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Photo: Bjørn-Kåre Iversen
Doctoral Research Fellow

Margherita Falavigna

Ph.D student in the Drug Transport and Delivery research group Department of Pharmacy
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Liposomes
Nano drug delivery systems
Permeation models
The phospholipid vesicle-based permeation assay (PVPA)

Ph.D student in the Drug Transport and Delivery research group

  • Falavigna, Margherita; Brurok, Sunniva; Klitgaard, Mette; Flaten, Gøril Eide. Simultaneous assessment of in vitro lipolysis and permeation in the mucus-PVPA model to predict oral absorption of a poorly water soluble drug in SNEDDSs. International Journal of Pharmaceutics 2021. ISSN 0378-5173.s doi: 10.1016/j.ijpharm.2021.120258.

  • Falavigna, Margherita; Klitgaard, Mette; Berthelsen, Ragna; Mullertz, Anette; Flaten, Gøril Eide. Predicting oral absorption of fenofibrate in lipid-based drug delivery systems by combining in vitro lipolysis with the mucus-PVPA permeability model. Journal of Pharmaceutical Sciences 2020. ISSN 0022-3549.s doi: 10.1016/j.xphs.2020.08.026.

  • Falavigna, Margherita; Pattacini, Martina; Wibel, Richard; Sonvico, Fabio; Skalko-Basnet, Natasa; Flaten, Gøril Eide. The Vaginal-PVPA: A Vaginal Mucosa-Mimicking In Vitro Permeation Tool for Evaluation of Mucoadhesive Formulations. Pharmaceutics 2020. ISSN 1999-4923.s doi: 10.3390/pharmaceutics12060568.

  • Falavigna, Margherita; Stein, Paul C.; Flaten, Gøril Eide; Di Cagno, Massimiliano Pio. Impact of mucin on drug diffusion: Development of a straightforward in vitro method for the determination of drug diffusivity in the presence of mucin. Pharmaceutics 2020; Volum 12:168 (2). ISSN 1999-4923.s 1 - 13.s doi: 10.3390/pharmaceutics12020168.

  • Falavigna, Margherita; Klitgaard, Mette; Steene, Erik; Flaten, Gøril Eide. Mimicking regional and fasted/fed state conditions in the intestine with the mucus-PVPA in vitro model: The impact of pH and simulated intestinal fluids on drug permeability. European Journal of Pharmaceutical Sciences 2019; Volum 132. ISSN 0928-0987.s 44 - 54.s doi: 10.1016/j.ejps.2019.02.035.

  • Falavigna, Margherita; Klitgaard, Mette; Brase, Christina; Ternullo, Selenia; Skalko-Basnet, Natasa; Flaten, Gøril Eide. Mucus-PVPA (mucus Phospholipid Vesicle-based Permeation Assay): An artificial permeability tool for drug screening and formulation development. International Journal of Pharmaceutics 2018; Volum 537 (1-2). ISSN 0378-5173.s 213 - 222.s doi: 10.1016/j.ijpharm.2017.12.038.

  • Falavigna, Margherita; Skalko-Basnet, Natasa; Cavallari, Cristina; Pini, Andrea; Luppi, Barbara; Di Cagno, Massimiliano Pio. Novel in situ gel-forming solid dosage form (gfSDF) prepared by the simple syringe-based moulding: A screening study. European Journal of Pharmaceutical Sciences 2017; Volum 105. ISSN 0928-0987.s 11 - 18.s doi: 10.1016/j.ejps.2017.05.008.

  • Falavigna, Margherita; Brurok, Sunniva; Klitgaard, Mette; Flaten, Gøril Eide. Simultaneous in vitro lipolysis-permeation model predicts in vivo drug absorption from lipid-based formulations. NordicPOP Annual Meeting 2021-03-16 - 2021-03-17 2021.

  • Falavigna, Margherita; Brurok, Sunniva; Klitgaard, Mette; Flaten, Gøril Eide. Simultaneous in vitro lipolysis-permeation model predicts in vivo drug absorption from lipid-based formulations. NFIF annual conference 2021-03-10 - 2021-03-11 2021.

  • Falavigna, Margherita; Klitgaard, Mette; Berthelsen, Ragna; Mullertz, Anette; Flaten, Gøril Eide. New combined in vitro lipolysis-permeation model predicts the in vivo absorption of fenofibrate from SNEDDS formulations. 2nd Nordic-POP Annual Meeting 2020-01-07 - 2020-01-09 2020.

  • Falavigna, Margherita; Klitgaard, Mette; Berthelsen, Ragna; Mullertz, Anette; Flaten, Gøril Eide. New combined in vitro lipolysis-permeation model predicts the in vivo absorption of fenofibrate from SNEDDS formulations. 3rd all WGs UNGAP spring meeting 2020 2020-02-11 - 2020-02-12 2020.

  • Falavigna, Margherita; Klitgaard, Mette; Steene, Erik; Flaten, Gøril Eide. Simulating the intestinal environment with the mucus-PVPA in vitro model: the impact of pH and simulated intestinal fluids on drug permeability. 1st Nordic-POP Annual Meeting 2019-01-14 - 2019-01-16 2019.

  • Falavigna, Margherita; Klitgaard, Mette; Skalko-Basnet, Natasa; Flaten, Gøril Eide. Mucus-PVPA: an in vitro permeability screening tool for the investigation of intestinal drug absorption. 3rd European Conference on Pharmaceutics 2019-03-25 - 2019-03-26 2019.

