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Researcher

Anett Kristin Larsen

Researcher
Department of Medical Biology




Research interests

In the SECVIR project we are investigating the ability of liver endothelial cells to take up and eliminate virus from the blood. The sinusoidal endothelium in liver has evolved into a specialized scavenger endothelium with important functions in host defence, removing large amounts of connective tissue molecules, lipids, other potential dangerous molecules like possibly virus, from the blood. Our main goal is to investigate if different types of virus is eliminated via the liver by these specialized LSEC and hereby increase our understanding of what role these cells play in the body's antiviral defence.

This work is a very exciting extension of my main research interest which is cellular mechanisms during infectious diseases, including zoonoses. During my Post Doc my main focus was cell biology and immunology in Arctic species, developing infection models in primary cell cultures isolated from wild animals. I am also very interested in the combined effects of climate- and environmental change on health and immune competence.

Publications in CRIStin


  • Olsvik, Pål Asgeir; Larsen, Anett Kristin; Berntssen, Marc; Goksøyr, Anders; Karlsen, Odd Andre; Yadetie, Fekadu; Sanden, Monica; Kristensen, Torstein. Effects of agricultural pesticides in aquafeeds on wild fish feeding on leftover pellets near fish farms. Frontiers in Genetics 2019; Volum 10:794. ISSN 1664-8021.s 1 - 18.s doi: 10.3389/fgene.2019.00794.

  • Nymo, Ingebjørg Helena; Rødven, Rolf; Beckmen, Kimberlee B.; Larsen, Anett Kristin; Tryland, Morten; Quakenbush, Lori; Godfroid, Jacques. Brucella antibodies in alaskan true seals and eared seals — two different stories. Frontiers in Veterinary Science 2018; Volum 5 (8). ISSN 2297-1769.s doi: 10.3389/fvets.2018.00008.

  • Larsen, Anett Kristin; Nymo, Ingebjørg Helena; Sørensen, Karen Kristine; Seppola, Marit; Rødven, Rolf; Jiménez de Bagüés, María Pilar; Al Dahouk, Sascha; Godfroid, Jacques. Concomitant Temperature Stress and Immune Activation may Increase Mortality Despite Efficient Clearance of an Intracellular Bacterial Infection in Atlantic Cod. Frontiers in Microbiology 2018; Volum 9 (2963). ISSN 1664-302X.s doi: 10.3389/fmicb.2018.02963.

  • Bhagwat, Sampada Satchidanand; Larsen, Anett Kristin; Seternes, Ole Morten; Bang, Berit. Mixed exposure to bacterial lipopolysaccharide and seafood proteases augments inflammatory signalling in an airway epithelial cell model (A549). Toxicology and industrial health 2016; Volum 32 (11). ISSN 0748-2337.s 1866 - 1874.s doi: 10.1177/0748233715590914.

  • Nymo, Ingebjørg Helena; Seppola, Marit; Sascha, Al Dahouk; Bakkemo, Katrine Ryvold Arnesen; Jiménez de Bagüés, María Pilar; Godfroid, Jacques; Larsen, Anett Kristin. Experimental challenge of atlantic cod (Gadus morhua) with a brucella pinnipedialis strain from hooded seal (Cystophora cristata). PLOS ONE 2016; Volum 11 (7). ISSN 1932-6203.s doi: 10.1371/journal.pone.0159272.

  • Larsen, Anett Kristin; Godfroid, Jacques; Nymo, Ingebjørg Helena. Brucella pinnipedialis in hooded seal (Cystophora cristata) primary epithelial cells. Acta Veterinaria Scandinavica 2016; Volum 58 (9). ISSN 1751-0147.s doi: 10.1186/s13028-016-0188-5.

  • Godfroid, Jacques; De Bolle, Xavier; Roop, R. Martin I.I.; O'Callaghan, David; Tsolis, Renée M.; Baldwin, Cynthia L.; Santos, Renato L.; McGiven, John A.; Olsen, Steven C.; Nymo, Ingebjørg Helena; Larsen, Anett Kristin; Al Dahouk, Sascha; Letesson, Jean-Jacques. The quest for a true One Health perspective of brucellosis. Rev Sci Tech Off Int Epizoot 2014; Volum 33 (2). ISSN 0253-1933.s 521 - 538.

