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Terje Johansen

Department of Medical Biology

Research projects

The Molecular Cancer Research Group performs basic research within the research areas autophagy, cell signaling and regulation of transcription. Specific protein-protein interactions and their functional consequences are being addressed in all projects using a set of biochemical-, cell biological- and  immunological tools. Bioimaging and proteomics are important in the research strategy of the group.  The pathways and proteins we study act in autophagy, cell proliferation control, anti-apoptotic signaling and establishment and maintenance of cell- and tissue polarity. These processes are deregulated in cancer development. The insight that basic research can provide into the normal regulation versus the dysregulation occurring in cancer cells is vital for identification of potential drug targets and subsequent development of future treatment rationales and strategies. Via studies of the atypical Protein Kinase C (aPKC) isozymes, iota and zeta, we have focused on detailed analyses of one of their scaffold proteins, p62/SQSTM1. Our results so far suggest that the p62 protein is a key player in selective autophagy of ubiquitinated protein aggregates. We have now also implicated another protein, NBR1 in selective autophagy of ubiqutinated substrates. Protein degradation in eukaryotic cells is carried out either by the proteasome or by autophagy. In autophagy a crescent-like double mebrane called the isolation membrane forms and enwraps part of the cytoplasm including both soluble components and damaged organelles, like mitochodria. When the isolation mebrane closes on itself an autophagosome is formed. Autophagosomes subsequently fuse with lysosomes where their contents are degraded. Recent research has highlighted that dysregulation or impairment of autophagy may have strong impact on cancer, neurodegenerative diseases such as Alzheimer’s and Parkinson’s, infections and immune responses.  Autophagy is basically a process whereby the cell can salvage nutrients during starvation and also dispose of toxic waste such as protein aggregates and damaged organelles. It has been thought of as a bulk degradation process but recent results from our group and others suggest that some proteins, like p62 and NBR1, act as cargo recptors for autophagic degradation of ubiqutinated substrates.

An important role for iotaPKC as an oncogene in human cancer was recently established and the aPKCs are central components protein complexes regualting cell polarity processes. In our group we also study proteins that we have found by yeast two-hybrid screens to interact with aPKCs in order to determine if these interaction partners are substrates or adapter/scaffold proteins or both. A challenge is then to unravel the biological roles of the interactions that we verify.

From the early nineties we have studied some members of the Pax family of organogenetic transcription factors. We have focused mostly on Pax6 which is responsible for proper development of the eyes, part of the brain and some of the endocrine cells of the pancreas. Current projects involve identification and analyses of novel interaction partners for Pax6 as well as studies of the dynamic movements of Pax family proteins in the nuclei of live cells. A major finding of ours is that the Pax proteins use also their DNA binding domains as protein-protein interactions, both intra- and intermolecularly.

We also study a large nuclear protein, called SPBP, that we have shown acts as a chromatin-binding cofactor in regulation of transcription mediated by different transcription factors.

Home page / Social Media

Blog / Website: https://uit.no/medbiologi/5500/

Publications in CRIStin

  • Jia, Jingyue; Abudu, Yakubu Princely; Claude-Taupin, Aurore; Gu, Yuexi; Kumar, Suresh; Choi, Seong Won; Peters, Ryan; Mudd, Michal H.; Allers, Lee; Salemi, Michelle; Phinney, Brett; Johansen, Terje; Deretic, Vojo. Galectins Control mTOR in Response to Endomembrane Damage. Molecular Cell 2018; Volum 70 (1). ISSN 1097-2765.s 120 - 135.s doi: 10.1016/j.molcel.2018.03.009.

  • Mejlvang, Jakob; Olsvik, Hallvard Lauritz; Svenning, Steingrim; Bruun, Jack-Ansgar; Abudu, Yakubu Princely; Bowitz Larsen, Kenneth; Brech, Andreas; Hansen, Tom Egil; Brenne, Hanne Britt; Hansen, Terkel; Stenmark, Harald Alfred; Johansen, Terje. Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy. Journal of Cell Biology 2018; Volum 217 (10). ISSN 0021-9525.s doi: 10.1083/jcb.201711002.

  • Fusco, Carmela; Mandriani, Barbara; Di Rienzo, Martina; Micale, Lucia; Malerba, Natascia; Cocciadiferro, Dario; Sjøttem, Eva; Augello, Bartolomeo; Squeo, Gabriella Maria; Pellico, Maria Teresa; Jain, Ashish; Johansen, Terje; Fimia, Gian Maria; Merla, Giuseppe. TRIM50 regulates Beclin 1 proautophagic activity. BBA - Molecular Cell Research 2018; Volum 1865 (6). ISSN 0167-4889.s 908 - 919.s doi: 10.1016/j.bbamcr.2018.03.011.

