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Head of Department

Gunbjørg Svineng

Head of Department
Department of Medical Biology

Job description:

Head of Department, Department of Medical Biology, 1st of Aug 2017-31st of Dec 2017.

Professor at Tumor Biology Research Group.

https://orcid.org/0000-0002-5947-5647




Research interests

Tumorbiology

Extracellular matrix degrading enzymes; uPAR and MMPs

Cell adhesion molecules; Integrins

Extracellular matrix proteins; Nephronectin

Metastasis related proteins; S100A4

CV

Head of Department, Department of Medical Biology, Faculty of Health Sciences, 1.08.2017-31.12.2017. 

Affiliated Sydney University, Charles Perkins Center and ANZAC Research Institute, Australia, 2016-2017.

Head of Tumor Biology Research Group, 2015-2016.

Visiting researcher at the Peter MacCallum Cancer Centre, Melbourne, Australia. 2010-2011.

Deputy leader Education, Department of Medical Biology, University of Tromsø from 2009-2016.

Leader Section of Medical Biochemistry 2006-2009.

Associate Professor in Medical Biochemistry at the Department of Medical Biology, University of Tromsø from 2005.

Researcher in Marine Biotechnology, The Norwegian College of Fishery Sciences, University of Tromsø from 2004-2005.

Post.doc. in the Molecular Cancer Research Group, Department of Medical Biology, University of Tromsø from 2001-2004. Supervisor: Prof. Terje Johansen.

PhD in Medical Sciences in 1999 from the Univeristy of Uppsala, Sweden. Supervisor: Prof. Staffan Johansson.

Master of Science, Molecular Biology, in 1993 from the Department of Medical Biology, University of Tromsø, Norway. Supervisor: Prof. Terje Johansen.

 

Publications in CRIStin


  • Toraskar, Jimita Prashant; Norvoll Magnussen, Synnøve; Hagen, Lars; Sharma, Animesh; Hoang, Linh; Bjørkøy, Geir; Svineng, Gunbjørg; Steigedal, Tonje S.. A Novel Truncated Form of Nephronectin Is Present in Small Extracellular Vesicles Isolated from 66cl4 Cells. (fulltekst) Journal of Proteome Research 2019; Volum 18 (3). ISSN 1535-3893.s 1237 - 1247.s doi: 10.1021/acs.jproteome.8b00859.

  • Solon-Biet, Samantha Marie; Cogger, Victoria Carroll; Pulpitel, Tamara; Wahl, Devin; Clark, Ximonie; Bagley, Elena E.; Gregoriou, Gabrielle C.; Senior, Alistair M.; Wang, Qiao-Ping; Brandon, Amanda E.; Perks, Ruth; O'Sullivan, John; Koay, Yen Chin; Bell-Anderson, Kim; Kebede, Melkam; Yau, Belinda; Atkinson, Clare; Svineng, Gunbjørg; Dodgson, Tim; Wali, Jibran A.; Piper, Matthew D.W.; Juricic, Paula; Partridge, Linda; Rose, Adam J.; Raubenheimer, David; Cooney, Gregory J.; Le Couteur, David George; Simpson, Stephen James. Branched-chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control. Nature Metabolism 2019; Volum 1 (5).s 532 - 545.s doi: 10.1038/s42255-019-0059-2.

  • Steigedal, Tonje S.; Toraskar, Jimita Prashant; Redvers, Richard P.; Valla, Marit; Magnussen, Synnøve; Bofin, Anna M.; Opdahl, Signe; Lundgren, Steinar; Eckhardt, Bedrich L.; Lamar, John Michael; Doherty, Judy; Hynes, Richard O.; Anderson, Robin L.; Svineng, Gunbjørg. Nephronectin is Correlated with Poor Prognosis in Breast Cancer and Promotes Metastasis via its Integrin-Binding Motifs. (fulltekst) Neoplasia 2018; Volum 20 (4). ISSN 1522-8002.s 387 - 400.s doi: 10.1016/j.neo.2018.02.008.