  • Nymo, Ingebjørg Helena; Tryland, Morten; Åsbakk, Kjetil; Godfroid, Jacques; Larsen, Anett Kristin. Brucella-infeksjoner hos sjøpattedyr - fortsatt ubesvarte spørsmål. Norsk Veterinærtidsskrift 2014; Volum 126 (5). ISSN 0332-5741.s 455 - 462.

  • Bhagwat, Sampada Satchidanand; Larsen, Anett Kristin; Winberg, Jan-Olof; Seternes, Ole Morten; Bang, Berit. Salmon and king crab trypsin stimulate interleukin-8 and matrix metalloproteinases via protease-activated receptor-2 in the skin keratinocytic HaCaT cell line. Food and Chemical Toxicology 2014; Volum 69. ISSN 0278-6915.s 303 - 311.s doi: 10.1016/j.fct.2014.04.030.

  • Nymo, Ingebjørg Helena; Godfroid, Jacques; Åsbakk, Kjetil; Larsen, Anett Kristin; Das Neves, Carlos G; Rødven, Rolf; Tryland, Morten. A protein A/G indirect enzyme-linked immunosorbent assay for the detection of anti-Brucella antibodies in Arctic wildlife. Journal of Veterinary Diagnostic Investigation 2013; Volum 25 (3). ISSN 1040-6387.s 369 - 375.s doi: 10.1177/1040638713485073.

  • Larsen, Anett Kristin; Kristiansen, kurt; Sylte, Ingebrigt; Seternes, Ole Morten; Bang, Berit. Differences in PAR-2 activating potential by king crab (Paralithodes camtschaticus), salmon (Salmo salar), and bovine (Bos taurus) trypsin. BMC Research Notes 2013; Volum 6. ISSN 1756-0500.s 281 - .s doi: 10.1186/1756-0500-6-281.

  • Larsen, Anett Kristin; Nymo, Ingebjørg Helena; Briquemont, Benjamin; Sørensen, Karen Kristine; Godfroid, Jacques. Entrance and survival of Brucella pinnipedialis hooded seal strain in human macrophages and epithelial cells. PLOS ONE 2013; Volum 8 (12). ISSN 1932-6203.s doi: 10.1371/journal.pone.0084861.

  • Larsen, Anett Kristin; Nymo, Ingebjørg Helena; Boysen, Preben; Tryland, Morten; Godfroid, Jacques. Entry and Elimination of Marine Mammal Brucella spp. by Hooded Seal (Cystophora cristata) Alveolar Macrophages In Vitro. PLOS ONE 2013; Volum 8 (7). ISSN 1932-6203.s doi: 10.1371/journal.pone.0070186.

  • Larsen, Anett Kristin; Seternes, ole morten; Larsen, Merethe; Kishimura, Hideki; Rudenskaya, Galina N; Bang, Berit. Purified sardine and king crab trypsin display individual differences in PAR-2-, NF-kappa B-, and IL-8 signaling. Toxicological & Environmental Chemistry 2011; Volum 93 (10). ISSN 0277-2248.s 1991 - 2011.s doi: 10.1080/02772248.2011.614380.

  • Bang, Berit; Larsen, Merethe; Larsen, Anett Kristin; Aasmoe, lisbeth. Proteases from Salmon Stimulate IL-8 in Airway Epithelial Cells. Journal of Toxicology and Environmental Health, Part A 2009; Volum 72 (9). ISSN 1528-7394.s 571 - 573.s doi: 10.1080/15287390902733499.

  • Larsen, Anett Kristin; Seternes, ole morten; Larsen, Merethe; Aasmoe, lisbeth; Bang, Berit. Salmon trypsin stimulates the expression of interleukin-8 via protease-activated receptor-2. Toxicology and Applied Pharmacology 2008; Volum 230. ISSN 0041-008X.s 276 - 282.s doi: 10.1016/j.taap.2008.02.019.

  • Sanchez Romano, Javier; Tryland, Morten; Nymo, Ingebjørg Helena; Larsen, Anett Kristin; Sørensen, Karen Kristine. Infectious keratoconjunctivitis in reindeer - The role of the reindeer alphaherpesvirus. 2019 ISBN 978-82-8266-163-8.

  • Olsvik, Pål Asgeir; Larsen, Anett Kristin; Berntssen, Marc; Goksøyr, Anders; Karlsen, Odd Andre; Yadetie, Fekadu; Sanden, Monica; Kristensen, Torstein. Effects of agricultural pesticides in aquafeeds on wild fish feeding on leftover pellets near fish farms. Conference talk. 20th International Symposium on Pollutant Responses in Marine Organisms 2019-05-18 - 2019-05-22 2019.