  • Kimura, Tomonori; Jia, Jingyue; Kumar, Suresh; Choi, Seong Won; Gu, Yuexi; Mudd, Michal H.; Dupont, Nicolas; Jiang, Shanya; Peters, Ryan; Farzam, Farzin; Jain, Ashish; Lidke, Keith A; Adams, Christopher M; Johansen, Terje; Deretic, Vojo. Dedicated SNAREs and specialized TRIM cargo receptors mediate secretory autophagy. EMBO Journal 2017; Volum 36. ISSN 0261-4189.s 42 - 60.s doi: 10.15252/embj.201695081.

  • Johansen, Terje; Birgisdottir, Åsa birna; Huber, J; Kniss, A; Dötsch, Volker; Kirkin, V; Rogov, Vladimir V. Methods for studying interactions between Atg8/LC3/GABARAP and LIR-containing proteins.. Methods in Enzymology 2017; Volum 587. ISSN 0076-6879.s doi: 10.1016/bs.mie.2016.10.023.

  • Lamark, Trond; Svenning, Steingrim; Johansen, Terje. Regulation of selective autophagy: the p62/SQSTM1 paradigm. Essays in Biochemistry 2017; Volum 61 (6). ISSN 0071-1365.s 609 - 624.s doi: 10.1042/EBC20170035.

  • Kimura, Tomonori; Jain, Ashish; Choi, Seong Won; Mandell, Michael A.; Johansen, Terje; Deretic, Vojo. TRIM-directed selective autophagy regulates immune activation. Autophagy 2017. ISSN 1554-8627.s doi: 10.1080/15548627.2016.1154254.

  • Kumar, Suresh; Chauhan, Santosh; Jain, Ashish; Ponpuak, Marisa; Choi, Seong Won; Mudd, Michal H.; Peters, Ryan; Mandell, Michael A.; Johansen, Terje; Deretic, Vojo. Galectins and TRIMs directly interact and orchestrate autophagic response to endomembrane damage. Autophagy 2017. ISSN 1554-8627.s doi: 10.1080/15548627.2017.1307487.

  • Kimuraa, Tomonori; Jia, Jingyue; Claude-Taupin, Aurore; Kumar, Suresh; Choi, Seong Won; Gu, Yuexi; Mudd, Michal H.; Dupont, Nicolas; Jiang, Shanya; Peters, Ryan; Farzam, Farzin; Jain, Ashish; Lidke, Keith A.; Adams, Christopher M.; Johansen, Terje; Deretic, Vojo. Cellular and molecular mechanism for secretory autophagy. Autophagy 2017. ISSN 1554-8627.s doi: 10.1080/15548627.2017.1307486.

  • Abreu, Susana; Kriegenburg, Franziska; Gomez-Sanchez, Ruben; Mari, Muriel; Sánchez-Wandelmer, Jana; Rasmussen, Mads Skytte; Soares Guimaraes, Rodrigo; Zens, Bettina; Schuschnig, Martina; Hardenberg, Ralph; Peter, Matthias; Johansen, Terje; Kraft, Claudine; Martens, Sascha; Reggiori, Fulvio. Conserved Atg8 recognition sites mediate Atg4 association with autophagosomal membranes and Atg8 deconjugation. EMBO Reports 2017; Volum 18 (5). ISSN 1469-221X.s 765 - 780.s doi: 10.15252/embr.201643146.

  • Rasmussen, Mads Skytte; Mouilleron, Stephane; Shrestha, Birendra Kumar; Wirth, Martina; Lee, Rebecca; Larsen, Kenneth Bowitz; Abudu, Yakubu Princely; O'Reilly, Nicola; Sjøttem, Eva; Tooze, Sharon A; Lamark, Trond; Johansen, Terje. ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8. Autophagy 2017; Volum 13 (5). ISSN 1554-8627.s 834 - 853.s doi: 10.1080/15548627.2017.1287651.