  • Toraskar, Jimita Prashant; Magnussen, Synnøve; Chawla, Konika; Svineng, Gunbjørg; Steigedal, Tonje S.. Nephronectin mediates p38 MAPK‐induced cell viability via its integrin binding enhancer motif. FEBS Open Bio 2018; Volum 8 (12). ISSN 2211-5463.s 1992 - 2001.s doi: 10.1002/2211-5463.12544.

  • Sylte, Ingebrigt; Dawadi, Rangita; Malla, Nabin; von Hofsten, Susannah; Nguyen, Tra-Mi; Solli, Ann Iren; Berg, Eli; Adekoya, Olayiwola; Svineng, Gunbjørg; Winberg, Jan-Olof. The selectivity of galardin and an azasugar-based hydroxamate compound for human Matrix metalloproteases and bacterial metalloproteases. PLOS ONE 2018; Volum 13 (8). ISSN 1932-6203.s doi: 10.1371/journal.pone.0200237.

  • Magnussen, Synnøve; Hadler-Olsen, Elin Synnøve; Costea, Daniela Elena; Berg, Eli; Cavalcanti Jacobsen, Cristiane de Albuquerque; Mortensen, Bente; Salo, Tuula; Martinez, Inigo Zubiavrre; Winberg, Jan-Olof; Uhlin-Hansen, Lars; Svineng, Gunbjørg. Cleavage of the urokinase receptor (uPAR) on oral cancer cells: Regulation by transforming growth factor - beta1 (TGF-beta1) and potential effects on migration and invasion. BMC Cancer 2017; Volum 17. ISSN 1471-2407.s doi: 10.1186/s12885-017-3349-7.

  • Åström, Pirjo; Juurikka, Krista; Hadler-Olsen, Elin Synnøve; Svineng, Gunbjørg; Cervigne, Nilva K.; Coletta, Ricardo D.; Risteli, Juha; Kauppila, Joonas H.; Skarp, Sini; Kuttner, Samuel; Oteiza, Ana; Sutinen, Meeri; Salo, Tuula. The interplay of matrix metalloproteinase-8, transforming growth factor-β1 and vascular endothelial growth factor-C cooperatively contributes to the aggressiveness of oral tongue squamous cell carcinoma. British Journal of Cancer 2017; Volum 117 (7). ISSN 0007-0920.s 1007 - 1016.s doi: 10.1038/bjc.2017.249.

  • Rikardsen, Oddveig G; Magnussen, Synnøve; Svineng, Gunbjørg; Hadler-Olsen, Elin Synnøve; Uhlin-Hansen, Lars; Steigen, Sonja Eriksson. Plectin as a prognostic marker in non-metastatic oral squamous cell carcinoma. BMC Oral Health 2015; Volum 15:98. ISSN 1472-6831.s doi: 10.1186/s12903-015-0084-9.

  • Magnussen, Synnøve; Rikardsen, Oddveig G; Hadler-Olsen, Elin Synnøve; Uhlin-Hansen, Lars; Steigen, Sonja Eriksson; Svineng, Gunbjørg. Urokinase Plasminogen Activator Receptor (uPAR) and Plasminogen Activator Inhibitor-1 (PAI-1) are potential predictive biomarkers in early stage Oral Squamous Cell Carcinomas (OSCC). PLOS ONE 2014; Volum 9:e101895 (7). ISSN 1932-6203.s doi: 10.1371/journal.pone.0101895.

  • Magnussen, Synnøve; Hadler-Olsen, Elin Synnøve; Latysheva, Nadezhda; Pirila, Emma; Steigen, Sonja Eriksson; Hanes, Robert; Salo, Tuula; Winberg, Jan-Olof; Uhlin-Hansen, Lars; Svineng, Gunbjørg. Tumour Microenvironments Induce Expression of Urokinase Plasminogen Activator Receptor (uPAR) and Concomitant Activation of Gelatinolytic Enzymes. PLOS ONE 2014; Volum 9:e0105929 (8). ISSN 1932-6203.s doi: 10.1371/journal.pone.0105929.

