, Ove Alexander Høgmoen; Leiros, Hanna-Kirsti S.; Samuelsen, Ørjan; Bayer, Annette; Rongved, Pål. Overcoming b-lactam resistance - A potential solution to multi-drug resistant bacteria. Organisk Kjemisk Vintermøte 2015 2015-01-08 - 2015-01-11 2015.

  • Leiros, Hanna-Kirsti S.. Enzymatic characterization and structural insight into Metallo-beta-Lactamases (MBL) and Serine-beta-lactamases (SBL). Pre-Centre for Infection Prevention and Treatment (preCIPT) 2015-10-14 - 2015.

  • Leiros, Hanna-Kirsti S.. Fighting Antibiotic Resistance Through Inhibitor Screening – Can Crystal Structures Help Out?. Norwegian Biochemical Society (NBS), avd Ås, Seminar serie 2015-06-23 - 2015-06-23 2015.

  • Leiros, Hanna-Kirsti S.. Can We Overcome beat-Lactamase-mediated Antibiotic Resistance Through Inhibitor Screening?. Norwegian Biochemical Society Contact Meeting 2015-02-09 - 2015-02-13 2015.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Akhter, Sundus; Zeeshan, Muhammad; Åstrand, Ove Alexander Høgmoen; Bayer, Annette; Rongved, Pål; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. The fight against metallo-beta-lactamases and antibiotic resistance. Annual BioStruct Conference, The National graduate school in structural biology 2015-09-27 - 2015-09-30 2015.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Akhter, Sundus; Zeeshan, Muhammad; Åstrand, Ove Alexander Høgmoen; Bayer, Annette; Rongved, Pål; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. The fight against metallo-beta-lactamases and antibiotic resistance. BioStruct Open Day 2015-03-20 - 2015-03-20 2015.

  • Christopeit, Tony; Carlsen, Trine Josefine Olsen; Skagseth, Susann; Lund, Bjarte Aarmo; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Using fragment screening to identify novel starting points for potent inhibitors of metallo-beta-lactamase VIM-2. Fragments 2015: Fifth RSC-BMCS Fragment-based Drug Discovery meeting 2015-03-22 - 2015-03-22 2015.

  • Christopeit, Tony; Lund, Bjarte Aarmo; Carlsen, Trine Josefine Olsen; Skagseth, Susann; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Using Fragment Screening to Identify Novel Starting Points for Potent Carbapenemase Inhibitors. Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC) 2015-09-17 - 2015-09-21 2015.

  • Lund, Bjarte Aarmo; Guttormsen, Yngve; Christopeit, Tony; Bayer, Annette; Leiros, Hanna-Kirsti S.. Design of OXA-48 class D beta-lactamase inhibitors by fragment-based drug design. Annual BioStruct Conference, The National graduate school in structural biology 2015-08-27 - 2015-08-30 2015.

  • Lund, Bjarte Aarmo; Christopeit, Tony; Bjerga, Gro Elin Kjæreng; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Combating antibiotic resistance: Fragment-based screening for class D β-lactamase inhibitors. BioStruct OpenDay 2015-03-20 - 2015-03-20 2015.

  • Lund, Bjarte Aarmo; Christopeit, Tony; Bjerga, Gro Elin Kjæreng; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Combating antibiotic resistance: Fragment-based screening for class D β-lactamase inhibitors.. Cambridge Healthtech Institute’s (CHI) Drug Discovery Chemistry conference. 2015-04-22 - 2015-04-23 2015.

  • Lund, Bjarte Aarmo; Bjerga, Gro Elin Kjæreng; Christopeit, Tony; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Fragment-based screening for class D β-lactamase inhibitors. Combating antibiotic resistance. 51st Norwegian Biochemical Society Contact Meeting, Svalbard 2015-02-09 - 2015-02-13 2015.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Christopeit, Tony; Akhter, Sundus; Zeeshan, Muhammad; Åstrand, Ove Alexander Høgmoen; Bayer, Annette; Rongved, Pål; Samulesen, Ørjan; Leiros, Hanna-Kirsti S.. The fight against metallo-beta-lactamases and antibiotic resistance. 51st Norwegian Biochemical Society Contact Meeting, Svalbard 2015-02-09 - 2015-02-13 2015.

