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Photo: INGAR LEIROS
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Department of Chemistry ingar.leiros@uit.no 77644064 +4795966895 TROM FPARK G 220

Ingar Leiros

Professor, Biomolecular and Structural Chemistry, Norstruct.

  • Alexeeva, Marina; Moen, Marivi Nabong; Xu, Xiang Ming; Rasmussen, Anette; Leiros, Ingar; Kirpekar, Finn; Klungland, Arne; Alsøe, Lene; Nilsen, Hilde; Bjelland, Svein. Intrinsic Strand-Incision Activity of Human UNG: Implications for Nick Generation in Immunoglobulin Gene Diversification. Frontiers in Immunology 2021; Volum 12. ISSN 1664-3224.s doi: 10.3389/fimmu.2021.762032.
  • Grøsvik, Kristin; Tesfahun, Almaz Nigatu; Muruzábal-Lecumberri, Izaskun; Haugland, Gyri Teien; Leiros, Ingar; Ruoff, Peter; Kvaløy, Jan Terje; Knævelsrud, Ingeborg; Ånensen, Hilde; Alexeeva, Marina; Sato, Kousuke; Matsuda, Akira; Alseth, Ingrun; Klungland, Arne; Bjelland, Svein. The Escherichia coli alkA Gene Is Activated to Alleviate Mutagenesis by an Oxidized Deoxynucleoside. Frontiers in Microbiology 2020; Volum 11. ISSN 1664-302X.s doi: 10.3389/fmicb.2020.00263.
  • Hillier, Heidi Therese; Altermark, Bjørn; Leiros, Ingar. The crystal structure of the tetrameric DABA-aminotransferase EctB, a rate-limiting enzyme in the ectoine biosynthesis pathway.. The FEBS Journal 2020; Volum 287. ISSN 1742-464X.s 4641 - 4641.s doi: 10.1111/febs.15265.
  • Berg, Kristel; Pedersen, Hege Lynum; Leiros, Ingar. Biochemical characterization of ferric uptake regulator (Fur) from Aliivibrio salmonicida. Mapping the DNA sequence specificity through binding studies and structural modelling. Biometals 2020; Volum 33. ISSN 0966-0844.s 169 - 185.s doi: 10.1007/s10534-020-00240-6.
  • Berg, Kristel; Leiros, Ingar; Williamson, Adele Kim. Temperature adaptation of DNA ligases from psychrophilic organisms. Extremophiles 2019; Volum 23 (3). ISSN 1431-0651.s 305 - 317.s doi: 10.1007/s00792-019-01082-y.
  • Piotrowski, Yvonne; Berg, Kristel; Klebl, David P.; Leiros, Ingar; Larsen, Atle Noralf. Characterization of an intertidal zone metagenome oligoribonuclease and the role of the intermolecular disulfide bond for homodimer formation and nuclease activity. FEBS Open Bio 2019; Volum 9 (10). ISSN 2211-5463.s 1674 - 1688.s doi: 10.1002/2211-5463.12720.
  • Grgic, Miriam; Williamson, Adele Kim; Bjerga, Gro Elin Kjæreng; Altermark, Bjørn; Leiros, Ingar. Biochemical characterization of ParI, an orphan C5-DNA methyltransferase from Psychrobacter arcticus 273-4. Protein Expression and Purification 2018; Volum 150. ISSN 1046-5928.s 100 - 108.s doi: 10.1016/j.pep.2018.05.012.
  • Bjerga, Gro Elin Kjæreng; Larsen, Øivind; ARSIN, Hasan; Williamson, Adele Kim; Garcia-Moyano, Antonio; Leiros, Ingar; Puntervoll, Pål. Mutational analysis of the pro-peptide of a marine intracellular subtilisin protease supports its role in inhibition. Proteins: Structure, Function, and Bioinformatics 2018. ISSN 0887-3585.s 1 - 13.s doi: 10.1002/prot.25528.
  • Jensen, Marianne Slang; Fredriksen, Lasse; Mackenzie, Alasdair; Pope, Phillip; Leiros, Ingar; Chylenski, Piotr; Williamson, Adele Kim; Christopeit, Tony; Østby, Heidi; Vaaje-Kolstad, Gustav; Eijsink, Vincent. Discovery and characterization of a thermostable two-domain GH6 endoglucanase from a compost metagenome. PLOS ONE 2018; Volum 13 (5). ISSN 1932-6203.s doi: 10.1371/journal.pone.0197862.
  • Kristiansen, Anders; Grgic, Miriam; Altermark, Bjørn; Leiros, Ingar. Properties and distribution of a metallo-β-lactamase (ALI-1) from the fish pathogen Aliivibrio salmonicida LFI1238. Journal of Antimicrobial Chemotherapy 2015; Volum 70 (3). ISSN 0305-7453.s 766 - 772.s doi: 10.1093/jac/dku433.
  • Pedersen, Hege Lynum; Johnson, Kenneth; McVey, Colin; Leiros, Ingar; Moe, Elin. Structure determination of uracil-DNA N-glycosylase from Deinococcus radiodurans in complex with DNA. Acta Crystallographica Section D: Biological Crystallography 2015; Volum 71. ISSN 0907-4449.s 2137 - 2149.s doi: 10.1107/S1399004715014157.
