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Professor

Brekke, Ole-Lars

Professor II Department of Clinical Medicine
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  • Bjugn, Frid Sofie Lichtwarck; Storjord, Elin; Kristensen, Roy Morten; Brekke, Ole-Lars. Safe usage of bicalutamide and goserelin in a male patient with acute intermittent porphyria and prostate cancer. Scandinavian Journal of Urology 2019. ISSN 2168-1805.s 1 - 4.s doi: 10.1080/21681805.2018.1563628.

  • Brekke, Ole-Lars; Christiansen, Dorte; Kisserli, Aymric; Fure, Hilde; Dahl, Jim André; Donvito, Béatrice; Reveil, Brigitte; Ludviksen, Judith K; Tabary, Thierry; Mollnes, Tom Eirik; Cohen, Jacques H.M.. Key role of the number of complement receptor 1 on erythrocytes for binding of Escherichia coli to erythrocytes and for leukocyte phagocytosis and oxidative burst in human whole blood. Molecular Immunology 2019; Volum 114. ISSN 0161-5890.s 139 - 148.s doi: 10.1016/j.molimm.2019.07.014.

  • Gravastrand, Caroline S.; Steinkjer, Bjørg; Halvorsen, Bente; Landsem, Anne; Skjelland, Mona; Jacobsen, Eva Astrid; Woodruff, Trent M.; Lambris, John D.; Mollnes, Tom Eirik; Brekke, Ole-Lars; Espevik, Terje; Rokstad, Anne Mari. Cholesterol Crystals Induce coagulation Activation through Complement-Dependent Expression of Monocytic Tissue Factor. (Fulltekst: https://www.jimmunol.org/content/203/4/853.long (Omtale: https://www.jimmunol.org/content/203/4.cover-expansion) Journal of Immunology 2019; Volum 203 (4). ISSN 0022-1767.s 853 - 863.s doi: 10.4049/jimmunol.1900503.

  • Hardersen, Randolf Inge; Enebakk, Terje; Christiansen, Dorte; Bergseth, Grete; Brekke, Ole-Lars; Mollnes, Tom Eirik; Lappegård, Knut Tore; Hovland, Anders. Granulocyte and monocyte CD11b expression during plasma separation is dependent on complement factor 5 (C5) ? an ex vivo study with blood from a C5-deficient individual. APMIS - Journal of Pathologiy, Microbiology and Immunology 2018; Volum 126 (4). ISSN 0903-4641.s 342 - 352.s doi: 10.1111/apm.12821.

  • Landsem, Anne; Fure, Hilde; Ludviksen, Judith K; Christiansen, Dorte; Lau, Corinna; Mathisen, Monica Dammen; Bergseth, Grete; Nymo, Stig Haugset; Lappegård, Knut Tore; Woodruff, T. M.; Espevik, Terje; Mollnes, Tom Eirik; Brekke, Ole-Lars. Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli-induced coagulation accompanied by Toll-like receptor 4.. Clinical and Experimental Immunology 2018. ISSN 0009-9104.s doi: 10.1111/cei.13240.

  • Storjord, Elin; Dahl, Jim André; Landsem, Anne; Ludviksen, Judith K; Karlsen, Marlene; Karlsen, Bård Ove; Brekke, Ole-Lars. Lifestyle factors including diet and biochemical biomarkers in acute intermittent porphyria: Results from a case-control study in northern Norway.. Molecular Genetics and Metabolism 2018. ISSN 1096-7192.s 1 - 17.s doi: 10.1016/j.ymgme.2018.12.006.

  • Høiland, Ina Isabella; Liang, Robin Amanda; Hindberg, Kristian; Latysheva, Nadezhda; Brekke, Ole-Lars; Mollnes, Tom Eirik; Hansen, John-Bjarne. Associations between complement pathways activity, mannose-binding lectin, and odds of unprovoked venous thromboembolism. Thrombosis Research 2018; Volum 169. ISSN 0049-3848.s 50 - 56.s doi: 10.1016/j.thromres.2018.06.019.

  • Skjeflo, Espen Waage; Christiansen, Dorte; Fure, Hilde; Ludviksen, Judith K; Woodruff, Trent M.; Espevik, Terje; Nielsen, Erik Waage; Brekke, Ole-Lars; Mollnes, Tom Eirik. Staphylococcus aureus-induced complement activation promotes tissue factor-mediated coagulation. Journal of Thrombosis and Haemostasis 2018; Volum 16 (5). ISSN 1538-7933.s 905 - 918.s doi: 10.1111/jth.13979.

  • Storjord, Elin; Dahl, Jim André; Landsem, Anne; Fure, Hilde; Ludviksen, Judith K; Goldbeck-Wood, Sandy; Karlsen, Bård Ove; Berg, Kristin Sandal; Mollnes, Tom Eirik; Nielsen, Erik Waage; Brekke, Ole Lars. Systemic inflammation in acute intermittent porphyria:a case–control study. Clinical and Experimental Immunology 2017; Volum 187 (3). ISSN 0009-9104.s 466 - 479.s doi: 10.1111/cei.12899.

  • Gravastrand, Caroline; Hamad, Shamal; Fure, Hilde; Steinkjer, Bjørg; Ryan, Liv; Oberholzer, José; Lambris, John D.; Lacík, Igor; Mollnes, Tom Eirik; Espevik, Terje; Brekke, Ole-Lars; Rokstad, Anne Mari. Alginate microbeads are coagulation compatible, while alginate microcapsules activate coagulation secondary to complement or directly through FXII. (Fulltekst: http://www.sciencedirect.com/science/article/pii/S1742706117303434 Acta Biomaterialia 2017; Volum 58. ISSN 1742-7061.s 158 - 167.s doi: 10.1016/j.actbio.2017.05.052.

  • Hennø, Linda Torrissen; Storjord, Elin; Christiansen, Dorte; Bergseth, Grete; Ludviksen, Judith K; Fure, Hilde; Barene, Svein; Nielsen, Erik Waage; Mollnes, Tom Eirik; Brekke, Ole Lars. Effect of the anticoagulant, storage time and temperature of blood samples on the concentrations of 27 multiplex assayed cytokines ? Consequences for defining reference values in healthy humans. (http://www.sciencedirect.com/science/article/pii/S1043466617301424) Cytokine 2017; Volum 97. ISSN 1043-4666.s 86 - 95.s doi: 10.1016/j.cyto.2017.05.014.

  • Barene, Svein; Holtermann, Andreas; Oseland, Harald; Brekke, Ole Lars; Krustrup, Peter. Effects on muscle strength, maximal jump height, flexibility and postural sway after soccer and Zumba exercise among female hospital employees: A 9-month randomized controlled trial. (http://www.tandfonline.com/doi/pdf/10.1080/02640414.2016.1140906?redirect=1) Journal of Sports Sciences 2016; Volum 34 (19). ISSN 0264-0414.s 1849 - 1858.s doi: 10.1080/02640414.2016.1140906.

  • Landsem, Anne; Fure, Hilde; Mollnes, Tom Eirik; Nielsen, Erik Waage; Brekke, Ole Lars. C1-inhibitor efficiently delays clot development in normal human whole blood and inhibits Escherichia coli-induced coagulation measured by thromboelastometry. Thrombosis Research 2016; Volum 143. ISSN 0049-3848.s 63 - 70.s doi: 10.1016/j.thromres.2016.04.024.

  • Ørning, Mathias Pontus; Hoem, Kine Samset; Coron, Abba Elizabeth; Skjåk-Bræk, Gudmund; Mollnes, Tom Eirik; Brekke, Ole Lars; Espevik, Terje; Rokstad, Anne Mari. Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation. (Fulltekst: http://www.sciencedirect.com/science/article/pii/S0168365916301535 Journal of Controlled Release 2016; Volum 229. ISSN 0168-3659.s 58 - 69.s doi: 10.1016/j.jconrel.2016.03.021.

