Flag icon Flag icon
Associate Professor

Eva Sjøttem

Associate professor
Department of Medical Biology

Research interests

Characterisation of molecular mechanisms involved in selectivity and regulation of the intracellular process autophagy. Autophagy is a crucial process for cellular homeostasis. It selectively degrades intracellular  destroyed or dangerous components, infectious agents or excess components. Autophagy is important for cell survival during various cellular stresses like starvation, infection and oxygen deprivation. Disregulated autophagy is implicated in various diseases like neurodegenerative diseases, Cardiac diseases, and cancer. Furthermore, autophagy has impact on iflammation ang ageing. Our Research Group has a specific focus on understanding the functional mechanisms of selective autophagy receptors, and how their expression and biological activities are regulated upon stress.


Coordinator, Bachelor course, MBI-2011 Molekylær Cellebiologi I

Coordinator PhD kurs Bio-8302 Molecular and Clinical Aspects of Cancer, Autumn

Coordinator PhD kurs Bio-8302 Molecular and Clinical Aspects of Cancer, Spring

Publications in CRIStin

  • Hoem, Gry; Larsen, Kenneth Bowitz; Øvervatn, Aud Karin; Brech, Andreas; Lamark, Trond; Sjøttem, Eva; Johansen, Terje. The FMRpolyGlycine protein mediates aggregate formation and toxicity independent of the CGG mRNA hairpin in a cellular model for FXTAS. Frontiers in Genetics 2019; Volum 10. ISSN 1664-8021.s doi: 10.3389/fgene.2019.00249.

  • Birgisdottir, Åsa birna; Mouilleron, Stephane; Bhujabal, Zambarlal; Wirth, Martina; Sjøttem, Eva; Evjen, gry; Zhang, Wenxin; Lee, Rebecca; O'Reilly, Nicola; Tooze, Sharon A; Lamark, Trond; Johansen, Terje. Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs. Autophagy 2019; Volum 15 (8). ISSN 1554-8627.s 1333 - 1355.s doi: 10.1080/15548627.2019.1581009.

  • Overå, Katrine Stange; Garcia Garcia, Juncal; Bhujabal, Zambarlal; Jain, Ashish; Øvervatn, Aud Karin; Larsen, Kenneth Bowitz; Deretic, Vojo; Johansen, Terje; Lamark, Trond; Sjøttem, Eva. TRIM32, but not its muscular dystrophy-associated mutant, positively regulates and is targeted to autophagic degradation by p62/SQSTM1. Journal of Cell Science 2019; Volum 132 (23). ISSN 0021-9533.s doi: 10.1242/jcs.236596.

  • Shrestha, Birendra Kumar; Rasmussen, Mads Skytte; Abudu, Yakubu Princely; Bruun, Jack-Ansgar; Larsen, Kenneth Bowitz; Alemu, Endalkachew Ashenafi; Sjøttem, Eva; Lamark, Trond; Johansen, Terje. NIMA-related kinase 9–mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1. Journal of Biological Chemistry 2019. ISSN 0021-9258.s doi: 10.1074/jbc.RA119.010068.

  • Fusco, Carmela; Mandriani, Barbara; Di Rienzo, Martina; Micale, Lucia; Malerba, Natascia; Cocciadiferro, Dario; Sjøttem, Eva; Augello, Bartolomeo; Squeo, Gabriella Maria; Pellico, Maria Teresa; Jain, Ashish; Johansen, Terje; Fimia, Gian Maria; Merla, Giuseppe. TRIM50 regulates Beclin 1 proautophagic activity. BBA - Molecular Cell Research 2018; Volum 1865 (6). ISSN 0167-4889.s 908 - 919.s doi: 10.1016/j.bbamcr.2018.03.011.

  • Hegge, Beate; Sjøttem, Eva; Mikkola, Ingvild. Generation of a PAX6 knockout glioblastoma cell line with changes in cell cycle distribution and sensitivity to oxidative stress. BMC Cancer 2018; Volum 18 (1). ISSN 1471-2407.s doi: 10.1186/s12885-018-4394-6.

  • Bhujabal, Zambarlal; Birgisdottir, Åsa birna; Sjøttem, Eva; Brenne, Hanne Britt; Øvervatn, Aud Karin; Habisov, Sabrina; Kirkin, Vladimir; Lamark, Trond; Johansen, Terje. FKBP8 recruits LC3A to mediate Parkin-independent mitophagy. EMBO Reports 2017; Volum 18 (6). ISSN 1469-221X.s 947 - 961.s doi: 10.15252/embr.201643147.

