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Researcher

Sören Abel

Researcher
Infection Biology, Research Group




Research interests

Research interests

The goal of my research is to decipher the molecular mechanisms that allow pathogens to adapt to the different environmental conditions they encounter during infection and transmission. I am particularly interested in the c-di-GMP signaling network and its impact on population dynamics, bacterial virulence and persistence under changing conditions. For more details, see the homepage of the Infection Biology Research Group.

 

CV

2002-2003: MSc (German 'Diplom') in Biochemistry &
                     Molecular Biology (University of Kiel, Germany)

2004-2008: PhD in Molecular Microbiology (University of Basel, Switzerland)

2008-2012: Postdoctoral Researcher (University of Basel, Switzerland)

2012-2015: Research Fellow (Harvard Medical School, USA),

                     Postdoctoral Research Fellow (Brigham and Women's Hospital, USA)

2015-2017: Visiting assistant professor (Harvard Medical School, USA)

since 2015: Young associate investigator (University of Tromsø (UiT) &
                     Centre for Molecular Medicine (NCMM), Norway,

                     Researcher (University Hospital of North Norway, Norway).

 

PUBLICATION LIST (see also here)

Martinecz A, Clarelli F, Abel S, and Abel zur Wiesch P.
Reaction Kinetic Models of Antibiotic Heteroresistance.
Int. J. Mol. Sci. (2019), 20(3965):1-16.

Zhang T, Abel S, Abel zur Wiesch P, Sasabe J, Davis BM, Higgins DE, and Waldor MK.
Deciphering the landscape of host barriers to Listeria monocytogenes infection.
PNAS (2017) 114(24):6334-9.

Hubbard PT, Chao MC, Abel S, Blondel CJ, Abel zur Wiesch P, Zhou X, Davis BM, and Waldor MK.
Genetic analysis of Vibrio parahaemolyticus intestinal colonization.
PNAS (2016) 113(22):6283-8.

Hatzios SK, Abel S, Martell J, Hubbard T, Sasabe J, Munera D, Clark L, Bachovchin DA, Qadri F, Ryan ET, Davis BM, Weerapana E, and Waldor MK.
Chemoproteomic profiling of host and pathogen enzymes active in cholera.
NAT CHEM BIOL (2016) 12 (4):268-74.

Chao MC, Abel S, Davis BM, and Waldor MK.
The design and analysis of transposon insertion sequencing experiments.
NAT REV MICROBIOL (2016) 14 (2):199-28.

Abel S and Waldor MK.
Infant Rabbit Model for Diarrheal Diseases.
CURR PROTOC MICROBIOL (2015) 38:6A.6.1-6A.6.15.

Abel S, Abel zur Wiesch P, Davis BM, and Waldor MK.
Analysis of bottlenecks in experimental models of infection.
PLOS PATHOGENS (2015) 11 (6), e1004823

Abel zur Wiesch P, Abel S, Gkotzis S, Ocampo P, Engelstädter J, Hinkley T, Magnus C, Waldor MK, Udekwu K, and Cohen T.
Classic reaction kinetics can explain complex patterns of antibiotic action.
SCI TRANSL MED (2015) 7 (287):287ra73.

Lori C*, Ozaki S*, Steiner S, Böhm R, Abel S, Dubey BN, Schirmer T, Hiller S, and Jenal U.
Second Messenger Cyclic di-GMP acts as a cell cycle oscillator to drive chromosome replication.
NATURE, (2015) 523 (7559):236–239.

Abel S, Abel zur Wiesch P, Chang H-H, Davis BM, Lipsitch M, and Waldor MK.
Sequence tag-based analysis of pathogen population dynamics.
NATURE METHODS (2015) 12 (3):223-6.

Pritchard JR*, Chao MC*, Abel S, Davis BM, Baranowski C, Zhang YJ, Rubin EJ, and Waldor MK.
ARTIST: High-resolution genome-wide assessment of fitness using transposon-insertion sequencing.
PLOS GENETICS (2014) 10 (11), e1004782

Abel zur Wiesch P*, Kouyos RD*, Abel S, Viechtbauer W, and Bonhoeffer S.
Cycling empirical antibiotic therapy in hospitals: meta-analysis and models.
PLOS PATHOGENS (2014) 10 (6), e1004225

Fumeaux C, Radhakrishnan SK, Ardissone S, Théraulaz L, Frandi A, Martins D, Nesper J, Abel S, Jenal U, and Viollier PH.
Cell cycle transition from S-phase to G1 in Caulobacter is mediated by ancestral virulence regulators.
NAT COM (2014) 5, doi:10.1038/ncomms5081.