  • Melani, Mariana; Valko, Ayelen; Romero, Nuria M; Aguilera, Milton O; Acevedo, Julieta M; Bhujabal, Zambarlal; Perez-Perri, Joel; De La Riva-Carrasco, Rocio V; Katz, Maximiliano J; Sorianello, Eleonora; D'Alessio, Cecilia; Juhasz, Gabor; Johansen, Terje; Colombo, Maria I; Wappner, Pablo. Zonda is a novel early component of the autophagy pathway in Drosophila. Molecular Biology of the Cell 2017; Volum 28 (22). ISSN 1059-1524.s 3070 - 3081.s doi: 10.1091/mbc.E16-11-0767.

  • Tusco, Radu; Jacomin, Anne-Claire; Jain, Ashish; Penman, Bridget S; Larsen, Kenneth Bowitz; Johansen, Terje; Nezis, Ioannis. Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responses. Nature Communications 2017; Volum 8. ISSN 2041-1723.s doi: 10.1038/s41467-017-01287-9.

  • Galluzzi, Lorenzo; Baehrecke, Eric H.; Ballabio, Andrea; Boya, Patricia; Bravo-San Pedro, José Manuel; Cecconi, Francesco; Choi, Augustine M.; Chu, Charleen T.; Codogno, Patrice; Colombo, Maria Isabel; Cuervo, Ana Maria; Debnath, Jayanta; Deretic, Vojo; Dikic, Ivan; Eskelinen, Eeva-Liisa; Fimia, Gian Maria; Fulda, Simone; Gewirtz, David A.; Green, Douglas R.; Hansen, Malene; Harper, J. Wade; Jäättelä, Marja; Johansen, Terje; Juhasz, Gabor; Kimmelman, Alec C.; Kraft, Claudine; Ktistakis, Nicholas T.; Kumar, Sharad; Levine, Beth; Lopez-Otin, Carlos; Madeo, Frank; Martens, Sascha; Martinez, Jennifer; Melendez, Alicia; Mizushima, Noboru; Münz, Christian; Murphy, Leon O.; Penninger, Josef M.; Piacentini, Mauro; Reggiori, Fulvio; Rubinsztein, David C.; Ryan, Kevin M.; Santambrogio, Laura; Scorrano, Luca; Simon, Anna Katharina; Simon, Hans-Uwe; Simonsen, Anne; Tavernarakis, Nektarios; Tooze, Sharon A.; Yoshimori, Tamotsu; Yuan, Junying; Yue, Zhenyu; Zhong, Qing; Kroemer, Guido. Molecular definitions of autophagy and related processes. EMBO Journal 2017; Volum 36 (13). ISSN 0261-4189.s 1811 - 1836.s doi: 10.15252/embj.201796697.

  • Bhujabal, Zambarlal; Birgisdottir, Åsa birna; Sjøttem, Eva; Brenne, Hanne Britt; Øvervatn, Aud Karin; Habisov, Sabrina; Kirkin, Vladimir; Lamark, Trond; Johansen, Terje. FKBP8 recruits LC3A to mediate Parkin-independent mitophagy. EMBO Reports 2017; Volum 18 (6). ISSN 1469-221X.s 947 - 961.s doi: 10.15252/embr.201643147.

  • Katheder, Nadja Sandra; Khezri, Rojyar; O'Farrell, Fergal; Schultz, Sebastian; Jain, Ashish; Rahman, Mohammed Mahidur; Schink, Kay Oliver; Theodossiou, Theodossis; Johansen, Terje; Juhász, Gábor; Bilder, David; Brech, Andreas; Stenmark, Harald Alfred; Rusten, Tor Erik. Microenvironmental autophagy promotes tumour growth. Nature 2017; Volum 541 (7637). ISSN 0028-0836.s 417 - 420.s doi: 10.1038/nature20815.

  • Puvirajesinghe, Tania M.; Bertucci, François; Jain, Ashish; Scerbo, Pierluigi; Belotti, Edwige; Audebert, Stéphane; Sebbagh, Michael; Lopez, Marc; Brech, Andreas; Finetti, Pascal; Charafe-Jauffret, Emmanuelle; Chaffanet, Max; Castellano, Rémy; Restouin, Audrey; Marchetto, Sylvie; Collette, Yves; Gonçalvès, Anthony; Macara, Ian; Birnbaum, Daniel; Kodjabachian, Laurent; Johansen, Terje; Borg, Jean-Paul. Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2-JNK signalling in breast cancer. Nature Communications 2016; Volum 7. ISSN 2041-1723.s doi: 10.1038/ncomms10318.

