Research interests

My research activity focuses on alterations in myocardial metabolism during obesity and type 2 diabetes and how such changes may influence the mechanical function of the heart, using the genetically diabetic (db/db) mouse, as well as diet-induced obese mice and rats as diabetic models. We have demonstrated marked changes in cardiac metabolism in these animals, with a clear over-reliance on fatty acid oxidation for energy production and a corresponding reduction in glucose oxidation. In addition, they show cardiomyopathy and/or reduced cardiac efficiency (the relationship between cardiac work and oxygen consumption), as well as reduced tolerance to ischemia-reperfusion.

We are investigating possible mechanisms of diabetes-induced cardiac dysfunction, hypothesizing that the metabolic disorders accompanying the diabetic state play a central role in the development of cardiac disease. Of particular interest is the transcriptional regulation of myocardial substrate supply and utilization via activation of the nuclear peroxisome proliferator-activated receptors (PPARs) - both in the heart, adipose tissue and liver. Current experimental activity includes use of various (lipid-lowering) PPAR agonists, exercise training and dietary modifications of metabolism to determine its impact on the mechanical function of the heart.

CV

Name: Terje Steinar Larsen

Present position and address: Professor, Cardiovascular Research Group, Institute of Medical Biology, University of Tromsø, N-9037 Tromsø, Norway.

Born: April 18, 1950, 8432 Alsvåg, Norway.

Status: Married, three children.

Private address: Ryllikveien 47, 9100 Kvaløysletta, Norway

Education:

1972-1976: University of Tromsø, Norway; Bachelor of Science

1976-1978: University of Tromsø, Norway; Master of Science

1978-1985: University of Tromsø, Norway; PhD

Professional experience and research positions:

1978-1980: Research Fellow (Department of Medical Physiology, University of Tromsø)

1980-1985: Research Fellow (Norwegian Research Council for Science and the Humanities), Department of Arctic Biology, University of Tromsø

1985-1986: Postdoctoral Fellow (Alberta Heritage Foundation for Medical Research), Faculty of Medicine, The University of Calgary, Canada

1986-1990: Postdoctoral Fellow (Norwegian Research Council), Department of Medical Physiology, University of Tromsø

1990-1992: Associate professor, Department of Medical Physiology, University of Tromsø

1992-1996: Professor, Chairman, Department of Medical Physiology, University of Tromsø

1996-1997: Sabbatical stay at The Faculty of Medicine, The University of Calgary, Canada

1997-present: Professor, Department of Medical Physiology, University of Tromsø.

1998-2005: Professor, Department of Medical Physiology, University of Tromsø/Chairman, Institute of Medical Biology, University of Tromsø.

1998-present: Professor & Chairman, Department of Medical Physiology, University of Tromsø

2009-present: Professor, Cardiovascular Research Group IMB; Chairman, Institute of Medical Biology, University of Tromsø.

Publications in CRIStin


  • Jansen, Kirsten; Moreno, Sonia; Garcia-Roves, Pablo M; Larsen, Terje. Dietary calanus oil recovers metabolic flexibility and rescues postischemic cardiac function in obese female mice. American Journal of Physiology. Heart and Circulatory Physiology 2019; Volum 317 (2). ISSN 0363-6135.s H290 - H299.s doi: 10.1152/ajpheart.00191.2019.

  • Moldes-Anaya, Angel; Sæther, Thomas; Uhlig, Silvio; Nebb, Hilde Irene; Larsen, Terje; Eilertsen, Hans Christian; Paulsen, Steinar Martin. Two Isomeric C16 Oxo-Fatty Acids from the Diatom Chaetoceros karianus Show Dual Agonist Activity towards Human Peroxisome Proliferator-Activated Receptors (PPARs) α/γ. (fulltekst) Marine Drugs 2017; Volum 15 (148). ISSN 1660-3397.s doi: 10.3390/md15060148.

  • Salma, Wahida; Franeková, Veronika; Lund, trine; Höper, Anje Christina; Ludvigsen, Stian; Lund, Jim; Aasum, Ellen; Ytrehus, Kirsti; Belke, Darrell D.; Larsen, Terje. Dietary Calanus oil antagonizes angiotensin II-induced hypertension and tissue wasting in diet-induced obese mice. Prostaglandins, Leukotrienes and Essential Fatty Acids 2016; Volum 108. ISSN 0952-3278.s 13 - 21.s doi: 10.1016/j.plefa.2016.03.006.

  • Cook, Chad M.; Larsen, Terje; Derrig, Linda D.; Kelly, Kathleen M; Tande, Kurt. Wax Ester Rich Oil From The Marine Crustacean, Calanus finmarchicus, is a Bioavailable Source of EPA and DHA for Human Consumption. Lipids 2016; Volum 51 (10). ISSN 0024-4201.s 1137 - 1144.s doi: 10.1007/s11745-016-4189-y.

  • Hagve, Martin; Gjessing, Petter Fosse; Fuskevåg, Ole-Martin; Larsen, Terje S; Irtun, Øivind. Skeletal muscle mitochondria exhibit decreased pyruvate oxidation capacity and increased ROS emission during surgery-induced acute insulin resistance. American Journal of Physiology. Endocrinology and Metabolism 2015; Volum 308 (8). ISSN 0193-1849.s E613 - E620.s doi: 10.1152/ajpendo.00459.2014.

  • Franeková, Veronika; Angin, Yeliz; Hoebers, Nicole T.H.; Coumans, Will A.; Simons, Peter J.; Glatz, Jan F.C.; Luiken, Joost J.F.P.; Larsen, Terje. Marine omega-3 fatty acids prevent myocardial insulin resistance and metabolic remodeling as induced experimentally by high insulin exposure. American Journal of Physiology - Cell Physiology 2015; Volum 308 (4). ISSN 0363-6143.s C297 - C307.s doi: 10.1152/ajpcell.00073.2014.

  • Lund, Jim; Hafstad, Anne Dragøy; Boardman, Neoma Tove; Rossvoll, Line; Rolim, Natale Pinheiro Lage; Ahmed, Muhammad Shakil; Florholmen, Geir; Attramadal, Håvard; Wisløff, Ulrik; Larsen, Terje; Aasum, Ellen. Exercise training promotes cardioprotection through oxygen-sparing action in high fat-fed mice. American Journal of Physiology. Heart and Circulatory Physiology 2015; Volum 308 (8). ISSN 0363-6135.s H823 - H829.s doi: 10.1152/ajpheart.00734.2014.

