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Doctoral Research Fellow

Christopher Frøhlich

Doctoral Research Fellow, Biomolecular and Structural Chemistry Department of Chemistry
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X-ray crystallography

Enzymes: expression, purification, kinetics

Inhibitor development and screening (cell and enzyme based)

Resistance development

Evolution

 

2014-2016  Master of Science in Analytical Chemistry

2011-2014  Bachelor of Science in Pharmaceutical Chemistry

2009-2016  Chemical Lab Technician at Merck Sharp and Dohme (Cologne) 

KJE-3402 - Protein Structure

F1301- Farmasøytisk kjemi

  • Frøhlich, Christopher; Gama, João Alves; Harms, Klaus; Hirvonen, Viivi H. A.; Lund, Bjarte Aarmo; van der Kamp, Marc W.; Johnsen, Pål Jarle; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Cryptic β-Lactamase Evolution Is Driven by Low β-Lactam Concentrations. mSphere 2021. ISSN 2379-5042.s doi: 10.1128/mSphere.00108-21.

  • Samuelsen, Ørjan; Åstrand, Ove Alexander Høgmoen; Frøhlich, Christopher; Heikal, Adam; Skagseth, Susann; Carlsen, Trine Josefine Olsen; Leiros, Hanna-Kirsti S.; Bayer, Annette; Schnaars, Christian; Kildahl-Andersen, Geir; Lauksund, Silje; Finke, Sarah; Huber, Sandra; Gjøen, Tor; Andresen, Adriana Magalhaes Santos; Økstad, Ole Andreas; Rongved, Pål. ZN148 Is a Modular Synthetic Metallo-beta-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens In Vivo. (https://aac.asm.org/content/early/2020/03/11/AAC.02415-19.long) Antimicrobial Agents and Chemotherapy 2020; Volum 64 (6). ISSN 0066-4804.s doi: 10.1128/AAC.02415-19.

  • Frøhlich, Christopher; Sørum, Vidar; Huber, Sandra; Samuelsen, Ørjan; Berglund, Fanny; Kristiansson, Erik; Kotsakis, Stathis D.; Marathe, Nachiket; Larsson, DG Joakim; Leiros, Hanna-Kirsti Schrøder. Structural and biochemical characterization of the environmental MBLs MYO-1, ECV-1 and SHD-1. Journal of Antimicrobial Chemotherapy 2020; Volum 75. ISSN 0305-7453.s 2554 - 2563.s doi: 10.1093/jac/dkaa175.

  • Muhammad, Zeeshan; Skagseth, Susann; Boomgaren, Marc; Akhter, Sundus; Frøhlich, Christopher; Ismael, Aya; Christopeit, Tony; Bayer, Annette; Leiros, Hanna-Kirsti S.. Structural studies of triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-β-lactamases. Bioorganic & Medicinal Chemistry 2020; Volum 28 (15). ISSN 0968-0896.s doi: https://doi.org/10.1016/j.bmc.2020.115598.

  • Kildahl-Andersen, Geir; Schnaars, Christian; Prandina, Anthony; Radix, Sylvie; Le Borgne, Marc; Jordheim, Lars Petter; Gjøen, Tor; Andresen, Adriana Magalhaes Santos; Lauksund, Silje; Fröhlich, Christopher; Samuelsen, Ørjan; Rongved, Pål; Åstrand, Ove Alexander Høgmoen. Synthesis and biological evaluation of zinc chelating compounds as metallo-β-lactamase inhibitors. MedChemComm 2019; Volum 10 (4). ISSN 2040-2503.s 528 - 537.s doi: 10.1039/c8md00578h.

  • Frøhlich, Christopher; Sørum, Vidar; Thomassen, Ane Molden; Johnsen, Pål Jarle; Leiros, Hanna-Kirsti S.; Samuelsen, Ørjan. OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs. mSphere 2019; Volum 4 (2). ISSN 2379-5042.s doi: 10.1128/mSphere.00024-19.

