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Kristin Andreassen Fenton

Department of Medical Biology

Job description:

Research and teaching

Research interests


Systemic lupus erythematosus

Lupus nephritis

anti-dsDNA antibodies

Mesangial cells

Tertiary lymphoid structures in autoimmuity and cancer


Associate professor fixed position (2012-present) 

Senior scientist funded by Health and rehabilitation (2009- 2011)

Post Doc funded by Health and rehabilitation (2005-2008)

Laboratory Manager/ Researcher. GenØk (2002-2004)

Postdoctoral Research Fellow. GenØk, Centre for Biosafety, Forskningsparken i Breivika, P.O. Box 6418, 9294 Tromsø, Norway (2001-2002) 

Dr. scient, Department of Molecular Genetics, Institute of Medical Biology, University of Tromsø (2000) 

Publications in CRIStin

  • Kuttner, Samuel; Knutsen Wickstrøm, Kristoffer; Kalda, Gustav; Dorraji, Seyed Esmaeil; Martin, armas maria montserrat; Oteiza, Ana; Jenssen, Robert; Fenton, Kristin Andreassen; Sundset, Rune; Axelsson, Jan. Machine learning derived input-function in a dynamic 18F-FDG PET study of mice. Biomedical engineering and physics express 2020. ISSN 2057-1976.

  • Dorraji, Seyed Esmaeil; Hovd, Aud-Malin Karlsson; Kanapathippillai, Premasany; Bakland, Gunnstein; Eilertsen, Gro Østli; Figenschau, Stine; Fenton, Kristin Andreassen. Mesenchymal stem cells and T cells in the formation of Tertiary Lymphoid Structures in Lupus Nephritis. Scientific Reports 2018; Volum 8. ISSN 2045-2322.s doi: 10.1038/s41598-018-26265-z.

  • Figenschau, Stine; Knutsen, Erik; Urbarova, Ilona; Fenton, Christopher Graham; Elston, Bryan; Perander, Maria; Mortensen, Elin Synnøve; Fenton, Kristin Andreassen. ICAM1 expression is induced by proinflammatory cytokines and associated with TLS formation in aggressive breast cancer subtypes. Scientific Reports 2018; Volum 8:11720. ISSN 2045-2322.s 1 - 12.s doi: 10.1038/s41598-018-29604-2.

  • Fenton, Kristin Andreassen. The effect of cell death in the initiation of lupus nephritis. Clinical and Experimental Immunology 2015; Volum 179 (1). ISSN 0009-9104.s 11 - 16.s doi: 10.1111/cei.12417.

  • Figenschau, Stine Linn; Fismen, Silje; Fenton, Kristin Andreassen; Fenton, Christopher Graham; Mortensen, Elin Synnøve. Tertiary lymphoid structures are associated with higher tumor grade in primary operable breast cancer patients. BMC Cancer 2015; Volum 15:101. ISSN 1471-2407.s doi: 10.1186/s12885-015-1116-1.

  • Kanapathippillai, Premasany; Hedberg, Annica; Fenton, Christopher Graham; Fenton, Kristin Andreassen. Nucleosomes contribute to increase mesangial cell chemokine expression during the development of lupus nephritis. Cytokine 2013; Volum 62 (2). ISSN 1043-4666.s 244 - 252.s doi: 10.1016/j.cyto.2013.03.016.

  • Hedberg, Annica; Kanapathippillai, Premasany; Rekvig, Ole Petter; Fenton, Kristin Andreassen. LMW Heparin Prevents Increased Kidney Expression of Proinflammatory Mediators in (NZBxNZW)F1 Mice. Clinical & Developmental Immunology 2013. ISSN 1740-2522.s doi: 10.1155/2013/791262.

  • Hedberg, Annica; Fismen, Silje; Fenton, Kristin Andreassen; Fenton, Christopher Graham; Østerud, Bjarne; Mortensen, Elin; Rekvig, Ole Petter. Heparin Exerts a Dual Effect on Murine Lupus Nephritis by Enhancing Enzymatic Chromatin Degradation and Preventing Chromatin Binding in Glomerular Membranes. Arthritis and Rheumatism 2011; Volum 63 (4). ISSN 0004-3591.s 1065 - 1075.s doi: 10.1002/art.30211.