  • Hallstensen, Randi; Bergseth, Grete; Foss, Stian; Jæger, Steinar; Gedde-Dahl, Thobias; Holt, jan; Christiansen, Dorte; Lau, Corinna; Brekke, Ole Lars; Armstrong, Elina; Stefanovic, Vedran; Andersen, Jan Terje; Sandlie, Inger; Mollnes, Tom Eirik. Eculizumab treatment during pregnancy does not affect the complement system activity of the newborn. Immunobiology 2015; Volum 220 (4). ISSN 0171-2985.s 452 - 459.s doi: 10.1016/j.imbio.2014.11.003.

  • Skjeflo, Espen Waage; Sagatun, Caroline; Dybwik, Knut; Aam, Sturla; Urving, Sven Haakon; Nunn, Miles A.; Fure, Hilde; Lau, Corinna; Brekke, Ole Lars; Huber-Lang, Markus; Espevik, Terje; Barratt-Due, Andreas; Nielsen, Erik Waage; Mollnes, Tom Eirik. Combined inhibition of complement and CD14 improved outcome in porcine polymicrobial sepsis. Critical Care 2015; Volum 19:415. ISSN 1364-8535.s doi: 10.1186/s13054-015-1129-9.

  • Landsem, Anne; Fure, Hilde; Christiansen, Dorte; Nielsen, Erik Waage; Østerud, Bjarne; Mollnes, Tom Eirik; Brekke, Ole Lars. The key roles of complement and tissue factor in Escherichia coli-induced coagulation in human whole blood. Clinical and Experimental Immunology 2015; Volum 182 (1). ISSN 0009-9104.s 81 - 89.s doi: 10.1111/cei.12663.

  • Lau, Corinna; Olstad, Ole Kristoffer; Holden, Marit; Nygård, Ståle; Fure, Hilde; Lappegård, Knut Tore; Brekke, Ole Lars; Espevik, Terje; Hovig, Johannes Eivind; Mollnes, Tom Eirik. Gene expression profiling of Gram-negative bacteria-induced inflammation in human whole blood: The role of complement and CD14-mediated innate immune response. Genomics Data 2015; Volum 5. ISSN 2213-5960.s 176 - 183.s doi: 10.1016/j.gdata.2015.05.019.

  • Lau, Corinna; Nygård, Ståle; Fure, Hilde; Olstad, Ole Kristoffer; Holden, Marit; Lappegård, Knut Tore; Brekke, Ole Lars; Espevik, Terje; Hovig, Johannes Eivind; Mollnes, Tom Eirik. CD14 and complement crosstalk and largely mediate the transcriptional response to Escherichia coli in human whole blood as revealed by DNA microarray. PLOS ONE 2015; Volum 10 (2). ISSN 1932-6203.s doi: 10.1371/journal.pone.0117261.

  • Barene, Svein; Krustrup, Peter; Jackman, Sarah; Brekke, Ole Lars; Holtermann, Andreas. Do soccer and Zumba exercise improve fitness and indicators of health among female hospital employees? A 12-week RCT. (Fulltekst: http://onlinelibrary.wiley.com/doi/10.1111/sms.12138/pdf Scandinavian Journal of Medicine & Science in Sports 2014; Volum 24 (6). ISSN 0905-7188.s 990 - 999.s doi: 10.1111/sms.12138.

  • Evjenth, Bjørg; Hansen, Tonje Elisabeth; Brekke, Ole Lars; Holt, Jan. Establishing IMMULITE® 2000 cut-off values for serum allergen-specific immunoglobulin and exploring their relationship to exhaled nitric oxide. Acta Paediatrica 2014; Volum 103 (7). ISSN 0803-5253.s 759 - 765.s doi: 10.1111/apa.12631.

  • Samstad, Eivind; Niyonzima, Nathalie; Nymo, Stig Haugset; Aune, Marie Hjelmseth; Ryan, Liv; Bakke, Siril Skaret; Lappegård, Knut Tore; Brekke, Ole Lars; Lambris, John D.; Damås, Jan Kristian; Latz, Eicke; Mollnes, Tom Eirik; Espevik, Terje. Cholesterol crystals induce complement-dependent inflammasome activation and cytokine release. Journal of Immunology 2014; Volum 192 (6). ISSN 0022-1767.s 2837 - 2845.s doi: 10.4049/jimmunol.1302484.

  • Barene, Svein; Krustrup, Peter; Brekke, Ole Lars; Holtermann, Andreas. Soccer and Zumba as health-promoting activities among female hospital employees: A 40-weeks cluster randomised intervention study. (Fulltekst: http://dx.doi.org/10.1080/02640414.2014.906043 Journal of Sports Sciences 2014; Volum 32 (16). ISSN 0264-0414.s 1539 - 1549.s doi: 10.1080/02640414.2014.906043.

  • Rokstad, Anne Mari; Brekke, Ole Lars; Steinkjer, Bjørg; Ryan, Liv; Kolláriková, Gabriela; Strand, Berit Løkensgard; Skjåk-Bræk, Gudmund; Lambris, John D.; Lacík, Igor; Mollnes, Tom Eirik; Espevik, Terje. The induction of cytokines by polycation containing microspheres by a complement dependent mechanism. Biomaterials 2013; Volum 34 (3). ISSN 0142-9612.s 621 - 630.s doi: 10.1016/j.biomaterials.2012.10.012.

  • Brekke, Ole Lars; Waage, Knut-Christian; Christiansen, Dorte; Fure, Hilde; Qu, H; Lambris, John D.; Østerud, Bjarne; Nielsen, Erik Waage; Mollnes, Tom Eirik. The Effects of Selective Complement and CD14 Inhibition on the E. coli -Induced Tissue Factor mRNA Upregulation, Monocyte Tissue Factor Expression, and Tissue Factor Functional Activity in Human Whole Blood. Springer Science+Business Media B.V. 2013 ISBN 978-1-4614-4118-2.s 123 - 136.s doi: 10.1007/978-1-4614-4118-2_8.

  • Landsem, Anne; Nielsen, Erik Waage; Fure, Hilde; Christiansen, Dorte; Ludviksen, Judith K; Lambris, J.D.; Østerud, Bjarne; Mollnes, Tom Eirik; Brekke, Ole Lars. C1-inhibitor efficiently inhibits Escherichia coli-induced tissue factor mRNA up-regulation, monocyte tissue factor expression and coagulation activation in human whole blood. Clinical and Experimental Immunology 2013; Volum 173 (2). ISSN 0009-9104.s 217 - 229.s doi: 10.1111/cei.12098.

  • Lau, Corinna; Gunnarsen, Kristin Støen; Høydahl, Lene Støkken; Andersen, Jan Terje; Berntzen, Gøril; Pharo, Anne Margrethe; Lindstad, Julie Katrine; Ludviksen, Judith K; Brekke, Ole Lars; Barratt-Due, Andreas; Nielsen, Erik Waage; Stokes, Christopher R.; Espevik, Terje; Sandlie, Inger; Mollnes, Tom Eirik. Chimeric Anti-CD14 IGG2/4 Hybrid Antibodies for Therapeutic Intervention in Pig and Human Models of Inflammation. (Fulltekst: http://www.jimmunol.org/content/191/9/4769.full Journal of Immunology 2013; Volum 191 (9). ISSN 0022-1767.s 4769 - 4777.s doi: 10.4049/jimmunol.1301653.

  • Christiansen, Dorte; Brekke, Ole Lars; Stenvik, Jørgen; Lambris, J.D.; Espevik, Terje; Mollnes, Tom Eirik. Differential Effect of Inhibiting MD-2 and CD14 on LPS- Versus Whole E. coli Bacteria-Induced Cytokine Responses in Human Blood. Advances in Experimental Medicine and Biology 2012; Volum 946. ISSN 0065-2598.s 237 - 251.s doi: 10.1007/978-1-4614-0106-3_14.