  • Bakkehaug, Jens Petter; Kildal, Anders Benjamin; Engstad, Erik Torgersen; Boardman, Neoma Tove; Næsheim, Torvind; Rønning, Leif R.; Aasum, Ellen; Larsen, Terje; Myrmel, Truls; How, Ole-Jakob. Myosin activator omecamtiv mecarbil increases myocardial oxygen consumption and impairs cardiac efficiency mediated by resting myosin ATPase activity. Circulation: Heart Failure 2015; Volum 8 (4). ISSN 1941-3289.s 766 - 775.s doi: 10.1161/CIRCHEARTFAILURE.114.002152.

  • Höper, Anje Christina; Salma, Wahida; Sollie, Selene Julie; Hafstad, Anne Dragøy; Lund, Jim; Khalid, Ahmed Murtaz; Raa, Jan; Aasum, Ellen; Larsen, Terje. Wax esters from the marine copepod calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice. Journal of Nutrition 2014; Volum 144 (2). ISSN 0022-3166.s 164 - 169.s doi: 10.3945/jn.113.182501.

  • Pedersen, Alice Marie; Salma, Wahida; Höper, Anje Christina; Larsen, Terje; Olsen, Ragnar Ludvig. Lipid profile of mice fed a high-fat diet supplemented with a wax ester-rich marine oil. European Journal of Lipid Science and Technology 2014; Volum 116 (12). ISSN 1438-7697.s 1718 - 1726.s doi: 10.1002/ejlt.201400052.

  • Stenberg, Thor Allan; Kildal, Anders Benjamin; Sanden, Espen; How, Ole-Jakob; Hagve, Martin; Ytrehus, Kirsti; Larsen, Terje; Myrmel, Truls. The acute phase of experimental cardiogenic shock is counteracted by microcirculatory and mitochondrial adaptations. PLOS ONE 2014; Volum 9 (9(e105213)). ISSN 1932-6203.s doi: 10.1371/journal.pone.0105213.

  • Höper, Anje Christina; Salma, Wahida; Khalid, Ahmed Murtaz; Hafstad, Anne Dragøy; Sollie, Selene Julie; Raa, Jan; Larsen, Terje; Aasum, Ellen. Oil from the marine zooplankton Calanus finmarchicus improves the cardiometabolic phenotype of diet-induced obese mice. British Journal of Nutrition 2013; Volum 110. ISSN 0007-1145.s 2186 - 2193.s doi: 10.1017/S0007114513001839.

  • Hafstad, Anne Dragøy; Lund, Jim; Hadler-Olsen, Elin Synnøve; Höper, Anje Christina; Larsen, Terje; Aasum, Ellen. High- and Moderate-Intensity Training Normalizes Ventricular Function and Mechanoenergetics hi Mice With Diet-Induced Obesity. Diabetes 2013; Volum 62 (7). ISSN 0012-1797.s 2287 - 2294.s doi: 10.2337/db12-1580.

  • von Lueder, Thomas Gero; Gravning, Jørgen A.; How, Ole-Jakob; Vinge, Leif Erik; Ahmed, Muhammad Shakil; Krobert, Kurt Allen; Levy, Finn Olav; Larsen, Terje; Smiseth, Otto A.; Aasum, Ellen; Attramadal, Håvard. Cardiomyocyte-restricted inhibition of G protein-coupled receptor kinase-3 attenuates cardiac dysfunction after chronic pressure overload. American Journal of Physiology. Heart and Circulatory Physiology 2012; Volum 303 (1). ISSN 0363-6135.s H66 - H74.s doi: 10.1152/ajpheart.00724.2011.

  • Khalid, Ahmed Murtaz; Hafstad, Anne Dragøy; Larsen, Terje; Severson, david lester; Boardman, Neoma Tove; Hagve, Martin; Berge, Rolf Kristian; Aasum, Ellen. Cardioprotective effect of the PPAR ligand tetradecylthioacetic acid in type 2 diabetic mice. American Journal of Physiology. Heart and Circulatory Physiology 2011; Volum 300 (6). ISSN 0363-6135.s H2116 - H2122.s doi: 10.1152/ajpheart.00357.2010.

  • Larsen, Terje. Obesity and heart disease. Public Science Review: European Science & Technology 2011. ISSN 2045-3876.s 212 - 213.

  • Larsen, Terje; Ytrehus, Kirsti. Hjertets patofysiologi. Gyldendal Norsk Forlag A/S 2011 ISBN 978-82-05-39914-3.s 151 - 179.

  • Hafstad, Anne Dragøy; Boardman, Neoma Tove; Lund, Jim; Hagve, Martin; Khalid, Ahmed Murtaz; Wisløff, Ulrik; Larsen, Terje; Aasum, Ellen. High intensity interval training alters substrate utilization and reduces oxygen consumption in the heart. Journal of applied physiology 2011; Volum 111 (5). ISSN 8750-7587.s 1235 - 1241.s doi: 10.1152/japplphysiol.00594.2011.

  • Hadler-Olsen, Elin Synnøve; Winberg, Jan-Olof; Reinholt, Finn P.; Larsen, Terje; Uhlin-Hansen, Lars; Jenssen, Trond Geir; Berg, Eli; Kolset, Svein Olav. Proteases in plasma and kidney of db /db mice as markers of diabetes-induced nephropathy. ISRN Endocrinology 2011. ISSN 2090-4630.s doi: 10.5402/2011/832642.

  • Boardman, Neoma Tove; Larsen, Terje; Severson, david lester; Essop, M Fadiel; Aasum, Ellen. Chronic and acute exposure of mouse hearts to fatty acids increases oxygen cost of excitation-contraction coupling. American Journal of Physiology. Heart and Circulatory Physiology 2011; Volum 300 (5). ISSN 0363-6135.s H1631 - H1636.s doi: 10.1152/ajpheart.01190.2010.