  • Rasmussen, Mads Skytte; Mouilleron, Stephane; Shrestha, Birendra Kumar; Wirth, Martina; Lee, Rebecca; Larsen, Kenneth Bowitz; Abudu, Yakubu Princely; O'Reilly, Nicola; Sjøttem, Eva; Tooze, Sharon A; Lamark, Trond; Johansen, Terje. ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8. Autophagy 2017; Volum 13 (5). ISSN 1554-8627.s 834 - 853.s doi: 10.1080/15548627.2017.1287651.

  • Jain, Ashish; Rusten, Tor Erik; Katheder, Nadja Sandra; Elvenes, Julianne; Bruun, Jack-Ansgar; Sjøttem, Eva; Lamark, Trond; Johansen, Terje. P62/sequestosome-1, autophagy-related gene 8, and autophagy in Drosophila are regulated by nuclear factor erythroid 2-related factor 2(NRF2), independent of transcription factor TFEB. Journal of Biological Chemistry 2015; Volum 290 (24). ISSN 0021-9258.s 14945 - 14962.s doi: 10.1074/jbc.M115.656116.

  • Darvekar, Sagar; Elvenes, Julianne; Brenne, Hanne; Johansen, Terje; Sjøttem, Eva. SPBP is a sulforaphane induced transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62/SQSTM1. PLOS ONE 2014; Volum 9 (1:e85262). ISSN 1932-6203.s doi: 10.1371/journal.pone.0085262.

  • Darvekar, Sagar; Rekdal, Cecilie; Johansen, Terje; Sjøttem, Eva. A Phylogenetic Study of SPBP and RAI1: Evolutionary Conservation of Chromatin Binding Modules. PLOS ONE 2013; Volum 8 (10). ISSN 1932-6203.s doi: 10.1371/journal.pone.0078907.

  • Darvekar, Sagar Ramesh; Eriksen, Agnete Bratsberg; Johansen, Terje; Sjøttem, Eva. Identification of two independent nucleosome-binding domains in the transcriptional co-activator SPBP. Biochemical Journal 2012; Volum 442. ISSN 0264-6021.s 65 - 75.s doi: 10.1042/BJ20111230.

  • Alemu, Endalkachew; Sjøttem, Eva; Outzen, heidi; Larsen, Kenneth Bowitz; Holm, turid; Bjørkøy, Geir; Johansen, Terje. Transforming growth factor-beta-inducible early response gene 1 is a novel substrate for atypical protein kinase Cs. Cellular and Molecular Life Sciences (CMLS) 2011; Volum 68 (11). ISSN 1420-682X.s 1953 - 1968.s doi: 10.1007/s00018-010-0541-1.

  • Elvenes, Julianne; Thomassen, Ernst Ivan; Johnsen, Sylvia Sagen; Kaino, Katrine; Sjøttem, Eva; Johansen, Terje. Pax6 Represses Androgen Receptor-Mediated Transactivation by Inhibiting Recruitment of the Coactivator SPBP. PLOS ONE 2011; Volum 6 (9). ISSN 1932-6203.s doi: 10.1371/journal.pone.0024659.

  • Jain, Ashish; Lamark, Trond; Sjøttem, Eva; Larsen, Kenneth Bowitz; Awuh, Jane Atesoh; Øvervatn, Aud Karin; McMahon, Michael; Hayes, John D; Johansen, Terje. p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription. Journal of Biological Chemistry 2010; Volum 285 (29). ISSN 0021-9258.s 22576 - 22591.s doi: 10.1074/jbc.M110.118976.

  • Elvenes, Julianne; Sjøttem, Eva; Holm, Turid; Bjørkøy, Geir; Johansen, Terje. Pax6 localizes to chromatin-rich territories and displays a slow nuclear mobility altered by disease mutations. Cellular and Molecular Life Sciences (CMLS) 2010; Volum 67. ISSN 1420-682X.s 4079 - 4094.s doi: 10.1007/s00018-010-0429-0.

  • Sjøttem, Eva; Rekdal, Cecilie; Svineng, Gunbjørg; Johnsen, Sylvia sagen; Klenow, Helle Bagterp; Uglehus, Rebecca dale; Johansen, Terje. The ePHD protein SPBP interacts with TopBP1 and together they co-operate to stimulate Ets1-mediated transcription. Nucleic Acids Research 2007; Volum 35 (19). ISSN 0305-1048.s 6648 - 6662.s doi: 10.1093/nar/gkm739.