  • Barratt-Due, Andreas; Pischke, Søren Erik; Brekke, Ole Lars; Thorgersen, Ebbe Billmann; Nielsen, Erik Waage; Espevik, Terje; Huber-Lang, Markus; Mollnes, Tom Eirik. Bride and groom in systemic inflammation - The bells ring for complement and Toll in cooperation. Immunobiology 2012; Volum 217 (11). ISSN 0171-2985.s 1047 - 1056.s doi: 10.1016/j.imbio.2012.07.019.

  • Rokstad, Anne Mari; Brekke, Ole Lars; Steinkjer, Bjørg; Ryan, Liv; Kolláriková, Gabriela; Strand, Berit Løkensgard; Skjåk-Bræk, Gudmund; Lacík, Igor; Espevik, Terje; Mollnes, Tom Eirik. Alginate microbeads are complement compatible, in contrast to polycation containing microcapsules, as revealed in a human whole blood model. Acta Biomaterialia 2011; Volum 7 (6). ISSN 1742-7061.s 2566 - 2578.s doi: 10.1016/j.actbio.2011.03.011.

  • Brekke, Ole Lars; Hellerud, Bernt C; Christiansen, Dorte; Fure, Hilde; Castellheim, Albert; Nielsen, Erik Waage; Pharo, Anne Margrethe; Lindstad, Julie Katrine; Bergseth, Grete; Leslie, G; Lambris, John D.; Brandtzæg, Petter; Mollnes, Tom Eirik. Neisseria meningitidis and Escherichia coli are protected from leukocyte phagocytosis by binding to erythrocyte complement receptor 1 in human blood. Molecular Immunology 2011; Volum 48 (15-16). ISSN 0161-5890.s 2159 - 2169.s doi: 10.1016/j.molimm.2011.07.011.

  • Barratt-Due, Andreas; Thorgersen, Ebbe Billmann; Lindstad, Julie Katrine; Pharo, Anne Margrethe; Brekke, Ole Lars; Christiansen, Dorte; Lambris, John D.; Mollnes, Tom Eirik. Selective inhibition of TNF-alpha or IL-1 beta does not affect E. coli-induced inflammation in human whole blood. Molecular Immunology 2010; Volum 47 (9). ISSN 0161-5890.s 1774 - 1782.s doi: 10.1016/j.molimm.2010.02.026.

  • Hovland, Anders Wilhelm; Brekke, Ole Lars; Aagnes, Inger; Flage, John Helge; Lappegård, Knut Tore. No evidence of impaired endothelial function or altered inflammatory state in patients with familial hypercholesterolemia treated with statins. Journal of Clinical Lipidology 2010; Volum 4 (4). ISSN 1933-2874.s 288 - 292.s doi: 10.1016/j.jacl.2010.02.011.

  • Castellheim, A; Brekke, Ole Lars; Espevik, T; Harboe, M; Harboe, M; Mollnes, Tom Eirik. Innate Immune Responses to Danger Signals in Systemic Inflammatory Response Syndrome and Sepsis. Scandinavian Journal of Immunology 2009; Volum 69 (6). ISSN 0300-9475.s 479 - 491.s doi: 10.1111/j.1365-3083.2009.02255.x.

  • Mollnes, Tom Eirik; Christiansen, D; Brekke, Ole Lars; Espevik, T. Hypothesis: Combined inhibition of complement and CD14 as treatment regimen to attenuate the inflammatory response. Advances in Experimental Medicine and Biology 2008; Volum 632. ISSN 0065-2598.s 253 - 263.s doi: 10.1007/978-0-387-78952_18.

  • Brekke, Ole Lars; Christiansen, D; Fure, H; Pharo, A; Fung, M; Riesenfeld, J; Mollnes, Tom Eirik. Combined inhibition of complement and CD14 abolish E-coli-induced cytokine-, chemokine- and growth factor-synthesis in human whole blood. Molecular Immunology 2008; Volum 45. ISSN 0161-5890.s 3804 - 3813.s doi: 10.1016/j.molimm.2008.05.017.

  • Nielsen, Erik Waage; Waage, Cristian; Fure, Hilde; Brekke, Ole Lars; Sfyroera, Georgia; Lambris, John D.; Lambris, JD; Mollnes, Tom Eirik. Effect of supraphysiologic levels of C1-inhibitor on the classical, lectin and alternative pathways of complement. Molecular Immunology 2007; Volum 44. ISSN 0161-5890.s doi: 10.1016/j.molimm.2006.10.003.

  • Brekke, Ole Lars; Christiansen, Dorte; Fure, Hilde; Fung, Michael; Mollnes, Tom Erik. The role of complement C3 opsonization, C5a receptor, and CD14 in E. coli-induced up-regulation of granulocyte and monocyte CD11b/CD18 (CR3), phagocytosis, and oxidative burst in human. Journal of Leukocyte Biology 2007; Volum 81. ISSN 0741-5400.s 1404 - 1413.s doi: 10.1189/jlb.0806538.

  • Lappegård, Knut Tore; Riesenfeld, J; Brekke, Ole Lars; Bergseth, Grethe; Lambris, JD; Mollnes, Tom Eirik. Differential effect of heparin coating and complement inhibition on artificial surface-induced eicosanoid production. Annals of Thoracic Surgery 2005; Volum 79. ISSN 0003-4975.s 917 - 923.

  • Bylesjo, Ingemar; Brekke, Ole lars; Prytz, Jan; Skjeflo, Trine; Salvesen, Rolf. Brain magnetic resonance imaging white-matter lesions and cerebrospinal fluid findings in patients with acute intermittent porphyria. European Neurology 2004; Volum 51. ISSN 0014-3022.s 1 - 5.

  • Mollnes, Tom Eirik; Brekke, O.L.; Fung, Michael; Fure, Hilde; Christiansen, Dorte; Bergseth, Grethe; Lappegård, Knut Tore; Videm, Vibeke; Köhl, J.; Lambris, J.D.. Essential role of the C5a receptor in E. coli-induced oxidative burst and phagocytosis revealed by a novel lepirudin-based human whole blood model of inflammation. Blood 2002; Volum 100. ISSN 0006-4971.s 1869 - 1877.

  • Sjursen, Wenche; Brekke, Ole Lars; Johansen, Berit. Secretory and cytosolic phospholipase A2 regulate the long term cytokine induced eicosanoid production in human keratinocytes. Cytokine 2000; Volum 12. ISSN 1043-4666.s 1189 - 1194.

  • Sjursen, Wenche; Brekke, Ole Lars; Johansen, Berit. Secretory and cytosolic phospholipase A2 regulate the long term cytokine induced eicosanoid production in human keratinocytes. Cytokine 2000; Volum 12. ISSN 1043-4666.s 1189 - 1194.

  • Gederaas, Odrun Arna; Lagerberg, Johan W.M.; Brekke, Ole-Lars; Berg, K; Dubbelman, TMAR. 5-aminilevulinic acid induced lipid peroxidation after illumination on humane colon carcinoma cells with effects of a-tocopherol stimulation. Cancer Letters 2000; Volum 159. ISSN 0304-3835.s 23 - 32.

  • Brekke, Ole-Lars; Sagen, E; Bjerve, Kristian S. Tumor necrosis factor-induced release of endogenous fatty acids analyzed by a highly sensitive high-performance liquid chromatography method. Journal of Lipid Research 1997; Volum 38. ISSN 0022-2275.s 1913 - 1922.