  • Ravuri, Chandra Sekhar; Svineng, Gunbjørg; Huseby, nils-erik. Differential regulation of gamma-glutamyltransferase and glutamate cysteine ligase expression after mitochondrial uncoupling: gamma-glutamyltransferase is regulated in an Nrf2- and NF kappa B-independent manner. Free radical research 2013; Volum 47 (5). ISSN 1071-5762.s 394 - 403.s doi: 10.3109/10715762.2013.781270.

  • Malla, Nabin; Berg, Eli; Theocharis, Achilleas D.; Svineng, Gunbjørg; Uhlin-Hansen, Lars; Winberg, Jan-Olof. Invitro reconstitution of complexes between pro-matrix metalloproteinase-9 and the proteoglycans serglycin and versican. The FEBS Journal 2013; Volum 280 (12). ISSN 1742-464X.s 2870 - 2887.s doi: 10.1111/febs.12291.

  • Ausbacher, Dominik; Svineng, Gunbjørg; Hansen, Terkel; Strøm, Morten B.. Anticancer mechanisms of action of two small amphipathic beta(2,2)-amino acid derivatives derived from antimicrobial peptides. Biochimica et Biophysica Acta - Biomembranes 2012; Volum 1818 (11). ISSN 0005-2736.s 2917 - 2925.s doi: 10.1016/j.bbamem.2012.07.005.

  • Fadnes, Bodil Irene; Husebekk, Anne; Svineng, Gunbjørg; Rekdal, Øystein; Yanagishita, Masaki; Kolset, Svein Olav; Uhlin-Hansen, Lars. The proteoglycan repertoire of lymphoid cells. Glycoconjugate Journal 2012; Volum 29 (7). ISSN 0282-0080.s 513 - 523.s doi: 10.1007/s10719-012-9427-9.

  • Svineng, Gunbjørg; Magnussen, Synnøve; Hadler-Olsen, Elin Synnøve. Plasmin and the plasminogen activator system in health and disease. Walter de Gruyter 2012 ISBN 978-3-11-025876-9.s 261 - 290.

  • Ravuri, Chandra Sekhar; Svineng, Gunbjørg; Pankiv, Serhiy; Huseby, nils-erik. Endogenous production of reactive oxygen species by the NADPH oxidase complexes is a determinant of gamma gamma-glutamyltransferase expression. Free radical research 2011; Volum 45 (5). ISSN 1071-5762.s 600 - 610.s doi: 10.3109/10715762.2011.564164.

  • Ljones, Hilde; Hadler-Olsen, Elin Synnøve; Magnussen, Synnøve; Rikardsen, Oddveig G; Steigen, sonja eriksson; Sundkvist, elisabeth; Loennechen, Thrina; Kanapathippillai, Premasany; Kildalsen, hanne; Winberg, Jan-Olof; Uhlin-Hansen, Lars; Svineng, Gunbjørg. S100A4 Expression in Xenograft Tumors of human carcinoma cell lines is induced by the tumor microenvironment. American Journal of Pathology 2011; Volum 178 (5). ISSN 0002-9440.s 2389 - 2396.s doi: 10.1016/j.ajpath.2011.01.022.

  • Hadler-Olsen, Elin Synnøve; Ljones, Hilde; Ravuri, Chandra Sekhar; Omair, Ahmad; Rikardsen, Oddveig G; Svineng, Gunbjørg; Kanapathippillai, Premasany; Winberg, Jan-Olof; Uhlin-Hansen, Lars. Organ specific regulation of tumour invasiveness and gelatinolytic activity at the invasive front. European Journal of Cancer 2011; Volum 47 (2). ISSN 0959-8049.s 305 - 315.s doi: 10.1016/j.ejca.2010.09.006.

  • Hadler-Olsen, Elin Synnøve; Kanapathippillai, Premasany; Berg, Eli; Svineng, Gunbjørg; Winberg, Jan-Olof; Uhlin-Hansen, Lars. Gelatin In Situ Zymography on Fixed, Paraffin-embedded Tissue: Zinc and Ethanol Fixation Preserve Enzyme Activity. Journal of Histochemistry and Cytochemistry 2010; Volum 58 (1). ISSN 0022-1554.s 29 - 39.s doi: 10.1369/jhc.2009.954354.