  • Mandell, Michael A.; Jain, Ashish; Kumar, Suresh; Castleman, Moriah J; Anwar, Tahira; Eskelinen, Eeva-Liisa; Johansen, Terje; Prekeris, Rytis; Deretic, Vojo. TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation. Journal of Cell Science 2016; Volum 129 (19). ISSN 0021-9533.s 3562 - 3573.s doi: 10.1242/jcs.190017.

  • Habisov, Sabrina; Huber, Jessica; Ichimura, Yoshinobu; Akutsu, Masato; Rogova, Natalia; Loehr, Frank; McEwan, David G.; Johansen, Terje; Dikic, Ivan; Doetsch, Volker; Komatsu, Masaaki; Rogov, Vladimir V; Kirkin, Vladimir. Structural and functional analysis of a novel interaction motif within UFM1-activating enzyme 5 (UBA5) required for binding to ubiquitin-like proteins and ufmylation. Journal of Biological Chemistry 2016; Volum 291 (17). ISSN 0021-9258.s 9025 - 9041.s doi: 10.1074/jbc.M116.715474.

  • Hewitt, Graeme; Carroll, Bernadette; Sarallah, Rezazadeh; Correia-Melo, Clara; Ogrodnik, Mikolaj; Nelson, Glyn; Otten, Elsje G; Manni, Diego; Antrobus, Robin; Morgan, Brian A; von Zglinicki, Thomas; Jurk, Diana; Seluanov, Andrei; Gorbunova, Vera; Johansen, Terje; Passos, João F; Korolchuk, Viktor I. SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair. Autophagy 2016; Volum 12 (10). ISSN 1554-8627.s 1917 - 1930.s doi: 10.1080/15548627.2016.1210368.

  • Chauhan, Santosh; Kumar, Suresh; Jain, Ashish; Ponpuak, Marisa; Mudd, Michal H.; Kimura, Tomonori; Choi, Seong Won; Peters, Ryan; Mandell, Michael; Bruun, Jack-Ansgar; Johansen, Terje; Deretic, Vojo. TRIMs and galectins globally cooperate and TRIM16 and galectin-3 co-direct autophagy in endomembrane damage homeostasis. Developmental Cell 2016; Volum 39 (1). ISSN 1534-5807.s 13 - 27.s doi: 10.1016/j.devcel.2016.08.003.

  • Goode, Alice; Butler, Kevin; Long, Jed; Cavey, James; Scott, Daniel; Shaw, Barry; Sollenberger, Jill; Gell, Christopher; Johansen, Terje; Oldham, Neil J.; Searle, Mark S.; Layfield, Robert. Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD. Autophagy 2016; Volum 12 (7). ISSN 1554-8627.s 1094 - 1104.s doi: 10.1080/15548627.2016.1170257.

  • Raiborg, Camilla; Wenzel, Eva; Pedersen, Nina Marie; Olsvik, Hallvard Lauritz; Schink, Kay Oliver; Schultz, Sebastian; Vietri, Marina; Nisi, Veronica; Bucci, Cecilia; Brech, Andreas; Johansen, Terje; Stenmark, Harald. Repeated ER-endosome contacts promote endosome translocation and neurite outgrowth. Nature 2015; Volum 520 (7546). ISSN 0028-0836.s 234 - 238.s doi: 10.1038/nature14359.

  • Kimura, Tomonori; Jain, Ashish; Choi, Seong Won; Mandell, Michael A.; Schroder, Kate; Johansen, Terje; Deretic, Vojo. TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity. Journal of Cell Biology 2015; Volum 210 (6). ISSN 0021-9525.s 973 - 989.s doi: 10.1083/jcb.201503023.

  • Dou, Zhixun; Xu, Caiyue; Donahue, Greg; Shimi, Takeshi; Pan, Ji-An; Zhu, Jiajun; Ivanov, Andrejs; Capell, Brian C.; Drake, Adam M.; Shah, Parisha P.; Catanzaro, Joseph M.; Ricketts, M. Daniel; Lamark, Trond; Adam, Stephen A.; Marmorstein, Ronen; Zong, Wei-Xing; Johansen, Terje; Goldman, Robert D.; Adams, Peter D.; Berger, Shelley L.. Autophagy mediates degradation of nuclear lamina. Nature 2015; Volum 527 (7576). ISSN 0028-0836.s 105 - 109.s doi: 10.1038/nature15548.