  • Fagerli, Rønnaug Aarflot; Wandel, Margareta; Olsen, Petra T.; Ek, Johan; Thorstensen, Ketil; Brekke, Ole-Lars; Borch-Iohnsen, Berit. Iron status and diet at two years of age: a longitudinal study of healthy Norwegian and immigrant children. Scandinavian Journal of Nutrition 1996; Volum 40 (2). ISSN 1102-6480.s 58 - 63.

  • Schjøtt, Jan; Brekke, Ole Lars; Jynge, Per; Bjerve, Kristian S; Hamazaki, Tomohito. Infusion of EPA and DHA lipid emulsions: effects on heart lipids and tolerance to ischaemia-reperfusion in the isolated rat heart. Scandinavian Journal of Clinical and Laboratory Investigation 1993; Volum 3. ISSN 0036-5513.s 31 - 39.

  • Storjord, Elin; Hennø, Linda Torrissen; Mollnes, Tom Eirik; Brekke, Ole-Lars. Analyse av cytokiner. Tidsskrift for Den norske legeforening 2020; Volum 140 (1). ISSN 0029-2001.s 1 - 3.s doi: 10.4045/tidsskr.18.0961.

  • Gravastrand, Caroline S.; Steinkjer, Bjørg; Halvorsen, Bente; Landsem, Anne; Skjelland, Mona; Jacobsen, Eva Astrid; Woodruff, Trent M.; Lambris, John D.; Mollnes, Tom Eirik; Brekke, Ole-Lars; Espevik, Terje; Rokstad, Anne Mari A.. Cholesterol crystals induce thromboinflammation. Conference on molecular mechanisms in Trondheim 2019-06-03 - 2019-06-06 2019.

  • Rokstad, Anne Mari; Gravastrand, Caroline S.; Halvorsen, Bente; Steinkjer, Bjørg; Skjelland, Mona; Jacobsen, Eva Astrid; Lambris, John D.; Mollnes, Tom Eirik; Brekke, Ole-Lars; Espevik, Terje. Cholesterol crystals induce coagulation that can be prevented by targeting complement. 11th International Conference on Complement Therapeutics 2018-06-23 - 2018-06-25 2018.

  • Gravastrand, Caroline; Steinkjer, Bjørg; Fure, Hilde; Ryan, Liv; Martins, Catia; Mollnes, Tom Eirik; Brekke, Ole Lars; Espevik, Terje; Rokstad, Anne Mari. Cholesterol crystals induce coagulation activation in a complement-dependent manner. Conference on Molecular Mechanisms of Inflammation 2016-05-30 - 2016-06-02 2016.

  • Rokstad, Anne Mari; Hamad, Shamal; Steinkjer, Bjørg; Fure, Hilde; Niyonzima, Nathalie; Ørning, Mathias Pontus; Lacík, Igor; Ryan, Liv; Mollnes, Tom Eirik; Espevik, Terje; Brekke, Ole Lars. Initial inflammatory and haemostatic mechanisms induced by endogenous and bioartificial surfaces in a whole blood model. NBS contact Meeting 2014 2014-01-23 - 2014-01-26 2014.

  • Rokstad, Anne Mari; Ørning, Mathias Pontus; Hamad, Shamal; Hoem, Kine Samseth; Steinkjer, Bjørg; Fure, Hilde; Ryan, Liv; Lacík, Igor; Mollnes, Tom Eirik; Brekke, Ole Lars; Espevik, Terje. Inflammatory and hemostatic activation induced by alginate microcapsules reveals novel mechanisms underlying their biocompatibility. Immune responces to biosurfaces: Mechanisms and therapeutic interventions 2014-09-27 - 2014-10-02 2014.

  • Aune, Marie Hjelmseth; Samstad, Eivind; Niyonzima, Nathalie; Nymo, Stig Haugset; Ryan, Liv; Lappegård, Knut Tore; Brekke, Ole Lars; Lambris, John D.; Damås, Jan Kristian; Latz, Eicke; Mollnes, Tom Eirik; Espevik, Terje. Cholesterol crystals induce complement-dependent inflammasome activation. NBS Contact Meeting 2014-01-23 - 2014-01-25 2014.

  • Samstad, Eivind; Niyonzima, Nathalie; Nymo, Stig Haugset; Aune, Marie Hjelmseth; Ryan, Liv; Brekke, Ole Lars; Sandanger, I; Aukrust, Pål; Damås, Jan Kristian; Latz, Eicke; Lambris, J.D.; Mollnes, Tom Eirik; Espevik, Terje. Cholesterol crystals induce inflammasome activation and cytolcine release in a complement-dependent manner. Molecular Immunology 2013; Volum 56 (3). ISSN 0161-5890.s 260 - 260.s doi: 10.1016/j.molimm.2013.05.061.

  • Nymo, Stig Haugset; Samstad, Eivind; Niyonzima, Nathalie; Aune, Marie Hjelmseth; Bergseth, Grete; Ryan, Liv; Brekke, Ole Lars; Latz, E; Lambris, J.D.; Espevik, Terje; Mollnes, Tom Eirik. Cholesterol crystals activate the complement system and are phagocytosed in a complement-dependent manner. Molecular Immunology 2013; Volum 56 (3). ISSN 0161-5890.s 246 - 246.s doi: 10.1016/j.molimm.2013.05.026.

  • Landsem, A; Fure, Hilde; Nielsen, Erik Waage; Mollnes, Tom Eirik; Brekke, Ole Lars. Effects of C1-inhibitor on clot development in human whole blood analyzed using rotational thromboelastography. Molecular Immunology 2013; Volum 56 (3). ISSN 0161-5890.s 271 - 271.s doi: 10.1016/j.molimm.2013.05.094.

  • Brekke, Ole Lars; Landsem, Anne; Fure, Hilde; Christiansen, Dorte; Nielsen, Erik Waage; Lambris, J.D.; Mollnes, Tom Eirik. Key role of tissue factor in complement-mediated coagulation activation by Escherichia coli and LPS. Molecular Immunology 2013; Volum 56 (3). ISSN 0161-5890.s 250 - 250.s doi: 10.1016/j.molimm.2013.05.036.

  • Rokstad, Anne Mari; Brekke, Ole Lars; Steinkjer, Bjørg; Ryan, Liv; Kolláriková, Gabriela; Lambris, John D.; Lacík, Igor; Mollnes, Tom Eirik; Espevik, Terje. Poly-cation containing alginate microcapsules induce cytokines by a complement-dependent mechanism. XXIV. International Complement Workshop (DOI: 10.1016/j.imbio.2012.08.263. ISSN: 0171-2985.) (Fulltekst: Immunobiologyvol.217issue11November,2012.p.1221 2012-10-10 - 2012-10-15 2012.

  • Rokstad, Anne Mari; Brekke, Ole Lars; Steinkjer, Bjørg; Ryan, Liv; Kolláriková, Gabriela; Lambris, John D.; Lacík, Igor; Mollnes, Tom Eirik; Espevik, Terje. Poly-cation containing alginate microcapsules induce cytokines by a complement-dependent mechanism. Immunobiology 2012; Volum 217 (11). ISSN 0171-2985.s 1221 - 1221.s doi: 10.1016/j.imbio.2012.08.263.

  • Christiansen, Dorte; Stenvik, Jørgen; Brekke, Ole Lars; Lambris, John D.; Espevik, Terje; Mollnes, Tom Eirik. Phagocytosis of Escherichia coli in human whole blood: Early complement dependency is succeeded by late CD14 dependency over time. Immunobiology 2012; Volum 217 (11). ISSN 0171-2985.s 1193 - 1193.s doi: 10.1016/j.imbio.2012.08.183.

  • Brekke, Ole Lars; Landsem, Anne; Fure, Hilde; Christiansen, Dorte; Nielsen, Erik Waage; Lambris, John D.; Mollnes, Tom Eirik. Escherichia coli-induced coagulation activation and pentraxin 3 release is highly dependent on complement and CD14. Immunobiology 2012; Volum 217 (11). ISSN 0171-2985.s 1167 - 1168.s doi: 10.1016/j.imbio.2012.08.112.

