portrett-Jan-Brox

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Brox, Jan

Professor II
Department of Medical Biology

Job description:

Positions/present employment       

Professor II in medical biochemistry, Department of Medical Biology, University of Tromsø

Member of Hematological Research Group

Member of the Scientific Board of the Tromsø Study no 6

Senior consultant in Medical biochemistry, University Hospital of North-Norway (main position) Division of Diagnostic Services , member of the Division`s leaderteam,University Hospital of North-Norway, Department ofLaboratory Medicine, member of the Department`s leaderteam, University Hospital of North-Norway




Research interests

Current research interests 

Arterial and venous thromboembolism, risk factors, cell signalling and pathobiochemistry.

Environmental pollution and human health.

CV

Academic degree

1979                Cand.med. (MD), University of Tromsø

1985                Dr. med (PhD in cardiovascular medicine) University of Tromsø

1988                MPH (Master of Public Health) University of Tromsø

 

Previous academic positions 

1979-82           Research fellow, Univ. of Tromsø .

1987-2002       Associate professor in Medical biochemistry, University of Tromsø (20%)

2002-               Professor II in Medical biochemistry, University of Tromsø (20% position)

 

Publications

60 original full papers in peer-reviewed journals listed in PubMed. Various abstracts  presented at and published in conjunction with scientific international meetings/conferences.

 

Supervision of students

Supervision/ co-supervision of master, PhD and post-doc students. 

Publications in CRIStin


  • Vik, Anders; Brodin, Ellen Elisabeth; Mathiesen, Ellisiv B.; Brox, Jan; Jørgensen, Lone; Njølstad, Inger; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne. Serum osteoprotegerin and renal function in the general population: The Troms? Study. Clinical Kidney Journal 2017; Volum 10 (1). ISSN 2048-8505.s 38 - 44.s doi: 10.1093/ckj/sfw095.

  • Bolann, Bjørn Johan; Huber, Sandra; Ruzzin, Jérôme; Brox, Jan; Huitfeldt, Henrik; Monsen, Anne Lise Bjørke. Er miljøgifter i norsk kosthold skadelig for barn?. Tidsskrift for Den norske legeforening 2017; Volum 137 (4). ISSN 0029-2001.s 295 - 297.s doi: 10.4045/tidsskr.16.0978.

  • Lerstad, Gunhild; Brodin, Ellen Elisabeth; Svartberg, Johan; Jorde, Rolf; Brox, Jan; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne. Associations between serum levels of calcium, parathyroid hormone and future risk of venous thromboembolism: The Tromsø study. European Journal of Endocrinology 2017; Volum 176 (5). ISSN 0804-4643.s 625 - 634.s doi: 10.1530/EJE-16-1037.

  • Lappegård, Jostein; Ellingsen, Trygve; Skjelbakken, Tove; Mathiesen, Ellisiv B.; Njølstad, Inger; Wilsgaard, Tom; Brox, Jan; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne. Red cell distribution width is associated with future risk of incident stroke: The Tromsø Study. Thrombosis and Haemostasis 2016; Volum 115 (1). ISSN 0340-6245.s 126 - 134.s doi: 10.1160/TH15-03-0234.

  • Averina, Maria; Johannesen, Sigrid; Brox, Jan. Diagnostic accuracy of silica clotting time method for lupus anticoagulant in a clinical population with various symptoms of antiphospholipid syndrome. Lupus 2016; Volum 25 (4). ISSN 0961-2033.s 418 - 422.s doi: 10.1177/0961203315617540.

  • Horvei, Lars Daae; Grimnes, Gro; Hindberg, Kristian; Mathiesen, Ellisiv B.; Njølstad, Inger; Wilsgaard, Tom; Brox, Jan; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne. C-reactive protein, obesity, and the risk of arterial and venous thrombosis. Journal of Thrombosis and Haemostasis 2016; Volum 14 (8). ISSN 1538-7933.s 1561 - 1571.s doi: 10.1111/jth.13369.