  • Moe, Elin; Assefa, Netsanet Gizaw; Leiros, Ingar; Torseth, Kathrin; Smalås, Arne O.; Willassen, Nils Peder. Reduced Hydrophobicity of the Minor Groove Intercalation Loop is Critical for Efficient Catalysis by Cold Adapted Uracil-DNA N-Glycosylase from Atlantic Cod. Journal of Thermodynamics & Catalysis 2015; Volum 6 (3). ISSN 2157-7544.s doi: 10.4172/2157-7544.1000155.
  • Leiros, Hanna-Kirsti S.; Skagseth, Susann; Edvardsen, Kine Susann Waade; Lorentzen, Marit Sjo; Bjerga, Gro Elin Kjæreng; Leiros, Ingar; Samuelsen, Ørjan. His224 alters the R2 drug binding site and Phe218 influences the catalytic efficiency of the metallo-β-lactamase VIM-7. Antimicrobial Agents and Chemotherapy 2014; Volum 58 (8). ISSN 0066-4804.s 4826 - 4836.s doi: 10.1128/AAC.02735-13.
  • Moe, Elin; Hall, D R; Leiros, Ingar; Monsen, Vivi Talstad; Timmins, Joanna; McSweeney, Sean. Structure-function studies of an unusual 3-methyladenine DNA glycosylase II (AlkA) from Deinococcus radiodurans. Acta Crystallographica Section D: Biological Crystallography 2012; Volum 68. ISSN 0907-4449.s 703 - 712.s doi: 10.1107/S090744491200947X.
  • Leiros, Hanna-Kirsti S.; Fedøy, Anita-Elin; Leiros, Ingar; Steen, Ida Helene. The complex structures of isocitrate dehydrogenase from Clostridium thermocellum and Desulfotalea psychrophila support a new active site locking mechanism. FEBS Open Bio 2012. ISSN 2211-5463.s doi: 10.1016/j.fob.2012.06.003.
  • Saradhi, Pardha; Leiros, Hanna-Kirsti S.; Ahmad, Rafi; Spencer, James; Leiros, Ingar; Walsh, Timothy R.; Sundsfjord, Arnfinn; Samuelsen, Ørjan. Structural and Computational Investigations of VIM-7: Insights into the Substrate Specificity of VIM Metallo-beta-Lactamases. Journal of Molecular Biology (JMB) 2011; Volum 411 (1). ISSN 0022-2836.s 174 - 189.s doi: 10.1016/j.jmb.2011.05.035.
  • Knævelsrud, Ingeborg; Moen, Marivi; Grøsvik, Kristin; Haugland, Gyri Teien; Birkeland, Nils-Kåre; Klungland, Arne; Leiros, Ingar; Bjelland, Svein. The Hyperthermophilic Euryarchaeon Archaeoglobus fulgidus Repairs Uracil by Single-Nucleotide Replacement. Journal of Bacteriology 2010; Volum 192 (21). ISSN 0021-9193.s 5755 - 5766.s doi: 10.1128/JB.00135-10.
  • Pedersen, hege lynum; Ahmad, Rafi; Riise, EK; Leiros, Hanna-Kirsti S.; Hauglid, Stefan; Espelid, S; Brandsdal, Bjørn Olav; Leiros, Ingar; Willassen, Nils P; Haugen, Peik. Experimental and computational characterization of the ferric uptake regulator from Aliivibrio salmonicida (Vibrio salmonicida). Journal of Microbiology 2010; Volum 48 (2). ISSN 1225-8873.s 174 - 183.s doi: 10.1007/s12275-010-9199-5.
  • Ræder, Inger Lin Uttakleiv; Moe, Elin; Willassen, Nils Peder; Smalås, Arne Oskar; Leiros, Ingar. Structure of uracil-DNA N-glycosylase (UNG) from Vibrio cholerae: mapping temperature adaptation through structural and mutational analysis. Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2010; Volum 66. ISSN 1744-3091.s 130 - 136.s doi: 10.1107/S1744309109052063.
  • Byeon, In-Ja L.; Dao, Khanh Kim; Jung, Jinwon; Keen, Thomas Jeffrey; Leiros, Ingar; Doskeland, Stein Ove; Martinez, Aurora; Gronenborn, Angela M.. Allosteric communication between cAMP binding sites in the RI subunit of protein kinase A revealed by NMR. Journal of Biological Chemistry 2010; Volum 285 (18). ISSN 0021-9258.s 14062 - 14070.s doi: 10.1074/jbc.M110.106666.
  • Knaevelsrud, I; Knaevelsrud, I; Slupphaug, G; Leiros, Ingar; Matsuda, A; Ruoff, P; Ruoff, P; Bjelland, S; Bjelland, S. Opposite-base dependent excision of 5-formyluracil from DNA by hSMUG1. International Journal of Radiation Biology 2009; Volum 85 (5). ISSN 0955-3002.s 413 - 420.s doi: 10.1080/09553000902818915.
