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Postdoctoral Fellow

Erik Knutsen

Postdoctoral Fellow
Department of Medical Biology

Research interests

The main focus of my research is within the field of non-coding RNAs and cancer. The class of non-coding RNAs have promising potential as novel targets for cancer therapy, and for this reason it is important to acquire more knowledge about the basic function of these RNA species. Some of the research project I have been involved in have shed light on the accuracy of methods for performing small RNA profiling, have identified important cancer associated miRNAs in neuroblastoma and meningioma, and have identified the small RNA content in exosomes from breast cancer cells in order to unravel their potential as biomarkers. Currently I'm focusing on the role of long non-coding RNAs in epithelial to mesenchymal transition and unraveling the functional role of the long non-coding RNA NEAT1 in breast cancer.


Research Experience

04-2017-Present, UiT The Arctic University of Norway, Postdoctoral fellow                     

PI: Maria Perander

02-2018-02-2019, University of Texas MD Anderson Cancer Center, Postdoctoral fellow                     

PI: George A. Calin

01-2017-04-2017, UiT The Arctic University of Norway, Associate professor

05-2016-12-2016, UiT The Arctic University of Norway, Head engineer

06-2011-12-2011, UiT The Arctic University of Norway, Scientific assistant

06-2010-08-2010, GenØk, Laboratory assistant

Publications in CRIStin

  • Hedberg, Annica; Knutsen, Erik; Løvhaugen, Anne Silje; Jørgensen, Tor Erik; Perander, Maria; Johansen, Steinar Daae. Cancer-specific SNPs originate from low-level heteroplasmic variants in human mitochondrial genomes of a matched cell line pair. Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis 2018; Volum 30 (1). ISSN 2470-1394.s 82 - 91.s doi: 10.1080/24701394.2018.1461852.

  • Lellahi, Seyed Mohammad; Rosenlund, Ingrid Arctander; Hedberg, Annica; Kiær, Liv Torill; Mikkola, Ingvild; Knutsen, Erik; Perander, Maria. The long noncoding RNA NEAT1 and nuclear paraspeckles are up-regulated by the transcription factor HSF1 in the heat shock response. Journal of Biological Chemistry 2018; Volum 293 (49). ISSN 0021-9258.s 18965 - 18976.s doi: 10.1074/jbc.RA118.004473.

  • Shen, Peng; Reineke, Lucas C.; Knutsen, Erik; Chen, Meng; Pichler, Martin; Ling, Hui; Calin, George A.. Metformin blocks MYC protein synthesis in colorectal cancer via mTOR-4EBP-eIF4E and MNK1-eIF4G-eIF4E signaling. Molecular Oncology 2018; Volum 12 (11). ISSN 1574-7891.s 1856 - 1870.s doi: 10.1002/1878-0261.12384.

  • Figenschau, Stine; Knutsen, Erik; Urbarova, Ilona; Fenton, Christopher Graham; Elston, Bryan; Perander, Maria; Mortensen, Elin Synnøve; Fenton, Kristin Andreassen. ICAM1 expression is induced by proinflammatory cytokines and associated with TLS formation in aggressive breast cancer subtypes. Scientific Reports 2018; Volum 8:11720. ISSN 2045-2322.s 1 - 12.s doi: 10.1038/s41598-018-29604-2.

  • Haldorsson, Skarphedinn; Rohatgi, Neha; Magnusdottir, Manuela; Choudhary, Kumari; Gudjónsson, Thorarinn; Knutsen, Erik; Barkovskaya, Anna; Hilmarsdòttir, Bylgja; Perander, Maria; Mælandsmo, Gunhild; Gudmundsson, Steinn; Rolfsson, Ottar. Metabolic re-wiring of isogenic breast epithelial cell lines following epithelial to mesenchymal transition. Cancer Letters 2017; Volum 396. ISSN 0304-3835.s 117 - 129.s doi: 10.1016/j.canlet.2017.03.019.