  • Lappegård, Jostein; Ellingsen, Trygve; Vik, Anders; Skjelbakken, Tove; Brox, Jan; Mathiesen, Ellisiv B.; Johnsen, Stein Harald; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne. Red cell distribution width and carotid atherosclerosis progression: The tromsø study. Thrombosis and Haemostasis 2015; Volum 113 (3). ISSN 0340-6245.s 649 - 654.s doi: 10.1160/TH14-07-0606.

  • Huber, Sandra; Brox, Jan. An automated high-throughput SPE micro-elution method for perfluoroalkyl substances in human serum. Analytical and Bioanalytical Chemistry 2015; Volum 407 (13). ISSN 1618-2642.s 3751 - 3761.s doi: 10.1007/s00216-015-8601-x.

  • Vik, Anders; Brodin, Ellen Elisabeth; Mathiesen, Ellisiv B.; Brox, Jan; Jørgensen, Lone; Njølstad, Inger; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne. Serum osteoprotegerin and future risk of cancer and cancer-related mortality in the general population: the Tromsø study. European Journal of Epidemiology 2014; Volum 30 (3). ISSN 0393-2990.s 219 - 230.s doi: 10.1007/s10654-014-9975-3.

  • Skjelbakken, Tove; Lappegård, Jostein; Ellingsen, Trygve; Barrett-Connor, Elizabeth; Brox, Jan; Løchen, Maja-Lisa; Njølstad, Inger; Wilsgaard, Tom; Mathiesen, Ellisiv B.; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne. Red cell distribution width is associated with incident myocardial infarction in a general population: The tromsø study. Journal of the American Heart Association 2014; Volum 3:e001109 (4). ISSN 2047-9980.s doi: 10.1161/JAHA.114.001109.

  • Brodin, Ellen Elisabeth; Lerstad, Gunhild; Grimnes, Guri; Brækkan, Sigrid Kufaas; Vik, Anders; Brox, Jan; Svartberg, Johan; Jorde, Rolf; Hansen, John-Bjarne. Serum levels of vitamin D are not associated with future risk of venous thromboembolism The Tromso Study. Thrombosis and Haemostasis 2013; Volum 109 (5). ISSN 0340-6245.s 885 - 890.s doi: 10.1160/TH12-10-0728.

  • Melbye, Hasse; Amundsen, Kristine; Brox, Jan; Eggen, Anne Elise. The Association Between Self-Reported Symptoms of Recent Airway Infection and CRP Values in a General Population. Inflammation 2012; Volum 35 (3). ISSN 0360-3997.s 1015 - 1022.s doi: 10.1007/s10753-011-9405-6.

  • Brodin, Ellen Elisabeth; Brækkan, Sigrid Kufaas; Vik, Anders; Brox, Jan; Hansen, John-Bjarne. Cystatin C is associated with risk of venous thromboembolism in subjects with normal kidney function - the Tromso study. Haematologica 2012; Volum 97 (7). ISSN 0390-6078.s 1008 - 1013.s doi: 10.3324/haematol.2011.057653.

  • Toft, Ingrid; Solbu, Marit Dahl; Kronborg, Jens; Mathisen, Ulla Dorte; Eriksen, Bjørn Odvar; Storhaug, Hilde-Merete; Melsom, Toralf; Løchen, Maja-Lisa; Mathiesen, Ellisiv B.; Njølstad, Inger; Wilsgaard, Tom; Brox, Jan. Cystatin C as risk factor for cardiovascular events and all-cause mortality in the general population. The Tromso Study. Nephrology, Dialysis and Transplantation 2012; Volum 27 (7). ISSN 0931-0509.s 2780 - 2787.s doi: 10.1093/ndt/gfr751.

  • Hansen, John-Bjarne; Fernández, José A.; Borch, Knut Håkon; Griffin, John H.; Brox, Jan; Brækkan, Sigrid Kufaas. Activated protein C plasma levels in the fasting and postprandial states among patients with previous unprovoked venous thromboembolism. Thrombosis Research 2012; Volum 129 (4). ISSN 0049-3848.s 502 - 507.s doi: 10.1016/j.thromres.2011.06.026.