  • Hadler-Olsen, Elin Synnøve; Ljones, Hilde; Rikardsen, Oddveig G; Steigen, Sonja Eriksson; Kanapathippillai, Premasany; Grenman, Reidar; Winberg, Jan-Olof; Svineng, Gunbjørg; Uhlin-Hansen, Lars. Stromal impact on tumor growth and lymphangiogenesis in human carcinoma xenografts. Virchows Archiv 2010; Volum 457 (6). ISSN 0945-6317.s 677 - 692.s doi: 10.1007/s00428-010-0980-y.

  • Huseby, nils-erik; Sundkvist, elisabeth; Svineng, Gunbjørg. Glutathione and Sulfur Containing Amino Acids: Antioxidant and Conjugation Activities. John Wiley & Sons 2009 ISBN 978-0-470-17085-4.s 93 - 120.

  • Larsen, Atle Noralf; Solstad, Terese; Svineng, Gunbjørg; Seppola, Marit; Jørgensen, Trond Ø.. Molecular characterisation of a goose-type lysozyme gene in Atlantic cod (Gadus morhua L.). Fish and Shellfish Immunology 2009; Volum 26 (1). ISSN 1050-4648.s 122 - 132.s doi: 10.1016/j.fsi.2008.03.021.

  • Elenjord, Renate; Allen, Jasmine Blue; Johansen, Harald Thidemann; Johansen, Harald T.; Kildalsen, hanne; Svineng, Gunbjørg; Mælandsmo, Gunhild; Loennechen, Thrina; Winberg, Jan-Olof. Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4. The FEBS Journal 2009; Volum 276 (18). ISSN 1742-464X.s 5275 - 5286.s doi: 10.1111/j.1742-4658.2009.07223.x.

  • Svineng, Gunbjørg; Ravuri, Chandra Sekhar; Rikardsen, Oddveig G; Huseby, Nils-Erik; Winberg, Jan-Olof. The role of reactive oxygen species in integrin and matrix metalloproteinase expression and function. Connective Tissue Research 2008; Volum 49. ISSN 0300-8207.s 197 - 202.s doi: 10.1080/03008200802143166.

  • Sjøttem, Eva; Rekdal, Cecilie; Svineng, Gunbjørg; Johnsen, Sylvia sagen; Klenow, Helle Bagterp; Uglehus, Rebecca dale; Johansen, Terje. The ePHD protein SPBP interacts with TopBP1 and together they co-operate to stimulate Ets1-mediated transcription. Nucleic Acids Research 2007; Volum 35 (19). ISSN 0305-1048.s 6648 - 6662.s doi: 10.1093/nar/gkm739.

  • Politz, Oliver; Gratchev, Alexei; McCourt, Peter Anthony; Schledzewski, Kai; Guillot, Pierre; Johansson, Sophie; Svineng, Gunbjørg; Franke, Paul; Kannicht, Catherine; Welten, Florian; Johansson, Staffan; Goerdt, Sergej. Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues. Biochemical Journal 2002; Volum 362. ISSN 0264-6021.s 155 - 164.

  • Anderssen, Sølvi; Sjøttem, Eva; Svineng, Gunbjørg; Johansen, Terje. Comparative Analyses of LTRs of the ERV-H Family of Primate-Specific Retrovirus-like ELements Isolated from Marmoset, African Green Monkey, and Man. Virology 1997; Volum 234. ISSN 0042-6822.s 14 - 30.

  • Magnussen, Synnøve; Toraskar, Jimita Prashant; Wilhelm, Imola; Hasko, Janos; Figenschau, Stine; Molnar, Judith; Seppola, Marit; Steigen, Sonja Eriksson; Steigedal, Tonje S.; Hadler-Olsen, Elin Synnøve; Anderson, Robin L.; Krizbai, Istvan; Svineng, Gunbjørg. Nephronectin promotes breast cancer brain metastatic colonization via its integrin-binding domains. 21st International Symposium on Signal Transduction at the Blood-Brain Barriers 2018-09-19 - 2018-09-21 2018.