  • Pedersen, hege lynum; Willassen, Nils Peder; Leiros, Ingar. The first structure of a cold-adapted superoxide dismutase (SOD): biochemical and structural characterization of iron SOD from Aliivibrio salmonicida. Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2009; Volum 65. ISSN 1744-3091.s 84 - 92.s doi: 10.1107/S1744309109001110.
  • Robertson, AB; Klungland, A; Rognes, T; Leiros, Ingar. DNA Repair in Mammalian Cells. Cellular and Molecular Life Sciences (CMLS) 2009; Volum 66 (6). ISSN 1420-682X.s 981 - 993.s doi: 10.1007/s00018-009-8736-z.
  • Knævelsrud, I.; Slupphaug, Geir; Leiros, Ingar; Matsuda, A.; Ruoff, Peter; Bjelland, Svein. Opposite-base dependent excision of 5-formyluracil from DNA by hSMUG1. (omtale) International Journal of Radiation Biology 2009; Volum 85 (5). ISSN 0955-3002.s 413 - 420.
  • Kapp, U.; Macedo, S.; Hall, David Richard; Leiros, Ingar; McSweeney, Sean; mitchell, edward. Structure of Deinococcus radiodurans tunicamycin-resistance protein (TmrD), a phosphotransferase. Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2008; Volum 64 (6). ISSN 1744-3091.s 479 - 486.
  • Ræder, Inger Lin Uttakleiv; Leiros, Ingar; Willassen, Nils Peder; Smalås, Arne Oskar; Moe, Elin. Uracil-DNA N-glycosylase (UNG) from the marine, psychrophilic bacterium Vibrio salmonicida shows cold adapted features A comparative analysis to Vibrio cholerae uracil-DNA N-glycosylase. Enzyme and Microbial Technology 2008; Volum 42 (7). ISSN 0141-0229.s 594 - 600.s doi: 10.1016/j.enzmictec.2008.02.005.
  • Leiros, Ingar; Nabong, Marivi P.; Grøsvik, Kristin; Ringvoll, Jeanette; Haugland, GT; Uldal, Lene; Reite, Karen; Olsbu, Inger K.; Knævelsrud, I.; Moe, Elin; Andersen, Ole A.; Birkeland, Nils-Kåre; Ruoff, Peter; Klungland, Arne; Bjelland, Svein. Structural basis for enzymatic excision of N-1-methyladenine and N-3-methylcytosine from DNA. EMBO Journal 2007; Volum 26. ISSN 0261-4189.
  • Stokke, R; Leiros, Ingar; Karlström, Mikael; Karlstrom, M; Yang, Nannan; Ladenstein, R; Birkeland, NK; Steen, IH. Thermal stability of isocitrate dehydrogenase from Archaeoglobus fulgidus studied by crystal structure analysis and engineering of chimers. Extremophiles 2007; Volum 11. ISSN 1431-0651.s doi: 10.1007/s00792-006-0060-z.
  • Leiros, Hanna-Kirsti S.; Pey, AL; Innselset, M; Innselset, Marte; Moe, Elin; Leiros, Ingar; Steen, IH; Martinez, A. Structure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H, a monomeric cold active enzyme with local flexibility around the active site and high overall stability. Journal of Biological Chemistry 2007; Volum 282. ISSN 0021-9258.s doi: 10.1074/jbc.M610174200.
  • Leiros, Ingar; Nabong, Marivi; Nabong, MP; Grosvik, K; Grøsvik, Kristin; Ringvoll, J; Ringvoll, Jeanette; Haugland, GT; Uldal, Lene; Uldal, L; Reite, K; Olsbu, IK; Knævelsrud, Ingeborg; Knaevelsrud, I; Moe, Elin; Andersen, Ole Andreas; Birkeland, NK; Ruoff, P; Klungland, A; Bjelland, S. Structural basis for enzymatic excision of N-1-methyladenine and N-3-methylcytosine from DNA. EMBO Journal 2007; Volum 26. ISSN 0261-4189.s doi: 10.1038/sj.emboj.7601662.
  • Timmins, J; Leiros, Ingar; McSweeney, S. Crystal structure and mutational study of RecOR provide insight into its mode of DNA binding. EMBO Journal 2007; Volum 26. ISSN 0261-4189.s 3260 - 3271.s doi: 10.1038/sj.emboj.7601760.
  • Leiros, Ingar; Wang, Ellen; Rasmussen, Tonni; Oksanen, Esko; Repo, Heidi; Petersen, S. B.; Heikinheimo, Pirkko; Hough, Edward. The 2.1 A structure of Aerococcus viridans L-lactate oxidase (LOX). Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2006; Volum 62 (12). ISSN 1744-3091.s 1185 - 1190.
  • Sørmo, Christopher; Leiros, Ingar; Brembu, T.; Winge, Per; Os, vibeke; Bones, Atle M. The crystal structure of Arabidopsis thaliana RAC7/ROP9: The first RAS superfamily GTPase from the plant kingdom. Phytochemistry 2006; Volum 67 (21). ISSN 0031-9422.s 2332 - 2340.
