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Bayer, Annette

Førsteamanuensis
Department of Chemistry




Research projects

Naturalproducts as inspiration for future drug candidates

* Synthesis of natural products and analogues

Metal-catalysed transformation for sustainable development

* Investigations into the mechanism of iridium-catalysed imine reduction

* Identification of reactive intermediates by NMR

* CO2 modification

Development of compounds that overcome antibiotic resistance by repotentiating save antibiotics

* Metallo-beta-lactamase inhibitors

* Fragment based drug design

Researcher profile in Cristin

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Publications in CRIStin


  • Vaitla, Janakiram; Bayer, Annette; Hopmann, Kathrin Helen. Synthesis of Indoles and Pyrroles Utilizing Iridium Carbenes Generated from Sulfoxonium Ylides. Angewandte Chemie International Edition 2017; Volum 56 (14). ISSN 1433-7851.s 4277 - 4281.s doi: 10.1002/anie.201610520.

  • Skagseth, Susann; Akhter, Sundus; Paulsen, Marianne H.; Zeeshan, Muhammad; Lauksund, Silje; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.; Bayer, Annette. Metallo-β-lactamase inhibitors by bioisosteric replacement: preparation, activity and binding. European Journal of Medicinal Chemistry 2017; Volum 135. ISSN 0223-5234.s 159 - 173.s doi: 10.1016/j.ejmech.2017.04.035.

  • Lund, Bjarte Aarmo; Christopeit, Tony; Guttormsen, Yngve; Bayer, Annette; Leiros, Hanna-Kirsti S.. Screening and Design of Inhibitor Scaffolds for the Antibiotic Resistance Oxacillinase-48 (OXA-48) through Surface Plasmon Resonance Screening. Journal of Medicinal Chemistry 2016; Volum 59 (11). ISSN 0022-2623.s 5542 - 5554.s doi: 10.1021/acs.jmedchem.6b00660.

  • Paulsen, Marianne H.; Engqvist, Magnus; Ausbacher, Dominik; Strøm, Morten B.; Bayer, Annette. Efficient and scalable synthesis of α,α-disubstituted β-amino amides. Organic and biomolecular chemistry 2016; Volum 14 (31). ISSN 1477-0520.s 7570 - 7578.s doi: 10.1039/c6ob01219a.

  • Pandey, Sunil Kumar; Guttormsen, Yngve; Haug, Bengt Erik; Hedberg, Christian; Bayer, Annette. A concise total synthesis of breitfussin A and B. Organic Letters 2015; Volum 17 (1). ISSN 1523-7060.s 122 - 125.s doi: 10.1021/ol503348n.

  • Demissie, Taye Beyene; Kostenko, Nataliya; Komorovsky, Stanislav; Repisky, Michal; Isaksson, Johan; Bayer, Annette; Ruud, Kenneth. Experimental and four-component relativistic DFT studies of tungsten carbonyl complexes. Journal of Physical Organic Chemistry 2015; Volum 28 (12). ISSN 0894-3230.s 723 - 731.s doi: 10.1002/poc.3476.

  • Lorentzen, Marianne; Bayer, Annette; Sydnes, Magne Olav; Jørgensen, Kåre Bredeli. Total synthesis of tubastrine and 3-dehydroxy tubastrine by microwave-assisted cross-coupling reactions. Tetrahedron 2015; Volum 71 (43). ISSN 0040-4020.s 8278 - 8284.s doi: 10.1016/j.tet.2015.09.003.

  • Hopmann, Kathrin Helen; Frediani, Luca; Bayer, Annette. Iridium-PHOX-mediated alkene hydrogenation: Isomerization influences the stereochemical outcome. Organometallics 2014; Volum 33 (11). ISSN 0276-7333.s 2790 - 2797.s doi: 10.1021/om5002843.

  • Hopmann, Kathrin Helen; Bayer, Annette. Enantioselective imine hydrogenation with iridium-catalysts: Reactions, mechanisms and stereocontrol. Coordination chemistry reviews 2014; Volum 268. ISSN 0010-8545.s 59 - 82.s doi: 10.1016/j.ccr.2014.01.023.

  • Melnes, Silje; Bayer, Annette; Gautun, Odd Reidar. Aryl N-methyliminodiacetic acid (MIDA) boronates from cyclotrimerization of ethynyl MIDA boronate with diynes. Tetrahedron 2013; Volum 69 (37). ISSN 0040-4020.s 7910 - 7915.s doi: 10.1016/j.tet.2013.07.027.