  • Magnussen, Synnøve; Toraskar, Jimita Prashant; Wilhelm, Imola; Hasko, Janos; Figenschau, Stine; Molnar, Judith; Seppola, Marit; Steigen, Sonja Eriksson; Steigedal, Tonje S.; Hadler-Olsen, Elin Synnøve; Krizbai, Istvan; Svineng, Gunbjørg. Nephronectin (Npnt) promotes breast cancer brain metastasis via its integrin binding domains. European Association for Cancer Research (EACR) Meeting 2017-11-27 - 2017-11-29 2017.

  • Magnussen, Synnøve; Wilhelm, Imola; Hasko, Janos; Molnar, Judith; Seppola, Marit; Hadler-Olsen, Elin Synnøve; Krizbai, Istvan; Svineng, Gunbjørg. The metastasis-promoting protein Nephronectin. Regional Helseforskningskonferanse 2016-11-02 - 2016-11-03 2016.

  • Svineng, Gunbjørg; Larsen, Terje Steinar. Bli ekspert på menneskekroppen og få en trygg og viktig jobb!. 2015.

  • Wirsing, Anna Maria; Solli, Ann Iren; Svineng, Gunbjørg; Winberg, Jan-Olof; Hadler-Olsen, Elin Synnøve. Intracellular Matrix Metalloproteinase-2 in skeletal muscle - a 3D skeletal muscle tissue engineering approach -. The 7th National PhD Conference in Medical Imaging 2015-11-16 - 2015-11-17 2015.

  • Wirsing, Anna Maria; Solli, Ann Iren; Svineng, Gunbjørg; Winberg, Jan-Olof; Hadler-Olsen, Elin Synnøve. Intracellular Matrix Metalloproteinase-2 in skeletal muscle: effect of glucose and oxidative stress. Gordon Research Conference on Matrix Metalloproteinases 2015-08-02 - 2015-08-07 2015.

  • Steigedal, Tonje Strømmen; Redvers, Richard; Eckhardt, Bedrich; Lamar, John Michael; Doherty, Judy; Hynes, Richard O.; Anderson, Robin; Svineng, Gunbjørg. The extracellular matrix protein Nephronectin (Npnt) promotes metastasis via its integrin binding domains. The 15th biennial Metastasis Research Congress 2014-06-28 - 2014-07-01 2014.

  • Svineng, Gunbjørg; Magnussen, Synnøve; Hadler-Olsen, Elin Synnøve; Latysheva, Nadezhda; Pirila, Emma; Steigen, Sonja Eriksson; Hanes, Robert; Jacobsen, Cristiane Cavalcanti; Berg, Eli; Salo, Tuula; Winberg, Jan-Olof; Uhlin-Hansen, Lars. Stromal induced expression of uPAR. Matrix Metalloproteinases Crucial Components of Molecular Networks and Disease Pathways 2013-05-19 - 2013-05-24 2013.

  • Steigedal, Tonje; Svineng, Gunbjørg; Redvers, Richard; Eckhardt, Bedrich; Lamar, John M.; Doherty, Judy; Hynes, Richard O.; Anderson, Robin. Cellular interactions with the extracellular matrix of tumor microenvironment. Ingrid S. Gribbestad Memorial 2013-09-11 - 2013-09-13 2013.

  • Redvers, Richard; Svineng, Gunbjørg; Eckhardt, Bedrich; Pouliot, Normand; Stanley, Keith; Reichardt, Louis; Adams, Tim; Smith, Yvonne; Anderson, Robin. The role of the extracellular matrix molecule Nephronectin/POEM in breast cancer metastasis. Lorne Cancer Conference 2011-02-10 - 2011-02-12 2011.

