Bilde av Seternes, Ole Morten
Photo: Bjørn-Kåre Iversen

Ole Morten Seternes


Job description

Ole Morten Seternes is a professor of Pharmacology and leads the Cell Signaling and Targeted Therapy Research Group at the Department of Pharmacy. His research interests focus on basic research into the mechanisms of cellular signaling, with a particular focus on kinases and phosphatases involved in the regulation of mitogen-activated kinase signalling pathways.

Biography

Ole Morten Seternes received all of his academic education from the University of Tromsø, now known as UiT The Arctic University of Norway. He obtained his Cand Scient degree (equivalent to a Master's degree) in 1992 from the Virology Research Group at the Department of Medical Biology, with Professor Terje Traavik as his supervisor. His Dr.scient degree (equivalent to a PhD degree) was obtained from the same department at the Medical Genetics Research Group in 1998, with a thesis entitled "The immediately early gene c-fos and the cAMP response element binding protein CREB: studies of transcriptional activity regulated by different signaling pathways," under the supervision of Professor Ugo Moens.
 From 1998-2001, he was granted a personal postdoctoral fellowship from the Norwegian Research Council to work in the ICRF (now Cancer Research UK) Stress Response Laboratory under the direction of Professor Steve Keyse at the University of Dundee in Dundee, Scotland, UK. After returning from the UK, he received a career development fellowship from the Norwegian Research Council to start his own research group at the Department of Medical Biology, University of Tromsø.
 In 2006, he became a senior research fellow of the Norwegian Cancer Society and was appointed as a full professor in Pharmacology and leader of the Cell Signaling and Targeted Therapy Research Group at the Department of Pharmacy in 2010.


