Bilde av Abel, Sören
Photo: Bjørn-Kåre Iversen
Bilde av Abel, Sören
Department of Pharmacy sab012@post.uit.no +4777646632 +47 909 86 484 Tromsø

Sören Abel


Group leader Infection Biology / NCMM Young Associate Investigator (YAI)


  • Julia Weikum, Jeroen F. van Dyck, Saranya Subramani, David P. Klebl, Merete Storflor, Stephen P. Muench et al.:
    The bacterial magnesium transporter MgtA reveals highly selective interaction with specific cardiolipin species
    BBA - Molecular Cell Research 2023 ARKIV / DOI
  • Colin Hemez, Fabrizio Clarelli, Adam C. Palmer, Christina Bleis, Sören Abel, Leonid Chindelevitch et al.:
    Mechanisms of antibiotic action shape the fitness landscapes of resistance mutations
    Computational and Structural Biotechnology Journal 2022 ARKIV / DOI
  • Aaron Nicholas Gillman, Alexandra Helleux, Sören Abel :
    A single step three-strain in vivo Gateway reaction
    Plasmid 2021 ARKIV / DOI
  • Aaron Nicholas Gillman, Anel Mahmutovic, Pia Abel zur Wiesch, Sören Abel :
    The Infectious Dose Shapes Vibrio Cholerae Within-Host Dynamics
    mSystems 2021 ARKIV / DOI
  • Anel Mahmutovic, Pia Abel zur Wiesch, Sören Abel :
    Selection or drift: the population biology underlying transposon insertion sequencing experiments.
    Computational and Structural Biotechnology Journal 2020 ARKIV / DOI
  • Fabrizio Clarelli, Adam Palmer, Bhupender Singh, Merete Storflor, Silje Lauksund, Ted Cohen et al.:
    Drug-target binding quantitatively predicts optimal antibiotic dose levels in quinolones
    PLoS Computational Biology 2020 ARKIV / DOI
  • Antal Martinecz, Fabrizio Clarelli, Sören Abel, Pia Abel zur Wiesch :
    Reaction Kinetic Models of Antibiotic Heteroresistance
    International Journal of Molecular Sciences 2019 ARKIV / DOI
  • Alyson R. Warr, Troy P. Hubbard, Diana Munera, Carlos J. Blondel, Pia Abel zur Wiesch, Sören Abel et al.:
    Transposon-insertion sequencing screens unveil requirements for EHEC growth and intestinal colonization
    PLoS Pathogens 2019 ARKIV / DOI
  • Ting Zhang, Sören Abel, Pia Abel zur Wiesch, Jumpei Sasabe, Brigid M. Davis, Darren E. Higgins et al.:
    Deciphering the landscape of host barriers to Listeria monocytogenes infection
    Proceedings of the National Academy of Sciences of the United States of America 2017 ARKIV / DOI
  • Troy Hubbard, Michael C Chao, Sören Abel, Carlos J Blondel, Pia Abel zur Wiesch, Xiaohui Zhou et al.:
    Genetic analysis of vibrio parahaemolyticus intestinal colonization
    Proceedings of the National Academy of Sciences of the United States of America 2016 DOI
  • Michael C Chao, Sören Abel, Brigid M. Davis, Matthew K. Waldor :
    The design and analysis of transposon insertion sequencing experiments
    Nature Reviews Microbiology 2016 DOI
  • Stavroula K Hatzios, Sören Abel, Julianne Martell, Troy Hubbard, Jumpei Sasabe, Diana Munera et al.:
    Chemoproteomic profiling of host and pathogen enzymes active in cholera
    Nature Chemical Biology 2016 DOI
  • Pia Abel zur Wiesch, Sören Abel, Spyridon Gkotzis, Paolo Ocampo, Jan Engelstädter, Trevor Hinkley et al.:
    Classic reaction kinetics can explain complex patterns of antibiotic action
    Science Translational Medicine 2015 DOI
  • Christian Lori, Shogo Ozaki, Samuel Steiner, Raphael Böhm, Sören Abel, Badri Nath Dubey et al.:
    Cyclic di-GMP acts as a cell cycle oscillator to drive chromosome replication
    Nature 2015 DOI