  • Olsvik, Hallvard Lauritz; Lamark, Trond; Takagi, Kenji; Larsen, Kenneth Bowitz; Evjen, gry; Øvervatn, Aud Karin; Mizushima, Tsunehiro; Johansen, Terje. FYCO1 contains a C-terminally extended, LC3A/B-preferring LC3-interacting region (LIR) motif required for efficient maturation of autophagosomes during basal autophagy. Journal of Biological Chemistry 2015; Volum 290 (49). ISSN 0021-9258.s 29361 - 29374.s doi: 10.1074/jbc.M115.686915.

  • Bruun, Jarle; Kolberg, Matthias; Ahlquist, Terje Cruickshank; Røyrvik, Ellen Christine; Nome, Torfinn; Leithe, Edward; Lind, Guro Elisabeth; Merok, Marianne Aarstad; Rognum, Torleiv Ole; Bjørkøy, Geir; Johansen, Terje; Lindblom, Annika; Sun, X-F.; Svindland, Aud; Liestøl, Knut; Nesbakken, Arild; Skotheim, Rolf Inge; Lothe, Ragnhild A. Regulator of chromosome condensation 2 identifies high-risk patients within both major phenotypes of colorectal cancer. Clinical Cancer Research 2015; Volum 21 (16). ISSN 1078-0432.s 3759 - 3770.s doi: 10.1158/1078-0432.CCR-14-3294.

  • Borel, Sophie; Robert-Herman, Veronique; Alfaisal, Jamal; Jain, Ashish; Faure, Mathias; Espert, Lucile; Chaloin, Laurent; Paillart, Jean-Christophe; Johansen, Terje; Biard-Piechaczyk, Martine. HIV-1 viral infectivity factor interacts With microtubule-assosiated protein light Chain 3 and inhibits autophagy. AIDS (London) 2015; Volum 29 (3). ISSN 0269-9370.s 275 - 286.s doi: 10.1097/QAD.0000000000000554.

  • Ciuffa, Rodolfo; Lamark, Trond; Tarafder, Abul K.; Guesdon, Audrey; Rybina, Sofia; Hagen, Wim J.H.; Johansen, Terje; Sachse, Carsten. The Selective Autophagy Receptor p62 Forms a Flexible Filamentous Helical Scaffold. Cell reports 2015; Volum 11 (5). ISSN 2211-1247.s 748 - 758.s doi: 10.1016/j.celrep.2015.03.062.

  • Jain, Ashish; Rusten, Tor Erik; Katheder, Nadja Sandra; Elvenes, Julianne; Bruun, Jack-Ansgar; Sjøttem, Eva; Lamark, Trond; Johansen, Terje. P62/sequestosome-1, autophagy-related gene 8, and autophagy in Drosophila are regulated by nuclear factor erythroid 2-related factor 2(NRF2), independent of transcription factor TFEB. Journal of Biological Chemistry 2015; Volum 290 (24). ISSN 0021-9258.s 14945 - 14962.s doi: 10.1074/jbc.M115.656116.

  • Bertrand, Matthieu; Petit, Valerie; Jain, Ashish; Amsellem, Raymonde; Johansen, Terje; Larue, Lionel; Codogno, Patrice; Beau, Isabelle. SQSTM1/p62 regulates the expression of junctional proteins through epithelialmesenchymal transition factors. Cell Cycle 2015; Volum 14 (3). ISSN 1538-4101.s 364 - 374.s doi: 10.4161/15384101.2014.987619.

  • Darvekar, Sagar; Elvenes, Julianne; Brenne, Hanne; Johansen, Terje; Sjøttem, Eva. SPBP is a sulforaphane induced transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62/SQSTM1. PLoS ONE 2014; Volum 9 (1:e85262). ISSN 1932-6203.s doi: 10.1371/journal.pone.0085262.

  • Mandell, Michael A.; Kimura, Tomonori; Jain, Ashish; Johansen, Terje; Deretic, Vojo. TRIM proteins regulate autophagy: TRIM5 is a selective autophagy receptor mediating HIV-1 restriction. Autophagy 2014. ISSN 1554-8627.s doi: 10.4161/15548627.2014.984278.

  • Mandell, Michael A.; Jain, Ashish; Arko-Mensah, John; Chauhan, Santosh; Kimura, Tomonori; Dinkins, Christina; Silvestri, Guido; Münch, Jan; Kirchhoff, Frank; Simonsen, Anne; Wei, Yongjie; Levine, Beth; Johansen, Terje; Deretic, Vojo. TRIM Proteins Regulate Autophagy and Can Target Autophagic Substrates by Direct Recognition. Developmental Cell 2014; Volum 30 (4). ISSN 1534-5807.s 394 - 409.s doi: 10.1016/j.devcel.2014.06.013.

