Susannah von Hofsten

Job description

I work as a researcher in the research group RAMP, where I mainly study the role of DNase I and NETs (neutrophil extracellular traps) in the autoimmune disease systemic lupus erythematosus.

I finished my PhD in June 2023, where I had been working with synthethic molecules inspired by marine products to try to determine whether they could have the potential to be used in future cancer therapy. Link to thesis

  • Susannah Beatrice von Hofsten, Kristin Andreassen Fenton, Hege Lynum Pedersen :
    Human and Murine Toll-like Receptor-Driven Disease in Systemic Lupus Erythematosus
    International Journal of Molecular Sciences 2024 DOI
  • Susannah von Hofsten, Manuel K Langer, Katja Korelin, Synnøve Norvoll Magnussen, Dominik Ausbacher, Trude Anderssen et al.:
    Amphipathic barbiturates as marine product mimics with cytolytic and immunogenic effects on head and neck squamous cell carcinoma cell lines
    Frontiers in Pharmacology 30. March 2023 ARKIV / DOI
  • Susannah von Hofsten, Marianne Hagensen Paulsen, Synnøve Magnussen, Dominik Ausbacher, Mathias Kranz, Annette Bayer et al.:
    The marine natural product mimic MPM-1 is cytolytic and induces DAMP release from human cancer cell lines
    Scientific Reports 2022 ARKIV / DOI
  • Eirik André Lindeløff Rustad, Susannah von Hofsten, Robin Kumar, Eirik Abrahamsen Lænsman, Gerd Berge, Natasa Skalko-Basnet :
    The pH-Responsive Liposomes—The Effect of PEGylation on Release Kinetics and Cellular Uptake in Glioblastoma Cells
    Pharmaceutics 2022 ARKIV / DOI
  • Ingebrigt Sylte, Rangita Dawadi, Nabin Malla, Susannah von Hofsten, Tra-Mi Nguyen, Ann Iren Solli et al.:
    The selectivity of galardin and an azasugar-based hydroxamate compound for human Matrix metalloproteases and bacterial metalloproteases
  • May-Britt Five, gerd Berge, Susannah von Hofsten, Kjersti Sellæg :
    Medisiner fra havet
  • Kjersti Sellæg, Susannah Beatrice von Hofsten, Anne Kristin McLaren Berge, Lennart Maximilian van Ligtenberg, Marcus Moe Mauseth, Athanasios Kournoutis et al.:
    Autofagi: cellenes spareblussmodus
  • Kjersti Sellæg, Susannah von Hofsten, Nikoline Lander Rasmussen, May-Britt Five :
    Fisking etter fremtidens medisiner - Havet er fullt av mysterier, bli med og let etter nyttige stoffer!
  • Susannah von Hofsten :
    Hvordan drepe kreftceller - Med inspirasjon fra marine naturprodukter
  • Susannah von Hofsten, Marianne Hagensen Paulsen, Manuel K Langer, Synnøve Norvoll Magnussen, Dominik Ausbacher, Annette Bayer et al.:
    A Compound Inspired by Arctic Marine Animals Kills Cancer Cells in vitro and in vivo
  • Susannah von Hofsten, Synnøve Norvoll Magnussen, Dominik Ausbacher, Marianne Hagensen Paulsen, Annette Bayer, Morten B. Strøm et al.:
    The Marine Natural Product Mimic MHP88 Shows Anticancer Activity and has the Potential to Cause Immunogenic Cell Death
    2020 ARKIV

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    Research interests

    • Immunology
    • Autoimmunity and tolerance
    • Systemic lupus erythematosus
    • Cancer and tumor microenvironment


    Fall 2023:

    • Co-supervisor for one master student in biomedicine
    • ODO-2008: seminars in immunology

    Previous teaching:

    • HEL-0700: assignment in academic writing
    • TPL-1010/TANN-114: immunology for dental nurse students
    • MBI-2010: co-supervisor for one bachelor student in biomedicine

    Member of project


    2023 - Researcher, RAMP, IMB, UiT

    2019 - 2023 PhD student, TBRG, IMB, UiT. Title of thesis: Anticancer activity of amphipathic barbiturates.

    • 2021-2022 Research stay (4 months) in Professor Tuula Salo's lab at the Department of Oral and Maxillofacial Diseases, University of Helsinki, Finland.

    2018 - 2019 Engineer for a MABIT financed project: Exploration of an anticancer marine natural product mimic.

    2016 - 2018 Master in biomedicine from UiT. Title of Master thesis: Exploring the in vitro expansion of CD4 T cells – For improved culturing of CD4 T cells linked to FNAIT.

    2013 - 2016 Bachelor in biomedicine from UiT. Title of bachelor thesis: Inhibition of metalloproteinases and the differences within the binding site in human and bacterial zinc metalloproteinases.

    2012 - 2013 One year study program in French language and culture from IEFE, Université Paul Valéry Montpellier III, France.

    2009 - 2012 High school, Kongsbakken VGS