  • Roth, Sarah A; Knutsen, Erik; Fiskaa, Tonje; Utnes, Peter Andree; Bhavsar, Swapnil Parashram; Hald, Øyvind; Løkke, Cecilie; Mestdagh, Pieter; Johansen, Steinar Daae; Flægstad, Trond; Einvik, Christer. Next generation sequencing of microRNAs from isogenic neuroblastoma cell lines isolated before and after treatment.. Cancer Letters 2016; Volum 372 (1). ISSN 0304-3835.s 128 - 136.s doi: 10.1016/j.canlet.2015.11.026.

  • Fiskaa, Tonje; Knutsen, Erik; Nikolaisen, Malene; Jørgensen, Tor Erik; Johansen, Steinar Daae; Perander, maria; Seternes, Ole Morten. Distinct small RNA signatures in extracellular vesicles derived from breast cancer cell lines. PLOS ONE 2016; Volum 11 (8). ISSN 1932-6203.s doi: 10.1371/journal.pone.0161824.

  • El-Gewely, M. Raafat; Andreassen, Morten; Walquist, Mari; Ursvik, Anita; Knutsen, Erik; Nystad, Mona; Coucheron, Dag H; Myrmel, Kristin Smistad; Hennig, Rune; Johansen, Steinar Daae. Differentially expressed micro RNAs in meningiomas grades I and II suggest shared biomarkers with malignant tumors. Cancers 2016; Volum 8:31 (3). ISSN 2072-6694.s doi: 10.3390/cancers8030031.

  • Knutsen, Erik; Perander, maria; Fiskaa, Tonje; Johansen, Steinar Daae. Performance Comparison and Data Analysis Strategies for MicroRNA Profiling in Cancer Research. Springer 2015 ISBN 978-3-319-15811-2.

  • Knutsen, Erik; Fiskaa, Tonje; Ursvik, anita; Jørgensen, Tor Erik; Perander, maria; Lund, Eiliv; Seternes, Ole Morten; Johansen, Steinar; Andreassen, morten. Performance Comparison of Digital microRNA Profiling Technologies Applied on Human Breast Cancer Cell Lines. PLOS ONE 2013; Volum 8 (10). ISSN 1932-6203.s doi: 10.1371/journal.pone.0075813.

  • Dragomir, Mihnea-Paul; Knutsen, Erik; Calin, George A.. SnapShot: Unconventional miRNA Functions. Cell 2018. ISSN 0092-8674.

  • Knutsen, Erik; Perander, maria; Johansen, Steinar Daae; Andreassen, morten. Study of functional RNA using high-throughput profiling technologies in a human cell model system. Cell Symposia: Functional RNA’s 2012-12-02 - 2012-12-04 2012.

  • Johansen, Steinar Daae; Andreassen, morten; Babiak, Igor; Bizuayehu, Teshome; Coucheron, Dag-Hugo; El-Gewely, M. Raafat; Emblem, Åse; Fiskaa, Tonje; Furmanek, Tomasz; Haugli, kari b.; Karlsen, Bård Ove; Klingan, Kevin; Knutsen, Erik; Jørgensen, Tor Erik; Moum, Truls Borg; Nordeide, Jarle Tryti; Okkenhaug, Siri; Rekvig, Ole Petter; Seternes, ole morten; Ursvik, anita. Investigating miRNAs and transcriptomes at our local SOLiD sequencing facility. The Norwegian Biochemical Society 47th Contact Meeting 2011-02-03 - 2011-02-06 2011.

  • Knutsen, Erik; Andreassen, morten; Fiskaa, Tonje; Ursvik, anita; Lund, Eiliv; Seternes, Ole Morten; Johansen, Steinar Daae. MiRNA expression profiling based on different high-throughput platforms reveals surprising variations. ncRNAs and Human Disease International symposium 2011-08-25 - 2011-08-26 2011.