  • Johansen, Steinar; Vader, Anna; Sjøttem, Eva; Nielsen, Henrik. In vivo expression of a group I intron HEG from the antisense strand of Didymium ribosomal DNA. RNA Biology 2006; Volum 3 (4). ISSN 1547-6286.s 157 - 162.

  • Haugen, Peik; Wikmark, Odd-Gunnar; Vader, Anna; Coucheron, Dag H.; Sjøttem, Eva; Johansen, Steinar D.. The recent transfer of a homing endonuclease gene. (omtale) Nucleic Acids Research 2005; Volum 33 (8). ISSN 0305-1048.s 2734 - 2741.

  • Haugen, Peik; Wikmark, Odd Gunnar; Vader, A; Coucheron, Dag-Hugo; Sjøttem, Eva; Johansen, Steinar. The recent transfer of a homing endonuclease gene. Nucleic Acids Research 2005; Volum 33. ISSN 0305-1048.

  • Johansen, Steinar Daae; Andreassen, morten; Birgisdottir, Åsa birna; Coucheron, Dag-Hugo; Einvik, Christer; Fiskaa, Tonje; Haugli, kari b.; Lundblad, Eirik Wasmuth; Sjøttem, Eva; SkjÆveland, ingrid; Wikmark, Odd Gunnar. Group I introns are very common in nuclear SSU rDNA and LSU rDNA of Myxomycetes. Scripta Botanica Belgica 2002; Volum 22. ISSN 0779-2387.s 43 - .

  • Rekdal, Cecilie; Sjøttem, Eva; Johansen, Terje. The nuclear factor SPBP contains different functional domains and stimulates the activity of various transcriptional activators. Journal of Biological Chemistry 2000; Volum 275 (51). ISSN 0021-9258.s 40288 - 40300.

  • Sjøttem, Eva; Rekdal, Cecilie; Johansen, Terje. Structural and functional analyses of DNA bending induced by Sp1 family transcription factors. Journal of Molecular Biology 1997; Volum 267 (3). ISSN 0022-2836.s 490 - 504.

  • Anderssen, Sølvi; Sjøttem, Eva; Svineng, Gunbjørg; Johansen, Terje. Comparative Analyses of LTRs of the ERV-H Family of Primate-Specific Retrovirus-like ELements Isolated from Marmoset, African Green Monkey, and Man. Virology 1997; Volum 234. ISSN 0042-6822.s 14 - 30.

  • Sjøttem, Eva; Anderssen, Sølvi; Johansen, Terje. The Promoter Activity of Long Terminal Repeats of the HERV-H Family of Human Retrovirus-Like Elements Is Critcally Dependent on Sp1 Family Proteins Interacting with a GC/GT Box Located Immediately 3´ to the TATA Box. Journal of Virology 1996; Volum 70 (1). ISSN 0022-538X.s 188 - 198.

  • Kristiansen, Agnete B.; Johansen, Terje; Sjøttem, Eva. SPBP associates with transcriptionally active chromatin and interacts with RNA polymerase II. EMBO Conference Series on Nuclear Structure and Dynamics 2007-09-01 - 2007-09-05 2007.

  • Sjøttem, Eva; Klenow, Helle Bagterp; Rekdal, Cecilie; Svineng, Gunbjørg; Johnsen, Sylvia Sagen; Uglehus, Rebecca Dale; Johansen, Terje. SPBP and TopBP1: Modulators of Androgen Receptor Activity. 7th EMBL Transcription Meeting 2006-08-26 - 2006-08-30 2006.

  • Johnsen, Sylvia sagen; Sjøttem, Eva; Johansen, Terje. SPBP: a putative co-activator of Androgen Receptor Activity. EMBO Workshop 2006-05-05 - 2006-05-08 2006.

  • Klenow, Helle Bagterp; Rekdal, Cecilie; Svineng, Gunbjørg; Sjøttem, Eva; Uglehus, Rebecca Dale; Johansen, Terje. SPBP and TopBP1 interact to enhance Ets-mediated activation of the c-myc promoter. Lorne meeting 2006-02-10 - 2006.

  • Haugen, Peik; Wikmark, Odd Gunnar; Vader, A; SjØttem, eva; Johansen, Steinar. The recent transfer of a homing endonuclease gene. Tenth Annual Meeting of the RNA Society 2005-05-24 - 2005-05-29 2005.