Abel S, Bucher T*, Nicollier M*, Hug I, Kaever V, Abel zur Wiesch P, and Jenal U.
Bi-modal distribution of the second messenger c-di-GMP controls cell fate and asymmetry during the Caulobacter cell cycle.
PLOS GENETICS (2013) 9 (9), e1003744 

Abel S*,  Chien P*, Wassmann P, Schirmer T, Kaever V, Laub MT, Baker TA, and Jenal U.
Regulatory cohesion of cell cycle and cell differentiation through interlinked phosphorylation and second messenger networks.
MOL CELL (2011) 43:550-60.

Diepold A, Amstutz M, Abel S, Sorg I, Jenal U, and Cornelis GR.
Deciphering the assembly of the Yersinia type III secretion injectisome.
EMBO (2010) 29 (11):1928-40.

Duerig A, Abel S, Folcher M, Nicollier M, Schwede T, Amiot N, Giese B, and Jenal U.
Second messenger-mediated spatiotemporal control of protein degradation regulates bacterial cell cycle progression.
GENES & DEVELOPMENT (2009) 23:93–104.

Paul R, Jaeger T*, Abel S*, Wiederkehr I, Folcher M, Biondi EG, Laub MT, and Jenal U.
Allosteric regulation of histidine kinases by their cognate response regulator determines cell fate.
CELL (2008) 133:452–61.

Paul R, Abel S, Wassmann P, Beck A, Heerklotz H, and Jenal U.
Activation of the diguanylate cyclase PleD by phosphorylation-mediated dimerization.
J BIOL CHEM (2007) 282 (40):29170-7.

Abel S*, Hundhausen C*, Mentlein R, Schulte A, Berkhout TA, Broadway N, Hartmann D, Sedlacek R, Dietrich S, Muetze B, Schuster B, Kallen KJ, Saftig P, Rose-John S, and Ludwig A.
The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10.
J IMMUNOL (2004) 172 (10):6362-72.

 

BOOK CHAPTERS

Abel S, and Jenal U.
Role of cyclic di-GMP in Caulobacter crescentus development and cell cycle control.
In Wolfe AJ, and Visick KL (ed.) in: The second messenger cyclic -di-GMP.
ASM PRESS, Washington, DC (2010):120-136.

 

HOMEPAGE

Infection Biology Research Group

Publications in CRIStin


  • Martinecz, Antal; Clarelli, Fabrizio; Abel, Sören; Abel zur Wiesch, Pia. Reaction Kinetic Models of Antibiotic Heteroresistance. International Journal of Molecular Sciences 2019; Volum 20 (16). ISSN 1422-0067.s doi: 10.3390/ijms20163965.

  • Warr, Alyson R; Hubbard, Troy P; Munera, Diana; Blondel, Carlos J; Abel zur Wiesch, Pia; Abel, Sören; Wang, Xiaoxue; Davis, Brigid M.; Waldor, Matthew K.. Transposon-insertion sequencing screens unveil requirements for EHEC growth and intestinal colonization. PLoS Pathogens 2019. ISSN 1553-7366.s doi: https://doi.org/10.1371/journal.ppat.1007652.

  • Zhang, Ting; Abel, Sören; Abel zur Wiesch, Pia; Sasabe, Jumpei; Davis, Brigid M.; Higgins, Darren E.; Waldor, Matthew K.. Deciphering the landscape of host barriers to Listeria monocytogenes infection. Proceedings of the National Academy of Sciences of the United States of America 2017; Volum 114 (24). ISSN 0027-8424.s 6334 - 6339.s doi: 10.1073/pnas.1702077114.