  • Kostenko, Nataliya; Eriksson, Anna Cecilia; Engqvist, Stig Olov Magnus; Villa Gonzalez, Susana; Bayer, Annette. Palladium(0)-Catalyzed Cross-Couplings of 2-Bromophosphinine. European Journal of Organic Chemistry 2013; Volum 2013 (22). ISSN 1434-193X.s 4756 - 4759.s doi: 10.1002/ejoc.201300710.

  • Lind, Karianne Fredenfeldt; Hansen, Espen; Østerud, Bjarne; Eilertsen, Karl-Erik; Bayer, Annette; Engqvist, Stig Olov Magnus; Leszczak, Kinga; Jørgensen, Trond Ø.; Andersen, Jeanette hammer. Antioxidant and Anti-Inflammatory Activities of Barettin. Marine Drugs 2013; Volum 11 (7). ISSN 1660-3397.s 2655 - 2666.s doi: 10.3390/md11072655.

  • Melnes, Silje; Bayer, Annette; Gautun, Odd Reidar. Cyclotrimerization of unsymmetrically bromo-substituted diynes: toward the synthesis of potential selective inhibitors of tyrosine kinase 2. Tetrahedron 2012; Volum 68 (40). ISSN 0040-4020.s 8463 - 8471.s doi: 10.1016/j.tet.2012.07.087.

  • Hopmann, Kathrin Helen; Bayer, Annette. On the Mechanism of Iridium-Catalyzed Asymmetric Hydrogenation of Imines and Alkenes: A Theoretical Study. Organometallics 2011; Volum 30 (9). ISSN 0276-7333.s 2483 - 2497.s doi: 10.1021/om1009507.

  • Endeshaw, Molla Mellese; Bayer, Annette; Hansen, Lars Kr; Gautun, Odd Reidar. Catalytic asymmetric hetero Diels-Alder reactions of N-sulfinyl dienophiles with chiral bis(oxazoline)copper(II) and -zinc(II) triflates. European Journal of Organic Chemistry 2006. ISSN 1434-193X.s 5249 - 5259.s doi: 10.1002/ejoc.200600083.

  • Bayer, Annette. Dihydroxylation of Carbon-Carbon Double Bonds. Springer 2004 ISBN 3-540-20983-2.s 21 - 42.

  • Bayer, Annette; Endeshaw, Molla Mellese; Gautun, Odd Reidar. Asymmetric hetero-Diels-Alder reactions of N-sulfinyl dienophiles using chiral bis(oxazoline)-copper(II) and -zinc(II) triflates. Journal of Organic Chemistry 2004; Volum 69. ISSN 0022-3263.s 7198 - 7205.

  • Källström, Klas; Hedberg, Christian; Brandt, Peter; Bayer, Annette; Andersson, Pher G.. Rationally designed ligands for asymmetric iridium-catalyzed hydrogenation of olefins. Journal of the American Chemical Society 2004; Volum 126. ISSN 0002-7863.s 14308 - 14309.

  • Bayer, Annette. Aminohydroxylation of Carbon-Carbon Double Bonds. Springer 2004 ISBN 3-540-20983-2.s 43 - 71.

  • Bayer, Annette; Hansen, Lars Kr.; Gautun, Odd Reidar. Asymmetric Diels-Alder reactions of N-sulfinyl dienophiles using chiral Ti(IV)Lewis acids. Tetrahedron: asymmetry 2002; Volum 13. ISSN 0957-4166.s 2407 - 2415.

  • Hansen, Lars Kr.; Bayer, Annette; Gautun, Odd Reidar. Benzyl (1R*,3S*)-3,6-dihydro-3-methyl-1(landa)4,2-thiazine-2-carboxylate 1-oxide. Acta Crystallographica Section E: Structure Reports Online 2002; Volum E58. ISSN 1600-5368.s o165 - o166.

  • Hansen, Lars Kr.; Bayer, Annette; Gautun, Odd Reidar. (1R*,3R*,6S*)-3,6-Dihydro-3,6-dimethyl-2-(toluene-4-sulfonyl)-1(landa)4,2-thiazine 1-oxide. Acta Crystallographica Section E: Structure Reports Online 2002; Volum E58. ISSN 1600-5368.s o198 - o199.