  • Sören Abel, Matthew K. Waldor :
    Infant rabbit model for diarrheal diseases
    Current Protocols in Microbiology 2015 DOI
  • Sören Abel, Pia Schulz Zur Wiesch, Brigid M. Davis, Matthew K. Waldor :
    Analysis of Bottlenecks in Experimental Models of Infection
    PLoS Pathogens 2015 ARKIV / DOI
  • Sören Abel, Pia Karoline Abel-Zur Wiesch Genannt Hülsho, Hsiao-Han Chang, Brigid M. Davis, Marc Lipstich, Matthew K. Waldor :
    Sequence tag-based analysis of microbial population dynamics
    Nature Methods 2015 DOI
  • Justin Pritchard, Michael C Chao, Sören Abel, Brigid M. Davis, Catherine Baranowski, Yanjia Zhang et al.:
    ARTIST: high-resolution genome-wide assessment of fitness using transposon-insertion sequencing
    PLoS Genetics 2014 DOI
  • Pia Karoline Abel-Zur Wiesch Genannt Hülsho, Roger D. Kouyos, Sören Abel, Wolfgang Viechtbauer, Sebastian Bonhoeffer :
    Cycling empirical antibiotic therapy in hospitals: meta-analysis and models
    PLoS Pathogens 2014 DOI
  • Coralie Fumeaux, Sunish Radhakrishnan, Silvia Ardissone, Laurance Theraulaz, Antonio Frandi, Daniel Martins et al.:
    Cell cycle transition from S-phase to G1 in Caulobacter is mediated by ancestral virulence regulators
    Nature Communications 2014 DOI
  • Sören Abel, Tabitha Bucher, Micael Nicollier, Isabelle Hug, Volkhard Kaever, Pia Karoline Abel-Zur Wiesch Genannt Hülsho et al.:
    Bi-modal distribution of the second messenger c-di-GMP controls cell fate and asymmetry during the caulobacter cell cycle
    PLoS Genetics 2013 DOI
  • Sören Abel, Peter Chien, Paul Wassmann, Tilman Schirmer, Volkhard Kaever, Michael Laub et al.:
    Regulatory cohesion of cell cycle and cell differentiation through interlinked phosphorylation and second messenger networks
    Molecular Cell 2011 DOI
  • Andreas Diepold, Marlise Amstutz, Sören Abel, Isabel Sorg, Urs Jenal, Guy Cornelis :
    Deciphering the assembly of the Yersinia type III secretion injectisome
    EMBO Journal 2010 DOI
  • Anna Duerig, Sören Abel, Marc Folcher, Micael Nicollier, Torsten Schwede, Nicolas Amiot et al.:
    Second messenger-mediated spatiotemporal control of protein degradation regulates bacterial cell cycle progression
    Genes & Development 2009 DOI
  • Ralf Paul, Tina Jaeger, Sören Abel, Irene Wiederkehr, Marc Folcher, Emanuele Biondi et al.:
    Allosteric regulation of histidine kinases by their cognate response regulator determines cell fate
    Cell 2008 DOI
  • Ralf Paul, Sören Abel, Paul Wassmann, Andreas Beck, Heiko Heerklotz, Urs Jenal :
    Activation of the diguanylate cyclase PleD by phosphorylation-mediated dimerization
    Journal of Biological Chemistry 2007 DOI
  • Øyvind Myrvoll Lorentzen, João Alves Gama, Klaus Harms, Sören Abel, Pål Jarle Johnsen :
    Genetic conflict between the SXT-element and a multidrug resistance plasmid in Vibrio cholerae
    2023
  • Øyvind Myrvoll Lorentzen, Christopher Fröhlich, Anne Sofie Haukefer, Sören Abel, Pål Jarle Johnsen :
    Evolution of Vibrio cholerae biofilms
    2023
  • Øyvind Myrvoll Lorentzen, João Alves Gama, Klaus Harms, Sören Abel, Pål Jarle Johnsen :
    Genetic conflict between the SXT-element and a multidrug resistance plasmid in Vibrio cholerae
    2023
  • Øyvind Myrvoll Lorentzen, Sören Abel, Pål Jarle Johnsen :
    Evolution of Vibrio cholerae biofilms
    2022
  • Anel Mahmutovic, Aaron Nicholas Gillman, Silje Lauksund, Natasha-Anne Robson Moe, Aimé Manzi, Merete Storflor et al.:
    RESTAMP – Rate estimates by sequence-tag analysis of microbial populations
    Computational and Structural Biotechnology Journal 2021 ARKIV / DOI
  • Sebastian Andres Acuña Maldonado, Ida Sundvor Opstad, Luis Enrique Villegas Hernandez, Mona Nystad, Milton O Aguilera, Merete Storflor et al.:
    Fluorescence Nanoscopy Using Multiple Signal Classiflcation Algorithm (MUSICAL): From Electromagnetics Inverse Scattering Problem to Optics Inverse Source Problem
    2019
  • Vidar Sørum, Anna Sollied Møller, Pål Jarle Johnsen, Ørjan Samuelsen, Sören Abel, Nicole L. Podnecky :
    Evolutionary stability of collateral effects in ciprofloxacin resistant clinical Escherichia coli strains
    2019
  • Vidar Sørum, Anna Sollied Møller, Sören Abel, Ørjan Samuelsen, Nicole L. Podnecky, Pål Jarle Johnsen :
    Evolutionary stability of collateral effects in ciprofloxacin resistant clinical Escherichia coli strains
    2019
  • Vidar Sørum, Emma Lu Øynes, Anna Møller, Nicole L. Podnecky, Sören Abel, Ørjan Samuelsen et al.:
    Evolutionary stability of collateral susceptibility networks in clinical Escherichia coli strains
    2019
  • Aimé Manzi, Sören Abel, Merete Storflor, Anel Mahmutovic :
    Bacterial replication and death rates during exposure to bacteriostatic antibiotics
    UiT Norges arktiske universitet 2019
  • Fabrizio Clarelli, Ted Cohen, Sören Abel, Bhupender Singh, Adam Palmer, Leonid Chindelevitch et al.:
    How molecular mechanisms of resistance affect resistance evolution
    2018
  • Sören Abel :
    The within host spread of Vibrio cholerae
    2018
  • Sören Abel, Anel Mahmutovic, Aaron Nicholas Gillman, Aime Manzi, Natasha-Anne Robson Moe, Silje Lauksund et al.:
    How to blast a biofilm
    2018
  • Fabrizio Clarelli, Bhupender Singh, Ted Cohen, Adam Palmer, Leonid Chindelevitch, Sören Abel et al.:
    Using models to understand how molecular mechanisms of resistance affect the risk of acquired drug resistance during treatment
    2018
  • Krishna Agarwal, Ida Sundvor Opstad, Jean-Claude Tinguely, Sören Abel, Trine Kalstad, Åsa birna Birgisdottir et al.:
    High-Speed, Multi-Color Live Cell Nanoscopy using MUSICAL
    2018
  • Fabrizio Clarelli, Bhupender Singh, Adam Palmer, Sören Abel, Ted Cohen, Pia Abel zur Wiesch :
    Quantitatively predicting antibiotic susceptibility from biochemical parameters: implications for antibiotic development and preventing resistance
    2018
  • Sören Abel :
    The within host spread of Vibrio cholerae
    2018
  • Sören Abel :
    The within host spread of Vibrio cholerae
    2018
  • Sören Abel :
    The within host spread of Vibrio cholerae
    2018
  • Ida Sundvor Opstad, Krishna Agarwal, Sören Abel, Balpreet Singh Ahluwalia :
    Multi-color nanoscopy of live-cell processes in E. Coli bacteria using MUSICAL
    2017
  • Fabrizio Clarelli, Leonid Chindelevitch, Bhupender Singh, Ted Cohen, Sören Abel, Pia Abel zur Wiesch :
    Using models to understand how molecular mechanisms of resistance affect the risk of acquired drug resistance during treatment
    2017
  • Christina Bleis, Sören Abel :
    Determining the cholerae acid tolerance genes by transposon insertion sequencing
    2017
  • Merete Storflor, Armin Schniers, Terkel Hansen, Sören Abel :
    Quantifying c-di-GMP during infections on a single cell level
    2017
  • Aaron Nicholas Gillman, Bhupender Singh, Sören Abel :
    Population Dynamics of V. cholerae
    2017