  • Olsvik, Pål A.; Larsen, Anett Kristin; Berntssen, Marc; Goksøyr, Anders; Karlsen, Odd Andre; Sanden, Monica; Kristensen, Torstein. Agricultural pesticides in aquafeeds might harm wild fish feeding on leftover pellets near fish farms.. 20th International Symposium on Pollutant Responses in Marine Organisms (PRIMO 20) 2019-05-19 - 2019-05-22 2019.

  • Bang, Berit; Larsen, Anett Kristin; Bhagwat, Sampada Satchidanand; Malla, Nabin; Seternes, Ole Morten; Winberg, Jan-Olof. Seafood proteases present in workplace bioaerosols – effects on inflammatory pathways in skin and airway cell models.. Regional Helsekonferanse 2016-11-02 - 2016-11-03 2016.

  • Bang, Berit; Larsen, Anett Kristin; Bhagwat, Sampada Satchidanand; Malla, Nabin; Seternes, Ole Morten; Winberg, Jan-Olof. Seafood proteases present in workplace bioaerosols – effects on inflammatory pathways in skin and airway cell models.. EAACI 2016 2016-06-12 - 2016-06-16 2016.

  • Godfroid, Jacques; Nymo, Ingebjørg Helena; Larsen, Anett Kristin; Åsbakk, Kjetil; Josefsen, Terje D.. Meldepliktige sykdommer hos rein. Norsk Veterinærtidsskrift 2014; Volum 126 (2). ISSN 0332-5741.s 243 - 249.

  • Nymo, Ingebjørg Helena; Tryland, Morten; Godfroid, Jacques; Larsen, Anett Kristin; Lie, Elisabeth; Letesson, Jean-Jacques. Brucella pinnipedialis in hooded seals (Cystophora cristata): infection biology and effect of PCB 153 exposure under experimental conditions. 2013 ISBN 978-82-7725-254-4.

  • Beckmen, Kimberly; Nymo, Ingebjørg Helena; Tryland, Morten; Åsbakk, Kjetil; Larsen, Anett Kristin; Godfroid, Jacques; Dau, Jim; Rødven, Rolf. Spatio-temporal trends in prevalence of anti-Brucella antibodies in barren-ground caribou (Rangifer tarandus granti) in Alaska - an example of enzootic equilibrium. 66th BRucella research conference 2013-12-07 - 2013-12-08 2013.

  • Larsen, Anett Kristin; Nymo, Ingebjørg Helena; Briquemont, Benjamin; Sørensen, Karen Kristine; Godfroid, Jacques. Brucella pinnipedialis hooded seal strain in cell models. 66th Brucella research conference 2013-12-07 - 2013-12-08 2013.

  • Larsen, Anett Kristin; Nymo, Ingebjørg Helena; Sørensen, Karen Kristine; Boysen, Preben; Tryland, Morten; Godfroid, Jacques. Entry of hooded seal (Cystophora cristata) alveolar macrophages by marine Brucella spp. 65th Brucella research conference 2012-12-01 - 2012-12-02 2012.

  • Larsen, Anett Kristin; Nymo, Ingebjørg Helena; Sørensen, Karen Kristine; Tryland, Morten; Godfroid, Jacques. Brucella pinnipedialis hooded seal (Cystophora cristata) strain invades human macrophages in culture. 61st International Conference of the WDA/10th Biennial Conference of the EWDA 2012-07-23 - 2012-07-27 2012.

  • Larsen, Anett Kristin; Larsen, Merethe; Seternes, Ole Morten; Bang, Berit. Proteases in Seafood as activators of inflammatory reactions in airway epithelial cells. Organic Dust Tromsø Symposium 2011-04-11 - 2011-04-13 2011.

  • Larsen, Anett Kristin; Bang, Berit; Seternes, Ole Morten. Proteases from seafood as activators of protease-activated receptor-2 in airway epithelial cells. 2010 ISBN 978-82-7589-284-1.

  • Larsen, Anett Kristin; Larsen, Merethe; Seternes, Ole Morten; Bang, Berit. Protease-activated signal pathways in airway cells. Purified salmon trypsin activates Nuclear factor kappa-B and induces interleukin-8 secretion in human airway epithelial cells (A549). XXVI Congress of the European Academy of Allergology and Clinical Immunology 2007-06-21 - 2007-06-23 2007.

  • Member of research group