  • Leiros, Hanna-Kirsti S.. Antibiotika resistens. Hvorfor virker ikke antibiotikaet når vi er syke? Hva gjør en kjemiker med det?. Kjemikonferansen 2015 2015-01-22 - 2015-01-22 2015.

  • Leiros, Hanna-Kirsti S.. On the Road Searching for Inhibitors against beta-Lactamases Involved in Antibiotic Resistance. The Norwegian Biochemical Society (NBS) Contact Meeting 2014 2014-01-23 - 2014-01-26 2014.

  • Leiros, Hanna-Kirsti S.; Beck, Ellen-Marie. 100 år med krystallografi, 100 years with crystallography.. Utstilling i glassmonter, 3.4x1 meter, Poster og gjenstander 2014-11-07 - 2015-04-07 2014.

  • Lund, Bjarte Aarmo; Bjerga, Gro Elin Kjæreng; Christopeit, Tony; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Structural view on antibiotic resistance. Fragment-based lead discovery for the inhibition of oxacillinases. 12th Beta-Lactamase Meeting 2014-06-28 - 2014-07-01 2014.

  • Lund, Bjarte Aarmo; Bjerga, Gro Elin Kjæreng; Christopeit, Tony; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Structural view on antibiotic resistance. Fragment-based lead discovery for the inhibition of oxacillinases. The 46th INTERNATIONAL SCHOOL OF CRYSTALLOGRAPHY 2014-05-30 - 2014-06-08 2014.

  • Christopeit, Tony; Carlsen, Trine Josefine Olsen; Skagseth, Susann; Lund, Bjarte Aarmo; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Characterization of substrate and inhibitor binding to different beta-lactamases using Surface Plasmon Resonance based biosensors. 12th Beta-Lactamase Meeting 2014-06-28 - 2014-07-01 2014.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Bjerga, Gro Elin Kjæreng; Bayer, Annette; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. The importance of residue Trp228 and Tyr233 in the metallo-beta-lactamase GIM-1. 12th Beta-Lactamase Meeting 2014-06-28 - 2014-07-01 2014.

  • Paulsen, Marianne H.; Engqvist, Stig Olov Magnus; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.; Skagseth, Susann; Leszczak, Kinga; Akhter, Sundus; Bayer, Annette. Synthesis of potential metallo-beta-lactamase inhibitors. Organisk kjemisk vintermøte OKV29 2014-01-09 - 2014-01-12 2014.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Bjerga, Gro Elin Kjæreng; Bayer, Annette; Samulesen, Ørjan; Leiros, Hanna-Kirsti S.. The importance of residue W228 and Y233 in the metallo-beta-lactamase GIM-1. The Norwegian Biochemical Society (NBS) Contact Meeting 2014 2014-01-23 - 2014-01-26 2014.

  • Skagseth, Susann; Edvardsen, Kine Susann Waade; Bjerga, Gro Elin Kjæreng; Lorentzen, marit sjo; Leiros, Ingar; Samulesen, Ørjan; Leiros, Hanna-Kirsti S.. Site-directed mutagenesis of metallo-beta-lactamase VIM-7 from the opportunistic human pathogenic bacteria Pseudomonas aeruginosa. NBS konferanse 2013-01-31 - 2013-02-03 2013.

  • Fonseca, Davi de Miranda; Baar, Cecilie Christensen; Assefa, Netsanet Gizaw; Moe, Elin; Liabakk, Nina-Beate; Leiros, Hanna-Kirsti S.; Aas, Per Arne; Skorpen, Frank; Krokan, Hans Einar. Thermo-sensitive human UNG-mutants. XII Annual SBDR Program Project Workshop 2013-04-11 - 2013-04-13 2013.