  • Prandina, Anthony; Radix, Sylvie; Le Borgne, Marc; Jordheim, Lars Petter; Bousfiha, Zineb; Fröhlich, Christopher; Leiros, Hanna-Kirsti S.; Samuelsen, Ørjan; Frøvold, Espen; Rongved, Pål; Åstrand, Ove Alexander Høgmoen. Synthesis and biological evaluation of new dipicolylamine zinc chelators as metallo-β-lactamase inhibitors. Tetrahedron 2019; Volum 75 (11). ISSN 0040-4020.s 1525 - 1540.s doi: 10.1016/j.tet.2019.02.004.

  • Schnaars, Christian; kildahl-Andersen, Geir; Prandina, Anthony; Popal, Roya; Radix, Sylvie; Le Borgne, Marc; Gjøen, Tor; Andresen, Adriana Magalhaes Santos; Heikal, Adam; Økstad, Ole Andreas Løchen; Fröhlich, Christopher; Samuelsen, Ørjan; Lauksund, Silje; Jordheim, Lars Petter; Rongved, Pål; Åstrand, Ove Alexander Høgmoen. Synthesis and preclinical evaluation of TPA-based zinc chelators as metallo-β-lactamase inhibitors. ACS Infectious Diseases 2018; Volum 4 (9). ISSN 2373-8227.s 1407 - 1422.s doi: 10.1021/acsinfecdis.8b00137.

  • Frøhlich, Christopher; Leiros, Hanna-Kirsti S.; Miton, Charlotte; Tokuriki, Nobuhiko. Ceftazidime drives the evolution of the carbapenemase OXA-48. GW4 Multidisciplinary Approaches to AMR: From Bench to Bedside and Beyond 2020 2020-12-01 - 2020-12-03 2020.

  • Frøhlich, Christopher; Johnsen, Pål Jarle; Schrøder Leiros, Hanna-Kirsti; Samuelsen, Ørjan. Evolution of OXA-48 under sub-MIC conditions. 3rd Annual Meeting of the National Graduate School in Infection Biology and and Antimicrobials 2019-11-05 - 2019-11-06 2019.

  • Frøhlich, Christopher; Leiros, Hanna-Kirsti S.; Johnsen, Pål Jarle; Samuelsen, Ørjan. Sub-inhibitory concentrations of ceftazidime drive evolution of the OXA-48 carbapenemase. ECCMID 2019 2019-04-13 - 2019-04-16 2019.

  • Frøhlich, Christopher; Sørum, Vidar; Leiros, Hanna-Kirsti S.; Johnsen, Pål Jarle; Samuelsen, Ørjan. Development of OXA-48 mediated ceftazidme-avibactam resistance is associated with an evolutionary trade-off. ECCMID 2018-04-24 - 2018.

  • Frøhlich, Christopher; Leiros, Hanna-Kirsti S.; Miton, Charlotte; Tokuriki, Nobuhiko. Ceftazidime drives the evolution of the carbapenemase OXA-48. GW4 Multidisciplinary Approaches to AMR: From Bench to Bedside and Beyond 2020 2020-12-01 - 2020-12-03 2020.

  • Frøhlich, Christopher; Johnsen, Pål Jarle; Schrøder Leiros, Hanna-Kirsti; Samuelsen, Ørjan. Evolution of OXA-48 under sub-MIC conditions. 3rd Annual Meeting of the National Graduate School in Infection Biology and and Antimicrobials 2019-11-05 - 2019-11-06 2019.

  • Frøhlich, Christopher; Leiros, Hanna-Kirsti S.; Johnsen, Pål Jarle; Samuelsen, Ørjan. Sub-inhibitory concentrations of ceftazidime drive evolution of the OXA-48 carbapenemase. ECCMID 2019 2019-04-13 - 2019-04-16 2019.

  • Frøhlich, Christopher; Sørum, Vidar; Leiros, Hanna-Kirsti S.; Johnsen, Pål Jarle; Samuelsen, Ørjan. Development of OXA-48 mediated ceftazidme-avibactam resistance is associated with an evolutionary trade-off. ECCMID 2018-04-24 - 2018.

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