  • The 50 latest publications is shown on this page. See all publications in Cristin here →


    Research interests

    Research interests

    The goal of my research is to decipher the molecular mechanisms that allow pathogens to adapt to the different environmental conditions they encounter during infection and transmission. I am particularly interested in the c-di-GMP signaling network and its impact on population dynamics, bacterial virulence and persistence under changing conditions. For more details, see the homepage of the Infection Biology Research Group.

     

    CV

    2002-2003: MSc (German 'Diplom') in Biochemistry &
                         Molecular Biology (University of Kiel, Germany)

    2004-2008: PhD in Molecular Microbiology (University of Basel, Switzerland)

    2008-2012: Postdoctoral Researcher (University of Basel, Switzerland)

    2012-2015: Research Fellow (Harvard Medical School, USA),

                         Postdoctoral Research Fellow (Brigham and Women's Hospital, USA)

    2015-2017: Visiting assistant professor (Harvard Medical School, USA)

    since 2015: Young associate investigator (University of Tromsø (UiT) &
                         Centre for Molecular Medicine (NCMM), Norway,

                         Researcher (University Hospital of North Norway, Norway).

     

    PUBLICATION LIST (see also here)

    Warr AR, Hubbard TP, Munera D, Blondel CJ, Abel Zur Wiesch P, Abel S, Wang X, Davis BM, Waldor MK.
    Transposon-insertion sequencing screens unveil requirements for EHEC growth and intestinal colonization.
    PLOS PATHOGENS (2019) 15(8):e1007652.

    Martinecz A, Clarelli F, Abel S, and Abel zur Wiesch P.
    Reaction Kinetic Models of Antibiotic Heteroresistance.
    INT J MOL SCI (2019) 20(3965):1-16.

    Zhang T, Abel S, Abel zur Wiesch P, Sasabe J, Davis BM, Higgins DE, and Waldor MK.
    Deciphering the landscape of host barriers to Listeria monocytogenes infection.
    PNAS (2017) 114(24):6334-9.

    Hubbard PT, Chao MC, Abel S, Blondel CJ, Abel zur Wiesch P, Zhou X, Davis BM, and Waldor MK.
    Genetic analysis of Vibrio parahaemolyticus intestinal colonization.
    PNAS (2016) 113(22):6283-8.

    Hatzios SK, Abel S, Martell J, Hubbard T, Sasabe J, Munera D, Clark L, Bachovchin DA, Qadri F, Ryan ET, Davis BM, Weerapana E, and Waldor MK.
    Chemoproteomic profiling of host and pathogen enzymes active in cholera.
    NAT CHEM BIOL (2016) 12 (4):268-74.

    Chao MC, Abel S, Davis BM, and Waldor MK.
    The design and analysis of transposon insertion sequencing experiments.
    NAT REV MICROBIOL (2016) 14 (2):199-28.

    Abel S and Waldor MK.
    Infant Rabbit Model for Diarrheal Diseases.
    CURR PROTOC MICROBIOL (2015) 38:6A.6.1-6A.6.15.

    Abel S, Abel zur Wiesch P, Davis BM, and Waldor MK.
    Analysis of bottlenecks in experimental models of infection.
    PLOS PATHOGENS (2015) 11 (6), e1004823

    Abel zur Wiesch P, Abel S, Gkotzis S, Ocampo P, Engelstädter J, Hinkley T, Magnus C, Waldor MK, Udekwu K, and Cohen T.
    Classic reaction kinetics can explain complex patterns of antibiotic action.
    SCI TRANSL MED (2015) 7 (287):287ra73.

