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Bilde av Hansen, Terkel
Photo: Bjørn-Kåre Iversen
Bilde av Hansen, Terkel
Department of Pharmacy terkel.hansen@uit.no +4777646160 Here you can find me

Terkel Hansen

Associate professor

  • Dmitri Svistounov, Marit Dahl Solbu, Trond Geir Jenssen, Ulla Dorte Mathisen, Terkel Hansen, Katja Benedikte Prestø Elgstøen et al.:
    Development of quantitative assay for simultaneous measurement of purine metabolites and creatinine in biobanked urine by liquid chromatography-tandem mass spectrometry
    Scandinavian Journal of Clinical and Laboratory Investigation 2022 ARKIV / DOI
  • Marianne Hagensen Paulsen, Dominik Ausbacher, Annette Bayer, Magnus Engqvist, Terkel Hansen, Tor Haug et al.:
    Antimicrobial activity of amphipathic α,α-disubstituted β-amino amide derivatives against ESBL–CARBA producing multi-resistant bacteria; effect of halogenation, lipophilicity and cationic character
    European Journal of Medicinal Chemistry 2019 ARKIV / DOI
  • Armin Schniers, Rasmus Goll, Yvonne Pasing, Sveinung Sørbye, Jon Florholmen, Terkel Hansen :
    Ulcerative colitis: Functional analysis of the in-depth proteome
    Clinical Proteomics 2019 ARKIV / DOI
  • Armin Schniers, Yvonne Pasing, Terkel Hansen :
    Lys-C/Trypsin Tandem-Digestion Protocol for Gel-Free Proteomic Analysis of Colon Biopsies
    Humana Press 2019 DOI
  • Joseph Diab, Terkel Hansen, Rasmus Goll, Hans Stenlund, Maria Ahnlund, Einar Jensen et al.:
    Lipidomics in ulcerative colitis reveal alteration in mucosal lipid composition associated with the disease state
    Inflammatory Bowel Diseases 2019 ARKIV / DOI
  • Joseph Diab, Terkel Hansen, Rasmus Goll, Hans Stenlund, Einar Jensen, Thomas Moritz et al.:
    Mucosal metabolomic profiling and pathway analysis reveal the metabolic signature of ulcerative colitis
    Metabolites 2019 ARKIV / DOI
  • Yvonne Pasing, Armin Schniers, Terkel Hansen :
    Straightforward Protocol for Gel-Free Proteomic Analysis of Adipose Tissue
    Humana Press 2018 DOI
  • Jakob Mejlvang, Hallvard Lauritz Olsvik, Steingrim Svenning, Jack-Ansgar Bruun, Yakubu Princely Abudu, Kenneth Bowitz Larsen et al.:
    Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy
    Journal of Cell Biology 17. July 2018 ARKIV / DOI
  • Joseph Diab, Rania Al-Mahdi, Sandra Gouveia, Terkel Hansen, Einar Jensen, Rasmus Goll et al.:
    A Quantitative Analysis of Colonic Mucosal Oxylipins and Endocannabinoids in Treatment-Naïve and Deep Remission Ulcerative Colitis Patients and the Potential Link With Cytokine Gene Expression
    Inflammatory Bowel Diseases 2018 ARKIV / DOI
  • Armin Schniers, Endre Anderssen, Christopher Graham Fenton, Rasmus Goll, Yvonne Pasing, Ruth H Paulssen et al.:
    The Proteome of Ulcerative Colitis in Colon Biopsies from Adults - Optimized Sample Preparation and Comparison with Healthy Controls
    PROTEOMICS - Clinical Applications 2017 DOI
  • Yvonne Pasing, Sayda Colnoe, Terkel Hansen :
    Proteomics of hydrophobic samples: Fast, robust and low-cost workflows for clinical approaches
    Proteomics 2017 FULLTEKST / DOI
  • Stian Henriksen, Terkel Hansen, Jack-Ansgar Bruun, Christine Hanssen Rinaldo :
    The Presumed Polyomavirus Viroporin VP4 of Simian Virus 40 or Human BK Polyomavirus Is Not Required for Viral Progeny Release
    Journal of Virology 2016 ARKIV / DOI
  • Anastasia Albert, Jacobus Johannes Eksteen, Johan Isaksson, Myagmarsuren Sengee, Terkel Hansen, Terje Vasskog :
    General approach to determine disulfide connectivity in cysteine-rich peptides by sequential alkylation on solid phase and mass spectrometry
    Analytical Chemistry 2016 DOI
  • Dominik Stelzl, Thorbjørn Terndrup Nielsen, Terkel Hansen, Massimiliano Pio Di Cagno :