  • Hatzios, Stavroula K; Abel, Sören; Martell, Julianne; Hubbard, Troy; Sasabe, Jumpei; Munera, Diana; Clark, Lars; Bachovchin, Daniel A; Qadri, F; Ryan, Edward T; Davis, Brigid M.; Weerapana, Eranthie; Waldor, Matthew K.. Chemoproteomic profiling of host and pathogen enzymes active in cholera. Nature Chemical Biology 2016; Volum 12 (4). ISSN 1552-4450.s 268 - 274.s doi: 10.1038/nchembio.2025.

  • Hubbard, Troy; Chao, Michael C; Abel, Sören; Blondel, Carlos J; Abel zur Wiesch, Pia; Zhou, Xiaohui; Davis, Brigid M.; Waldor, Matthew K.. Genetic analysis of vibrio parahaemolyticus intestinal colonization. Proceedings of the National Academy of Sciences of the United States of America 2016; Volum 113 (22). ISSN 0027-8424.s 6283 - 6288.s doi: 10.1073/pnas.1601718113.

  • Chao, Michael C; Abel, Sören; Davis, Brigid M.; Waldor, Matthew K.. The design and analysis of transposon insertion sequencing experiments. Nature Reviews Microbiology 2016; Volum 14 (2). ISSN 1740-1526.s 119 - 128.s doi: 10.1038/nrmicro.2015.7.

  • Abel zur Wiesch, Pia; Abel, Sören; Gkotzis, Spyridon; Ocampo, Paolo; Engelstädter, Jan; Hinkley, Trevor; Magnus, Carsten; Waldor, Matthew K.; Udekwu, Klas; Cohen, Ted. Classic reaction kinetics can explain complex patterns of antibiotic action. Science Translational Medicine 2015; Volum 7 (287). ISSN 1946-6234.s doi: 10.1126/scitranslmed.aaa8760.

  • Abel, Sören; Schulz Zur Wiesch, Pia; Davis, Brigid M.; Waldor, Matthew K.. Analysis of Bottlenecks in Experimental Models of Infection. PLoS Pathogens 2015; Volum 11:e1004823 (6). ISSN 1553-7366.s doi: 10.1371/journal.ppat.1004823.

  • Lori, Christian; Ozaki, Shogo; Steiner, Samuel; Böhm, Raphael; Abel, Sören; Dubey, Badri Nath; Schirmer, Tilman; Hiller, Sebastian; Jenal, Urs. Cyclic di-GMP acts as a cell cycle oscillator to drive chromosome replication. Nature 2015; Volum 523 (7559). ISSN 0028-0836.s 236 - 239.s doi: 10.1038/nature14473.

  • Abel, Sören; Waldor, Matthew K.. Infant rabbit model for diarrheal diseases. Current Protocols in Microbiology 2015; Volum 2015. ISSN 1934-8525.s 6A.6.1 - 6A.6.15.s doi: 10.1002/9780471729259.mc06a06s38.

  • Sørum, Vidar; Øynes, Emma Lu; Møller, Anna; Podnecky, Nicole L.; Abel, Sören; Samuelsen, Ørjan; Johnsen, Pål Jarle. Evolutionary stability of collateral susceptibility networks in clinical Escherichia coli strains. ECCMID 2019 2019-04-13 - 2019.

  • Maldonado, Andrés; Opstad, Ida Sundvor; Hernández, Luis; Nystad, Mona; Aguilera, Milton O; Storflor, Merete; Øie, Cristina Ionica; Abel, Sören; Birgisdottir, Åsa birna; Kalstad, Trine; Wolfson, Deanna; Tinguely, Jean-Claude; Myrmel, Truls; McCourt, Peter Anthony; Johansen, Terje; Ahluwalia, Balpreet Singh; Agarwal, Krishna. Fluorescence Nanoscopy Using Multiple Signal Classification Algorithm (MUSICAL): From Electromagnetics Inverse Scattering Problem to Optics Inverse Source Problem. PhotonIcs & Electromagnetics Research Symposium 2019-06-17 - 2019.

  • Manzi, Aimé; Abel, Sören; Storflor, Merete; Mahmutovic, Anel. Bacterial replication and death rates during exposure to bacteriostatic antibiotics. 2019.