  • Rösner, Assami; How, Ole-Jakob; Aarsæther, Erling Johan; Stenberg, Thor Allan; Andreasen, Thomas Vennø; Kondratiev, Timofei; Larsen, Terje; Myrmel, Truls. High Resolution Speckle Tracking Dobutamine Stress Echocardiography Reveals Heterogeneous Responses in Different Myocardial Layers: Implication for Viability Assessments. Journal of the American Society of Echocardiography 2010; Volum 23 (4). ISSN 0894-7317.s 439 - 447.s doi: 10.1016/j.echo.2009.12.023.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; Hagve, Martin; Lund, trine; Larsen, Terje; Severson, DL; Clarke, Kieran; Berge, Rolf; Aasum, Ellen. Cardiac peroxisome proliferator-activated receptor-alpha activation causes increased fatty acid oxidation, reducing efficiency and post-ischaemic functional loss. Cardiovascular Research 2009; Volum 83 (1). ISSN 0008-6363.s 519 - 526.s doi: 10.1093/cvr/cvp132.

  • Boardman, Neoma Tove; Hafstad, Anne Dragøy; Larsen, Terje; Severson, DL; Aasum, Ellen. Increased O-2 cost of basal metabolism and excitation-contraction coupling in hearts from type 2 diabetic mice. American Journal of Physiology. Heart and Circulatory Physiology 2009; Volum 296 (5). ISSN 0363-6135.s H1373 - H1379.s doi: 10.1152/ajpheart.01264.2008.

  • Stensløkken, Kåre-Olav; Rutkovskiy, Arkady; Kaljusto, Mari-Liis; Hafstad, Anne Dragøy; Larsen, Terje; Vaage, Jarle. Inadvertent phosphorylation of survival kinases in isolated perfused hearts: a word of caution. Basic Research in Cardiology 2009; Volum 104 (4). ISSN 0300-8428.s 412 - 423.s doi: 10.1007/s00395-009-0780-1.

  • Stølen, Tomas O.; Høydal, Morten Andre; Kemi, Ole J.; Catalucci, Daniele; Ceci, Marcelle; Aasum, Ellen; Larsen, Terje; Rolim, Natalie; Condorelli, Gianluigi; Smith, Godfrey L.; Wisløff, Ulrik. Interval Training Normalizes Cardiomyocyte Function, Diastolic Ca2+ Control, and SR Ca2+ Release Synchronicity in a Mouse Model of Diabetic Cardiomyopathy. (fulltekst) Circulation Research 2009; Volum 105. ISSN 0009-7330.s 527 - 536.s doi: 10.1161/CIRCRESAHA.109.199810.

  • Krishnan, Jaya; Suter, Marianne; Windak, Renata; Krebs, Tatiana; Felley, Allison; Montessuit, Christophe; Tokarska-Schlattner, Malgorzata; Aasum, Ellen; Bogdanova, Anna; Perriard, Evelyne; Perriard, Jean-Claude; Larsen, Terje; Pedrazzini, Thierry; Krek, Wilhelm. Activation of a HIF1 alpha-PPAR gamma Axis Underlies the Integration of Glycolytic and Lipid Anabolic Pathways in Pathologic Cardiac Hypertrophy. Cell Metabolism 2009; Volum 9 (6). ISSN 1550-4131.s 512 - 524.s doi: 10.1016/j.cmet.2009.05.005.

  • Aasum, Ellen; Khalid, Ahmed Murtaz; Gudbrandsen, Oddrun Anita; How, Ole-Jakob; Berge, Rolf; Larsen, Terje. Fenofibrate modulates cardiac and hepatic metabolism and increases ischemic tolerance in diet-induced obese mice. Journal of Molecular and Cellular Cardiology 2008; Volum 44 (201). ISSN 0022-2828.s 201 - 209.s doi: 10.1016/j.yjmcc.2007.08.020.

  • Vinge, Leif Erik; Von Lueder, Thomas; Aasum, Ellen; Qvigstad, Eirik; Gravning, Jørgen A.; How, Ole-Jakob; Edvardsen, Thor; Bjørnerheim, Reidar; Ahmed, M. Shakil; Mikkelsen, Birthe W.; Øie, Erik; Attramadal, Toril; Skomedal, Tor; Smiseth, Otto A; Koch, Walter J.; Larsen, Terje; Attramadal, Håvard. Cardiac-Restricted Expression of The Carboxyl-Terminal Fragment of GRK3 Uncovers Distinct Functions of GRK3 in Regulation of Cardiac Contractility and Growth – GRK3 controls cardiac a1-adrenergic receptor responsiveness. Journal of Biological Chemistry 2008; Volum 283. ISSN 0021-9258.s 10601 - 10610.s doi: 10.1074/jbc.M708912200.

  • Larsen, Terje; Aasum, Ellen. Metabolic (in)flexibility of the diabetic heart. Cardiovascular Drugs and Therapy 2008; Volum 22. ISSN 0920-3206.s 91 - 95.s doi: 10.1007/s10557-008-6083-1.

  • How, Ole-Jakob; Larsen, Terje; Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; Myhre, Eivind S. P.; Myrray, AJ; Boardman, Neoma; Cole, M; Clarke, Kieran; Severson, David Lester; Aasum, Ellen. Rosiglitazone treatment improves cardiac efficiency in hearts from diabetic mice. Archives of Physiology and Biochemistry 2007; Volum 113 (4). ISSN 1381-3455.s 211 - 220.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; How, Ole-Jakob; Larsen, Terje; Aasum, Ellen. Glucose and insulin improve cardiac efficiency and postischemic functional recovery in perfused hearts from type 2 diabetic (db/db) mice. American Journal of Physiology. Endocrinology and Metabolism 2007; Volum 292. ISSN 0193-1849.s E1288 - E1294.s doi: 10.1152/ajpendo.00504.2006.

  • Hafstad, Anne Dragøy; Solevåg, Geir Helge; Severson, david lester; Larsen, Terje; Aasum, Ellen. Perfused hearts from type 2 diabetic (db/db) mice show metabolic responsiveness to insulin. American Journal of Physiology. Heart and Circulatory Physiology 2006; Volum 290. ISSN 0363-6135.s H1763 - H1769.

  • How, Ole-Jakob; Aasum, Ellen; Severson, David Lester; Chan, A; Essop, M Fadiel; Larsen, Terje. Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice. Diabetes 2006; Volum 55. ISSN 0012-1797.s 466 - 473.