  • Rubio, Noemi; Verrax, Julien; Dewaele, Michael; Verfaillie, Tom; Johansen, Terje; Piette, Jacques; Agostinis, Patrizia. P38MAPK-regulated induction of p62 and NBR1 after photodynamic therapy promotes autophagic clearance of ubiquitin aggregates and reduces reactive oxygen species levels by supporting Nrf2-antioxidant signaling. Free Radical Biology & Medicine 2014; Volum 67. ISSN 0891-5849.s 292 - 303.s doi: 10.1016/j.freeradbiomed.2013.11.010.

  • Rogov, Vladimir; Dötsch, Volker; Johansen, Terje; Kirkin, Vladimir. Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy. Molecular Cell 2014; Volum 53 (2). ISSN 1097-2765.s 167 - 178.s doi: 10.1016/j.molcel.2013.12.014.

  • Deosaran, Elizabeth; Larsen, Kenneth Bowitz; Hua, Rong; Sargent, Graeme; Wang, Yuqing; Kim, Sarah; Lamark, Trond; Jauregui, Miluska; Law, Kelsey; Lippincott-Schwartz, Jennifer; Brech, Andreas; Johansen, Terje; Kim, Peter K.. NBR1 acts as an autophagy receptor for peroxisomes. Journal of Cell Science 2013; Volum 126 (4). ISSN 0021-9533.s 939 - 952.s doi: 10.1242/jcs.114819.

  • Svenning, Steingrim; Johansen, Terje. Selective autophagy. Essays in Biochemistry 2013; Volum 55. ISSN 0071-1365.s 79 - 92.s doi: 10.1042/BSE0550079.

  • Darvekar, Sagar; Rekdal, Cecilie; Johansen, Terje; Sjøttem, Eva. A Phylogenetic Study of SPBP and RAI1: Evolutionary Conservation of Chromatin Binding Modules. PLoS ONE 2013; Volum 8 (10). ISSN 1932-6203.s doi: 10.1371/journal.pone.0078907.

  • Birgisdottir, Åsa birna; Lamark, Trond; Johansen, Terje. The LIR motif - crucial for selective autophagy. Journal of Cell Science 2013; Volum 126 (15). ISSN 0021-9533.s 3237 - 3247.s doi: 10.1242/jcs.126128.

  • Darvekar, Sagar Ramesh; Eriksen, Agnete Bratsberg; Johansen, Terje; Sjøttem, Eva. Identification of two independent nucleosome-binding domains in the transcriptional co-activator SPBP. Biochemical Journal 2012; Volum 442. ISSN 0264-6021.s 65 - 75.s doi: 10.1042/BJ20111230.

  • Kleine, Henning; Herrmann, Andreas; Lamark, Trond; Forst, Alexandra H.; Verheugd, Patricia; Lüscher-Firzlaff, Juliane; Lippok, Barbara; Feijs, Karla LH; Herzog, Nicolas; Kremmer, Elisabeth; Johansen, Terje; Müller-Newen, Gerhard; Lüscher, Bernhard. Dynamic subcellular localization of the mono-ADP-ribosyltransferase ARTD10 and interaction with the ubiquitin receptor p62. (fulltekst) Cell Communication and Signaling 2012; Volum 10:28. ISSN 1478-811X.s doi: 10.1186/1478-811X-10-28.

  • Lamark, Trond; Johansen, Terje. Aggrephagy: Selective Disposal of Protein Aggregates by Macroautophagy. International Journal of Cell Biology 2012. ISSN 1687-8876.s doi: 10.1155/2012/7336905.

  • Aichem, Annette; Kalveram, Birte; Spinnenhirn, Valentina; Kluge, Kathrin; Catone, Nicola; Johansen, Terje; Groettrup, Marcus. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. Journal of Cell Science 2012; Volum 125 (19). ISSN 0021-9533.s 4576 - 4585.s doi: 10.1242/jcs.107789.

  • Alemu, Endalkachew Ashenafi; Lamark, Trond; Torgersen, Knut Martin; Birgisdottir, Åsa birna; Larsen, Kenneth Bowitz; Jain, Ashish; Olsvik, Hallvard Lauritz; Øvervatn, Aud Karin; Kirkin, Vladimir; Johansen, Terje. ATG8 Family Proteins Act as Scaffolds for Assembly of the ULK Complex SEQUENCE REQUIREMENTS FOR LC3-INTERACTING REGION (LIR) MOTIFS. Journal of Biological Chemistry 2012; Volum 287 (47). ISSN 0021-9258.s doi: 10.1074/jbc.M112.378109.