  • Grønsberg, Idun; Nordgård, Lise; Fenton, Kristin Andreassen; Hegge, Beate; Nielsen, Kaare Magne; Bardocz, Susan; Pusztai, Arpad; Traavik, Ingemar Terje. Uptake and Organ Distribution of Feed Introduced Plasmid DNA in Growing or Pregnant Rats. Food and Nutrition Sciences 2011; Volum 2. ISSN 2157-944X.s 377 - 386.s doi: 10.4236/fns.2011.24053.

  • Jørgensen, Mariann Hellvik; Rekvig, Ole Petter; Jacobsen, Rasmus S.; Jacobsen, Søren; Fenton, Kristin Andreassen. Circulating levels of chromatin fragments are inversely correlated with anti-dsDNA antibody levels in human and murine systemic lupus erythematosus. Immunology Letters 2011; Volum 138 (2). ISSN 0165-2478.s 179 - 186.s doi: 10.1016/j.imlet.2011.04.006.

  • Mjelle, Janne erikke; Rekvig, Ole Petter; van der Vlag, Johan; Fenton, Kristin Andreassen. Nephritogenic antibodies bind in glomeruli through interaction with exposed chromatin fragments and not with renal cross-reactive antigens. Autoimmunity 2011; Volum 44 (5). ISSN 0891-6934.s 373 - 383.s doi: 10.3109/08916934.2010.541170.

  • Fenton, Kristin Andreassen; TØmmerÅs, berit; Marion, Tony Norman; Rekvik, Ole Petter. Pure anti-dsDNA mAbs need chromatin structures to promote glomerular mesangial deposits in BALB/c mice. Autoimmunity 2010; Volum 43 (2). ISSN 0891-6934.s 179 - 188.s doi: 10.3109/08916930903305633.

  • Hedberg, Annica; Fismen, Silje; Fenton, Kristin Andreassen; Mortensen, Elin; Rekvig, Ole Petter. Deposition of chromatin-IgG complexes in skin of nephritic MRL-lpr/lpr mice is associated with increased local matrix metalloprotease activities. Experimental Dermatology 2010; Volum 19 (8). ISSN 0906-6705.s E265 - E274.s doi: 10.1111/j.1600-0625.2010.01064.x.

  • Fenton, Kristin Andreassen; TØmmerÅs, berit; Marion, Tony Norman; Rekvik, Ole Petter. Pure anti-dsDNA mAbs need chromatin structures to promote glomerular mesangial deposits in BALB/c mice. Autoimmunity 2009. ISSN 0891-6934.s doi: 10.3109/08916930903305633.

  • Fismen, Silje; Hedberg, Annica; Fenton, Kristin Andreassen; Jacobsen, S; Krarup, E; Kamper, AL; Rekvik, Ole Petter; Mortensen, Elin. Circulating chromatin-anti-chromatin antibody complexes bind with high affinity to dermo-epidermal structures in murine and human lupus nephritis. Lupus 2009; Volum 18 (7). ISSN 0961-2033.s 597 - 607.s doi: 10.1177/0961203308100512.

  • Fenton, Kristin Andreassen; Fismen, Silje; Hedberg, Annica; Seredkina, Natalya; Fenton, Christopher Graham; Mortensen, Elin; Rekvik, Ole Petter. Anti-dsDNA Antibodies Promote Initiation, and Acquired Loss of Renal Dnase1 Promotes Progression of Lupus Nephritis in Autoimmune (NZBxNZW)F1 mice. PLOS ONE 2009; Volum 4 (12). ISSN 1932-6203.s doi: 10.1371/journal.pone.0008474.