  • Moe, Elin; Leiros, Ingar; Smalås, Arne Oskar; McSweeney, Sean. The crystal structure of mismatch-specific uracil-DNA glycosylase (MUG) from Deinococcus radiodurans reveals a novel catalytic residue and broad substrate specificity. Journal of Biological Chemistry 2006; Volum 281. ISSN 0021-9258.
  • Leiros, Ingar; Moe, Elin; Smalås, Arne Oskar; McSweeney, Sean. Structure of the uracil-DNA N-glycosylase (UNG) from Deinococcus radiodurans. Acta Crystallographica Section D: Biological Crystallography 2005; Volum 61. ISSN 0907-4449.
  • Timmins, Joanna; Leiros, Hanna-Kirsti S.; Leonard, Gordon; Leiros, Ingar; McSweeney, Sean. Crystal structure of maltooligosyltrehalose trehalohydrolase from Deinococcus radiodurans in complex with disaccharides. Journal of Molecular Biology (JMB) 2005; Volum 347 (5). ISSN 0022-2836.s 949 - 963.
  • Johnsen, Line; Dalhus, Bjørn; Leiros, Ingar; Nissen-meyer, Jon. 1.6-Angstroms crystal structure of EntA-im. A bacterial immunity protein conferring immunity to the antimicrobial activity of the pediocin-like bacteriocin enterocin A. Journal of Biological Chemistry 2005; Volum 280 (19). ISSN 0021-9258.s 19045 - 19050.
  • Leiros, Ingar; Timmins, Joanna; Hall, David Richard; McSweeney, Sean. Crystal structure and DNA-binding analysis of RecO from Deinococcus radiodurans. EMBO Journal 2005; Volum 24 (5). ISSN 0261-4189.s 906 - 918.
  • Moe, Elin; Leiros, Ingar; Riise, Ellen Kristin; Olufsen, Magne; Lanes, Olav; Smalås, Arne Oskar; Willassen, Nils Peder. Optimisation of the surface electrostatics as a strategy for cold adaptation of uracil-DNA N-glycosylase (UNG) from Atlantic cod (Gadus morhua). Journal of Molecular Biology (JMB) 2004; Volum 343 (5). ISSN 0022-2836.s 1221 - 1230.
  • Leiros, Hanna-Kirsti S.; Leiros, Hanna Kirsti Schrøder; Brandsdal, Bjørn Olav; Andersen, Ole Andreas; Os, vibeke; Leiros, Ingar; Leiros, Ingar; Helland, Ronny; Otlewski, J.; Otlewski, Jacek; Willassen, Nils Peder; Smalås, Arne Oskar. Trypsin specificity as elucidated by LIE calculations, X-ray structures, and association constant measurements. Protein Science 2004; Volum 13. ISSN 0961-8368.s 1056 - 1070.
  • Leiros, Ingar; Leiros, Ingar; McSweeney, S.; McSweeney, Sean; Hough, Edward. The reaction mechanism of phospholipase D from Streptomyces sp strain PMF. snapshots along the reaction pathway reveal a pentacoordinate reaction intermediate and an unexpected final product. Journal of Molecular Biology (JMB) 2004; Volum 339. ISSN 0022-2836.s 805 - 820.
  • Stenvik, jØrgen; Solstad, therese; Strand, cato; Leiros, Ingar; Jørgensen, Trond Ø.. Cloning and analyses of a BPI/LBP cDNA of the Atlantic cod (Gadus morhua L.). Developmental and Comparative Immunology 2004; Volum 28. ISSN 0145-305X.s 307 - 323.
  • Helland, Ronny; Czapinska, Honorata; Leiros, Ingar; Olufsen, Magne; Otlewski, Jacek; Smalås, Arne Oskar. Structural Consequences of Accommodation of Four Non-cognate Amino Acid Residues in the S1 Pocket of Bovine Trypsin and Chymotrypsin. Journal of Molecular Biology (JMB) 2003; Volum 333 (4). ISSN 0022-2836.s 845 - 861.
  • Leiros, Ingar; Moe, Elin; Lanes, Olav; Smalås, Arne Oskar; Willassen, Nils Peder. The crystal structure of uracil-DNA-glycosylase from Atlantic cod (Gadus morhua) reveals cold-adaptation fetures. Acta Crystallographica Section D: Biological Crystallography 2003; Volum 59. ISSN 0907-4449.s 1357 - 1365.
  • Heikinheimo, Pirkko a; Helland, Ronny; Leiros, Hanna-Kirsti S.; Leiros, Ingar; Karlsen, Solveig; Evjen, gry; Ravelli, Raimond; Schoehn, Guy; Ruigrok, Rob; McSweeney, Sean; Hough, Edward. The structure of the bovine lysosomal a-mannosidase suggests a novel mechanism for low pH activation. Journal of Molecular Biology (JMB) 2003; Volum 327 (3). ISSN 0022-2836.s 631 - 644.
  • Lanes, Olav; Leiros, Ingar; Smalås, Arne Oskar; Willassen, Nils Peder. Identification, cloning, and expression of uracil-DNA glycosylase from Atlantic cod (gadus morhua): charcterization and homology modeling of the cold-active catalytic domain. Extremophiles 2002; Volum 6. ISSN 1431-0651.s 73 - 86.