  • Benedicte Sjo Tislevoll, Monica Hellesøy, Oda Helen Eck Fagerholt, Stein-Erik Gullaksen, Aashish Srivastava, Even Birkeland et al.:
    Early response evaluation by single cell signaling profiling in acute myeloid leukemia
    Nature Communications 2023 ARKIV / DOI
  • Fadia Boudghene-Stambouli, Mathilde Soulez, Natalia Ronkina, Anneke Dörrie, Alexey Kotlyarov, Ole Morten Seternes et al.:
    On the Therapeutic Potential of ERK4 in Triple-Negative Breast Cancer
    Cancers 2023 ARKIV / DOI
  • Erik Knutsen, Saikat Das Sajib, Tonje Fiskaa, James Bradley Lorens, Thorarinn Gudjonsson, Gunhild Mari Mælandsmo et al.:
    Identification of a core EMT signature that separates basal-like breast cancers into partial- and post-EMT subtypes
    Frontiers in Oncology 2023 ARKIV / DOI
  • Joaquim Javary, Eugénie Goupil, Mathilde Soulez, Evgeny Kanshin, Antoine Bouchard, Ole Morten Seternes et al.:
    Phosphoproteomic analysis identifies supervillin as an ERK3 substrate regulating cytokinesis and cell ploidy
    Journal of Cellular Physiology 2022 ARKIV / DOI
  • Lisa Zeyen Øyås, Ole Morten Seternes, Ingvild Mikkola :
    Crosstalk between p38 MAPK and GR Signaling
    International Journal of Molecular Sciences 2022 ARKIV / DOI
  • Anup Shrestha, Henrike Bruckmüller, Hanne Kildalsen, Gurjit Kaur, Matthias Gaestel, Hilde Ljones Wetting et al.:
    Phosphorylation of steroid receptor coactivator-3 (SRC-3) at serine 857 is regulated by the p38 MAPK-MK2 axis and affects NF-κB-mediated transcription
    Scientific Reports 2020 ARKIV / DOI
  • Dennis Bela-Ong, Linn Greiner-Tollersrud, Yorick Andreas van der Wal, Ingvill Jensen, Ole Morten Seternes, Jorunn Jørgensen :
    Infection and microbial molecular motifs modulate transcription of the interferon-inducible gene ifit5 in a teleost fish
    Developmental and Comparative Immunology 2020 ARKIV / DOI
  • Anna Lucja Czarna, Wang Jinhua, Diana Zelencova, Yao Liu, Xianming Deng, Hwan Geun Choi et al.:
    Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors
    Journal of Medicinal Chemistry 2018 ARKIV / DOI
  • Ole Morten Seternes, Andrew M Kidger, Stephen M Keyse :
    Dual-specificity MAP kinase phosphatases in health and disease
    BBA - Molecular Cell Research 2018 ARKIV / DOI
  • Maria Perander, Rania Al-Mahdi, Thomas Clemens Jensen, Jennifer Ann Lillebo Nunn, Hanne Kildalsen, Bjarne Herold Johansen et al.:
    Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2
    Scientific Reports 2017 ARKIV / DOI
  • Maria Perander, Stephen M Keyse, Ole Morten Seternes :
    New insights into the activation, interaction partners and possible functions of MK5/PRAK
    Frontiers in Bioscience 2016
  • Sampada Satchidanand Bhagwat, Anett Kristin Larsen, Ole Morten Seternes, Berit Bang :
    Mixed exposure to bacterial lipopolysaccharide and seafood proteases augments inflammatory signalling in an airway epithelial cell model (A549)
    Toxicology and industrial health 2016 ARKIV / DOI
  • Jennifer L. Whiting, Leah Ogier, Katherine A Forbush, Paula Bucko, Janani Gopalan, Ole Morten Seternes et al.:
    AKAP220 manages apical actin networks that coordinate aquaporin-2 location and renal water reabsorption
    Proceedings of the National Academy of Sciences of the United States of America 2016 DOI
  • Tonje Fiskaa, Erik Knutsen, Malene Nikolaisen, Tor Erik Jørgensen, Steinar Daae Johansen, maria Perander et al.:
    Distinct small RNA signatures in extracellular vesicles derived from breast cancer cell lines
    PLOS ONE 2016 ARKIV / DOI
  • Ka Bian, Naveen Reddy Muppani, Lobna Elkhadragy, Wei Wang, Cheng Zhang, Tenghui Chen et al.:
    ERK3 regulates TDP2-mediated DNA damage response and chemoresistance in lung cancer cells
    OncoTarget 2015 ARKIV / DOI
  • Rania Al-Mahdi, Nouf Babteen, Kiruthikah Thillai, Mark Holt, Bjarne Herold Johansen, Hilde Ljones Wetting et al.:
    A novel role for atypical MAPK kinase ERK3 in regulating breast cancer cell morphology and migration
    Cell Adhesion & Migration 2015 DOI
  • Jennifer L. Whiting, Patrick J. Nygren, Brian J. Tunquist, Lorene K. Langeberg, Ole Morten Seternes, John D. Scott :
    Protein kinase A opposes the phosphorylation-dependent recruitment of glycogen synthase kinase 3β to A-kinase Anchoring Protein 220
    Journal of Biological Chemistry 2015 ARKIV / DOI