  • Bayer, Annette; Gautun, Odd Reidar. Highly enantioselective hetero Diels-Alder reactions of N-sulfinyl dienophiles promoted by copper(II)- and zinc(II)-chiral bis(oxazoline) complexes. Tetrahedron: asymmetry 2001; Volum 12 (21). ISSN 0957-4166.s 2937 - 2939.

  • Hansen, Lars Kr; Bayer, Annette; Gautun, Odd Reidar. exo-3,6-Dihydro-3-methyl-2-(toluene-4-sulfonyl)-1_4,2-thiazine 1-oxide. Acta Crystallographica Section E: Structure Reports Online 2001; Volum E57. ISSN 1600-5368.s o1109 - o1110.

  • Bayer, Annette; Svendsen, John Sigurd. Substrate Binding in the Asymmetric Dihydroxylation Reaction � Investigation of the Stereoselectivity in the Dihydroxylation of Cs-Symmetric Divinylcarbinol Derivatives. European Journal of Organic Chemistry 2001. ISSN 1434-193X.s 1769 - 1780.

  • Bayer, Annette; Gautun, Odd Reidar. Asymmetric N-sulfinyl dienophile Diels-Alder cycloadditions using chiral Ti(IV)-based Lewis Acids. Tetrahedron Letters 2000; Volum 41. ISSN 0040-4039.s 3743 - 3746.

  • Henderson, RJ; Burkow, Ivan C.; Buzzi, M; Bayer, Annette. Effects of docosahexaenoic (22:6n-3), tetracosapentaenoic (24:5n-3) and tetracosahexaenoic (24:6n-3) acids on the desaturation and elongation of n-3 polyunsaturated fatty acids in trout liver microsomes. Biochimica et Biophysica Acta 1998; Volum 1392. ISSN 0006-3002.s 309 - 319.

  • Bayer, Annette; Leiros, Hanna-Kirsti S.; Akhter, Sundus; Lund, Bjarte Aarmo; Christopeit, Tony; Ismael, Aya. Towards Antibiotic Resistance Breakers: Fragment-Based Design of OXA- 48 Inhibitors. FRAGMENTS2017 2017-03-05 - 2017-03-07 2017.

  • Vaitla, Janakiram; Bayer, Annette; Hopmann, Kathrin Helen. Sulfones and Sulfoxonium Ylides in Cascade Reactions: New Approaches to Heterocycles​.. Organic Chemistry Winter meeting (OKV - 31), Skeikampen, Oslo, Norway. 2017-01-12 - 2017-01-15 2017.

  • Guttormsen, Yngve; Pandey, Sunil Kumar; Haug, Bengt Erik; Bayer, Annette. Halogenation of electron rich heterocycles: Where does it go?. Organisk Kjemisk Vintermøte 2017 2017-01-12 - 2017-01-15 2017.

  • Bayer, Annette. Synthesis of artic marine natural products. Organikerdagerne 2016-06-14 - 2016-06-17 2016.

  • Bayer, Annette. Synthesis of artic marine natural products. Annual meeting of the CO2 Activation Centre at Århus University 2016-11-17 - 2016-11-18 2016.

  • Pandey, Sunil Kumar; Guttormsen, Yngve; Haug, Bengt Erik; Hedberg, Christian; Bayer, Annette. Total Synthesis of Breitfussin A and B. 21st International Conference on Organic Synthesis 2016-12-11 - 2016-12-16 2016.

  • Lund, Bjarte Aarmo; Akhter, Sundus; Guttormsen, Yngve; Christopeit, Tony; Isaksson, Johan; Bayer, Annette; Leiros, Hanna-Kirsti S.. Structure-guided drug design for the antibiotic resistance enzyme OXA-48. 7th Annual BioStruct Conference 2016-08-25 - 2016-08-28 2016.

  • Ahkter, Sundus; Lund, Bjarte Aarmo; Guttormsen, Yngve; Christopeit, Tony; Bayer, Annette; Leiros, Hanna-Kirsti S.. Addressing Antibiotic Resistance: Fragment-Based Design of OXA-48 Inhibitors. 31. Organisk Kjemisk Vintermøte 2016-01-07 - 2016-01-10 2016.