  • Bossi, L.; D'Arrigo, P.; Pedrocchi-Fantoni, G.; Mele, A.; Servi, S.; Leiros, Ingar. The substrate requirements of phospholipase D. Journal of Molecular Catalysis B: Enzymatic 2001; Volum 11. ISSN 1381-1177.s 433 - 438.
  • Leiros, Ingar; Lanes, Olav; Sundheim, Ottar; Helland, Ronny; Smalås, Arne O; Willassen, Nils P. Crystallization and preliminary X-ray diffraction analysis of a cold-adapted uracil-DNA glycosylase from Atlantic cod (Gadus morhua). Acta Crystallographica Section D: Biological Crystallography 2001; Volum 57 (11). ISSN 0907-4449.s 1706 - 1708.s doi: 10.1107/S0907444901013427.
  • Leiros, Ingar; Lanes, Olav; Sundheim, Ottar; Helland, Ronny; Smalås, Arne Oskar; Willassen, Nils Peder. Crystallization and preliminary X-ray diffraction analysis of a cold-adapted uracil-DNA glycosylase from Atlantic cod (Gadus morhua). Acta Crystallographica Section D: Biological Crystallography 2001; Volum 57. ISSN 0907-4449.s 1706 - 1708.
  • Leiros, Ingar; Secundo, F.; Cambonelli, Carlo; Servi, S.; Hough, Edward. The first crystal structure of a phospholipase D. Structure 2000; Volum 8. ISSN 0969-2126.s 655 - 667.
  • Leiros, Ingar; Hough, Edward; D'Arrigo, P.; Carrea, G.; Pedrocchi-Fantoni, G.; Secundo, F.; Servi, S.. Crystallization and preliminary X-ray diffraction studies of Phospholipase D from Streptomyces sp. Acta Crystallographica Section D: Biological Crystallography 2000; Volum 56. ISSN 0907-4449.s 466 - 468.
  • Helland, Ronny; Leiros, Ingar; Berglund, Gunnar Inge; Willassen, Nils Peder; Smalås, Arne Oskar. The crystal structure of anionic salmon trypsin in complex with bovine pancreatic trypsin inhibitor. European Journal of Biochemistry (EJB) 1998; Volum 256 (2). ISSN 0014-2956.s 317 - 324.
  • Trondsen, Susann; Leiros, Ingar; Altermark, Bjørn. Expression and characterization of wood-degrading enzymes from a shipworm digestive system. The 56th Norwegian Biochemical Society (NBS) contact meeting 2020-01-23 - 2020-01-26 2020.
  • Hillier, Heidi Therese; Altermark, Bjørn; Leiros, Ingar. Enzymes in The Ectoine Biosynthesis Pathway. The 56th Norwegian Biochemical Society (NBS) contact meeting 2020-01-23 - 2020-01-26 2020.
  • Trondsen, Susann; Leiros, Ingar; Altermark, Bjørn. Shipworm-associated bacteria - a novel source of cold-adapted wood-degrading enzymes. The 3rd Annual BioCat Meeting 2019-06-05 - 2019-06-07 2019.
  • Trondsen, Susann; Leiros, Ingar; Ræder, Inger Lin Uttakleiv; Pandur, Seila; Altermark, Bjørn. Tapping into the proteome of shipworm symbionts - a novel source of cold-adapted lignocellulases. Norwegian Biochemical Society 55th Contact Meeting 2019-01-24 - 2019-01-27 2019.
  • Trondsen, Susann; Altermark, Bjørn; Leiros, Ingar. Shipworm-associated bacteria - A novel source of cold-adapted wood-degrading enzymes. The 3rd Annual BioCat Meeting 2019-06-05 - 2019-06-07 2019.
  • Hillier, Heidi Therese; Altermark, Bjørn; Leiros, Ingar. Enzymes in the ectoine biosynthesis pathway. The 11th Joint BER II and BESSY II User Meeting 2019-12-04 - 2019-12-06 2019.
  • Hillier, Heidi Therese; Leiros, Ingar; Altermark, Bjørn. Characterizing Enzymes in The Ectoine Biosynthesis Pathway. BioTrans 2019 Groningen the 14th International Symposium on Biocatalysis and Biotransformations 2019-07-07 - 2019-07-11 2019.
  • Hillier, Heidi Therese; Altermark, Bjørn; Leiros, Ingar. Characterizing Enzymes in The Ectoine Biosynthesis Pathway. Synchrotron Data-Collection Workshop in Berlin (Bessy-II) 2019-07-04 - 2019-07-06 2019.
  • Hillier, Heidi Therese; Altermark, Bjørn; Leiros, Ingar. Characterizing Enzymes in The Ectoine Biosynthesis Pathway. The 3rd Annual BioCat Meeting 2019-06-05 - 2019-06-07 2019.
  • Hillier, Heidi Therese; Altermark, Bjørn; Leiros, Ingar. Characterizing enzymes in the biosynthesis pathway of Ectoine. The 6th Novel Enzymes Conference 2018-10-09 - 2018-10-12 2018.