  • Eilertsen, Karl-Erik; Mæhre, Hanne K; Jensen, Ida-Johanne; Devold, hege; Olsen, Jan Ole; Klykken Lie, Reidun; Brox, Jan; Berg, Vivian; Elvevoll, Edel Oddny; Østerud, Bjarne. A Wax Ester and Astaxanthin-Rich Extract from the Marine Copepod Calanus finmarchicus Attenuates Atherogenesis in Female Apolipoprotein E-Deficient Mice. (sammendrag) Journal of Nutrition 2012; Volum 142 (3). ISSN 0022-3166.s 508 - 512.s doi: 10.3945/jn.111.145698.

  • Vik, Anders; Mathiesen, Ellisiv B.; Brox, Jan; Wilsgaard, Tom; Njølstad, Inger; Jørgensen, Lone; Hansen, John-Bjarne. Serum osteoprotegerin is a predictor for incident cardiovascular disease and mortality in a general population: the Tromso Study. Journal of Thrombosis and Haemostasis 2011; Volum 9 (4). ISSN 1538-7933.s 638 - 644.s doi: 10.1111/j.1538-7836.2011.04222.x.

  • Jørgensen, Lone; Hansen, John-Bjarne; Brox, Jan; Mathiesen, Ellisiv B.; Vik, Anders; Jacobsen, Bjarne K.. Serum osteoprotegerin levels are related to height loss: The Tromsø Study. (fulltekst) European Journal of Epidemiology 2011; Volum 26 (4). ISSN 0393-2990.s 305 - 312.s doi: 10.1007/s10654-011-9555-8.

  • Hald, Erin Mathiesen; Brækkan, Sigrid Kufaas; Mathiesen, Ellisiv B.; Njølstad, Inger; Wilsgaard, Tom; Brox, Jan; Hansen, John-Bjarne. High-sensitivity C-reactive protein is not a risk factor for venous thromboembolism: the Tromso study. Haematologica 2011; Volum 96 (8). ISSN 0390-6078.s 1189 - 1194.s doi: 10.3324/haematol.2010.034991.

  • Jørgensen, Lone; Vik, Anders; Emaus, Nina; Brox, Jan; Hansen, John-Bjarne; Mathiesen, Ellisiv B.; Vestergaard, P. Bone loss in relation to serum levels of osteoprotegerin and nuclear factor-kappa B ligand: the Tromso Study. Osteoporosis International 2010; Volum 21 (6). ISSN 0937-941X.s 931 - 938.s doi: 10.1007/s00198-009-1035-6.

  • Berg, Vivian; Sveinbjørnsson, Baldur; Bendiksen, Signy; Brox, Jan; Meknas, Khaled; Figenschau, Yngve. Human articular chondrocytes express ChemR23 and chemerin; ChemR23 promotes inflammatory signalling upon binding the ligand chemerin 21-157. Arthritis Research & Therapy 2010; Volum 12 (6). ISSN 1478-6362.s doi: 10.1186/ar3215.

  • Vik, Anders; Mathiesen, Ellisiv B.; Brox, jan; Wilsgaard, Tom; Njølstad, Inger; Jørgensen, Lone; Hansen, John-Bjarne. Relation between serum osteoprotegerin and carotid intima media thickness in a general population - The Tromsø Study. Journal of Thrombosis and Haemostasis 2010; Volum 8 (10). ISSN 1538-7933.s 2133 - 2139.s doi: 10.1111/j.1538-7836.2010.03990.x.

  • Vik, Anders; Mathiesen, Ellisiv B.; Johnsen, Stein Harald; Brox, Jan; Wilsgaard, Tom; Njølstad, Inger; Hansen, John-Bjarne. Serum osteoprotegerin, sRANKL and carotid plaque formation and growth in a general population - the Troms circle divide study. Journal of Thrombosis and Haemostasis 2010; Volum 8 (5). ISSN 1538-7933.s 898 - 905.s doi: 10.1111/j.1538-7836.2010.03790.x.

  • Jørgensen, Lone; Vik, Anders; Emaus, Nina; Brox, jan; Hansen, John-Bjarne; Mathiesen, Ellisiv B.; Vestergaard, P. Bone loss in relation to serum levels of osteoprotegerin and nuclear factor-kappa B ligand: the Tromsø Study. Osteoporosis International 2009 (Aug 22). ISSN 0937-941X.