  • Leiros, Hanna-Kirsti S.. Metallo-beta-Lactamases Cause Clinical Problems due to Antibiotic Resistance. Can Crystal Structures Help Out?. Norsk Biokjemisk Selskap (NBS) 49th Contact Meeting 2013-01-31 - 2013-02-03 2013.

  • Leiros, Hanna-Kirsti S.. Radiation damage. BioStruct- Synchrotron Data Collection, ESRF 2013-09-09 - 2013-09-13 2013.

  • Fedøy, Anita-Elin; Leiros, Hanna-Kirsti S.; Steen, Ida Helene; Birkeland, Nils-Kåre. Bacterial subfamiliy II isocitrate dehydrogenase: adaptations to low and high temperatures. Extremophiles 2012 2012-09-10 - 2012-09-13 2012.

  • Leiros, Hanna-Kirsti S.. Antibiotikaresistent - hva nå. Science - who cares? 2010-09-02 - 2010.

  • Leiros, Hanna-Kirsti S.. Antibiotika resistens: en utfordring både for forskere og kliniske behandlere. Populærvitenskaplige fordragsserie (Fulltekst: http://webtv.uit.no/mediasite/SilverlightPlayer/Default.aspx?peid=dd381ad927fe4b859ab395f92994df25 2010-12-03 - 2010.

  • Leiros, Hanna-Kirsti S.; Pey, Angel L.; Innselset, M; Moe, Elin; Leiros, Ingar; Steen, Ida Helene; Martinez, Aurora. Crystal Structure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H reveals a monomeric cold active enzyme with local flexibility around the active site and high overall stability. Norwegian Biochemical Society (NBS) contact meeting 2008 2008-01-17 - 2008-01-20 2008.

  • Fedøy, Anita-Elin; Yang, Nannan; Martinez, Aurora; Leiros, Hanna-Kirsti S.; Steen, Ida Helene. A cold-active enzyme with an unusual high thermal stability: Isocitrate dehydrogenase from the psychrophilic bacterium Desulfotalea psychrophila. The Norwegian Biochemical Society 44th Contact Meeting 2008-01-17 - 2008-01-20 2008.

  • Fedøy, Anita-Elin; Yang, Nannan; Martinez, Aurora; Leiros, Hanna-kirsti S.; Steen, Ida Helene. A cold-active enzyme with an unusual high thermal stability: Isocitrate dehydrogenase from the psycrophilic bacterium Desulfotalea psycrophila. Extremophiles 2008 2008-09-07 - 2008-09-11 2008.

  • Leiros, Hanna-Kirsti S.. A structural view on antibiotic resistance: DrNimA (DR0842) from Deinococcus radiodurans. Combating Antibiotic Resistance-Development of Inhibitors against Antibiotic Resistance Enzymes. 2008-08-13 - 2008-08-13 2008.

  • Leiros, Hanna-Kirsti S.. Radiation Damage and Dose-Rate effects on heavy atoms. Guest lecture at Department of Chemistry, University of Oslo, Norway. 2007-10-19 - 2007-10-19 2007.

  • Leiros, Hanna-Kirsti S.. Crystal Structure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H - reveals a monomeric cold active enzyme with local flexibility around the active site and high overall stability. 9th International Conference on Biology and Synchrotron Radiation 2007-08-12 - 2007-08-17 2007.

  • Leiros, Hanna-Kirsti S.. Radiation damage: How to avid it while colleting X-ray data and how to use it solving new protein structures. 19th Nordic Structural Chemistry Meeting 2007-01-08 - 2007-01-11 2007.

  • Leiros, Hanna-Kirsti S.. Radiation damage: How to avoid it while collecting X-ray data and how to use it. 19th Nordic Structural Chemistry Meeting, NSM 19 2007-01-08 - 2007-01-11 2007.