    Lori C*, Ozaki S*, Steiner S, Böhm R, Abel S, Dubey BN, Schirmer T, Hiller S, and Jenal U.
    Second Messenger Cyclic di-GMP acts as a cell cycle oscillator to drive chromosome replication.
    NATURE, (2015) 523 (7559):236–239.

    Abel S, Abel zur Wiesch P, Chang H-H, Davis BM, Lipsitch M, and Waldor MK.
    Sequence tag-based analysis of pathogen population dynamics.
    NATURE METHODS (2015) 12 (3):223-6.

    Pritchard JR*, Chao MC*, Abel S, Davis BM, Baranowski C, Zhang YJ, Rubin EJ, and Waldor MK.
    ARTIST: High-resolution genome-wide assessment of fitness using transposon-insertion sequencing.
    PLOS GENETICS (2014) 10 (11), e1004782

    Abel zur Wiesch P*, Kouyos RD*, Abel S, Viechtbauer W, and Bonhoeffer S.
    Cycling empirical antibiotic therapy in hospitals: meta-analysis and models.
    PLOS PATHOGENS (2014) 10 (6), e1004225

    Fumeaux C, Radhakrishnan SK, Ardissone S, Théraulaz L, Frandi A, Martins D, Nesper J, Abel S, Jenal U, and Viollier PH.
    Cell cycle transition from S-phase to G1 in Caulobacter is mediated by ancestral virulence regulators.
    NAT COM (2014) 5, doi:10.1038/ncomms5081.

    Abel S, Bucher T*, Nicollier M*, Hug I, Kaever V, Abel zur Wiesch P, and Jenal U.
    Bi-modal distribution of the second messenger c-di-GMP controls cell fate and asymmetry during the Caulobacter cell cycle.
    PLOS GENETICS (2013) 9 (9), e1003744 

    Abel S*,  Chien P*, Wassmann P, Schirmer T, Kaever V, Laub MT, Baker TA, and Jenal U.
    Regulatory cohesion of cell cycle and cell differentiation through interlinked phosphorylation and second messenger networks.
    MOL CELL (2011) 43:550-60.

    Diepold A, Amstutz M, Abel S, Sorg I, Jenal U, and Cornelis GR.
    Deciphering the assembly of the Yersinia type III secretion injectisome.
    EMBO (2010) 29 (11):1928-40.

    Duerig A, Abel S, Folcher M, Nicollier M, Schwede T, Amiot N, Giese B, and Jenal U.
    Second messenger-mediated spatiotemporal control of protein degradation regulates bacterial cell cycle progression.
    GENES & DEVELOPMENT (2009) 23:93–104.

    Paul R, Jaeger T*, Abel S*, Wiederkehr I, Folcher M, Biondi EG, Laub MT, and Jenal U.
    Allosteric regulation of histidine kinases by their cognate response regulator determines cell fate.
    CELL (2008) 133:452–61.

    Paul R, Abel S, Wassmann P, Beck A, Heerklotz H, and Jenal U.
    Activation of the diguanylate cyclase PleD by phosphorylation-mediated dimerization.
    J BIOL CHEM (2007) 282 (40):29170-7.

    Abel S*, Hundhausen C*, Mentlein R, Schulte A, Berkhout TA, Broadway N, Hartmann D, Sedlacek R, Dietrich S, Muetze B, Schuster B, Kallen KJ, Saftig P, Rose-John S, and Ludwig A.
    The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10.
    J IMMUNOL (2004) 172 (10):6362-72.

     

    BOOK CHAPTERS

    Abel S, and Jenal U.
    Role of cyclic di-GMP in Caulobacter crescentus development and cell cycle control.
    In Wolfe AJ, and Visick KL (ed.) in: The second messenger cyclic -di-GMP.
    ASM PRESS, Washington, DC (2010):120-136.

     

    HOMEPAGE

    Infection Biology Research Group