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Bilde av Jamaly, Simin
Bilde av Jamaly, Simin
Department of Medical Biology simin.jamaly@uit.no +47 46949074

Simin Jamaly

Researcher

Job description

Member of the RNA and Molecular Pathology (RAMP) group .

Project Leader (PI) for the project with title of "Early Diagnosis of Chronic Kidney Disorders in Autoimmune Patients" funded by MABIT.

Holds a secondary position as a senior researcher at the Rheumatology Department, Oslo University Hospital (Rikshospitalet).

Work package leader at Health South-East RHF (Rikshospitalet) for the project "Biomarker Development for Early Diagnosis of Lupus Nephritis Using Liquid Biopsies."

Co-principal investigator in the European initiative LUpuS Inception-Cohort Developing (ELUCIDATE), a multi-national, multi-centric, prospective inception cohort for patients with systemic lupus erythematosus.

Has significant experience in study design and management of clinical trials related to biomarker development.

Collaborates with Beth Israel Deaconess Medical Center | BIDMC of Boston at Harvard Medical School, Karolinska Institutet in Sweden, and Aarhus University Hospital in Denmark.

  • Mehrdad Rakaee, Elio Adib, Biagio Ricciuti, Lynette M. Sholl Sholl, Weiwei Shi, Joao V. Alessi et al.:
    Association of machine learning-based assessment of tumor-infiltrating lymphocytes on standard histologic images with outcomes of immunotherapy in patients with NSCLC
    JAMA Oncology 17. November 2022 DOI
  • Simin Jamaly, Maria Tsokos, Rhea Bhargava, Olga Brook, Hecht Jonathan, Reza Abdi et al.:
    Complement activation and increased expression of Syk, mucin-1 and CaMK4 in kidneys of patients with COVID-19
    Clinical Immunology 2021 DOI
  • Simin Jamaly, Mehrdad Rakaee, Reza Abdi, George tsokos, Kristin Andreassen Fenton :
    Interplay of immune and kidney resident cells in the formation of tertiary lymphoid structures in lupus nephritis
    Autoimmunity Reviews 2021 ARKIV / DOI
  • Mehrdad Rakaee, Thomas Karsten Kilvær, Simin Jamaly, Thomas Berg, Erna-Elise Paulsen, Marte Berglund et al.:
    Tertiary lymphoid structure score: a promising approach to refine the TNM staging in resected non-small cell lung cancer
    British Journal of Cancer 2021 DOI
  • Cathrine Ramberg, Simin Jamaly, Nadezhda Latysheva, line Wilsgård, Timofey Sovershaev, Omri Snir et al.:
    A modified clot-based assay to measure negatively charged procoagulant phospholipids
    Scientific Reports 2021 ARKIV / DOI
  • Mehrdad Rakaee, Lill-Tove Busund, Simin Jamaly, Erna-Elise Paulsen, Elin Richardsen, Sigve Andersen et al.:
    Prognostic Value of Macrophage Phenotypes in Resectable Non–Small Cell Lung Cancer Assessed by Multiplex Immunohistochemistry
    Neoplasia 12. February 2019 ARKIV / DOI
  • Simin Jamaly, Cathrine Ramberg, Randi Olsen, Nadezhda Latysheva, Paul Webster, Timofey Sovershaev et al.:
    Impact of preanalytical conditions on plasma concentration and size distribution of extracellular vesicles using Nanoparticle Tracking Analysis
    Scientific Reports 2018 ARKIV / DOI
  • Simin Jamaly, Manu Basavaraju, Irina Starikova, Randi Olsen, Sigrid Kufaas Brækkan, John-Bjarne Hansen :
    Elevated Plasma Levels of P‐Selectin Glycoprotein Ligand‐1 Positive Microvesicles in Patients with Unprovoked Venous Thromboembolism
    Journal of Thrombosis and Haemostasis 2018 ARKIV / DOI
  • Irina Starikova, Simin Jamaly, Antonio Sorrentino, T Blondal, Nadezhda Latysheva, Mikhail Sovershaev et al.:
    Differential expression of plasma miRNAs in patients with unprovoked venous thromboembolism and healthy control individuals
    Thrombosis Research 2015 DOI
  • Simin Jamaly, Mehrdad Rakaee, Rao Raghavendra, Gita patil, Suresh Thakur, Poongothai Ramaswamy et al.:
    Relationship between p53 overexpression, human papillomavirus infection, and lifestyle in Indian patients with head and neck cancers
    Tumour Biology 2012 DOI
  • Mehrdad Rakaee, Elio Adib, Biagio Ricciuti, Lynette M. Sholl, Weiwei Shi, Joao V Alessi et al.:
    Computational pathology by Artificial Intelligence (AI) on quantifying the lymphocytic infiltration predicts the immunotherapy response in NSCLC
    2022
  • Mehrdad Rakaee, Elio Adib, Biagio Ricciuti, Lynette M. Sholl, Weiwei Shi, Joao V.Alessi et al.:
    Artificial intelligence in digital pathology approach identifies the predictive impact of tertiary lymphoid structures with immune-checkpoints therapy in NSCLC
    2022
  • Masataka umeda, Abhigyam Satyam, Nobuya Yoshida, Rhea Bhargava, Ryo Hisada, Simin Jamaly et al.:
    Hypoxia promotes the expression of ADAM9 by tubular epithelial cells which enhances TGF-B1 activation and promotes tissues fibrosis in lupus nephritis
    2021
  • Simin Jamaly :
    Role of Extracellular Vesicles in the Pathogenesis of Venous Thromboembolism
    Nord universitet 2018
  • Simin Jamaly :
    The Norwegian tradition of skiing
    2016 FULLTEKST
  • Cathrine Ramberg, Simin Jamaly, Nadezhda Latysheva, Erin Mathiesen Hald, Vladimir Tichelaar, John Bjarne Hansen :
    IMPACT OF A FAT-TOLERANCE TEST ON PLASMA CONCENTRATION AND SIZE DISTRIBUTION OF EXTRACELLULAR VESICLES ASSESSED BY NANOPARTICLE TRACKING ANALYSIS
    2015
  • Irina Starikova, Simin Jamaly, Antonio Sorrentino, Thorarinn Blondal, Nadezhda Latysheva, Cathrine Ramberg et al.:
    DIFFERENTIAL EXPRESSION OF MIRNAS IN PLASMA AND PERIPHERAL BLOOD MONONUCLEAR CELLS COLLECTED FROM PATIENTS WITH UNPROVOKED VENOUS THTOMBOEMBOLISM AND HEALTHY CONTROL INDIVIDUALS
    2015
  • Simin Jamaly, Irina Starikova, Vladimir Tichelaar, Cathrine Ramberg, Nadezhda Latysheva, John Bjarne Hansen :
    PATIENTS WITH UNPROVOKED VENOUS THROMBOEMBOLISM HAVE HIGHER CONCENTRATION OF LARGE EXTRACELLULAR VESICLES WITH AUGMENTED POTENTIAL TO INITIATE COAGULATION ACTIVATION
    2015
  • Simin Jamaly :
    Når skal man avslutte behandling etter blodpropp?
    2014 FULLTEKST
  • Simin Jamaly, Irina Starikova, Michael Sovershaev, John-Bjarne Hansen :
    High expression levels of P-selectin glycoprotein ligand-1 positive microparticles in people with unprovoked venous thromboembolism
    2013
  • Simin Jamaly, Irina Starikova, Michael Sovershaev, John-Bjarne Hansen :
    Increased levels of P-selectin glycoprotein ligand-1 positive microparticles in patients with unprovoked venous thromboembolism
    2013
  • Irina Starikova, Simin Jamaly, Michael Sovershaev, T Blondal, Antonio Sorrentino, John-Bjarne Hansen :
    The role of microRNA in the pathogenesis of venous thromboembolism
    2013