  • Clarelli, Fabrizio; Cohen, Ted; Abel, Sören; Singh, Bhupender; Palmer, Adam; Chindelevitch, Leonid; Abel zur Wiesch, Pia. How molecular mechanisms of resistance affect resistance evolution. Challenges and new concepts in antibiotics research conference 2018-03-19 - 2018-03-21 2018.

  • Abel, Sören. The within host spread of Vibrio cholerae. BIO 445: Quantitative Life Sciences: from Infectious Diseases to Ecosystems 2018-11-29 - 2018-12-21 2018.

  • Abel, Sören. The within host spread of Vibrio cholerae. BIO 445: Quantitative Life Sciences: from Infectious Diseases to Ecosystems 2018-11-29 - 2018-12-21 2018.

  • Abel, Sören. The within host spread of Vibrio cholerae. Quantitative Life Sciences: from Infectious Diseases to Ecosystems 2018-12-06 - 2018-12-06 2018.

  • Clarelli, Fabrizio; Singh, Bhupender; Palmer, Adam; Abel, Sören; Cohen, Ted; Abel zur Wiesch, Pia. Quantitatively predicting antibiotic susceptibility from biochemical parameters: implications for antibiotic development and preventing resistance. 11th edition of the International Workshop on Clinical Pharmacology of Tuberculosis Drugs 2018-10-23 - 2018-10-23 2018.

  • Agarwal, Krishna; Opstad, Ida Sundvor; Tinguely, Jean-Claude; Abel, Sören; Kalstad, Trine; Birgisdottir, Åsa birna; Myrmel, Truls; Ahluwalia, Balpreet Singh. High-Speed, Multi-Color Live Cell Nanoscopy using MUSICAL. Focus on Microscopy 2018-03-25 - 2018-03-28 2018.

  • Abel, Sören. The within host spread of Vibrio cholerae. VAAM summer school: Mechanisms of gene regulation 2018-09-17 - 2018-09-19 2018.

  • Abel, Sören; Mahmutovic, Anel; Gillman, Aaron Nicholas; Manzi, Aime; Robson Moe, Natasha-Anne; Lauksund, Silje; Lorentzen, Øyvind; Aarag, Elizabeth; Kloos, Julia Maria; Hegstad, Kristin; Cavanagh, Pauline; Bleis, Christina; Storflor, Merete. How to blast a biofilm. Forskningsdagene 2018 2018-09-23 - 2018-09-23 2018.

  • Clarelli, Fabrizio; Singh, Bhupender; Cohen, Ted; Palmer, Adam; Chindelevitch, Leonid; Abel, Sören; Abel zur Wiesch, Pia. Using models to understand how molecular mechanisms of resistance affect the risk of acquired drug resistance during treatment. International Study Group for Systems Biology (ISGSB) Conference 2018-09-24 - 2018-09-28 2018.

  • Storflor, Merete; Schniers, Armin; Hansen, Terkel; Abel, Sören. Quantifying c-di-GMP during infections on a single cell level. ASM Conference on Vibrio2017: The Biology of Vibrios 2017-11-12 - 2017-11-15 2017.

  • Bleis, Christina; Abel, Sören. Determining the cholerae acid tolerance genes by transposon insertion sequencing. ASM Conference on Vibrio2017: The Biology of Vibrios 2017-11-12 - 2017-11-15 2017.

  • Gillman, Aaron Nicholas; Singh, Bhupender; Abel, Sören. Population Dynamics of V. cholerae. ASM Conference on Vibrio2017: The Biology of Vibrios 2017-11-12 - 2017-11-15 2017.

  • Clarelli, Fabrizio; Chindelevitch, Leonid; Singh, Bhupender; Cohen, Ted; Abel, Sören; Abel zur Wiesch, Pia. Using models to understand how molecular mechanisms of resistance affect the risk of acquired drug resistance during treatment. Epidemics 6 Sixth International Conference on Infectious Disease Dynamics 2017-11-29 - 2017-12-01 2017.

  • Opstad, Ida Sundvor; Agarwal, Krishna; Abel, Sören; Ahluwalia, Balpreet Singh. Multi-color nanoscopy of live-cell processes in E. Coli bacteria using MUSICAL. Progress In Electromagnetics Research Symposium 2017-11-19 - 2017-11-22 2017.

  • Member of research group