Clinical pharmacy and drug consumption on population level, mainly focusing on antibiotics.
Birth date 18.1.1959
1985 Candidatus pharmaciae, University of Oslo (UiO)
1999 Master of Public Health, University of Tromsø (UiT)
2009 PhD. UiT
1986-98 Hospital pharmacy.
1998-2008 Regional Drug Information Centre of North Norway.
2008-09 PhD student.
2009- UiT. Associate professor. IPSUM Research group.
1999-2000 Board member. National Board of Pharmacovigilance
2008-2012 Board member. National Board of Reimbursement
2010- Board member. Norwegian Society of Pharmacoepidemiology
2016- Board member. Regional Health Authority
Research and development (International journals)
Rygnestad T, Småbrekke L, Nesje L, Talsethagen H, Rogne P, Myhr K, Bentzen, I. Impact of improved treatment of Sexually Transmitted disease on HIV infection. Lancet 1995; 346 (8983): 1157.
Småbrekke L, Braathen P. Drugs with lactose in patients with lactose intolerance? Tidsskr Nor Medical Association 2000; 120 (19): 2303-4.
Småbrekke L. Large differences in the consumption profile of antibiotics at two university hospitals in Norway. Nor J Epidemiol 2001; 11 (1): 61-5.
Småbrekke L, Berild D, Giaever A, et al. Educational Intervention for Parents and Health Care providers Leads to Reduced Antibiotic Use in Otitis Media. Scand J Infect Dis 2002; 34 (9): 657-9.
Simonsen GS, Småbrekke L, Monnet DL, Sørensen TL et al. Prevalence of resistance two ampicillin, gentamicin and vancomycin in Enterococcus faecalis and E. faecium from clinical specimens and use of antimicrobials in five Nordic hospitals. J Antimicrob Chemother 2003: 51 (2): 323-31.
Berild D, Småbrekke L, Halvorsen DS et al. Clostridium difficile Infections related to antibiotic use and infection control facilities in two university hospitals. J Hosp Infect 2003; 54 (3): 202-6.
Klingenberg C, Småbrekke L, Lier T, Flægstad T. Validation of a simplified netilmicin dosage regimen in infants. Scand J Infect Dis 2004; 36 (6-7): 474-9.
Raknes G, Småbrekke L. Echinacea spp and upper respiratory tract infections. Tidsskr Nor Medical Association 2006; 126: 2526-7.
Småbrekke L, Melbye H. Pharmacological treatment of acute cough. Tidsskr Nor Medical Association 2009:129 (10): 998-9.
Klingenberg C, Småbrekke L, Døllner H, Simonsen GS. Oral antibiotic treatment of urinary tract infection in children. Tidsskr Nor Medical Association 2009; 129 (13): 1342-4.
Nordmo E, Aronsen L, Wasland K, Småbrekke L, Vorren S. Severe apnea in an infant exposed two lamotrigine in breast milk. Ann Pharmacother 2009; 43 (11): 1893-7
Garcia BH, Småbrekke L, Trovik T, Giverhaug T. Application of the MAT-CHDSP two assess guideline adherence in prevention of coronary heart disease after percutaneous coronary intervention. Eur J Clin Pharmacol 2013; 69 (3): 703-9.
Utnes J, Småbrekke L, Garcia BH. MAT-CAP: a novel medication assessment tool to explore adherence two clinical practice guidelines in community acquired pneumonia. Pharmacoepidemiol Drug Saf 2014 Sep;23 (9): 933-41.
Garcia BH, Trovik T, Giver Haug T, L Småbrekke. Pharmacist-led follow-up program after discharge from hospital to improve secondary prevention of coronary heart disease. Submitted.
Garcia BH, Storli LS, Småbrekke L. A pharmacist-led follow-up program for patients with coronary heart disease in North Norway-a qualitative study exploring patient experiences. BMC Research Notes.2014, 7:197. DOI: 10.1186/1756-0500-7-197
Zykov I, Sundsfjord A, Småbrekke L, Samuelsen Ø. The antimicrobial activity of mecillinam, nitrofurantoin, temocillin and fosfomycin and comparative analysis of resistance patterns in a nationwide collection of ESBL-producing Escherichia coli in Norway 2010-2011. Infectious diseases 2015. http://dx.doi.org/10.3109/23744235.2015.1087648.
Melis M, Biagi C, Nonino F, Buccellato E, Donati M, Småbrekke L, Vaccheri A, Motola D. Drug induced progressive multifocal leukoencephalopathy: A comprehensive analysis of the WHO adverse drug reaction database. CNS drugs 2015; 29: 879-91
Høgli JU, Garcia BH, Skjold F, Skogen V, Småbrekke L. An audit and feedback intervention study increased appropriate antibiotic prescribing at a Norwegian hospital. BMC Infect Dis 2016;16(1):96. doi: 10.1186/s12879-016-1426-1.
Antibiotics to outpatients in Norway – assessing effect of latitude and municipality population size using quantile regression. Haugen P, Simonsen GS, Primicerio R, Furberg AS, Småbrekke L. Pharmaceutical Statistics 2016; (submitted)
Exploring antibiotic prescribing in Norway using multivariate analysis. Haugen P, Simonsen GS, Primicerio R, Furberg AS, Småbrekke L. Pharmaceutical Statistics 2016; (submitted)
Raknes G, Småbrekke L. The Norwegian Low Dose Naltrexone tsunami. Patient and prescriber characteristics, and dispense patterns. A cohort study. Pharmacoepidemiol Drug Saf 2016; doi: 10.1002/pds.4110.
Raknes G, Småbrekke L. Low Dose Naltrexone and opioid consumption: a drug utilization cohort study based on data from the Norwegian prescription database. Pharmacoepidemiol Drug Saf 2017; DOI: 10.1002/pds.4201
Supervision of PhD students
Beate Garcia (Dissertation in 2012 – A thesis in clinical pharmacy)
June Utnes (Dissertation October 2015 – A thesis in clinical pharmacy)
Paul Haugen (Dissertation March 2015 – A thesis in pharmacoepidemiology)
Ilya Zykov (Project in microbiology)
Tomas Zimba (Project in microbiology)
Supervision of Master students
Approxemately 25 students in the pharmacy program in Norway, Malawi and Mozambique. Eight medical students (fifth year semester thesis).
Bachelor-/Master level in epidemiology/pharmacoepidemiology. Also teaching at courses PhD courses in EPINOR
2013 NORHED. Antimicrobial stewardship and conservancy in Africa. For further information: http://www.norad.no/en/support/norhed/projects?index=30
I'm responsible for the courses Far-2101 and Far-3101, and contributes in teaching in several other courses for pharmacy students, and PhD students.
The research projects are mainly focused on consumption of antibiotrics, and are based on data from population studies (e.g. TheTromsø studies), the Norwegian Prescription Database and clinical data from hospital practice.