  • Hadler-Olsen, Elin Synnøve; Ravuri, Chandra Sekhar; Wetting, Hilde Ljones; Rikardsen, Oddveig G; Steigen, sonja eriksson; Svineng, Gunbjørg; Winberg, Jan-Olof; Uhlin-Hansen, Lars. Stromal Impact on Tumor Invasiveness and Gelatinolytic Activity at the Invasive Front. FEBS Advanced Lecture Course 2011matrix Pathobiology, Signalling and Molecular Targets 2011-09-02 - 2011-09-07 2011.

  • Ausbacher, Dominik; Hansen, Terkel; Svineng, Gunbjørg; Strøm, Morten B.. Mechanisms of cancer cell death induced by two novel cationic beta-peptidomimetics. Biopolymers 2011; Volum 96 (4). ISSN 0006-3525.s 456 - 457.

  • Ausbacher, Dominik; Hansen, Terkel; Svineng, Gunbjørg; Strøm, Morten B.. Mechanisms of cancer cell death induced by two novel cationic β-peptidomimetics. American Peptide Symposium 2011-06-25 - 2011-06-30 2011.

  • Hadler-Olsen, Elin Synnøve; Ljones, Hilde; Rikardsen, O; Steigen, sonja eriksson; Winberg, Jan-Olof; Svineng, Gunbjørg; Uhlin-Hansen, Lars. Stromal impact on tumor growth and lymphangiogenesis in human carcinoma xenografts. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS) 2010; Volum 118 (3). ISSN 0903-4641.s 245 - 245.

  • Sjøli, Stian; Adekoya, Olayiwola; Jiang, Yang; Akselsen, O; Hansen, VT; Svineng, Gunbjørg; Sylte, Ingebrigt; Winberg, Jan-Olof. Novel Inhibitors of Matrix Metalloprotease-9 and-14. The FEBS Journal 2010; Volum 277. ISSN 1742-464X.s 265 - 265.

  • Hadler-Olsen, Elin Synnøve; Ravuri, Chandra Sekhar; Ljones, Hilde; Rikardsen, Oddveig G; Steigen, sonja eriksson; Svineng, Gunbjørg; Winberg, Jan-Olof; Uhlin-hansen, lars. Organ specific stromal influence on tumor invasiveness and proteolytic activity at the invasive front. European Journal of Cancer 2010. ISSN 0959-8049.s doi: 10.1111/j.1600-0463.2009.02578.x.

  • Ravuri, Chandra Sekhar; Magnussen, Synnøve; Winberg, Jan-Olof; Huseby, Nils-Erik; Svineng, Gunbjørg. The effect of elevated levels of reactive oxygen species on oral squamous carcinoma cell adhesion and invasion. FEBS Advanced lecture Course, Matrix Pathobiology, Signaling and Molecular targets 2007-05-21 - 2007-05-26 2007.

  • Larsen, Atle Noralf; Helland, Ronny; Svineng, Gunbjørg; Jørgensen, Trond Ø.. Identification, cloning and recombinant expression of a goose-type lysozyme from Atlantic cod (Gadus Morhua). The 7th Nordic symposium on Fish Immunology 2007-06-18 - 2007-06-22 2007.

  • Sjøttem, Eva; Klenow, Helle Bagterp; Rekdal, Cecilie; Svineng, Gunbjørg; Johnsen, Sylvia Sagen; Uglehus, Rebecca Dale; Johansen, Terje. SPBP and TopBP1: Modulators of Androgen Receptor Activity. 7th EMBL Transcription Meeting 2006-08-26 - 2006-08-30 2006.

  • Klenow, Helle Bagterp; Rekdal, Cecilie; Svineng, Gunbjørg; Sjøttem, Eva; Uglehus, Rebecca Dale; Johansen, Terje. SPBP and TopBP1 interact to enhance Ets-mediated activation of the c-myc promoter. Lorne meeting 2006-02-10 - 2006.

  • Svineng, Gunbjørg. Genetic modifications of oral cancer cell lines. Annual meeting for the Tumor Biology Research Group 2006-11-14 - 2006-11-15 2006.

  • Member of research group