  • Oakes, ND; Thalen, P; Aasum, Ellen; Edgley, A; Larsen, Terje; Furler, SM; Ljung, B; Severson, David Lester. Cardiac metabolism in mice: tracer method developments and in vivo application revealing profound metabolic inflexibility in diabetes. American Journal of Physiology. Endocrinology and Metabolism 2006; Volum 290. ISSN 0193-1849.

  • Pellieux, C; Aasum, Ellen; Larsen, Terje; Montessuit, C; Papageorgiou, I; Pedrazzini, T; Lerch, R. Overexpression of angiotensinogen in the myocardium induces downregulation of the fatty acid oxidation pathway. Journal of Molecular and Cellular Cardiology 2006; Volum 41. ISSN 0022-2828.s 459 - 466.

  • Bratkovski, Serguei; Aasum, Ellen; Riemersma, Rudolph; Myhre, Eivind S. P.; Larsen, Terje. Reduced coronary reserve in response to short-term ischaemia and vasoactive drugs in ex vivo hearts from diabetic mice. Acta Physiologica 2006; Volum 186. ISSN 1748-1708.s 171 - 177.

  • Aasum, Ellen; Cooper, Marie; Severson, David Lester; Larsen, Terje. Effect of BM 17.0744, a PPAR alpha ligand, on the metabolism of perfused hearts from control and diabetic mice. Canadian Journal of Physiology and Pharmacology 2005; Volum 83. ISSN 0008-4212.s 183 - 190.

  • How, Ole-Jacob; Aasum, Ellen; Kunnathu, S; Severson, David Lester; Myhre, Eivind S.p.; Larsen, Terje. Influence of substrate supply on cardiac efficiency, as measured by pressure-volume analysis in ex vivo mouse hearts. American Journal of Physiology. Heart and Circulatory Physiology 2005; Volum 288. ISSN 0363-6135.s H2979 - H2985.

  • Henden, Thale; Aasum, Ellen; Folkow, Lars; Mjøs, Ole Danbolt; Lathrop, David A; Larsen, Terje. Endogenous glycogen prevents Ca2+ overload and hypercontracture in harp seal myocardial cells during simulated ischemia. Journal of Molecular and Cellular Cardiology 2004; Volum 37. ISSN 0022-2828.s 43 - 50.s doi: 10.1016/j.yjmcc.2004.03.013.

  • Carley, Andrew; Semeniuk, LM; Shimoni, Y; Aasum, Ellen; Larsen, Terje; Berger, JP; Severson, David Lester. Treatment of type 2 diabetic db/db mice with a novel PPAR gamma agonist improves cardiac metabolism but not contractile function. American Journal of Physiology. Endocrinology and Metabolism 2004; Volum 286. ISSN 0193-1849.s E449 - E455.

  • Bratkovski, Serguei; Aasum, Ellen; Birkeland, CH; Riemersma, Rudolph; Myhre, Eivind SP; Larsen, Terje. Measurement of coronary flow reserve in isolated hearts from mice. Acta Physiologica Scandinavica 2004; Volum 181. ISSN 0001-6772.s 167 - 172.

  • Severson, David Lester; Aasum, Ellen; Belke, Darrell D; Larsen, Terje; Semeniuk, LM; Shimomi, Y. Diabetes and cardiac dysfunction. 2003.s 373 - 385.

  • Aasum, Ellen; Hafstad, Anne Dragøy; Larsen, Terje. Changes in substrate metabolism in isolated mouse hearts following ischemia-reperfusion. Molecular and Cellular Biochemistry 2003; Volum 249. ISSN 0300-8177.s 97 - 103.

  • Aasum, Ellen; Hafstad, Anne Dragøy; Severson, David Lester; Larsen, Terje. Cardiac Age-dependent changes in metabolism, contractile function and ischemic sensitivity in hearts from db/db mice. Diabetes 2003; Volum 52. ISSN 0012-1797.s 434 - 441.

  • Elvenes, Odd Petter; Korvald, Christian; Irtun, Øivind; Larsen, Terje; Sørlie, Dag Glen. Both glucose-insulin-potassium and glutamine inwarm blood cardioplegia increase the rates of myocardial glucose and free fatty acid oxidation. Scandinavian Cardiovascular Journal 2002; Volum 36. ISSN 1401-7431.s 19 - 26.

  • Elvenes, Odd Petter; Korvald, Christian; Ytrebø, Lars Marius; Irtun, Øivind; Myrmel, Truls; Larsen, Terje; Sørlie, Dag Glen. Myocardial metabolism and efficiency after warm continuous blood cardioplegia. Annals of Thoracic Surgery 2000; Volum 69. ISSN 0003-4975.s 1799 - 1805.

  • Schmidt, Tom; Larsen, Terje. Botolv onomastikkens harding. Veneskrift til Botolv Helleland på 70-årsdagen 9. juni 2010. Novus Forlag 2010 ISBN 978-82-7099-569-1.s 1 - 11.

  • Harsson, Margit; Larsen, Terje. Namn frå by og bø. Veneskrift til Tom Schmidt på 60-årsdagen 26. juni 2008. 2008 ISBN 978-82-92596-16-6.s 83 - 92.

  • Bakkehaug, Jens Petter; Kildal, Anders Benjamin; Engstad, Erik Torgersen; Boardman, Neoma Tove; Næsheim, Torvind; Rønning, Leif R.; Aasum, Ellen; Larsen, Terje; Myrmel, Truls; How, Ole-Jakob. Response to Letter Regarding Article, "Myosin Activator Omecamtiv Mecarbil Increases Myocardial Oxygen Consumption and Impairs Cardiac Efficiency Mediated by Resting Myosin ATPase Activity". Circulation: Heart Failure 2015; Volum 8 (6). ISSN 1941-3289.s 1142 - 1142.s doi: 10.1161/CIRCHEARTFAILURE.115.002548.

  • Ytrehus, Kirsti; Larsen, Terje; Christensen, Geir Arve; Stensløkken, Kåre-Olav; Levy, Finn Olav. In memory of Guro Valen (1960-2014). Journal of Molecular and Cellular Cardiology 2015; Volum 79. ISSN 0022-2828.s 254 - 255.s doi: 10.1016/j.yjmcc.2014.11.026.