  • Nymo, Stig; Samstad, Eivind; Niyonzima, Nathalie; Bergseth, Grethe; Christiansen, Dorte; Ryan, Liv; Brekke, Ole Lars; Lappegard, Knut Tore; Damas, Jan Kristian; Latz, Eicke; Lambris, John D.; Espevik, Terje; Mollnes, Tom Eirik. Complement dependency of cholesterol crystal-induced inflammation - I. Pathway activation mechanisms, cytokine responses and endothelial cell activation. Immunobiology 2012; Volum 217 (11). ISSN 0171-2985.s 1157 - 1157.s doi: 10.1016/j.imbio.2012.08.079.

  • Landsem, Anne; Nielsen, Erik Waage; Christiansen, Dorte; Mollnes, Tom Eirik; Brekke, Ole Lars. C1-inhibitor efficiently inhibits Escherichia coli-induced tissue factor mRNA up-regulation, monocyte tissue factor expression and coagulation activation in human whole blood. Immunobiology 2012; Volum 217 (11). ISSN 0171-2985.s 1142 - 1142.s doi: 10.1016/j.imbio.2012.08.040.

  • Fure, Hilde; Landsem, A; Christiansen, Dorte; Brekke, Ole Lars; Nielsen, Erik Waage; Lambris, J.D.; Mollnes, Tom Eirik. C1 inhibitor efficiently inhibits Escherichia coli and LPS-induced tissue factor expression on monocytes and mRNA upregulation in human whole blood. Molecular Immunology 2011; Volum 48 (14). ISSN 0161-5890.s 1669 - 1669.s doi: 10.1016/j.molimm.2011.06.230.

  • Brekke, Ole Lars; Christiansen, Dorte; Gay, B. Donvito; Fure, Hilde; Reveil, Bert; Kisserli, A.; Mollnes, Tom Eirik; Cohen, J. H. M.. Key role of the number of erythrocyte CR1 on the initial erythrocyte binding, phagocytosis and oxidative burst by Escherichia coli in human whole blood. Molecular Immunology 2011; Volum 48 (14). ISSN 0161-5890.s 1672 - 1673.s doi: 10.1016/j.molimm.2011.06.241.

  • Lau, Corinna; Nygård, Ståle; Fure, Hilde; Lappegård, Knut Tore; Brekke, Ole Lars; Hovig, Eivind; Mollnes, Tom Eirik. Challenging pattern recognition cross-talk: A gene profiling perspective of human Gram-negative bacteriaemia. Molecular Immunology 2011; Volum 48 (14). ISSN 0161-5890.s 1691 - 1691.s doi: 10.1016/j.molimm.2011.06.297.

  • Rokstad, Anne Mari; Ryan, Liv; Steinkjer, Bjørg; Brekke, Ole Lars; Qi, Meirigeng; Oberholzer, José; Strand, Berit Løkensgard; Skjåk-Bræk, Gudmund; Lacík, Igor; Mollnes, Tom Erik; Espevik, Terje. Inflammatory responses of alginate microspehers evaluated by a human and baboon whole blood model. 13th world Congress of IPITA International Pancreas and Islets Transplant Association 2011-06-01 - 2011-06-04 2011.

  • Aagnes, Inger; Hovland, Anders; Flage, John Helge; Brekke, Ole Lars; Lappegård, Knut Tore. NO EVIDENCE OF IMPAIRED ENDOTHELIAL FUNCTION OR ALTERED INFLAMMATORY STATE IN PATIENTS WITH FAMILIAL HYPERCHOLESTEROLEMIA USING STATINS. Atherosclerosis Supplements 2010; Volum 11 (2). ISSN 1567-5688.s 146 - 146.

  • Fure, Hilde; Brekke, Ole Lars; Lambris, J.D.; Mollnes, Tom Eirik. Key role of CD14 in the E. coli- and LPS-induced mRNA down regulation of the C5a receptors CD88 and C5L2. Molecular Immunology 2010; Volum 47 (13). ISSN 0161-5890.s 2241 - 2241.s doi: 10.1016/j.molimm.2010.05.135.

  • Christiansen, D; Brekke, Ole Lars; Stenvik, Jørgen; Lambris, JD; Espevik, Terje; Mollnes, Tom Eirik. Differential effect of inhibiting MD-2 and CD14 on LPS- versus whole E. coli bacteria-induced cytokine responses in human blood. Molecular Immunology 2010; Volum 47 (13). ISSN 0161-5890.s 2231 - 2231.s doi: 10.1016/j.molimm.2010.05.105.

  • Ludviksen, J.K.; Hennø, L.T.; Brekke, O.L.; Christiansen, D.; Fure, H.; Nielsen, EW; Mollnes, Tom Eirik. Elevated cytokine concentrations in serum compared to plasma samples from healthy humans is not explained by in vitro complement activation. Molecular Immunology 2010; Volum 47 (13). ISSN 0161-5890.s 2236 - 2236.s doi: 10.1016/j.molimm.2010.05.118.

  • Brekke, Ole Lars; Hellerud, BC; Christiansen, Dorte; Fure, Hilde; Bergseth, G; Bergseth, Grethe; Leslie, G; Lambris, J; Mollnes, Tom Eirik. Key role of complement receptor 1 in the initial binding of Escherichia coli and Neisseria meningitidis to erythrocytes in human whole blood. Molecular Immunology 2009; Volum 46 (14). ISSN 0161-5890.s 2824 - 2824.s doi: 10.1016/j.molimm.2009.05.204.

  • Brekke, Ole Lars; CHRISTIANSEN, DANIELA; Christiansen, D; Hellerud, BC; Fure, H; Bergseth, Grete; Leslie, G; Lambris, JD; Lambris, J; Mollnes, Tom Eirik. Key role of complement receptor 1 in the initial binding of Escherichia coli and Neisseria meningitidis to erythrocytes in human whole blood. Molecular Immunology 2008; Volum 45 (16). ISSN 0161-5890.s 4149 - 4149.s doi: 10.1016/j.molimm.2008.08.162.

  • Brekke, Ole Lars; Christiansen, Dorte; Fure, Hilde; Fung, Michael; Mollnes, Tom Eirik. Inhibition of complement and CD14 efficiency inhibits a broad panel of E.coli-induced inflammatory reactions in human whole blood. 11 European Meeting on Complement in human disease 2007-09-08 - 2007-09-11 2007.

  • Waage, C; Nielsen, Erik Waage; Fure, H; Brekke, Ole Lars; Sfyroera, G; Lambris, JD; Lambris, JD; Mollnes, Tom Eirik. Effect of supraphysioloogic levels of C1-inhibitor on the classical, lectin, and alternative pathways of complement. Molecular Immunology 2007; Volum 44. ISSN 0161-5890.s doi: 10.1016/j.molimm.2006.07.250.

  • Christiansen, Dorte; Brekke, Ole Lars; Fure, Hilde; Fung, Michael; Mollnes, Tom Eirik. Inhibition of complement and CD14 abolishes E-coli-induced cytokine gene upregulation and protein synthesis. Molecular Immunology 2007; Volum 44. ISSN 0161-5890.s doi: 10.1016/j.molimm.2006.07.034.

  • Waage, C; Nielsen, EW; Fure, H; Brekke, Ole Lars; Sfyroera, G; Lambris, JD; Mollnes, Tom Eirik. Effect of supraphysiologic levels of C1-inhibitor on the classical, lectin and alternative pathways of complement. Molecular Immunology 2007; Volum 44. ISSN 0161-5890.s 254 - 254.