  • Elvevoll, Edel Oddny; Eilertsen, Karl-Erik; Brox, jan; Dragnes, Bjørn Tore; Falkenberg, pÅl; Olsen, Jan Ole; kirkhus, bente; lamglait, Amadine; Østerud, Bjarne. Seafood diets: Hypolipidemic and antiatherogenic effects of taurine and n-3 fatty acids. Atherosclerosis 2008; Volum 200. ISSN 0021-9150.s 396 - 402.s doi: 10.1016/j.atherosclerosis.2007.12.021.

  • Notø, Ann-Trude With; Mathiesen, Ellisiv B.; Brox, jan; Bjorkegren, J; Hansen, John-Bjarne. The apoC-I content of VLDL particles is associated with plaque size in persons with carotid atherosclerosis. Lipids 2008; Volum 43. ISSN 0024-4201.s 673 - 679.s doi: 10.1007/s11745-008-3193-2.

  • Notø, Ann-Trude With; Mathiesen, Ellisiv B.; Brox, jan; Bjoerkegren, J; Hansen, John-Bjarne. Delayed metabolism of postprandial triglyceride-rich lipoproteins in subjects with echolucent carotid plaques. Lipids 2008; Volum 43. ISSN 0024-4201.s 353 - 360.s doi: 10.1007/s11745-008-3159-4.

  • Nystad, Tove; Utsi, Egil; Selmer, Randi Marie; Brox, Jan; Melhus, Marita; Lund, Eiliv. Distribution of apoB/apoA-1 ratio and blood lipids in Sami, Kven and Norwegian populations: the SAMINOR study. International Journal of Circumpolar Health 2008; Volum 67 (1). ISSN 1239-9736.s 67 - 81.

  • Vik, Anders; Mathiesen, Ellisiv B.; Notø, Ann-Trude With; Sveinbjørnsson, Baldur; Brox, jan; Hansen, John-Bjarne. Serum osteoprotegerin is inversely associated with carotid plaque echogenicity in humans. Atherosclerosis 2007; Volum 191. ISSN 0021-9150.s 128 - 134.s doi: 10.1016/j.atherosclerosis.2006.03.002.

  • Melbye, Hasse; Halvorsen, Dag; Hartz, Ingeborg; Medbø, Astri; Brox, jan; Eggen, Anne Elise; Njølstad, Inger. Bronchial airflow limitation, smoking, body mass index, and statin use are strongly associated with the C-reactive protein level in the elderly. The Tromso Study 2001. Respiratory Medicine 2007; Volum 101 (12). ISSN 0954-6111.s 2541 - 2547.s doi: 10.1016/j.rmed.2007.07.018.

  • Elvevoll, Edel Oddny; Barstad, Harald; Breimo, Einar Sigurd; Brox, Jan; Eilertsen, Karl-Erik; Lund, Trine; Olsen, Jan Ole; Østerud, Bjarne. Enhanced Incorporation of n-3 Fatty Acids from fish Compared with fish Oil. Lipids 2006; Volum 41. ISSN 0024-4201.s 1109 - 1114.s doi: 10.1007/s11745-006-5060-3.

  • Averina, Maria; Nilssen, Odd-Ragnar; Arkhipovsky, VL; Kalinin, AG; Brox, Jan. C-reactive protein and alcohol consumption: Is there a U-shaped association? Results from a population-based study in Russia - The Arkhangelsk study. Atherosclerosis 2006; Volum 188. ISSN 0021-9150.s 309 - 315.

  • Vik, Anders; Mathiesen, Ellisiv B.; Notø, Ann-Trude With; Sveinbjørnsson, Baldur; Brox, Jan; Hansen, John-Bjarne. Serum osteoprotegerin is inversely associated with carotid plaque echogenicity in humans. Atherosclerosis 2006. ISSN 0021-9150.

  • Nilssen, Odd-Ragnar; Averina, Maria; Brenn, Tormod; Brox, Jan; Kalinin, A; Archipovski, V. Alcohol consumption and its relation to risk factors for cardiovascular disease in the north-west of Russia: the Arkhangelsk study. International Journal of Epidemiology 2005; Volum 34. ISSN 0300-5771.s 781 - 788.

