The goal of my research is to decipher the molecular mechanisms that allow pathogens to adapt to the different environmental conditions they encounter during infection and transmission. I am particularly interested in the c-di-GMP signaling network and its impact on population dynamics, bacterial virulence and persistence under changing conditions. For more details, see the homepage of the Infection Biology Research Group.
2002-2003: MSc (German 'Diplom') in Biochemistry &
Molecular Biology (University of Kiel, Germany)
2004-2008: PhD in Molecular Microbiology (University of Basel, Switzerland)
2008-2012: Postdoctoral Researcher (University of Basel, Switzerland)
2012-2015: Research Fellow (Harvard Medical School, USA),
Postdoctoral Research Fellow (Brigham and Women's Hospital, USA)
2015-2017: Visiting assistant professor (Harvard Medical School, USA)
since 2015: Young associate investigator (University of Tromsø (UiT) &
Centre for Molecular Medicine (NCMM), Norway,
Researcher (University Hospital of North Norway, Norway).
PUBLICATION LIST (see also here)
Martinecz A, Clarelli F, Abel S, and Abel zur Wiesch P.
Reaction Kinetic Models of Antibiotic Heteroresistance.
Int. J. Mol. Sci. (2019), 20(3965):1-16.
Zhang T, Abel S, Abel zur Wiesch P, Sasabe J, Davis BM, Higgins DE, and Waldor MK.
Deciphering the landscape of host barriers to Listeria monocytogenes infection.
PNAS (2017) 114(24):6334-9.
Hubbard PT, Chao MC, Abel S, Blondel CJ, Abel zur Wiesch P, Zhou X, Davis BM, and Waldor MK.
Genetic analysis of Vibrio parahaemolyticus intestinal colonization.
PNAS (2016) 113(22):6283-8.
Hatzios SK, Abel S, Martell J, Hubbard T, Sasabe J, Munera D, Clark L, Bachovchin DA, Qadri F, Ryan ET, Davis BM, Weerapana E, and Waldor MK.
Chemoproteomic profiling of host and pathogen enzymes active in cholera.
NAT CHEM BIOL (2016) 12 (4):268-74.
Chao MC, Abel S, Davis BM, and Waldor MK.
The design and analysis of transposon insertion sequencing experiments.
NAT REV MICROBIOL (2016) 14 (2):199-28.
Abel S and Waldor MK.
Infant Rabbit Model for Diarrheal Diseases.
CURR PROTOC MICROBIOL (2015) 38:6A.6.1-6A.6.15.
Abel S, Abel zur Wiesch P, Davis BM, and Waldor MK.
Analysis of bottlenecks in experimental models of infection.
PLOS PATHOGENS (2015) 11 (6), e1004823
Abel zur Wiesch P, Abel S, Gkotzis S, Ocampo P, Engelstädter J, Hinkley T, Magnus C, Waldor MK, Udekwu K, and Cohen T.
Classic reaction kinetics can explain complex patterns of antibiotic action.
SCI TRANSL MED (2015) 7 (287):287ra73.
Lori C*, Ozaki S*, Steiner S, Böhm R, Abel S, Dubey BN, Schirmer T, Hiller S, and Jenal U.
Second Messenger Cyclic di-GMP acts as a cell cycle oscillator to drive chromosome replication.
NATURE, (2015) 523 (7559):236–239.
Abel S, Abel zur Wiesch P, Chang H-H, Davis BM, Lipsitch M, and Waldor MK.
Sequence tag-based analysis of pathogen population dynamics.
NATURE METHODS (2015) 12 (3):223-6.
Pritchard JR*, Chao MC*, Abel S, Davis BM, Baranowski C, Zhang YJ, Rubin EJ, and Waldor MK.
ARTIST: High-resolution genome-wide assessment of fitness using transposon-insertion sequencing.
PLOS GENETICS (2014) 10 (11), e1004782
Abel zur Wiesch P*, Kouyos RD*, Abel S, Viechtbauer W, and Bonhoeffer S.
Cycling empirical antibiotic therapy in hospitals: meta-analysis and models.
PLOS PATHOGENS (2014) 10 (6), e1004225
Fumeaux C, Radhakrishnan SK, Ardissone S, Théraulaz L, Frandi A, Martins D, Nesper J, Abel S, Jenal U, and Viollier PH.
Cell cycle transition from S-phase to G1 in Caulobacter is mediated by ancestral virulence regulators.
NAT COM (2014) 5, doi:10.1038/ncomms5081.
Abel S, Bucher T*, Nicollier M*, Hug I, Kaever V, Abel zur Wiesch P, and Jenal U.
Bi-modal distribution of the second messenger c-di-GMP controls cell fate and asymmetry during the Caulobacter cell cycle.
PLOS GENETICS (2013) 9 (9), e1003744
Abel S*, Chien P*, Wassmann P, Schirmer T, Kaever V, Laub MT, Baker TA, and Jenal U.
Regulatory cohesion of cell cycle and cell differentiation through interlinked phosphorylation and second messenger networks.
MOL CELL (2011) 43:550-60.
Diepold A, Amstutz M, Abel S, Sorg I, Jenal U, and Cornelis GR.
Deciphering the assembly of the Yersinia type III secretion injectisome.
EMBO (2010) 29 (11):1928-40.
Duerig A, Abel S, Folcher M, Nicollier M, Schwede T, Amiot N, Giese B, and Jenal U.
Second messenger-mediated spatiotemporal control of protein degradation regulates bacterial cell cycle progression.
GENES & DEVELOPMENT (2009) 23:93–104.
Paul R, Jaeger T*, Abel S*, Wiederkehr I, Folcher M, Biondi EG, Laub MT, and Jenal U.
Allosteric regulation of histidine kinases by their cognate response regulator determines cell fate.
CELL (2008) 133:452–61.
Paul R, Abel S, Wassmann P, Beck A, Heerklotz H, and Jenal U.
Activation of the diguanylate cyclase PleD by phosphorylation-mediated dimerization.
J BIOL CHEM (2007) 282 (40):29170-7.
Abel S*, Hundhausen C*, Mentlein R, Schulte A, Berkhout TA, Broadway N, Hartmann D, Sedlacek R, Dietrich S, Muetze B, Schuster B, Kallen KJ, Saftig P, Rose-John S, and Ludwig A.
The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10.
J IMMUNOL (2004) 172 (10):6362-72.
Abel S, and Jenal U.
Role of cyclic di-GMP in Caulobacter crescentus development and cell cycle control.
In Wolfe AJ, and Visick KL (ed.) in: The second messenger cyclic -di-GMP.
ASM PRESS, Washington, DC (2010):120-136.
Infection Biology Research Group