  • Brekke, Ole Lars; Christiansen, D; Fure, H; Fung, M; Mollnes, Tom Eirik. Inhibition of complement and CD14 efficiently inhibits a broad panel of E-coli-induced inflammatory reactions in human whole blood. Molecular Immunology 2007; Volum 44. ISSN 0161-5890.s 3925 - 3925.s doi: 10.1016/j.molimm.2007.06.043.

  • Storjord, Elin; Brekke, Ole Lars; Nielsen, Erik Waage. Safe usage of isotretinoin in a woman with latent acute intermittent porphyria. Acta Dermato-Venereologica 2007; Volum 87. ISSN 0001-5555.s doi: 10.2340/00015555-0178.

  • Hustad, Kari Vekseth; Staub, Uwe Hans; i Buo, Margareta; Hardersen, Randolf; Jaeger, Steinar; Brekke, Ole Lars. Incidental findings with tc-99m MIBI imaging for parathyroid adenoma. Clinical Nuclear Medicine 2007; Volum 32. ISSN 0363-9762.s 548 - 550.

  • Brekke, Ole Lars; Christiansen, Dorte; Fure, Hilde; Mollnes, Tom Eirik. betydningen av komplementsystemet og CD14 for E.coli-indusert cytokin- og chemokinsyntese i en human fullblodsmodell for sepsis. Vårmøte Klinisk Kjemi 2007-04-23 - 2007-04-25 2007.

  • Nielsen, Erik Waage; Waage, Christian; Fure, Hilde; Brekke, Ole Lars; Sfyroera, Georgia; Lambris, JD; Mollnes, Tom Eirik. Effect of supraphysiologic levels of C1-inhibitor on the classical, lectin and alternative pathways of complement. Regional forskningskonferanse innen medisin og helse 2006-11-01 - 2006-11-02 2006.

  • Nielsen, Erik Waage; Waage, Christian; Fure, Hilde; Brekke, Ole Lars; Sfyroera, Georgia; Lambris, JD; Mollnes, Tom Eirik. Effect of supraphysiological levels of C1-inhibitor on the classical, lectin and alternative pathways of complement. ABSTRACT. Regional forskningskonferanse innen medisin og helse 2006.

  • Christiansen, D; Brekke, Ole lars; Fure, H; Fung, M; Mollnes, Tom Eirik. The role of iC3b opsonization, C5a receptor and CD14 in E-coli-induced upregulation of leukocyte CD11b (CR3), phagocytosis and oxidative burst in human whole blood. Molecular Immunology 2004; Volum 41. ISSN 0161-5890.s 221 - 222.

  • Brekke, O.L.; Fure, H.; Christiansen, D.; Fung, M.; Mollnes, Tom Eirik. Differential role of C5a receptor and CD14 in E. coli-induced upregulation of granulocyte and monocyte CD11b (CR3) in human whole blood. Molecular Immunology 2003; Volum 40. ISSN 0161-5890.s 180 - 181.

  • Brekke, O.L.; Fure, H.; Christiansen, D.; Lappegård, K.T.; Fung, M.; Lambris, J.D.; Mollnes, Tom Eirik. Key role of the C5a receptor in E. coli-induced oxidative burst and phagocytosis studied in a novel human whole blood model of inflammation. Int. Immunopharmacol, 2 2002-01-01 - 2002.

  • Gederaas, Odrun; Lagerberg, Johan W.M.; Brekke, Ole Lars; Berg, Kristian; Dubbelman, Tom M.A.R. 5-Aminolevulinic acid induced lipid peroxidation after light exposure on human colon carcinoma cells and effects of alpha-tocopherol treatment. 9th Congress European Society for Photobiology 2001-09-08 - 2001.

  • Brekke, Ole-Lars; Sagen, E; Bjerve, Kristian S. Specificity of intra- and extracellular release of endogenous fatty acids during tumor necrosis factor-induced apoptosis. 8th International TNF Congress on Tumor Necrosis Factor and Related Cytokines. 2000.

  • Brekke, Ole-Lars; Sagen, Erling; Bjerve, Kristian S. Spcificity of intra- and extracellular release of endogenous fatty acids during tumor necrosis factor-induced apoptosis. 8th International TNF Congress on Tumor Necrosis Factor and Related Cytokines 2000.

  • Arntzen, KJ; Rahimipoor, S; Brekke, O-L; Austgulen, Rigmor. Marine fatty acids reduce prostaglandin production in term decidual cells. Placenta 1996; Volum 17. ISSN 0143-4004.s A54 - .

  • Arntzen, KJ; Brekke, O-L; Austgulen, Rigmor. Tumor necrosis factor and prostaglandin production in fetal membranes. The International Cytokine Society, 3rd Annual Conference 1995-06-15 - 1995.

  • Arntzen, KJ; Brekke, O-L; Austgulen, Rigmor. Tumor necrosis factor and prostaglandin production from fetal membranes. IV Meeting of The European Placenta Group 1995-09-15 - 1995.

  • Arntzen, KJ; Brekke, O-L; Austgulen, Rigmor. Tumor necrosis factor and prostaglandin production in fetal membranes. Placenta 1995; Volum 16. ISSN 0143-4004.s A4 - .

  • Arntzen, KJ; Brekke, O-L; Austgulen, Rigmor. Tumor necrosis factor and prostaglandin production in fetal membranes. Cytokine 1995; Volum 7. ISSN 1043-4666.s 662 - .

  • Storjord, Elin; Hennø, Linda Torrissen; Mollnes, Tom Eirik; Brekke, Ole-Lars. Analyse av cytokiner. Tidsskrift for Den norske legeforening 2020; Volum 140 (1). ISSN 0029-2001.s 1 - 3.s doi: 10.4045/tidsskr.18.0961.

  • Gravastrand, Caroline S.; Steinkjer, Bjørg; Halvorsen, Bente; Landsem, Anne; Skjelland, Mona; Jacobsen, Eva Astrid; Woodruff, Trent M.; Lambris, John D.; Mollnes, Tom Eirik; Brekke, Ole-Lars; Espevik, Terje; Rokstad, Anne Mari A.. Cholesterol crystals induce thromboinflammation. Conference on molecular mechanisms in Trondheim 2019-06-03 - 2019-06-06 2019.

  • Rokstad, Anne Mari; Gravastrand, Caroline S.; Halvorsen, Bente; Steinkjer, Bjørg; Skjelland, Mona; Jacobsen, Eva Astrid; Lambris, John D.; Mollnes, Tom Eirik; Brekke, Ole-Lars; Espevik, Terje. Cholesterol crystals induce coagulation that can be prevented by targeting complement. 11th International Conference on Complement Therapeutics 2018-06-23 - 2018-06-25 2018.

  • Gravastrand, Caroline; Steinkjer, Bjørg; Fure, Hilde; Ryan, Liv; Martins, Catia; Mollnes, Tom Eirik; Brekke, Ole Lars; Espevik, Terje; Rokstad, Anne Mari. Cholesterol crystals induce coagulation activation in a complement-dependent manner. Conference on Molecular Mechanisms of Inflammation 2016-05-30 - 2016-06-02 2016.

  • Rokstad, Anne Mari; Hamad, Shamal; Steinkjer, Bjørg; Fure, Hilde; Niyonzima, Nathalie; Ørning, Mathias Pontus; Lacík, Igor; Ryan, Liv; Mollnes, Tom Eirik; Espevik, Terje; Brekke, Ole Lars. Initial inflammatory and haemostatic mechanisms induced by endogenous and bioartificial surfaces in a whole blood model. NBS contact Meeting 2014 2014-01-23 - 2014-01-26 2014.