  • Sydnes, Magne Olav; Lindback, Emil; Lorentzen, Marianne; Jørgensen, Kåre Bredeli; Bayer, Annette. Synthesis of Antimicrobial Natural Products and their Analogues – Martinelline and Tubastrine. 14th Annual Congress of International Drug Discovery Science and Technology 2016-06-16 - 2016-06-18 2016.

  • Lund, Bjarte Aarmo; Christopeit, Tony; Ahkter, Sundus; Guttormsen, Yngve; Isaksson, Johan; Bayer, Annette; Leiros, Hanna-Kirsti S.. Structure-Guided Drug Design for the Antibiotic Resistance Enzyme OXA-48. ASM Microbe 2016 2016-06-16 - 2016-06-20 2016.

  • Lund, Bjarte Aarmo; Ahkter, Sundus; Guttormsen, Yngve; Christopeit, Tony; Bayer, Annette; Leiros, Hanna-Kirsti S.. Structure-guided drug design for the antibiotic resistance enzyme OXA-48. 52nd Norwegian Biochemical Society Contact Meeting, Tromsø 2016-01-21 - 2016-01-24 2016.

  • Lorentzen, Marianne; Bayer, Annette; Sydnes, Magne Olav; Jørgensen, Kåre Bredeli. Total Synthesis of Tubastrine and 3-Dehydroxy Tubastrine. Organisk Kjemisk Vintermøte OKV31 2016-01-07 - 2016-01-10 2016.

  • Fairhurst, Magnus John E.; Bayer, Annette; Haug, Bengt Erik. Synthesis of Analogues of the Bioactive Compound Barettin. 31. Organisk Kjemisk Vintermøte 2016-01-07 - 2016-01-10 2016.

  • Vaitla, Janakiram; Bayer, Annette; Hopmann, Kathrin Helen. Iridium-Catalyzed Synthesis of Indoles and Pyrroles from Sulfoxonium Ylides.. 21st International Conference on Organic Synthesis (ICOS), Mumbai, India. 2016-12-11 - 2016-12-16 2016.

  • Åstrand, Ove Alexander Høgmoen; Leiros, Hanna-Kirsti S.; Samuelsen, Ørjan; Bayer, Annette; Rongved, Pål. Overcoming b-lactam resistance - A potential solution to multi-drug resistant bacteria. Organisk Kjemisk Vintermøte 2015 2015-01-08 - 2015-01-11 2015.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Akhter, Sundus; Zeeshan, Muhammad; Åstrand, Ove Alexander Høgmoen; Bayer, Annette; Rongved, Pål; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. The fight against metallo-beta-lactamases and antibiotic resistance. BioStruct Open Day 2015-03-20 - 2015-03-20 2015.

  • Lund, Bjarte Aarmo; Guttormsen, Yngve; Christopeit, Tony; Bayer, Annette; Leiros, Hanna-Kirsti S.. Design of OXA-48 class D beta-lactamase inhibitors by fragment-based drug design. Annual BioStruct Conference, The National graduate school in structural biology 2015-08-27 - 2015-08-30 2015.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Christopeit, Tony; Akhter, Sundus; Zeeshan, Muhammad; Åstrand, Ove Alexander Høgmoen; Bayer, Annette; Rongved, Pål; Samulesen, Ørjan; Leiros, Hanna-Kirsti S.. The fight against metallo-beta-lactamases and antibiotic resistance. 51st Norwegian Biochemical Society Contact Meeting, Svalbard 2015-02-09 - 2015-02-13 2015.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Akhter, Sundus; Zeeshan, Muhammad; Åstrand, Ove Alexander Høgmoen; Bayer, Annette; Rongved, Pål; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. The fight against metallo-beta-lactamases and antibiotic resistance. Annual BioStruct Conference, The National graduate school in structural biology 2015-09-27 - 2015-09-30 2015.

  • Pandey, Sunil Kumar; Guttormsen, Yngve; Haug, Bengt Erik; Bayer, Annette; Hedberg, Christian. Total synthesis of breitfussin A and B.. 30. Organisk kjemisk vintermøte OKV30 2015-01-08 - 2015-01-11 2015.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Bjerga, Gro Elin Kjæreng; Bayer, Annette; Samulesen, Ørjan; Leiros, Hanna-Kirsti S.. The importance of residue W228 and Y233 in the metallo-beta-lactamase GIM-1. The Norwegian Biochemical Society (NBS) Contact Meeting 2014 2014-01-23 - 2014-01-26 2014.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Bjerga, Gro Elin Kjæreng; Bayer, Annette; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. The importance of residue Trp228 and Tyr233 in the metallo-beta-lactamase GIM-1. 12th Beta-Lactamase Meeting 2014-06-28 - 2014-07-01 2014.