  • Sæther, Thomas; Moldes-Anaya, Angel; Norrheim-Larsen, Laila; Larsen, Terje; Paulsen, Steinar M; Nebb, Hilde Irene. Two near identical oxylipins from the diatom Chaetoceros karianus show isoform-specific agonist activity towards human peroxisome proliferator-activated receptors (PPARs). Throne Holst Symposium 2014-06-10 - 2014-06-10 2014.

  • Moldes-Anaya, Angel; Sæther, Thomas; Larsen, Laila Norrheim; Larsen, Terje; Nebb, Hilde Irene; Paulsen, Steinar. Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae. BIOPROSP_2013 2013-02-20 - 2013-02-22 2013.

  • Sæther, Thomas; Moldes-Anaya, Angel; Norrheim-Larsen, Laila; Larsen, Terje; Paulsen, Steinar M; Nebb, Hilde Irene. Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae. Throne Holst Symposium 2013-05-06 - 2013-05-06 2013.

  • Salma, Wahida; Höper, Anje Christina; Lund, trine; Ludvigsen, Stian; Ytrehus, Kirsti; Aasum, Ellen; Larsen, Terje. Dietary supply with Calanus oil antagonizes angiotensin IIinduced hypertension, cardiac hypertrophy and cachexia in obese mice. Society for heart and vascular metabolism (SHVM) 2013-09-29 - 2013-10-02 2013.

  • Sæther, Thomas; Moldes-Anaya, Angel; Larsen, Laila Norrheim; Larsen, Terje; Paulsen, Steinar; Nebb, Hilde Irene. Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae. Keystone Symposia - Nuclear Receptors and Friends: Roles in Energy Homeostasis and Metabolic Dysfunction 2013-04-03 - 2013-04-08 2013.

  • Moldes-Anaya, Angel; Sæther, Thomas; Norrheim-Larsen, Laila; Nebb, Hilde Irene; Larsen, Terje; Paulsen, Steinar. Identifying natural products with agonist or modulatory activity against human nuclear receptors in extracts from cultured marine microalgae. 14th. International Symposium on Marine Natural Products and 8th. European Conference on Marine Natural Products (MANAPRO) 2013-09-15 - 2013.

  • Larsen, Terje. Calanusolje har oppsiktsvekkende egenskaper. (data) (fulltekst) 2013.

  • Pedersen, Alice Marie; Salma, Wahida; Höper, Anje Christina; Larsen, Terje; Olsen, Ragnar Ludvig. Digestion and absorption of marine wax esters as a dietary supplement. 27th Nordic Lipidforums Symposium 2013-06-17 - 2013-06-19 2013.

  • Pedersen, Alice Marie; Höper, Anje Christina; Salma, Wahida; Larsen, Terje; Olsen, Ragnar Ludvig. Digestion and absorption of Calanus Oil. BIOPROSP_13 2013-02-20 - 2013-02-22 2013.

  • Alves, Marcia; Wisloff, Ulrik; Roman-Campos, Danilo; Almeida, Pedro; Larsen, Terje; Alvarez-Leite, Jaqueline; Guatimosim, Silvia. Lipotoxicity In Cardiomyocytes: Reversal By Aerobic Training. Medicine & Science in Sports & Exercise 2012; Volum 44. ISSN 0195-9131.s 832 - 832.

  • Salma, Wahida; Höper, Anje Christina; Khalid, Ahmed Murtaz; Sollie, Selene Julie; Lund, Jim; Hafstad, Anne Dragøy; Aasum, Ellen; Larsen, Terje. Wax ester purified from Calanus oil reduces visceral obesity and low-grade inflammation in adipose tissue during high fat feeding. 10th annual meeting of the Society for Heart and Vascular Metabolism 2012-06-24 - 2012-06-27 2012.

  • Salma, Wahida; Sollie, Selene Julie; Höper, Anje Christina; Khalid, Ahmed Murtaz; Lund, Jim; Hafstad, Anne Dragøy; Larsen, Terje; Aasum, Ellen. Dietary supplementation with Calanus oil reduces visceral fat deposition and improves insulin sensitivity during high fat feeding. 10th annual meeting of the Society for Heart and Vascular Metabolism 2012-06-24 - 2012-06-27 2012.

  • Hafstad, Anne Dragøy; Lund, Jim; Hagve, Martin; Hadler-Olsen, Elin Synnøve; Höper, Anje Christina; Larsen, Terje; Aasum, Ellen. High and moderate intensity training prevent diet-induced impairments in cardiac mechanoenergetics and ventricular function. 10th annual meeting of the Society for Heart and Vascular Metabolism 2012-06-24 - 2012-06-27 2012.

  • Höper, Anje Christina; Larsen, Terje; Khalid, Ahmed Murtaz; Salma, Wahida; Sollie, Selene Julie; Lund, Jim; Hafstad, Anne Dragøy; Aasum, Ellen. Low-dose supplementation with Calanus oil attenuates visceral adiposity and low-grade inflammation during high fat feeding. 3rd international congress on abdominal obesity 2012-07-09 - 2012-07-12 2012.

  • Hafstad, Anne Dragøy; Lund, Jim; Larsen, Terje; Aasum, Ellen. Cardiovascular Research Group, Faculty of Health Sciences, University of Tromsø, Norway. Exercise training prevent obesity-induced impairment of myocardial function and mechanoenergetics, as well as mitochondrial capacity and fatty acid-induced proton leak. 10th Annual CHFR Symposium 2012-09-20 - 2012-09-21 2012.

  • Lund, Jim; Hafstad, Anne Dragøy; Larsen, Terje; Aasum, Ellen. High and moderate intensity training prevent obesity-related oxygen waste and development of left ventricular dysfunction in the presence of high fat. 10th annual meeting of the Society for Heart and Vascular Metabolism 2012-06-24 - 2012-06-27 2012.

  • Hafstad, Anne Dragøy; Lund, Jim; Høper, Anje Christina; Hadler-Olsen, Elin Synnøve; Hagve, Martin; Wisløff, Ulrik; Larsen, Terje; Aasum, Ellen. Exercise improves ventricular function and decreases myocardial oxygen waste in diet-induced obese mice. Circulation 2011; Volum 124. ISSN 0009-7322.s A14938 - .