  • Averina, Maria; Nilssen, Odd-Ragnar; Brenn, tormod; Brox, Jan; Arkhypovsky, VL; Kalinin, AG. Social and lifestyle determinants of depression, anxiety, sleeping disorders and self-evaluated quality of life in Russia. A population-based study in Arkhangelsk. Social Psychiatry and Psychiatric Epidemiology 2005 (40). ISSN 0933-7954.s 511 - 518.

  • Averina, Maria; Nilssen, Odd; Brenn, Tormod; Brox, Jan; Arkhipovsky, VL; Kalinin, AG. Factors behind the increase in cardiovascular mortality in Russia: Apolipoprotein AI and B distribution in the Arkhangelsk study 2000. Clinical Chemistry 2004; Volum 50. ISSN 0009-9147.s 346 - 354.

  • Melbye, Hasse; Hvidsten, Dag; Holm, Arne; Nordbo, SA; Brox, Jan. The course of C-reactive protein response in untreated upper respiratory tract infection. British Journal of General Practice 2004; Volum 54. ISSN 0960-1643.s 653 - 658.

  • Eilertsen, Karl-Erik; Olsen, Jan Ole; Brox, Jan; Østerud, Bjarne. Association of the -159 C --> T polymorphism in the CD14 promoter with variations in serum lipoproteins in healthy subjects. Blood Coagulation and Fibrinolysis 2003; Volum 14 (7). ISSN 0957-5235.s 663 - 670.

  • Brox, Jan; Bjørnstad, Eyvin; Olaussen, Kirsten. Hemoglobin, iron, nutrition and lifstyle among adolescents in a coastal and an inland community in Nothern Norway. (omtale) International Journal of Circumpolar Health 2003; Volum 62 (2). ISSN 1239-9736.s 130 - 141.

  • Brox, Jan; Bjørnstad, Eyvin. Blood lipids, fatty acids, diet and lifestyre parameters in adolescents from a region i nothern Norway with a high mortality from coronary heart disease. European Journal of Clinical Nutrition 2002; Volum 56. ISSN 0954-3007.s 694 - 700.

  • Brox, Jan; Bjørnstad, Eyvin; Olaussen, Kirsten. A long-term seal- and cod liver oil supplementation in hypercholesterolemic subjects. Lipids 2001; Volum 36 (1). ISSN 0024-4201.s 7 - 13.

  • Brox, Jan; Olaussen, Kirsten; Østerud, Bjarne; Elvevoll, Edel Oddny; Bjørnstad, Eivin; Brenn, Tormod; Brattebø, Guttorm; Iversen, Hanne. A long-term seal- and cod-liver-oil supplementation in hypercholesterolemic subjects. Lipids 2001; Volum 36 (1). ISSN 0024-4201.s 7 - 13.s doi: 10.1007/s11745-001-0661-4.

  • Brox, Jan; Huber, Sandra. Etterlyser mer forskning på hvordan miljøgifter påvirker barn. 2017.

  • Averina, Maria; Huber, Sandra; Brox, Jan; Furberg, Anne-Sofie. Serum Perfluoroalkyl substances (PFAS)in schoolchildren from Northern Norway: dietary impact.. 7th International Conference on Environmental Pollution and Remeditation (ICEPR'17) 2017-06-06 - 2017-06-08 2017.

  • Huber, Sandra; Averina, Maria; Njølstad, Inger; Furberg, Anne-Sofie; Bolann, Bjørn Johan; Kjær, Mette; Brox, Jan. Perfluoroalkyl substances in different cohorts from North Norway. International Conference on Arctic Science: Bringing Knowledge to Action 2017-04-24 - 2017-04-27 2017.

  • Huber, Sandra; Brox, Jan. Litt om miljøgifter i mennesker og Miljøgiftlaboratoriet ved Universitetssykehuset i Nord Norge. NSMB nettundervisning 2016-06-01 - 2016.

  • Huber, Sandra; Warner, Nicholas Alexander; Nøst, Therese Haugdahl; Brox, Jan. Atmospheric pressure gas chromatography triple quadrupole mass spectrometry for trace analysis of legacy POPs in epidemiological studies. Det 15. norske seminar i massespektrometri 2015-01-18 - 2015-01-21 2015.