  • Falavigna, Margherita; Klitgaard, Mette; Steene, Erik; Flaten, Gøril Eide. Simulating the intestinal environment with the mucus-PVPA in vitro model: the impact of pH and simulated intestinal fluids on drug permeability.. UNGAP Spring meeting 2019 2019-02-12 - 2019-02-13 2019.

  • Falavigna, Margherita; Brase, Christina; Klitgaard, Mette; Skalko-Basnet, Natasa; Flaten, Gøril Eide. Mucus-PVPA : a permeability-screening tool for drug discovery and formulation development in mucosal tissues. First all WGs UNGAP Meeting. Intestinal absorption: what is happening inside and beyond? 2018-03-08 - 2018-03-09 2018.

  • Falavigna, Margherita; Klitgaard, Mette; Brase, Christina; Ternullo, Selenia; Skalko-Basnet, Natasa; Flaten, Gøril Eide. The mucus-PVPA (phospholipid vesicle-based permeation assay) as a permeability-screening tool to elucidate essential drug properties in drug discovery and formulation development in mucosal tissues. Northern Pharma Network and Nordic POP Kick off-meeting 2018 2018-01-29 - 2018-01-31 2018.

  • Falavigna, Margherita. How is mucus influencing drug permeability in the PVPA?. Young Scientist Satellite Conference 2017, 6th Pharmaceutical Sciences World Congress 2017-05-19 - 2017-05-21 2017.

  • Falavigna, Margherita; Brase, Christina; Klitgaard, Mette; Skalko-Basnet, Natasa; Flaten, Gøril Eide. How is mucus influencing drug permeability in the PVPA?. 6th FIP Pharmaceutical Sciences World Congress 2017-05-21 - 2017-05-24 2017.

  • Falavigna, Margherita; Brurok, Sunniva; Klitgaard, Mette; Flaten, Gøril Eide. Simultaneous in vitro lipolysis-permeation model predicts in vivo drug absorption from lipid-based formulations. NordicPOP Annual Meeting 2021-03-16 - 2021-03-17 2021.

  • Falavigna, Margherita; Brurok, Sunniva; Klitgaard, Mette; Flaten, Gøril Eide. Simultaneous in vitro lipolysis-permeation model predicts in vivo drug absorption from lipid-based formulations. NFIF annual conference 2021-03-10 - 2021-03-11 2021.

  • Falavigna, Margherita; Klitgaard, Mette; Berthelsen, Ragna; Mullertz, Anette; Flaten, Gøril Eide. New combined in vitro lipolysis-permeation model predicts the in vivo absorption of fenofibrate from SNEDDS formulations. 2nd Nordic-POP Annual Meeting 2020-01-07 - 2020-01-09 2020.

  • Falavigna, Margherita; Klitgaard, Mette; Berthelsen, Ragna; Mullertz, Anette; Flaten, Gøril Eide. New combined in vitro lipolysis-permeation model predicts the in vivo absorption of fenofibrate from SNEDDS formulations. 3rd all WGs UNGAP spring meeting 2020 2020-02-11 - 2020-02-12 2020.

  • Falavigna, Margherita; Klitgaard, Mette; Steene, Erik; Flaten, Gøril Eide. Simulating the intestinal environment with the mucus-PVPA in vitro model: the impact of pH and simulated intestinal fluids on drug permeability. 1st Nordic-POP Annual Meeting 2019-01-14 - 2019-01-16 2019.

  • Falavigna, Margherita; Klitgaard, Mette; Skalko-Basnet, Natasa; Flaten, Gøril Eide. Mucus-PVPA: an in vitro permeability screening tool for the investigation of intestinal drug absorption. 3rd European Conference on Pharmaceutics 2019-03-25 - 2019-03-26 2019.

  • Falavigna, Margherita; Klitgaard, Mette; Steene, Erik; Flaten, Gøril Eide. Simulating the intestinal environment with the mucus-PVPA in vitro model: the impact of pH and simulated intestinal fluids on drug permeability.. UNGAP Spring meeting 2019 2019-02-12 - 2019-02-13 2019.

  • Falavigna, Margherita; Brase, Christina; Klitgaard, Mette; Skalko-Basnet, Natasa; Flaten, Gøril Eide. Mucus-PVPA : a permeability-screening tool for drug discovery and formulation development in mucosal tissues. First all WGs UNGAP Meeting. Intestinal absorption: what is happening inside and beyond? 2018-03-08 - 2018-03-09 2018.

  • Falavigna, Margherita; Klitgaard, Mette; Brase, Christina; Ternullo, Selenia; Skalko-Basnet, Natasa; Flaten, Gøril Eide. The mucus-PVPA (phospholipid vesicle-based permeation assay) as a permeability-screening tool to elucidate essential drug properties in drug discovery and formulation development in mucosal tissues. Northern Pharma Network and Nordic POP Kick off-meeting 2018 2018-01-29 - 2018-01-31 2018.

  • Falavigna, Margherita. How is mucus influencing drug permeability in the PVPA?. Young Scientist Satellite Conference 2017, 6th Pharmaceutical Sciences World Congress 2017-05-19 - 2017-05-21 2017.

  • Falavigna, Margherita; Brase, Christina; Klitgaard, Mette; Skalko-Basnet, Natasa; Flaten, Gøril Eide. How is mucus influencing drug permeability in the PVPA?. 6th FIP Pharmaceutical Sciences World Congress 2017-05-21 - 2017-05-24 2017.

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    Member of research group