  • Hagve, Martin; Sanden, Espen; Aasum, Ellen; Larsen, Terje. Palmitate-induced uncoupling reduces oxidative stress in cardiac mitochondria respiring on complex II substrate. 9th annual meeting of the Society for Heart and Vascular Metabolism (SHVM) 2011-06-17 - 2011-06-21 2011.

  • Hafstad, Anne Dragøy; Lund, Jim; Høper, Anje Christina; Hadler-Olsen, Elin Synnøve; Hagve, Martin; Wisløff, Ulrik; Larsen, Terje; Aasum, Ellen. High intensity interval training normalizes cardiac energetics and ventricular function in diet-induced obese mice. 9th annual meeting of the Society for Heart and Vascular Metabolism (SHVM) 2011-06-17 - 2011-06-21 2011.

  • Hafstad, Anne Dragøy; Lund, Jim; Høper, Anje Christina; Hadler-Olsen, Elin Synnøve; Hagve, Martin; Wisløff, Ulrik; Larsen, Terje; Aasum, Ellen. Exercise improves ventricular function and decreases myocardial oxygen waste in diet-induced obese mice. Scientific Sessions 2011 of the American Heart Association 2011-11-12 - 2011-11-16 2011.

  • Høper, Anje Christina; Larsen, Terje; Lund, Jim; Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; Aasum, Ellen. Oil extracted from the marine copepod Calanus finmarchicus reduces diet-induced obesity and insulin resistance, and improves aerobic capacity in mice. BIOPROSP 2011 2011-02-23 - 2011-02-25 2011.

  • Høper, Anje Christina; Khalid, Ahmed Murtaz; Fuglesteg, Britt Nanny; Aasum, Ellen; Larsen, Terje. Visceral fat deposition is attenuated by calanus oil supplementation in rats on a high fat diet. Cardiovascular Research 2010; Volum 87. ISSN 0008-6363.s S131 - S131.

  • Boardman, Neoma; Sejersted, Ole M; Sjaastad, Ivar; Larsen, Terje; Christensen, Geir Arve; Aasum, Ellen. Increased oxygen cost for contractile function and decreased oxygen cost for excitation-contraction coupling in mice with inducible cardiomyoctye-specific excision of the Serca2 gene. 8th Annual CHFR Symposium 2010-09-30 - 2010-10-01 2010.

  • Hafstad, Anne Dragøy; Boardman, Neoma Tove; Lund, Jim; Hagve, Martin; Wisløff, Ulrik; Larsen, Terje; Aasum, Ellen. Metabolic adaptations in the physiologically hypertrophied heart. 7th annual meeting of the Society for Heart and Vascular Metabolism (SHVM) 2009-08-23 - 2009-08-26 2009.

  • Hafstad, Anne Dragøy; Boardman, Neoma Tove; Lund, Jim; Hagve, Martin; Wisløff, Ulrik; Larsen, Terje; Aasum, Ellen. Exercise-induced Increase In Cardiac Efficiency - The Impact of Intensity. Circulation 2009. ISSN 0009-7322.s S880 - .

  • Khalid, Ahmed Murtaz; Larsen, Terje. Treatment of Obesity and Type 2 Diabetes with PPAR alpha Agonists - Effects on Myocardial Metabolism, Gene Expression and Ventricular Function. 2009 ISBN 978-82-7589-219-3.

  • Hafstad, Anne Dragøy; Boardman, Neoma Tove; Lund, Jim; Hagve, Martin; Wisløff, Ulrik; Larsen, Terje; Aasum, Ellen. Exercise-induced Increase In Cardiac Efficiency - The Impact of Intensity. American Heart Association 2009-11-14 - 2009-11-18 2009.

  • Aasum, Ellen; Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; Berge, Rolf; Larsen, Terje. TTA - the first PPAR ligand shown to increase fatty acid oxidation in normal and diabetic myocardium when administered in vivo. ISHR, Heart failure 2009 2009-05-30 - 2009-06-02 2009.

  • Khalid, Ahmed Murtaz; Aasum, Ellen; Hafstad, Anne Dragøy; Clarke, K; Berge, Rolf; Larsen, Terje. TTA is a pan PPAR ligand which markedly stimulates fatty acid oxidation following in vivo administration. Cardiovascular Drugs and Therapy 2008; Volum 22. ISSN 0920-3206.s 142 - 143.

  • Stenslokken, KO; Rutkovsky, A; Kaijusto, ML; Hafstad, Anne Dragøy; Larsen, Terje; Vaage, J. Degree of phosphorylation of survival kinases in isolated mouse hearts depends on the mode of perfusion. Journal of Molecular and Cellular Cardiology 2008; Volum 44. ISSN 0022-2828.s 711 - 825.s doi: 10.1016/j.yjmcc.2008.02.234.

  • Khalid, Ahmed Murtaz; Aasum, Ellen; Hafstad, Anne Dragøy; Larsen, Terje. Reduced lipid supply without a concomitant reduced glucose supply fails to alter the metabolic phenotype of diabetic hearts. Journal of Molecular and Cellular Cardiology 2008; Volum 44 (4). ISSN 0022-2828.s 803 - .s doi: 10.1016/j.yjmcc.2008.02.219.

  • Boardman, Neoma Tove; Hafstad, Anne Dragøy; Larsen, Terje; Severson, david lester; Aasum, Ellen. Oxygen cost of E-C coupling in the diabetic heart. Hjerteforum 2008; Volum 2. ISSN 0802-1465.s 128 - .

  • Khalid, Ahmed Murtaz; Hafstad, Anne Dragøy; Lund, trine; Larsen, Terje; Severson, david lester; Berge, Rolf; Clarke, Kieran; Aasum, Ellen. Administration of tetradecylthioacetic acid (TTA) in mice accelerates myocardial FA oxidation via increased expression of pparα target genes. Hjerteforum 2008; Volum 2. ISSN 0802-1465.s 126 - .

  • Khalid, Ahmed Murtaz; Hafstad, Anne Dragøy; Lund, trine; Larsen, Terje; Severson, david lester; Berge, Rolf; Clarke, Kieran; Aasum, Ellen. Administration of tetradecylthioacetic acid (TTA) in mice accelerates myocardial FA oxidation via increased expression of pparα target genes. Kardiologisk vintermøte 2008-02-01 - 2008-02-03 2008.