  • Sampada Satchidanand Bhagwat, Anett Kristin Larsen, Jan-Olof Winberg, Ole Morten Seternes, Berit Bang :
    Salmon and king crab trypsin stimulate interleukin-8 and matrix metalloproteinases via protease-activated receptor-2 in the skin keratinocytic HaCaT cell line
    Food and Chemical Toxicology (FCT) 2014 DOI
  • Anett Kristin Larsen, kurt Kristiansen, Ingebrigt Sylte, Ole Morten Seternes, Berit Bang :
    Differences in PAR-2 activating potential by king crab (Paralithodes camtschaticus), salmon (Salmo salar), and bovine (Bos taurus) trypsin
    BMC Research Notes 2013 ARKIV / DOI
  • Erik Knutsen, Tonje Fiskaa, anita Ursvik, Tor Erik Jørgensen, maria Perander, Eiliv Lund et al.:
    Performance Comparison of Digital microRNA Profiling Technologies Applied on Human Breast Cancer Cell Lines
    PLOS ONE 2013 ARKIV / DOI
  • Ilona Urbarova, Bård Ove Karlsen, Siri Okkenhaug, Ole Morten Seternes, Steinar Johansen, Åse Emblem :
    Digital Marine Bioprospecting: Mining New Neurotoxin Drug Candidates from the Transcriptomes of Cold-Water Sea Anemones
    Marine Drugs 2012 ARKIV / DOI
  • Anett Kristin Larsen, ole morten Seternes, Merethe Larsen, Hideki Kishimura, Galina N Rudenskaya, Berit Bang :
    Purified sardine and king crab trypsin display individual differences in PAR-2-, NF-kappa B-, and IL-8 signaling
    Toxicological & Environmental Chemistry 2011 ARKIV / DOI
  • Steinar D. Johansen, Åse Emblem, Bård Ove Karlsen, Siri Okkenhaug, Hilde Hansen, Truls Moum et al.:
    Approaching marine bioprospecting in hexacorals by RNA deep sequencing
    New Biotechnology 2010 DOI
  • ole morten Seternes, Bjarne Herold Johansen, Beate Hegge, Mona Johannessen, Stephen M Keyse, Ugo Moens :
    Both Binding and Activation of p38 Mitogen-Activated Protein Kinase (MAPK) Play Essential Roles in Regulation of the Nucleocytoplasmic Distribution of MAPK-Activated Protein Kinase 5 by Cellular Stress
    Molecular and Cellular Biology 2010 DOI
  • espen Åberg, Knut Martin Torgersen, Bjarne Herold Johansen, Stephen M Keyse, maria Perander, ole morten Seternes :
    Docking of PRAK/MK5 to the Atypical MAPKs ERK3 and ERK4 Defines a Novel MAPK Interaction Motif
    Journal of Biological Chemistry 2009 DOI
  • maria Perander, espen Åberg, Bjarne Herold Johansen, Bo Dreyer, Ingrid Jenny Guldvik, heidi Outzen et al.:
    The Ser(186) phospho-acceptor site within ERK4 is essential for its ability to interact with and activate PRAK/MK5
    Biochemical Journal 2008 DOI
  • maria Perander, Stephen M Keyse, ole morten Seternes :
    Does MK5 reconcile classical and atypical MAP kinases?
    Frontiers in Bioscience 2008
  • Tom Egil Hansen, Pål Puntervoll, A.W. Borgland, ole morten Seternes, Gerald Eigen, Jorunn B Jørgensen et al.:
    Atlantic salmon possess three mitogen activated protein kinase kinase 6 paralogs responding differently to stress
    The FEBS Journal 2008 DOI
  • Anett Kristin Larsen, ole morten Seternes, Merethe Larsen, lisbeth Aasmoe, Berit Bang :
    Salmon trypsin stimulates the expression of interleukin-8 via protease-activated receptor-2
    Toxicology and Applied Pharmacology 2008 DOI
  • espen Michaelsen, maria Perander, Bjarne Herold Johansen, Catherine Julien, Sylvain Meloche, Stephen M Keyse et al.:
    Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAPK ERK4/MAPK4
    Journal of Biological Chemistry 2006
  • Nico Hendrickx, Cédric Volanti, Ugo Moens, ole morten Seternes, Peter De Witte, Jackie R Vandenheede :
    Up-regulation of cyclooxygenase-2 and apoptosis resistance by p38 MAPK in hypericin-mediated photodynamic therapy of human cancer cells
    Journal of Biological Chemistry 2004
  • Ole Morten Seternes, Theresa Mikalsen, Bjarne Johansen, Espen Michaelsen, CG Armstrong, NA Morrice et al.:
    Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway
    EMBO Journal 2004 DOI
  • Mona Johannessen, Marit Pedersen Delghandi, Ole Morten Seternes, Bjarne Johansen, Ugo Lionel Moens :
    Synergistic activation of CREB-mediated transcription by forskolin and phorbol ester requires PKC and depends on the glutamine-rich Q2 transactivation domain
    Cellular Signalling 2004
  • Mona Johannessen, Petter Angell Olsen, Rita Irene Sørensen, Bjarne Johansen, Ole Morten Seternes, Ugo Lionel Moens :