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  • Sjøttem, Eva; Anderssen, Sølvi; Johansen, Terje. The Promoter Activity of Long Terminal Repeats of the HERV-H Family of Human Retrovirus-Like Elements Is Critcally Dependent on Sp1 Family Proteins Interacting with a GC/GT Box Located Immediately 3´ to the TATA Box. Journal of Virology 1996; Volum 70 (1). ISSN 0022-538X.s 188 - 198.

  • Nornes, Svanhild; Mikkola, Ingvild; Krauss, Stefan; Delghandi, Madjid; Perander, maria; Johansen, Terje. Zebrafish Pax9 Encodes Two Proteins with Distinct C-terminal Transactivating Domains of Different Potency Negatively Regulated by Adjacent N-terminal Sequences. Journal of Biological Chemistry 1996; Volum 271 (43). ISSN 0021-9258.s 26914 - 26923.

  • Mandell, Michael A.; Jain, Ashish; Kumar, Suresh; Castleman, Moriah J.; Anwar, Tahira; Eskelinen, Eeva-Liisa; Johansen, Terje; Prekeris, Rytis; Deretic, Vojo. Correction: TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation [J. Cell Sci. 129, (3562-3573)] 10.1242/jcs.190017. Journal of Cell Science 2017; Volum 130 (6). ISSN 0021-9533.s 1194 - 1194.s doi: 10.1242/jcs.202499.

  • Johansen, Terje; Lamark, Trond. Selective autophagy goes exclusive. Nature Cell Biology 2014; Volum 16 (5). ISSN 1465-7392.s 395 - 397.s doi: 10.1038/ncb2961.

  • Kalvari, Ioanna; Tsompanis, Stelios; Mulakkal, Nitha C; Osgood, Richard; Johansen, Terje; Nezis, Ioannis; Promponas, Vasilis J. iLIR: A web resource for prediction of Atg8-family interacting proteins. Autophagy 2014; Volum 10 (5). ISSN 1554-8627.s 913 - 925.s doi: 10.4161/auto.28260.

  • Hansen, Tom Egil; Johansen, Terje. Following autophagy step by step. BMC Biology 2011; Volum 9. ISSN 1741-7007.s doi: 10.1186/1741-7007-9-39.

  • Olsvik, Ørjan; Johannessen, Mona; Johansen, Terje. Evig liv. 2010.

  • Nezis, Ioannis; Shravage, Bhupendra V; Sagona, Antonia; Johansen, Terje; Baehrecke, Eric H.; Stenmark, Harald. Autophagy as a trigger for cell death Autophagic degradation of inhibitor of apoptosis dBruce controls DNA fragmentation during late oogenesis in Drosophila. Autophagy 2010; Volum 6 (8). ISSN 1554-8627.s 1214 - 1215.s doi: 10.1083/jcb.201002035.

  • Pankiv, Serhiy; Johansen, Terje. FYCO1 Linking autophagosomes to microtubule plus end-directing molecular motors. Autophagy 2010; Volum 6 (4). ISSN 1554-8627.s 550 - 552.

  • Kirkin, Vladimir; Lamark, Trond; Johansen, Terje; Dikic, Ivan. NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets. Autophagy 2009; Volum 5 (5). ISSN 1554-8627.s 732 - 733.

  • McCabe, PS; Mellis, D; Duthie, A; Simonsen, A; Johansen, Terje; Rogers, MJ; Helfrich, MH; Hocking, LJ. Autophagy in osteoclasts: A possible role in the pathogenesis of Paget's Disease of Bone. Calcified Tissue International 2008; Volum 83 (1). ISSN 0171-967X.s 16 - 17.

  • Hocking, LJ; Duthie, A; Mellis, D; Simonsen, A; Johansen, Terje; Helfrich, MH; Rogers, MJ. Novel interaction between SQSTM1 and ALFY in human osteoclasts and effect of SQSTM1 mutations. Calcified Tissue International 2008; Volum 82. ISSN 0171-967X.s S86 - S86.

  • Kristiansen, Agnete B.; Johansen, Terje; Sjøttem, Eva. SPBP associates with transcriptionally active chromatin and interacts with RNA polymerase II. EMBO Conference Series on Nuclear Structure and Dynamics 2007-09-01 - 2007-09-05 2007.