  • Boardman, Neoma Tove; Hafstad, Anne Dragøy; Larsen, Terje; Severson, david lester; Aasum, Ellen. Oxygen cost of E-C coupling in the diabetic heart. Kardiologisk vintermøte 2008-02-01 - 2008-02-03 2008.

  • Boardman, Neoma Tove; Hafstad, Anne Dragøy; Larsen, Terje; Severson, david lester; Aasum, Ellen. The O2 cost of basal metabolism and excitation-contraction coupling is increased in hearts from type 2 diabetic mice. 6th annual meeting of the SHVM 2008-06-29 - 2008-07-01 2008.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; Boardman, Neoma Tove; Larsen, Terje; Aasum, Ellen. The pan ppar ligand tta has a direct cardiometabolic effect in normal and diabetic mice. 6th annual meeting of the SHVM 2008-06-29 - 2008-07-01 2008.

  • Khalid, Ahmed Murtaz; Aasum, Ellen; Larsen, Terje. Reduced lipid supply without a concomitant reduced glucose supply fails to alter the metabolic phenotype of diabetic hearts. ISHR XXVIII European Section Meeting 2008-05-28 - 2008-05-31 2008.

  • Khalid, Ahmed Murtaz; Aasum, Ellen; Hafstad, Anne Dragøy; Clarke, Kieran; Berge, Rolf; Larsen, Terje. TTA is a pan PPAR ligand which markedly stimulates fatty acid oxidation following in vivo administration. 4th annual meeting of the Society for Heart and Vascular Metabolism 2007-06-18 - 2007-06-20 2007.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; How, Ole-Jakob; Berge, Rolf; Larsen, Terje; Aasum, Ellen. In vivo administration of tetradecylthioacetic acid (TTA) in mice causes cardiac inefficiency and reduced post-ischemic ventricular function. Journal of Molecular and Cellular Cardiology 2007; Volum 42. ISSN 0022-2828.s doi: 10.1016/j.yjmcc.2007.03.784.

  • Stølen, Thomas; Kemi, Ole J.; Høydal, Morten A.; Bye, Anja; Tjonna, Arnt E.; Hafstad, Anne Dragøy; Larsen, Terje; Smith, Godfrey L.; Wisløff, Ulrik. Reversed Ryr-leakage And Improved Contractile Function In Cardiomyocytes From Type-2 Diabetic Heart After Exercise Training. Medicine & Science in Sports & Exercise 2007; Volum 39. ISSN 0195-9131.

  • Gravning, J; Von Lueder, Thomas; Edvardsen, T; Vinge, Leif Erik; How, Ole-Jakob; Aasum, Ellen; Ahmed, MS; Larsen, Terje; Smiseth, Otto A; Attramadal, Håvard. Inhibition of G protein-coupled receptor kinase-3 (GRK3) rescues cardiac dysfunction after pressure overload. European Heart Journal 2007; Volum 28. ISSN 0195-668X.

  • How, Ole-Jakob; Aasum, Ellen; Larsen, Terje. Work-independent assessment of efficiency in ex vivo working rodent hearts within the PVA-MVO2 framework. Acta Physiologica 2007; Volum 190. ISSN 1748-1708.s 171 - 175.s doi: 10.1111/j.1748-1716.2006.01681.x.

  • Stølen, Thomas; Kemi, Ole J.; Høydal, Morten A.; Bye, Anja; Hafstad, Anne Dragøy; Larsen, Terje; Smith, Godfrey L.; Wisløff, Ulrik. Reversed RyR-leakage and improved contractile function in cardiomyocytes from type-2 diabetic heart after exercise training. ESC Congress 2007 2007-08-31 - 2007-09-05 2007.

  • Larsen, Terje. Ischemia-reperfusion injury and diabetes – influence of cardiac metabolism. the DACRA and Faculty of Health Sciences PhD Course (Pathophysiology of Heart Ischemia-Reperfusion) 2007-09-10 - 2007-09-12 2007.

  • Larsen, Terje. Metabolic inflexibility of the diabetic heart. the 5th Annual Conference of the Society for Heart and vascular Metabolism 2007-06-18 - 2007-06-20 2007.

  • Larsen, Terje. Myocardial metabolism and ischemic tolerance in type 2 diabetes. Research Symposium of the Norwegian Cardiology Society 2007-01-26 - 2007-01-28 2007.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; How, Ole-Jakob; Berge, Rolf; Larsen, Terje; Aasum, Ellen. In vivo administration of tetradecylthioacetic acid (TTA) in mice causes cardiac inefficiency and reduced post-ischemic ventricular function. XIX World congress of the ISHR 2007-06-22 - 2007-06-25 2007.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; How, Ole-Jakob; Larsen, Terje; Aasum, Ellen. Glucose and insulin improve energy metabolism, efficiency and ischemic tolerance in hearts from type 2 diabetic mice. Diabeteskonferansen 2007-02-07 - 2007-02-09 2007.

  • How, Ole-Jakob; Larsen, Terje; Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; Myhre, Eivind S. P.; Severson, david lester; Aasum, Ellen. Rosiglitazone improves cardiac efficiency and recovery of ventricular function following ischemia in hearts from type 2 diabetic mice. Heart Failure 2006 2006-06-13 - 2006-06-21 2006.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; How, Ole-Jakob; Larsen, Terje; Aasum, Ellen. Changing myocardial energy utilization from fat to glucose improves post-ischemic recovery in hearts from type 2 diabetic (db/db) mice. Journal of Molecular and Cellular Cardiology 2006; Volum 40 (6). ISSN 0022-2828.s 932 - .

  • Aasum, Ellen; Khalid, Ahmed Murtaz; Gudbrandsen, OA; Larsen, Terje; Berge, Rolf. Indirect and direct effects of PPAR ligands on myocardial metabolism. Journal of Molecular and Cellular Cardiology 2006; Volum 40. ISSN 0022-2828.s 931 - 932.

  • Aasum, Ellen; Hafstad, Anne Dragøy; How, Ole-Jakob; Khalid, Ahmed Murtaz; Larsen, Terje. Improved cardiac metabolism enhances cardiac efficiency and ischemic tolerance in type 2 diabetes. Circulation 2006; Volum 114 (18). ISSN 0009-7322.