    β-CD-dextran polymer for efficient sequestration of cholesterol from phospholipid bilayers: Mechanistic and safe-toxicity investigations
    International Journal of Pharmaceutics 2015 DOI
  • Terkel Hansen, Michel Albers, Christian Hedberg, Albert Sickmann :
    Adenylylation, MS, and proteomics—Introducing a “new” modification to bottom-up proteomics
    Proteomics 2013 DOI
  • André Engesland, Merete L. Skar, Terkel Hansen, Natasa Skalko-Basnet, Gøril Eide Flaten :
    New Applications of Phospholipid Vesicle-Based Permeation Assay: Permeation Model Mimicking Skin Barrier
    Journal of Pharmaceutical Sciences 25. March 2013 DOI
  • Terkel Hansen, Dominik Ausbacher, Zack Georg Zachariassen, Trude Anderssen, Martina Havelkova, Morten B. Strøm :
    Anticancer activity of small amphipathic β2,2-amino acid derivatives
    European Journal of Medicinal Chemistry 2012 DOI
  • Terkel Hansen, Morten Kaare Moe, Trude Anderssen, Morten B. Strøm :
    Metabolism of small antimicrobial β2,2-amino acid derivatives by murine liver microsomes
    European journal of drug metabolism and pharmacokinetics 2012 DOI
  • Veronika Tørfoss, Dominik Ausbacher, Cristiane de Albuquerque Cavalcanti Jacobsen, Terkel Hansen, Bjørn Olav Brandsdal, Martina Havelkova et al.:
    Synthesis of anticancer heptapeptides containing a unique lipophilic β2,2-amino acid building block
    Journal of Peptide Science 2012 DOI
  • Dominik Ausbacher, Gunbjørg Svineng, Terkel Hansen, Morten B. Strøm :
    Anticancer mechanisms of action of two small amphipathic beta(2,2)-amino acid derivatives derived from antimicrobial peptides
    Biochimica et Biophysica Acta - Biomembranes 19. July 2012 DOI
  • Terkel Hansen, Dominik Ausbacher, Gøril Eide Flaten, Martina Havelkova, Morten B. Strøm :
    Synthesis of Cationic Antimicrobial beta(2,2)-Amino Acid Derivatives with Potential for Oral Administration
    Journal of Medicinal Chemistry 2011 DOI
  • Terkel Hansen, Tore Alst, Martina Havelkova, Morten B. Strøm :
    Antimicrobial Activity of Small beta-Peptidomimeties Based on the Pharmacophore Model of Short Cationic Antimicrobial Peptides
    Journal of Medicinal Chemistry 2010 DOI
  • Sietske Grijseels, Torbjørn Norberg Myhre, Terje Vasskog, Terkel Hansen, Marie Mardal :
    Development and validation of an LC-HRMS analytical platform for a long-term, clinical metabolome profiling study
    2022
  • Joseph Diab, Terkel Hansen, Rasmus Goll, Hans Stenlund, Einar Jensen, Thomas Moritz et al.:
    Metabolomics Coupled with Pathway Analysis Reveal the Metabolic Fingerprint in Ulcerative Colitis
    2020
  • Joseph Diab, Terkel Hansen, Rasmus Goll, Hans Stenlund, Einar Jensen, Thomas Moritz et al.:
    Metabolomics for improved patient stratification in inflammatory bowel disease: Characterisation of the ulcerative colitis metabolome
    Journal of Crohn's and Colitis 2020 DOI
  • Joseph Diab, Terkel Hansen, Rasmus Goll, Einar Jensen, Thomas Moritz, Jon Florholmen et al.:
    DOP15 Metabolomics coupled with pathway analysis characterise metabolic changes in treatment-naive ulcerative colitis patients
    Journal of Crohn's and Colitis 2019 DOI
  • Joseph Diab, Terkel Hansen, Rasmus Goll, Hans Stenlund, Maria Ahnlund, Einar Jensen et al.:
    Lipidomics in ulcerative colitis reveal disruption of mucosal lipid composition associated with the disease state
    American Journal of Gastroenterology 2019 DOI
  • Joseph Diab, Terkel Hansen, Rasmus Goll, Einar Jensen, Jon Florholmen, Guro Forsdahl :
    Metabolomics coupled with pathway analysis characterise metabolic changes in treatment-naive ulcerative colitis patients
    2019
  • Joseph Diab, Rania Al-Mahdi, Sandra Gouveia, Terkel Hansen, Einar Jensen, Rasmus Goll et al.:
    Analysis of Colonic Mucosal Oxylipins and Endocannabinoids in Inflammatory Bowel Disease