  • Guttormsen, Yngve; Riedel, Jan; Bayer, Annette; Hedberg, Christian. Total Synthesis of Breitfussin A. Organisk kjemisk vintermøte OKV29 2014-01-09 - 2014-01-12 2014.

  • Paulsen, Marianne H.; Engqvist, Stig Olov Magnus; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.; Skagseth, Susann; Leszczak, Kinga; Akhter, Sundus; Bayer, Annette. Synthesis of potential metallo-beta-lactamase inhibitors. Organisk kjemisk vintermøte OKV29 2014-01-09 - 2014-01-12 2014.

  • Hansen, Jørn H; Bayer, Annette. Havets hemmeligheter blir medisiner. Dagavisen Nordlys 2013.

  • Ove Alexander, Høgmoen Åstrand; Edvardsen, Kine Susann Waade; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.; Bayer, Annette; Rongved, Pål. Metallo-β-lactamase inhibitors. 2013.

  • Kostenko, Nataliya; Bayer, Annette. Exploring New Routes to 2-Functionalised Phosphinines. Organic Days XXIII 2012-06-12 - 2012-06-15 2012.

  • Melnes, Silje; Gautun, Odd Reidar; Bayer, Annette. "Studies towards the synthesis of potential therapeutic agents against the hematologic cancer multiple myeloma. 18th International Conference on Organic Synthesis 2010-08-01 - 2010-08-06 2010.

  • Endeshaw, Molla; Bayer, Annette; Gautun, Odd Reidar. Catalytic asymmetric hetero Diels-Alder reactions of the N-sulfinyl dienophiles. CHIRALITY 2004, 16th International Symposium and Exhibits on Chirality 2004-06-11 - 2004-06-14 2004.

  • Endeshaw, Molla M; Bayer, Annette; Gautun, Odd Reidar. Catalytic asymmetric hetero Diels-Alder reactions of the N-sulfinyl dienophiles. Organisk Kjemisk Vintermøte 2003 2003-01-09 - 2003-01-12 2003.

  • Bayer, Annette. Asymmetric Hetero Diels-Alder Reactions of N-Sulfinyl Dienophiles Mediated by Chiral Lewis Acids. 2002 ISBN 82-497-0074-0.

  • Bayer, Annette; Gautun, Odd Reidar. N-Sulfinyl Compounds in Asymmetric Diels-Alder Reactions. 16. Organisk kjemisk vintermøte 2001-01-11 - 2001-01-14 2001.

  • Bayer, Annette; Gautun, Odd Reidar. Enantioselective Diels-Alder Reactions of N-Sulfinyl Compounds Promoted by Chiral Ti(IV)-Based Lewis Acids. 12. International Symposium on Homogenous Catalysis 2000-08-27 - 2000-09-01 2000.

  • Bayer, Annette; Gautun, Odd Reidar. N-Sulfinyl Compounds in Catalytic Asymmetric Diels-Alder Reactions. 14. Organisk kjemisk vintermøte 1999-01-07 - 1999-01-10 1999.

  • Bayer, Annette; Svendsen, John Sigurd. Catalytic Asymmetric Dihydroxylation of 1,5-Diphenyl-1,4-pentadien-3-ol Derivatives. A Model for Kinetic Resolution. 13. Organisk kjemisk vintermøte 1998-01-08 - 1998-01-11 1998.

  • Bayer, Annette; Svendsen, John Sigurd. Kinetic Resolution in the AD reaction. 12. Organisk kjemisk vintermøte 1997-01-09 - 1997-01-12 1997.

  • Henderson, RJ; Buzzi, M; Burkow, IC; Bayer, Annette; Park, MT. Inhibitory Effects of Long Chain n-3 Polyunsaturated Fatty Acids on the Desaturases and Elongases of Trout Liver Microsomes. 4. International Congress on Essential Fatty Acids and Eicosanoids 1997-07-20 - 1997-07-24 1997.

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