  • Williamson, Adele Kim; Hjerde, Erik; Sarre, Aili; Leiros, Ingar; Berg, Kristel; Leiros, Hanna-Kirsti S.. Discovery and design of novel DNA ligases for biotechnology. 6th International Conference on Novel Enzymes 2018 2018-10-09 - 2018-10-12 2018.
  • Hillier, Heidi Therese; Altermark, Bjørn; Leiros, Ingar. Ectoine: an osmolyte from the model organism Chromohalobacter salexigens. The 2nd Annual BioCat Meeting 2018-06-04 - 2018-06-06 2018.
  • Gurung, Man Kumari; Berg, Tor Olav; Halsør, Marie-Josée Haglund; Altermark, Bjørn; Leiros, Ingar; Helland, Ronny; Rothweiler, Ulli; Smalås, Arne O.; Ræder, Inger Lin Uttakleiv. Efficient production of sialic acids- Using enzymes for biomass conversion. Eurocarb 2017 2017-07-02 - 2017-07-06 2017.
  • Larsen, Øivind; Arsin, Hasan; Stokke, Runar; Garcia-Moyano, Antonio; Puntervoll, Pål; Leiros, Ingar; Smalås, Arne O.; Steen, Ida Helene; Bjerga, Gro Elin Kjæreng. Discovery of proteases for bioconversion of marine biomass. Bioprosp 2017 2017-03-08 - 2017-03-10 2017.
  • Gurung, Man Kumari; Berg, Tor Olav; Halsør, Marie-Josée Haglund; Altermark, Bjørn; Leiros, Ingar; Helland, Ronny; Rothweiler, Ulli; Smalås, Arne O.; Ræder, Inger Lin Uttakleiv. Efficient production of sialic acids- Using enzymes for biomass conversion. BIOPROSP2017 2017-03-08 - 2017-03-10 2017.
  • Berg, Tor Olav; Halsør, Marie-Josée Haglund; Gurung, Man Kumari; Altermark, Bjørn; Leiros, Ingar; Rothweiler, Ulli; Helland, Ronny; Smalås, Arne O.; Ræder, Inger Lin Uttakleiv. From marine rest raw materials to sialic acids: Using enzymes for biomass conversion. Frontiers in Sialic Acid Research 2016-04-23 - 2016-04-25 2016.
  • Berg, Tor Olav; Altermark, Bjørn; Leiros, Ingar; Helland, Ronny; Ræder, Inger Lin Uttakleiv. Production of sialic acids and derivatives by enzyme catalysis. NBS Contact meeting 2016 2016-01-21 - 2016-01-23 2016.
  • Berg, Tor Olav; Altermark, Bjørn; Leiros, Ingar; Helland, Ronny; Ræder, Inger Lin Uttakleiv. Biocatalytical production of sialic acids and derivatives. Annual BioStruct Conference 2015 2015-08-27 - 2015-08-30 2015.
  • Moe, Elin; Leiros, Ingar; Hall, David; Sarre, Aili; Smalås, Arne O.; McSweeney, Sean; Timmins, Joanna. Base Excision Repair (BER) in Deinococcus radiodurans. Tomas Lindahl Conference on DNA repair 2015-06-17 - 2015-06-21 2015.
  • Skagseth, Susann; Edvardsen, Kine Susann Waade; Bjerga, Gro Elin Kjæreng; Lorentzen, marit sjo; Leiros, Ingar; Samulesen, Ørjan; Leiros, Hanna-Kirsti S.. Site-directed mutagenesis of metallo-beta-lactamase VIM-7 from the opportunistic human pathogenic bacteria Pseudomonas aeruginosa. NBS konferanse 2013-01-31 - 2013-02-03 2013.
  • Grgic, Miriam; Bjerga, Gro Elin Kjæreng; Altermark, Bjørn; Leiros, Ingar. C5-methyltransferase from cold-adapted organism. Norwegian Biochemical Society 48TH CONTACT MEETING 2012-02-19 - 2012-02-22 2012.
  • Gurung, Man Kumari; Ræder, Inger Lin Uttakleiv; Altermark, Bjørn; Leiros, Ingar; Ökvist, Mats; Smalås, Arne O.. Exploring sialic acid synthesizing enzymes from Aliivibrio salmonicida. The Norwegian Biochemical Society 48th Contact meeting 2012-01-19 - 2012-01-22 2012.
  • Ökvist, Mats; Ræder, Inger Lin Uttakleiv; Leiros, Ingar; Smalås, Arne O.. Structure of Sialic Acid Biosynthesis Enzyme PtmG from Aliivibrio Salmonicida. The Norwegian Biochemical Society 47th Contact meeting 2011-02-03 - 2011-02-06 2011.
  • Ræder, Inger Lin Uttakleiv; Gurung, Man Kumari; Altermark, Bjørn; Leiros, Ingar; Ökvist, Mats; Smalås, Arne O.. Sialic acid biosynthesis in Aliivibrio salmonicida. BIOPROSP 2011 2011-02-23 - 2011-02-25 2011.