    2019
  • Joseph Diab, Rania Al-Mahdi, Sandra Gouveia, Terkel Hansen, Thomas Moritz, Einar Jensen et al.:
    A quantitative analysis of colonic mucosal oxylipins and endocannabinoids in Ulcerative Colitis patients and cytokines gene expression
    2018
  • Joseph Diab, Terkel Hansen, Einar Jensen, Terje Vasskog, Rasmus Goll, Jon Florholmen et al.:
    Lipidomics and Metabolomics in Inflammatory Bowel Disease: From pathology to clinical development prediction
    2018
  • Joseph Diab, Sandra Gouveia, Terkel Hansen, Einar Jensen, Moritz Thomas, Rasmus Goll et al.:
    Altered colonic mucosal oxylipins and endocannabinoids levels in treatment-naive and deep remission Ulcerative Colitis patients
    2018
  • Joseph Diab, Rasmus Goll, Terkel Hansen, Einar Jensen, Thomas Moritz, Jon Florholmen et al.:
    Lipidomics in Ulcerative Colitis Reveal Disruption of Mucosal Lipids Composition in Association with the Disease State
    2018
  • Joseph Diab, Sandra Gouveia, Terkel Hansen, Einar Jensen, Moritz Thomas, Rasmus Goll et al.:
    Altered colonic mucosal oxylipins and endocannabinoids levels in treatment-naive and deep remission Ulcerative Colitis patients
    Journal of Crohn's and Colitis 2018 DOI
  • Merete Storflor, Armin Schniers, Terkel Hansen, Sören Abel :
    Quantifying c-di-GMP during infections on a single cell level
    2017
  • Dominik Stelzl, Thorbjørn Terndrup Nielsen, Terkel Hansen, Massimiliano Pio Di Cagno :
    β-CD-dextran for efficient sequestration of cholesterol from phospholipid bilayers: Mechanistic and safe-toxicity investigations
    2016
  • André Engesland, Merete L. Skar, Terkel Hansen, Natasa Skalko-Basnet, Gøril Eide Flaten :
    Development of an artificial in vitro permeation skin model
    2012
  • Dominik Ausbacher, Terkel Hansen, Gunbjørg Svineng, Morten B. Strøm :
    Mechanisms of cancer cell death induced by two novel cationic beta-peptidomimetics
    Biopolymers 2011
  • Dominik Ausbacher, Terkel Hansen, Gunbjørg Svineng, Morten B. Strøm :
    Mechanisms of cancer cell death induced by two novel cationic β-peptidomimetics
    2011
  • Terkel Hansen, Alst Tore, Martina Havelkova, Morten B. Strøm :
    Antimicrobial activity of small β-peptidomimetics fulfilling the pharmacophore model of short cationic antimicrobial peptides
    2010
  • Terkel Hansen, Dominik Ausbacher, Martina Havelkova, Morten B. Strøm :
    Bactericidal activity of small β-peptidomimetics
    2010

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    Research interests

    - Mass spectrometry

    - Clinical proteomics

    - System biology

    - Metabolomics, metabonomics

    - Quantification of small molecules, including endogeneous and exogeneous compounds, metabolites, amino acids etc.


    Member of research group

    Natural Products and Medicinal Chemistry   English content Forskningsgruppe i naturstoff- og legemiddelkjemi   Norsk innhold

    Member of project

    Mapping antimicrobial resistance through a mass spectrometry (MS) based multi-omics approach

    CV

    Scientific background:

    2012: Associate professor, University of Tromsø, UiT

    2011: Post. Doc. Leibniz–Institut für Analytische Wissenschaften – ISAS, Dortmund, Germany

    2011: Associate professor, University of Tromsø, UiT - temporary position

    2011: Philosophiae Doctor (PhD) in Pharmacy from University of Tromsø, UiT

    2007: PhD student at University of Tromsø, UiT: Thesis entitled “Antimicrobial and anticancer β-peptidomimetics - Synthesis and biological evaluation of a new class of highly potent compounds.”

    2006: Scientific assistant

    2006: Master of Pharmacy, University of Tromsø, UiT. Thesis entitled: “Synthesis of lipophilic β-amino acid derivatives as building blocks for biological active peptidomimetics.”