  • Fenton, Kristin Andreassen; Mjelle, Janne erikke; Jakobsen, Søren; Olsen, randi; Rekvik, Ole Petter. Renal expression of polyomavirus large T antigen is associated with nephritis in human systemic lupus erythematosus. Molecular Immunology 2008; Volum 45. ISSN 0161-5890.s 3117 - 3124.s doi: 10.1016/j.molimm.2008.03.001.

  • van Bavel, Casandra C.; Fenton, Kristin Andreassen; Rekvik, Ole Petter; van der Vlag, Johan; Berden, Jo H.. Glomerular targets of nephritogenic autoantibodies in systemic lupus erythematosus. Arthritis and Rheumatism 2008; Volum 58. ISSN 0004-3591.s 1892 - 1899.s doi: 10.1002/art.23626.

  • Mortensen, Elin; Fenton, Kristin Andreassen; Rekvik, Ole Petter. Lupus nephritis - The central role of nucleosomes revealed. American Journal of Pathology 2008; Volum 172. ISSN 0002-9440.s 275 - 283.s doi: 10.2353/ajpath.2008.070563.

  • Bendiksen, signy; Mortensen, Elin; Olsen, randi; Fenton, Kristin Andreassen; Kalaaji, manar; Jørgensen, Leif; Rekvik, Ole Petter. Glomerular expression of large polyomavirus T antigen in binary tet-off regulated transgenic mice induces apoptosis, release of chromatin and initiates a lupus-like nephritis. Molecular Immunology 2008; Volum 45 (3). ISSN 0161-5890.s 728 - 729.s doi: 10.1016/j.molimm.2007.07.010.

  • Mjelle, Janne erikke; Rekvik, Ole Petter; Fenton, Kristin Andreassen. Nucleosomes possess a high affinity for glomerular laminin and collagen IV and bind nephritogenic antibodies in murine lupus-like nephritis. Annals of the Rheumatic Diseases 2007; Volum 66. ISSN 0003-4967.s 1661 - 1668.s doi: 10.1136/ard.2007.070482.

  • Kalaaji, manar; Fenton, Kristin Andreassen; Mortensen, Elin; Olsen, randi; Sturfelt, G; Alm, P; Rekvik, Ole Petter. Glomerular apoptotic nucleosomes are central target structures for nephritogenic antibodies in human SLE nephritis. Kidney International 2007; Volum 71. ISSN 0085-2538.s doi: 10.1038/

  • Fenton, Kristin Andreassen; Rekvik, Ole Petter. A central role of nucleosomes in lupus nephritis. Annals of the New York Academy of Sciences 2007; Volum 1108. ISSN 0077-8923.s 104 - 113.s doi: 10.1196/annals.1422.012.

  • Myhre, Marit Renee; Fenton, Kristin Andreassen; Egger, Julia Friederike; Nielsen, Kaare Magne; Traavik, Terje I. The 35S CaMV plant virus promoter is active in human enterocyte-like cells. European Food Research and Technology 2006; Volum 222 (1-2). ISSN 1438-2377.s 185 - 193.s doi: 10.1007/s00217-005-0154-3.

  • Fenton, Kristin Andreassen; Figenschau, Stine; Mortensen, Elin Synnøve. ICAM1 er uttrykt i trippel negative brystkreftceller og vev. Best Practice Nordic Onkologi/Hematologi 2018; Volum 8 (40).s 46 - 48.

  • Fenton, Kristin Andreassen; Mjelle, Janne erikke; Olsen, R; Kalaaji, manar; Rekvik, Ole Petter. Electron dense deposits in the GBM of (NZBxNZW)F1 mice constitute chromatin that represents target for in vivo bound autoantibodies. 5th International Congress of Autoimmunity 2006-11-23 - 2006-12-03 2006.

  • Eggert, Julia Friederike; Fenton, Kristin Andreassen; Goldfain, olga; Hegge, Beate; Myhr, AI; Nordgård, Lise; Olsen, Elisabeth; Ursvik, anita; Traavik, Terje. Absence of Proof is not a Proof of Absence. Risks of Genetically Modified Organisms. Queenstown Molecular Biology Meeting, Queenstown, New Zealand 2002-09-01 - 2002-09-04 2002.