  • Leiros, Hanna-Kirsti S.. Phenylalanine hydroxylase from the cold adapted bacterium Colwellia psychrerythraea 34: - Biochemical and structural properties. NorStruct seminar at Sommarøy, Norway 2006-12-07 - 2006-12-08 2006.

  • Fedøy, Anita-Elin; Yang, Nannan; Leiros, Hanna-Kirsti S.; Birkeland, Nils-Kåre; Steen, Ida Helene. Biochemical and structural basis of cold-adaptation in isocitrate dehydrogenase from Desulfotalea psychrophila. Extremophiles 2006 2006-09-17 - 2006-09-21 2006.

  • Steen, Ida Helene; Fedøy, Anita-Elin; Yang, Nannan; Leiros, Hanna-Kirsti S.; Karlström, Mikael; Ladenstein, Rudolf; Birkeland, Nils-Kåre. Biochemical characterization and structure analysis of extremophilic isocitrate dehydrogenase. From functional genomics to natural products of marine microorganisms 2006-06-21 - 2006-06-24 2006.

  • Timmins, Joanna; Leiros, Hanna-Kirsti S.; Leonard, Gordon; Leiros, Ingar; McSweeney, Sean. Crystal Structure of Maltooligosyltrehalose Trehalohydrolase from D. radiodurans. ESRF Highlights 2005 2006.s 68 - 70.

  • Leiros, Hanna-Kirsti schrøder; McSweeney, Seán M.. Radiation Damage and Dose-Rate effects on heavy atoms. Gjesteforelesning 2005-10-19 - 2005-10-19 2005.

  • Leiros, Hanna-Kirsti S.. Is the Deinococcus radiodurans protein DR2241 a chelatase? Inserting Fe or Co2+ into Hemes?. ESRF Macro Molecular science day, Col de Porte, Grenoble, France. 2005-06-14 - 2005-06-14 2005.

  • Hall, David Richard; Leiros, Ingar; Leiros, Hanna-Kirsti S.; Micossi, E.; Gordon, E.; Macedo, S.; Kapp, U.; Jamin, C.; Timmins, Joanna; Leonard, Gordon; McSweeney, Sean. Structural Genomics at the ESRF: Studying Deinococcus radiodurans. ESRF Highlights 2003 2004.s 29 - 29.

  • Heikinheimo, Pirkko a; Helland, Ronny; Leiros, Hanna-Kirsti S.; Leiros, Ingar; Karlsen, Solveig; Evjen, gry; Ravelli, Raimond; Schoehn, Guy; Ruigrok, Rob; Tollersrud, ole kristian; McSweeney, Sean; Hough, Edward. Structure of the Bovine Lysosomal a-Mannosidase, the Enzyme Involved in the Lysosomal Storage Disease a-Mannosidosis. ESRF Highlights 2002 2003.s 12 - 13.

  • Leiros, Hanna-Kirsti S.. Comparison of psychrophilic and mesophilic trypsins : elucidating the basis of cold-adaptation. 1999.

  • Helland, Ronny; Berglund, Gunnar; Hansen, Lars Kr; Heimstad, Eldbjørg S.; Hordvik, Asbjørn; Leiros, Ingar; Leiros, Hanna-Kirsti S.; Os, vibeke; Outzen, Heidi; Willassen, Nils Peder; Smalås, Arne Oskar. Structure-Function Relation Studies of Enzymes from Cold Adapted Species. Higher European Research Course for Users of Large Experimental Systems (HERCULES) 1995-02-26 - 1995-04-07 1995.

  • Leiros, Hanna-Kirsti S.. Crystallographic studies of cationic trypsin from the North Atlantic salmon (Salmo salar). 1995.

  • Here is a summary of the project shown at NRK TV in the program “Schrödingers katt”, 5.3.2015, which is called “Krystaller mot antibiotikaresistens”.

     

     

     

    [Loading...]

    Member of research group