  • Rokstad, Anne Mari; Ørning, Mathias Pontus; Hamad, Shamal; Hoem, Kine Samseth; Steinkjer, Bjørg; Fure, Hilde; Ryan, Liv; Lacík, Igor; Mollnes, Tom Eirik; Brekke, Ole Lars; Espevik, Terje. Inflammatory and hemostatic activation induced by alginate microcapsules reveals novel mechanisms underlying their biocompatibility. Immune responces to biosurfaces: Mechanisms and therapeutic interventions 2014-09-27 - 2014-10-02 2014.

  • Aune, Marie Hjelmseth; Samstad, Eivind; Niyonzima, Nathalie; Nymo, Stig Haugset; Ryan, Liv; Lappegård, Knut Tore; Brekke, Ole Lars; Lambris, John D.; Damås, Jan Kristian; Latz, Eicke; Mollnes, Tom Eirik; Espevik, Terje. Cholesterol crystals induce complement-dependent inflammasome activation. NBS Contact Meeting 2014-01-23 - 2014-01-25 2014.

  • Samstad, Eivind; Niyonzima, Nathalie; Nymo, Stig Haugset; Aune, Marie Hjelmseth; Ryan, Liv; Brekke, Ole Lars; Sandanger, I; Aukrust, Pål; Damås, Jan Kristian; Latz, Eicke; Lambris, J.D.; Mollnes, Tom Eirik; Espevik, Terje. Cholesterol crystals induce inflammasome activation and cytolcine release in a complement-dependent manner. Molecular Immunology 2013; Volum 56 (3). ISSN 0161-5890.s 260 - 260.s doi: 10.1016/j.molimm.2013.05.061.

  • Nymo, Stig Haugset; Samstad, Eivind; Niyonzima, Nathalie; Aune, Marie Hjelmseth; Bergseth, Grete; Ryan, Liv; Brekke, Ole Lars; Latz, E; Lambris, J.D.; Espevik, Terje; Mollnes, Tom Eirik. Cholesterol crystals activate the complement system and are phagocytosed in a complement-dependent manner. Molecular Immunology 2013; Volum 56 (3). ISSN 0161-5890.s 246 - 246.s doi: 10.1016/j.molimm.2013.05.026.

  • Landsem, A; Fure, Hilde; Nielsen, Erik Waage; Mollnes, Tom Eirik; Brekke, Ole Lars. Effects of C1-inhibitor on clot development in human whole blood analyzed using rotational thromboelastography. Molecular Immunology 2013; Volum 56 (3). ISSN 0161-5890.s 271 - 271.s doi: 10.1016/j.molimm.2013.05.094.

  • Brekke, Ole Lars; Landsem, Anne; Fure, Hilde; Christiansen, Dorte; Nielsen, Erik Waage; Lambris, J.D.; Mollnes, Tom Eirik. Key role of tissue factor in complement-mediated coagulation activation by Escherichia coli and LPS. Molecular Immunology 2013; Volum 56 (3). ISSN 0161-5890.s 250 - 250.s doi: 10.1016/j.molimm.2013.05.036.

  • Rokstad, Anne Mari; Brekke, Ole Lars; Steinkjer, Bjørg; Ryan, Liv; Kolláriková, Gabriela; Lambris, John D.; Lacík, Igor; Mollnes, Tom Eirik; Espevik, Terje. Poly-cation containing alginate microcapsules induce cytokines by a complement-dependent mechanism. XXIV. International Complement Workshop (DOI: 10.1016/j.imbio.2012.08.263. ISSN: 0171-2985.) (Fulltekst: Immunobiologyvol.217issue11November,2012.p.1221 2012-10-10 - 2012-10-15 2012.

  • Rokstad, Anne Mari; Brekke, Ole Lars; Steinkjer, Bjørg; Ryan, Liv; Kolláriková, Gabriela; Lambris, John D.; Lacík, Igor; Mollnes, Tom Eirik; Espevik, Terje. Poly-cation containing alginate microcapsules induce cytokines by a complement-dependent mechanism. Immunobiology 2012; Volum 217 (11). ISSN 0171-2985.s 1221 - 1221.s doi: 10.1016/j.imbio.2012.08.263.

  • Christiansen, Dorte; Stenvik, Jørgen; Brekke, Ole Lars; Lambris, John D.; Espevik, Terje; Mollnes, Tom Eirik. Phagocytosis of Escherichia coli in human whole blood: Early complement dependency is succeeded by late CD14 dependency over time. Immunobiology 2012; Volum 217 (11). ISSN 0171-2985.s 1193 - 1193.s doi: 10.1016/j.imbio.2012.08.183.

  • Brekke, Ole Lars; Landsem, Anne; Fure, Hilde; Christiansen, Dorte; Nielsen, Erik Waage; Lambris, John D.; Mollnes, Tom Eirik. Escherichia coli-induced coagulation activation and pentraxin 3 release is highly dependent on complement and CD14. Immunobiology 2012; Volum 217 (11). ISSN 0171-2985.s 1167 - 1168.s doi: 10.1016/j.imbio.2012.08.112.

  • Nymo, Stig; Samstad, Eivind; Niyonzima, Nathalie; Bergseth, Grethe; Christiansen, Dorte; Ryan, Liv; Brekke, Ole Lars; Lappegard, Knut Tore; Damas, Jan Kristian; Latz, Eicke; Lambris, John D.; Espevik, Terje; Mollnes, Tom Eirik. Complement dependency of cholesterol crystal-induced inflammation - I. Pathway activation mechanisms, cytokine responses and endothelial cell activation. Immunobiology 2012; Volum 217 (11). ISSN 0171-2985.s 1157 - 1157.s doi: 10.1016/j.imbio.2012.08.079.

  • Landsem, Anne; Nielsen, Erik Waage; Christiansen, Dorte; Mollnes, Tom Eirik; Brekke, Ole Lars. C1-inhibitor efficiently inhibits Escherichia coli-induced tissue factor mRNA up-regulation, monocyte tissue factor expression and coagulation activation in human whole blood. Immunobiology 2012; Volum 217 (11). ISSN 0171-2985.s 1142 - 1142.s doi: 10.1016/j.imbio.2012.08.040.

  • Fure, Hilde; Landsem, A; Christiansen, Dorte; Brekke, Ole Lars; Nielsen, Erik Waage; Lambris, J.D.; Mollnes, Tom Eirik. C1 inhibitor efficiently inhibits Escherichia coli and LPS-induced tissue factor expression on monocytes and mRNA upregulation in human whole blood. Molecular Immunology 2011; Volum 48 (14). ISSN 0161-5890.s 1669 - 1669.s doi: 10.1016/j.molimm.2011.06.230.

  • Brekke, Ole Lars; Christiansen, Dorte; Gay, B. Donvito; Fure, Hilde; Reveil, Bert; Kisserli, A.; Mollnes, Tom Eirik; Cohen, J. H. M.. Key role of the number of erythrocyte CR1 on the initial erythrocyte binding, phagocytosis and oxidative burst by Escherichia coli in human whole blood. Molecular Immunology 2011; Volum 48 (14). ISSN 0161-5890.s 1672 - 1673.s doi: 10.1016/j.molimm.2011.06.241.

  • Lau, Corinna; Nygård, Ståle; Fure, Hilde; Lappegård, Knut Tore; Brekke, Ole Lars; Hovig, Eivind; Mollnes, Tom Eirik. Challenging pattern recognition cross-talk: A gene profiling perspective of human Gram-negative bacteriaemia. Molecular Immunology 2011; Volum 48 (14). ISSN 0161-5890.s 1691 - 1691.s doi: 10.1016/j.molimm.2011.06.297.

  • Rokstad, Anne Mari; Ryan, Liv; Steinkjer, Bjørg; Brekke, Ole Lars; Qi, Meirigeng; Oberholzer, José; Strand, Berit Løkensgard; Skjåk-Bræk, Gudmund; Lacík, Igor; Mollnes, Tom Erik; Espevik, Terje. Inflammatory responses of alginate microspehers evaluated by a human and baboon whole blood model. 13th world Congress of IPITA International Pancreas and Islets Transplant Association 2011-06-01 - 2011-06-04 2011.