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    Research interests

    At the RNA and Molecular Pathology (RAMP) research group, my primary focus is on the early detection and thorough monitoring of chronic kidney disorders, specifically lupus nephritis. I'm deeply invested in the development of a biomarker that could identify the presence of lupus nephritis even before tangible clinical symptoms, like proteinuria. Furthermore, I'm on a mission to craft a biomarker that could potentially eliminate the need for kidney biopsies, which are currently the golden and standard method for kidney disorders diagnosis. This urgency is amplified by the fact that about 20% of lupus nephritis patients undergo multiple biopsies to check the effectiveness of their treatments.

    To achieve these goals, I'm engaged in several distinct projects. One of the standout initiatives, generously funded by MABIT, is "Early Diagnosis of Chronic Kidney Disorders in Autoimmune Patients." Within this project, I'm deeply exploring the avenues of personalized medicine and cutting-edge drug development. Alongside this, I'm serving as a full–time senior researcher at the Rheumatology Department of Rikshospitalet in Oslo. Here, I'm leading a prospective study that's slated to run from 2024 to 2026, aiming to closely monitor systemic lupus erythematosus (SLE) patients across various stages of their illness.

    I've also played a key role in launching a multi-national, multi-center prospective cohort, specifically tailored for patients with SLE. Across all these endeavors, my commitment to rigorous study design and top-notch clinical trial management, particularly in the field of biomarker development, remains steadfast.


    Member of research group

    RNA and molecular pathology research group (RAMP)   Norsk innhold

    Member of project

    Lupus Nephritis-disease mechanisms, detection and therapy

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