  • Ökvist, Mats; Ræder, Inger Lin Uttakleiv; Leiros, Ingar; Smalås, Arne O.. Structure of sialic acid biosynthesis enzyme PtmG from Aliivibrio salmonicida. BIOPROSP 2011 2011-02-23 - 2011-02-25 2011.
  • Gurung, Man Kumari; Ræder, Inger Lin Uttakleiv; Altermark, Bjørn; Leiros, Ingar; Ökvist, Mats; Smalås, Arne O.. Sialic acid biosynthesis in Aliivibrio salmonicida. The Norwegian Biochemical Society 47th Contact meeting 2011-02-03 - 2011-02-06 2011.
  • Altermark, Bjørn; Ræder, Inger Lin Uttakleiv; Hadrovic, Martina; Leiros, Ingar; Smalås, Arne O.. Sialic Acid Synthesis in Aliivibrio salmonicida. 4th International BIOPROSP Conference on Marine Biotechnology 2009-02-24 - 2009-02-25 2009.
  • Ræder, Inger Lin Uttakleiv; Altermark, Bjørn; Hadrovic, Martina; Leiros, Ingar; Smalås, Arne O.. Sialic acid synthesis in Aliivibrio salmonicida. EUROCARB 2009 2009-07-19 - 2009-07-24 2009.
  • Timmins, Joanna; Leiros, Ingar; McSweeney, Sean. Structural insights into the early steps of homologous recombination in bacteria. ESRF Highlights 2007 2008.s 66 - 67.
  • Leiros, Hanna-Kirsti S.; Pey, Angel L.; Innselset, M; Moe, Elin; Leiros, Ingar; Steen, Ida Helene; Martinez, Aurora. Crystal Structure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H reveals a monomeric cold active enzyme with local flexibility around the active site and high overall stability. Norwegian Biochemical Society (NBS) contact meeting 2008 2008-01-17 - 2008-01-20 2008.
  • Moe, Elin; Leiros, Ingar; Hall, David Richard; Smalås, Arne Oskar; McSweeney, Sean. Structure/function studies of Base Excision Repair (BER) enzymes from the extreme radiation resistant bacterium Deinococcus radiodurans. The Norwegian Biochemical Society 44th Contact meeting 2008-01-17 - 2008-01-20 2008.
  • Leiros, Ingar. Methods in structural determinations. Genome repair and regulation 2008-03-31 - 2008-04-01 2008.
  • Leiros, Ingar. Structures in DNA repair and regulation. Genome repair and regulation 2008-03-31 - 2008-04-01 2008.
  • Leiros, Ingar. Structural basis for enzymatic excision of N1-methyladenine and N3-methylcytosine from DNA. BFYS 2007 2007-05-11 - 2007-05-13 2007.
  • Leiros, Ingar. Structural basis for enzymatic excision of N1- methyladenine and N3-methylcytosine from DNA. Norwegian Synchrotron Users Meeting 2007-06-04 - 2007-06-05 2007.
  • Leiros, Ingar; Brembu, Tore; Winge, Per; Os, Vibeke; Bones, Atle M.. The crystal structure of Arabidopsis thaliana RAC7: A RAS superfamily GTPase from the plant kingdom. The AtRAC7 protein structure is named Structure of the Month by the BESSY Protein Structure Factory (data) 2007-03-01 - 2007-07-03 2007.
  • Leiros, Ingar; Nabong, Marivi P.; Haugland, Gyri Teien; Ringvoll, Jeanette; Grøsvik, Kristin; Moe, Elin; Knævelsrud, Ingeborg; Reite, Karen; Andersen, Ole Andreas; Birkeland, Nils-Kåre; Klungland, Arne; Bjelland, Svein. Excision of 1-methyladenine and 3-methylcytosine from DNA by AfAlkA of Archaeoglobus fulgidus.. Erling Seeberg symposium on DNA repair, 2006-05-28 - 2006-06-02 2006.
  • Moe, Elin; Timmins, Joanna; Hall, David Richard; Leiros, Ingar; McSweeney, Sean. Structure-function studies of DNA repair proteins from Deinococcus radiodurans. International Conference on Structural Genomics 2006 2006-10-22 - 2006-10-26 2006.
  • Ræder, Inger Lin Uttakleiv; Leiros, Ingar; Willassen, Nils Peder; Smalås, Arne Oskar; Moe, Elin. Uracil-DNA N-glycosylase (UNG) from the marine psychrophilic bacterium Vibrio salmonicida shows cold adapted features. BIOPROSP 2006 2006-10-11 - 2006-10-12 2006.
  • Timmins, Joanna; Leiros, Hanna-Kirsti S.; Leonard, Gordon; Leiros, Ingar; McSweeney, Sean. Crystal Structure of Maltooligosyltrehalose Trehalohydrolase from D. radiodurans. ESRF Highlights 2005 2006.s 68 - 70.
  • Leiros, Ingar; Nabong, Marivi P.; Haugland, GT; Ringvoll, Jeanette; Grøsvik, K; Grøsvik, K; Moe, Elin; Knævelsrud, I.; Knævelsrud, I.; Reite, Karen; Andersen, Ole A.; Birkeland, Nils-Kåre; Klungland, Arne; Bjelland, Svein; Bjelland, Svein. Excision of 1-methyladenine and 3-methylcytosine from DNA by AfAlkA of Archaeoglobus fulgidus. Erling Seeberg symposium on DNA repair 2006-05-30 - 2006-06-05 2006.