  • Aagnes, Inger; Hovland, Anders; Flage, John Helge; Brekke, Ole Lars; Lappegård, Knut Tore. NO EVIDENCE OF IMPAIRED ENDOTHELIAL FUNCTION OR ALTERED INFLAMMATORY STATE IN PATIENTS WITH FAMILIAL HYPERCHOLESTEROLEMIA USING STATINS. Atherosclerosis Supplements 2010; Volum 11 (2). ISSN 1567-5688.s 146 - 146.

  • Fure, Hilde; Brekke, Ole Lars; Lambris, J.D.; Mollnes, Tom Eirik. Key role of CD14 in the E. coli- and LPS-induced mRNA down regulation of the C5a receptors CD88 and C5L2. Molecular Immunology 2010; Volum 47 (13). ISSN 0161-5890.s 2241 - 2241.s doi: 10.1016/j.molimm.2010.05.135.

  • Christiansen, D; Brekke, Ole Lars; Stenvik, Jørgen; Lambris, JD; Espevik, Terje; Mollnes, Tom Eirik. Differential effect of inhibiting MD-2 and CD14 on LPS- versus whole E. coli bacteria-induced cytokine responses in human blood. Molecular Immunology 2010; Volum 47 (13). ISSN 0161-5890.s 2231 - 2231.s doi: 10.1016/j.molimm.2010.05.105.

  • Ludviksen, J.K.; Hennø, L.T.; Brekke, O.L.; Christiansen, D.; Fure, H.; Nielsen, EW; Mollnes, Tom Eirik. Elevated cytokine concentrations in serum compared to plasma samples from healthy humans is not explained by in vitro complement activation. Molecular Immunology 2010; Volum 47 (13). ISSN 0161-5890.s 2236 - 2236.s doi: 10.1016/j.molimm.2010.05.118.

  • Brekke, Ole Lars; Hellerud, BC; Christiansen, Dorte; Fure, Hilde; Bergseth, G; Bergseth, Grethe; Leslie, G; Lambris, J; Mollnes, Tom Eirik. Key role of complement receptor 1 in the initial binding of Escherichia coli and Neisseria meningitidis to erythrocytes in human whole blood. Molecular Immunology 2009; Volum 46 (14). ISSN 0161-5890.s 2824 - 2824.s doi: 10.1016/j.molimm.2009.05.204.

  • Brekke, Ole Lars; CHRISTIANSEN, DANIELA; Christiansen, D; Hellerud, BC; Fure, H; Bergseth, Grete; Leslie, G; Lambris, JD; Lambris, J; Mollnes, Tom Eirik. Key role of complement receptor 1 in the initial binding of Escherichia coli and Neisseria meningitidis to erythrocytes in human whole blood. Molecular Immunology 2008; Volum 45 (16). ISSN 0161-5890.s 4149 - 4149.s doi: 10.1016/j.molimm.2008.08.162.

  • Brekke, Ole Lars; Christiansen, Dorte; Fure, Hilde; Fung, Michael; Mollnes, Tom Eirik. Inhibition of complement and CD14 efficiency inhibits a broad panel of E.coli-induced inflammatory reactions in human whole blood. 11 European Meeting on Complement in human disease 2007-09-08 - 2007-09-11 2007.

  • Waage, C; Nielsen, Erik Waage; Fure, H; Brekke, Ole Lars; Sfyroera, G; Lambris, JD; Lambris, JD; Mollnes, Tom Eirik. Effect of supraphysioloogic levels of C1-inhibitor on the classical, lectin, and alternative pathways of complement. Molecular Immunology 2007; Volum 44. ISSN 0161-5890.s doi: 10.1016/j.molimm.2006.07.250.

  • Christiansen, Dorte; Brekke, Ole Lars; Fure, Hilde; Fung, Michael; Mollnes, Tom Eirik. Inhibition of complement and CD14 abolishes E-coli-induced cytokine gene upregulation and protein synthesis. Molecular Immunology 2007; Volum 44. ISSN 0161-5890.s doi: 10.1016/j.molimm.2006.07.034.

  • Waage, C; Nielsen, EW; Fure, H; Brekke, Ole Lars; Sfyroera, G; Lambris, JD; Mollnes, Tom Eirik. Effect of supraphysiologic levels of C1-inhibitor on the classical, lectin and alternative pathways of complement. Molecular Immunology 2007; Volum 44. ISSN 0161-5890.s 254 - 254.

  • Brekke, Ole Lars; Christiansen, D; Fure, H; Fung, M; Mollnes, Tom Eirik. Inhibition of complement and CD14 efficiently inhibits a broad panel of E-coli-induced inflammatory reactions in human whole blood. Molecular Immunology 2007; Volum 44. ISSN 0161-5890.s 3925 - 3925.s doi: 10.1016/j.molimm.2007.06.043.

  • Storjord, Elin; Brekke, Ole Lars; Nielsen, Erik Waage. Safe usage of isotretinoin in a woman with latent acute intermittent porphyria. Acta Dermato-Venereologica 2007; Volum 87. ISSN 0001-5555.s doi: 10.2340/00015555-0178.

  • Hustad, Kari Vekseth; Staub, Uwe Hans; i Buo, Margareta; Hardersen, Randolf; Jaeger, Steinar; Brekke, Ole Lars. Incidental findings with tc-99m MIBI imaging for parathyroid adenoma. Clinical Nuclear Medicine 2007; Volum 32. ISSN 0363-9762.s 548 - 550.

  • Brekke, Ole Lars; Christiansen, Dorte; Fure, Hilde; Mollnes, Tom Eirik. betydningen av komplementsystemet og CD14 for E.coli-indusert cytokin- og chemokinsyntese i en human fullblodsmodell for sepsis. Vårmøte Klinisk Kjemi 2007-04-23 - 2007-04-25 2007.

  • Nielsen, Erik Waage; Waage, Christian; Fure, Hilde; Brekke, Ole Lars; Sfyroera, Georgia; Lambris, JD; Mollnes, Tom Eirik. Effect of supraphysiologic levels of C1-inhibitor on the classical, lectin and alternative pathways of complement. Regional forskningskonferanse innen medisin og helse 2006-11-01 - 2006-11-02 2006.

  • Nielsen, Erik Waage; Waage, Christian; Fure, Hilde; Brekke, Ole Lars; Sfyroera, Georgia; Lambris, JD; Mollnes, Tom Eirik. Effect of supraphysiological levels of C1-inhibitor on the classical, lectin and alternative pathways of complement. ABSTRACT. Regional forskningskonferanse innen medisin og helse 2006.

  • Christiansen, D; Brekke, Ole lars; Fure, H; Fung, M; Mollnes, Tom Eirik. The role of iC3b opsonization, C5a receptor and CD14 in E-coli-induced upregulation of leukocyte CD11b (CR3), phagocytosis and oxidative burst in human whole blood. Molecular Immunology 2004; Volum 41. ISSN 0161-5890.s 221 - 222.

  • Brekke, O.L.; Fure, H.; Christiansen, D.; Fung, M.; Mollnes, Tom Eirik. Differential role of C5a receptor and CD14 in E. coli-induced upregulation of granulocyte and monocyte CD11b (CR3) in human whole blood. Molecular Immunology 2003; Volum 40. ISSN 0161-5890.s 180 - 181.

  • Brekke, O.L.; Fure, H.; Christiansen, D.; Lappegård, K.T.; Fung, M.; Lambris, J.D.; Mollnes, Tom Eirik. Key role of the C5a receptor in E. coli-induced oxidative burst and phagocytosis studied in a novel human whole blood model of inflammation. Int. Immunopharmacol, 2 2002-01-01 - 2002.

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