  • Sovershaev, Mikhail; Egorina, elena; Gruber, Franz; Bjorkoy, G.; Johansen, Terje. Extracellular Signal-Regulated Protein Kinase 5 Mediates Resistance of Human Chronic Myeloid Leukemia K562 Cells to Imatinib. American Society of Hematology 48th Annual Meeting 2006-12-08 - 2006-12-12 2006.

  • Gruber, Franz; Hjorth-Hansen, H; Mikkola, ingvild; Stenke, L; Johansen, Terje. A novel Bcr-Abl splice isoform is associated with the L248V mutation in CML patients with acquired resistance to imatinib. Leukemia 2006; Volum 20 (11). ISSN 0887-6924.s 2057 - 2060.

  • Sletten, Camilla J; Johansen, Terje; Bjørkøy, Geir; Lamark, Trond. Self-interaction and polyubiquitin binding by the p62-binding scaffold protein NBR1. 2006.

  • Jæger, Maria; Johansen, Terje; Lamark, Trond; Bjørkøy, Geir. Mapping of a nuclear localization signal and a nuclear export signal in the scaffold protein p62/SQSTM1. 2006.

  • Johansen, Terje. A missing link in the degradation of polybiqutinated protein aggregates by autophagy. IMB-seminar 2006-03-10 - 2006.

  • Johansen, Terje. Oppbygging og ledelse av en molekylærbiologisk forskningsgruppe. Regional forskningskonferanse innen medisin og helse 2006-11-01 - 2006.

  • Bjørkøy, Geir; Lamark, Trond; Pankiv, Serliy; Brech, A; Outzen, heidi; Perander, maria; Øvervatn, Aud; Stenmark, H; Johansen, Terje. P62/SQSTM1: A direct link betwwen polyubiquitinated preotein aggregates and LC3. Invited oral presentation 2006-11-16 - 2006-11-16 2006.

  • Bjørkøy, Geir; Lamark, Trond; Pankiv, Serliy; Brech, A; Outzen, heidi; Øvervatn, Aud; Stenmark, H; Johansen, Terje. p62 as a direct link between protein aggregates and the autophgic machinery. Invited oral pesentation 2006-05-05 - 2006-05-05 2006.

  • Bjørkøy, Geir; Lamark, Trond; Pankiv, Serliy; Brech, A; Outzen, heidi; Perander, maria; Øvervatn, Aud; Stenmark, H; Johansen, Terje. P62/SQSTM1: A direct link betwwen polyubiquitinated preotein aggregates and LC3. 4th International Symposium on Autophagy: Exploring the Froniers of Autophagy Research 2006-10-01 - 2006-10-05 2006.

  • Johnsen, Sylvia sagen; Sjøttem, Eva; Johansen, Terje. SPBP: a putative co-activator of Androgen Receptor Activity. EMBO Workshop 2006-05-05 - 2006-05-08 2006.

  • Elvenes, Julianne; Thomassen, Ernst Ivan; Holm, turid; Johansen, Terje. The recognition Helix of Homeodomains Interacts with the Paired Domain of Pax Family Proteins. 7th EMBL Transcription Meeting 2006-08-26 - 2006-08-30 2006.

  • Klenow, Helle Bagterp; Rekdal, Cecilie; Svineng, Gunbjørg; Sjøttem, Eva; Uglehus, Rebecca Dale; Johansen, Terje. SPBP and TopBP1 interact to enhance Ets-mediated activation of the c-myc promoter. Lorne meeting 2006-02-10 - 2006.

  • Sjøttem, Eva; Klenow, Helle Bagterp; Rekdal, Cecilie; Svineng, Gunbjørg; Johnsen, Sylvia Sagen; Uglehus, Rebecca Dale; Johansen, Terje. SPBP and TopBP1: Modulators of Androgen Receptor Activity. 7th EMBL Transcription Meeting 2006-08-26 - 2006-08-30 2006.

  • Bjørkøy, Geir; Lamark, Trond; Pankiv, Serliy; Brech, A; Outzen, heidi; Perander, maria; Øvervatn, Aud; Stenmark, H; Johansen, Terje. P62/SQSTM1: A direct link betwwen polyubiquitinated preotein aggregates and LC3. Imaging Week 2006-11-13 - 2006-11-15 2006.

  • Mikkola, ingvild; Hogseth, Rune; Johansen, Terje. Chromatin Immunoprecipitation (ChIP) as a method for identification of new target genes for Pax6. The 6th EMBL Transcription meeting 2004-01-01 - 2004.

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