  • Moe, Elin; Leiros, Ingar; Smalås, Arne Oskar; McSweeney, Sean. Crystallisation and structure determination of uracil-DNA glycosylases from Deinococcus radiodurans and Vibrio salmonicida. A Collaboration between ESRF and NorStruct. The 3rd Norwegian User Meeting - Application of Synchrotron radiation 2005-03-10 - 2005-03-11 2005.
  • Moe, Elin; Leiros, Ingar; Smalås, Arne Oskar; McSweeney, Sean. Crystallisation and structure determination of a mismatch specific DNA glycosylase (MUG) from Deinococcus radiodurans. Functional genomics in the Nordic Countries 2005-09-05 - 2005.
  • Leiros, Ingar. Progress on the RecO/RecOR projects. MX Science Days, Col de Porte 2005-06-13 - 2005-06-13 2005.
  • Hall, David Richard; Leiros, Ingar; Leiros, Hanna-Kirsti S.; Micossi, E.; Gordon, E.; Macedo, S.; Kapp, U.; Jamin, C.; Timmins, Joanna; Leonard, Gordon; McSweeney, Sean. Structural Genomics at the ESRF: Studying Deinococcus radiodurans. ESRF Highlights 2003 2004.s 29 - 29.
  • Moe, Elin; Leiros, Ingar; Smalås, Arne Oskar; McSweeney, Sean. Structure determination of mismatch specific uracil-DNA glycosylase (MUG) from the radiation resistant bacteria Deinococcus radiodurans. VI European Protein science meeting 2004-04-30 - 2005-05-04 2004.
  • Moe, Elin; Leiros, Ingar; Smalås, Arne Oskar; Willassen, Nils Peder. Screening for cold adapted enzymes. BIOPROSP 2004 2004-10-13 - 2004-10-14 2004.
  • Leiros, Ingar. The crystal structure of RecO from Deinococcus radiodurans. Understanding the mechanism of DNA-protein interaction. ESRF Science Days 2004-05-16 - 2004-05-18 2004.
  • Leiros, Ingar. The crystal structure of RecO from Deinococcus radiodurans. Understanding the mechanism of DNA-protein interaction. PSB-IVMS Science day 2004-06-18 - 2004-06-18 2004.
  • Leiros, Ingar. The crystal structure of RecO from Deinococcus radiodurans: Understanding the mechanism of DNA-protein interaction. PSB Newsletter September 2004 2004.s 8 - 8.
  • Heikinheimo, Pirkko a; Helland, Ronny; Leiros, Hanna-Kirsti S.; Leiros, Ingar; Karlsen, Solveig; Evjen, gry; Ravelli, Raimond; Schoehn, Guy; Ruigrok, Rob; Tollersrud, ole kristian; McSweeney, Sean; Hough, Edward. Structure of the Bovine Lysosomal a-Mannosidase, the Enzyme Involved in the Lysosomal Storage Disease a-Mannosidosis. ESRF Highlights 2002 2003.s 12 - 13.
  • Hough, Edward; McSweeney, Sean; Leiros, Ingar. A Multidisciplinary Study. Solution of the Structure and Reaction Mechanism of Phospholipase D from Streptomyces sp. strain PMF. ESRF Highlights 1999 2000.s 17 - 18.
  • Leiros, Ingar. X-ray analysis of PLD. NorFa Phospholipase A2 Workshop 1998-09-03 - 1998-09-06 1998.
  • Helland, Ronny; Berglund, Gunnar; Hansen, Lars Kr; Heimstad, Eldbjørg S.; Hordvik, Asbjørn; Leiros, Ingar; Leiros, Hanna-Kirsti S.; Os, vibeke; Outzen, Heidi; Willassen, Nils Peder; Smalås, Arne Oskar. Structure-Function Relation Studies of Enzymes from Cold Adapted Species. Higher European Research Course for Users of Large Experimental Systems (HERCULES) 1995-02-26 - 1995-04-07 1995.
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    Research interests

    Teaching

    • Project leader: BioCat (2016-2024). BioCat is a national graduate school in biocatalysis, granted by The Norwegian Research Council. It is established to provide expertise and tools for research and research education within biocatalysis in Norway. The school is open to all PhD-students and their research groups within the field. Biocatalysis is important in many areas including  biomedicine, biotechnology,  microbiology, and (bio)nanoscience.  Additionally, biocatalysis is becomming increasingly important industrial processes and in various diagnostics-, gene- and biotechnologies, and is expected to be important in the transition of the society to a bio-based economy. Six Norwegian universities, 4 research institutes and the Industrial Biotechnology Network Norway, constitute the BioCat consortium. This collaboration represents a unification of many strong research groups, giving the students great access to both the expertise, facilities and training offered by the Norwegian biocatalysis research community.

    Member of research group

    Biomolecular and Structural Chemistry   English content
    FPARK G 220

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