    A role of the TATA box and the general co-activator hTAFII130/135 in promoter-specific trans-activation by simian virus 40 small t antigen
    Journal of General Virology 2003 DOI
  • Nico Hendrickx, Cédric Volanti, Ugo Lionel Moens, Ole Morten Seternes, Peter De Witte, Jackie R Vandenheede et al.:
    Up-regulation of cyclooxygenase-2 and apoptosis resistance by p38 MAPK in hypericin-mediated photodynamic therapy of human cancer cells
    Journal of Biological Chemistry 2003 DOI
  • Mona Johannessen, Petter Angell Olsen, Bjarne Johansen, Ole Morten Seternes, Ugo Lionel Moens :
    Activation of the coactivator foru-and-a-half-LIM-only protein FHL2 and the c-fos promoter through inhibition of protein phosphatase 2A
    Biochemical Pharmacology 2003
  • Benedicte Sjo Tislevoll, Monica Hellesøy, Oda Helen Eck Fagerholt, Stein-Erik Gullaksen, Aashish Srivastava, Even Birkeland et al.:
    Author Correction: Early response evaluation by single cell signaling profiling in acute myeloid leukemia (Nature Communications, (2023), 14, 1, (115), 10.1038/s41467-022-35624-4)
    Nature Communications 2023 DOI
  • Berit Bang, Anett Kristin Larsen, Sampada Satchidanand Bhagwat, Nabin Malla, Ole Morten Seternes, Jan-Olof Winberg :
    Seafood proteases present in workplace bioaerosols – effects on inflammatory pathways in skin and airway cell models.
    2016
  • Berit Bang, Anett Kristin Larsen, Sampada Satchidanand Bhagwat, Nabin Malla, Ole Morten Seternes, Jan-Olof Winberg :
    Seafood proteases present in workplace bioaerosols – effects on inflammatory pathways in skin and airway cell models.
    2016
  • espen Åberg, Ole Morten Seternes, Richard Alan Engh, Franz Gruber :
    Fra Mutasjon til Medisin
    2013
  • Anett Kristin Larsen, Merethe Larsen, Ole Morten Seternes, Berit Bang :
    Proteases in Seafood as activators of inflammatory reactions in airway epithelial cells
    2011
  • Erik Knutsen, morten Andreassen, Tonje Fiskaa, anita Ursvik, Eiliv Lund, Ole Morten Seternes et al.:
    MiRNA expression profiling based on different high-throughput platforms reveals surprising variations
    2011
  • Steinar Daae Johansen, morten Andreassen, Igor Babiak, Teshome Bizuayehu, Dag-Hugo Coucheron, M. Raafat El-Gewely et al.:
    Investigating miRNAs and transcriptomes at our local SOLiD sequencing facility
    2011
  • maria Perander, Trine Stiberg, Lene Elisabeth Myhren, Espen Hansen, ole morten Seternes, Lars Herfindal et al.:
    Characterization of cytotoxic activities in extracts from two marine invertebrates
    2011
  • Anett Kristin Larsen, Berit Bang, Ole Morten Seternes :
    Proteases from seafood as activators of protease-activated receptor-2 in airway epithelial cells
    UiT Norges arktiske universitet 2010
  • Anett Kristin Larsen, Merethe Larsen, Ole Morten Seternes, Berit Bang :
    Protease-activated signal pathways in airway cells. Purified salmon trypsin activates Nuclear factor kappa-B and induces interleukin-8 secretion in human airway epithelial cells (A549)
    2007
  • Merethe Larsen, Berit Bang, ole morten Seternes, Anett K. Larsen :
    Protease-activated signal pathways in airway cells. Purified salmon trypsin activates nuclear factor kappa-B and induces interleukin-8 secretion in human airway epithelial cells (A549)
    Allergy. European Journal of Allergy and Clinical Immunology 2007
  • ole morten Seternes :
    The atypical MAP kinases ERK3 and 4 defines novel signaling pathways
    2006
  • ole morten Seternes :
    The atypical MAP kinases ERK3 and 4 defines novel signaling pathways
    2006
  • Espen Åberg, maria Perander, Bjarne Herold Johansen, Catherine Julien, Sylvain Meloche, Stephen M Keyse et al.:
    Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAP kinase ERK4/MAPK4
    2006

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    Research interests

    The focus of the research is on basic cellular signaling, with a particular interest in the role of protein kinases and phosphatases in regulating MAP kinase signaling in human cancer. This includes the study of classical MAP kinases, such as p38 MAPK (MAPK14), as well as atypical MAPK kinases, such as ERK3 (MAPK6) and ERK4 (MAPK4). Additionally, the research examines negative regulators of MAP kinases, such as the family of MAP kinase phosphatases.  

    Teaching

    Teach in the courses:

    FAR2206 and FAR2207