  • Flaten, Magne; Aslaksen, Per M; BjØrkedal, espen; Brox, Jan; Lyby, Peter Solvoll. The role of experimenter gender in placebo analgesia.. Meeting of the Society for Psychophysiological Research 2015-09-30 - 2016-10-04 2015.

  • Flaten, Magne Arve; Aslaksen, Per M; Brox, Jan; Lyby, Peter Solvoll; BjØrkedal, espen. THE ROLE OF EXPERIMENTER GENDER IN PLACEBO ANALGESIA. Society for Psychophysiological Research meeting 2015-09-30 - 2015-10-04 2015.

  • Huber, Sandra; Brox, Jan. Automated high-throughput sample preparation method for analysis of perfluoroalkyl substances in human serum and plasma by UHPLC-MS/MS. International Symposium on Chromatography 2014-09-14 - 2014-09-18 2014.

  • Huber, Sandra; Warner, Nicholas Alexander; Nøst, Therese Haugdahl; Brox, Jan. Atmospheric pressure gas chromatography triple quadrupole mass spectrometry as a powerful tool for trace analysis of legacy POPs in epidemiological studies. International Symposium on Chromatography 2014-09-14 - 2014-09-18 2014.

  • Huber, Sandra; Warner, Nicholas Alexander; Nøst, Therese Haugdahl; Brox, Jan. Atmospheric pressure gas chromatography triple quadrupole mass spectrometry as a powerful tool for trace analysis of pesticides in epidemiological studies. Nordic Environmental Chemistry Conference 2014-07-11 - 2014-07-13 2014.

  • Huber, Sandra; Warner, Nicholas Alexander; Nøst, Therese Haugdahl; Brox, Jan. The Analysis of DDTs and Chlordanes and their Metabolites by Gas Chromatography Tandem Mass Spectrometry: Comparing Atmospheric Pressure Ionisation with Electron Impact and Chemical Ionisation. XXXVIII Colloquium Spectroscopium Internationale 2013-06-16 - 2013-06-20 2013.

  • Vik, Anders; Isaksen, vidar; Brox, Jan; Hansen, John-Bjarne. Ei kvinne i 50-åra med hovudverk, uklart syn og utslett. Tidsskrift for Den norske legeforening 2012; Volum 132 (10). ISSN 0029-2001.s 1246 - 1248.s doi: 10.4045/tidsskr.11.1056.

  • Huber, Sandra; Sandanger, Torkjel M; Brox, Jan; Figenschau, Yngve Anton. Persistent organic pollutants in human plasma of males from two communities in northern Norway. Organohalogen Compounds 2006; Volum 68. ISSN 1026-4892.s 1601 - 1604.

  • Huber, Sandra; Sandanger, Torkjel M; Brox, Jan; Figenschau, Yngve Anton. Persistent organic pollutants in human plasma of males from two communities in northern Norway. 26th International Symposium on Halogenated Persistent Organic Pollutants - Dioxin 2006 2006-08-21 - 2006-08-25 2006.

  • Vik, A; Mathiesen, Ellisiv B; Notø, Ann-Trude With; Sveinbjørnsson, Baldur; Brox, Jan; Hansen, John-Bjarne. Serum osteoprotegerin is inversely associated with carotid plaque echogenicity in humans. Atherosclerosis Supplements 2005; Volum 6. ISSN 1567-5688.s 91 - 91.

  • Østerud, Bjarne; Elvevoll, Edel Oddny; Breimo, Einar Sigurd; Brox, jan; Eilertsen, Karl-Erik; Lund, Trine; Olsen, Jan Ole. The Eskimo Diet: More Than Omega-3 Fatty Acids. Journal of Thrombosis and Haemostasis 2005; Volum 3. ISSN 1538-7933.

  • Østerud, Bjarne; Brox, jan; Breimo, Einar Sigurd; Eilertsen, Karl-Erik; Elvevoll, Edel Oddny; Lund, Trine; Olsen, Jan Ole. Interleukin-8 (IL-8) Generation in Whole Blood Is Related to Markers of Atherosclerosis. Journal of Thrombosis and Haemostasis 2005; Volum 3. ISSN 1538-7933.

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