  • Graving, JA; Von Leuder, T; Edvardsen, T; How, Ole-Jakob; Aasum, Ellen; Ahmed, MS; Vinge, Leif Erik; Mikkelsen, BV; Larsen, Terje; Smiseth, Otto A; Attramadal, Håvard. Inhibition of G protein-coupled receptor kinase-3 (GRK3) rescues cardiac dysfunction after pressure overload. Circulation 2006; Volum 114. ISSN 0009-7322.s 97 - 97.

  • Aasum, Ellen; Hafstad, Anne Dragøy; How, Ole-Jakob; Khalid, Ahmed Murtaz; Severson, david lester; Larsen, Terje. Chronic and acute metabolic interventions improve cardiac metabolism and enhances cardiac efficiency and ischemic tolerance in type 2 diabetes. Circulation 2006; Volum 114. ISSN 0009-7322.s 136 - 136.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; How, Ole-Jakob; Larsen, Terje; Aasum, Ellen. Elevated glucose and insulin improves cardiac efficiency and post-ischemic functional recovery in perfused hearts from type 2 diabetic (db/db) mice. Cardiovascular Drugs and Therapy 2006; Volum 20. ISSN 0920-3206.s 408 - 409.

  • How, Ole-Jakob; Larsen, Terje; Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; Myhre, Eivind S. P.; Severson, david lester; Aasum, Ellen. Rosiglitazone treatment improves cardiac efficiency and post-ischemic functional recovery in hearts from diabetic mice. Cardiovascular Drugs and Therapy 2006; Volum 20. ISSN 0920-3206.s 410 - 411.

  • How, Ole-Jacob; Larsen, Terje. Oxygen wastage in the diabetic heart. Ventricular energetics in the isolated mouse heart using PVA-MVO2 technology. (data) (omtale) 2006 ISBN 82-7589-165-5.

  • Stølen, Thomas; Kemi, Ole J.; Høydal, Morten A.; Bye, Anja; Tjonna, Arnt E.; Hafstad, Anne Dragøy; Larsen, Terje; Smith, Godfrey L.; Wisløff, Ulrik. Reversed RyR-leakage And Improved Contractile Function In Cardiomyocytes From Type-2 Diabetic Heart After Exercise Training. Seminar on Exercise in Medicine 2006-12-14 - 2006-12-15 2006.

  • Larsen, Terje. Myocardial Metabolism and Ischemic Tolerance in Type 2 Diabetes. Department of Pharmacology, University of Athens 2006-10-13 - 2006.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; How, Ole-Jakob; Larsen, Terje; Aasum, Ellen. The type 2 diabetic heart is not an insulin resistant organ. Exercise in Medicine 2006-12-14 - 2006-12-15 2006.

  • Aasum, Ellen; Hafstad, Anne Dragøy; How, Ole-Jakob; Khalid, Ahmed Murtaz; Severson, david lester; Larsen, Terje. Chronic and acute metabolic interventions improve cardiac metabolism and enhances cardiac efficiency and ischemic tolerance in type 2 diabetes. 2006 Scientific Session 2006-11-12 - 2006-11-15 2006.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; How, Ole-Jakob; Larsen, Terje; Aasum, Ellen. Changing myocardial energy utilization from fat to glucose improves post-ischemic recovery in hearts from type 2 diabetic (db/db) mice. 26th Annual Scientific Sessions, European Section 2006-06-14 - 2006-06-16 2006.

  • Aasum, Ellen; Khalid, Ahmed Murtaz; Gudbrandsen, OA; Larsen, Terje; Berge, Rolf. Indirect and direct effects of PPAR ligands on myocardial metabolism. 26th European Section Meeting of the International Society for Heart Research 2006-06-14 - 2006-06-17 2006.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; How, Ole-Jakob; Larsen, Terje; Aasum, Ellen. Elevated glucose and insulin improve cardiac efficiency and post-ischemic functional recovery in perfused hearts from type 2 diabetic (db/db) mice. 4th Annual Meeting of the Society for Heart and Vascular Metabolism 2006-09-06 - 2006-09-09 2006.

  • Graving, JA; Von Lueder, Thomas; Edvardsen, T; How, Ole-Jakob; Aasum, Ellen; Ahmed, MS; Vinge, LE; Mikkelsen, BV; Larsen, Terje; Smiseth, Otto A; Attramadal, Håvard. Inhibition of G Protein-Coupled Receptor Kinase-3 (GRK3) rescues Cardiac dysfunction after pressure overload. 2006 Scientific Session 2006-11-12 - 2006-11-15 2006.

  • How, Ole-Jakob; Larsen, Terje; Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; Myhre, Eivind S. P.; Severson, david lester; Aasum, Ellen. Rosiglitazone treatment improves cardiac efficiency and post-ischemic functional recovery in hearts from diabetic mice. 4th. Annual meeting 2006-09-06 - 2006-09-09 2006.

  • Henden, thale; Scrimgour, A.G.; Folkow, Lars; Larsen, Terje. Glycogen metabolism in seal and pig myocardium during normoxic and ischemic conditions. European Section of International Society for Heart Research 2005-06-21 - 2005-06-25 2005.

  • How, Ole-Jacob; Aasum, Ellen; Severson, David Lester; Larsen, Terje. Altered pressure-volume relationships in hearts from diabetic mice: a possible mechanism of diabetic cardiomyopathy?. Journal of Molecular and Cellular Cardiology 2005; Volum 38. ISSN 0022-2828.s 1029 - 1029.

  • Vader, Marit Arianne; Essop, M Fadiel; Hafstad, Anne Dragøy; Larsen, Terje; Aasum, Ellen. Acute effects of ppar ligands on cardiac metabolism. Journal of Molecular and Cellular Cardiology 2005; Volum 38. ISSN 0022-2828.s 1077 - 1077.

  • Henden, Thale; Scrimgeour, A.G.; Folkow, Lars; Larsen, Terje. Glycogen metabolism in seal and pig myocardium during normoxic and ischemic conditions. Journal of Molecular and Cellular Cardiology 2005; Volum 38. ISSN 0022-2828.s 1028 - 1028.

  • Pellieux, Corrinne; Aasum, Ellen; Larsen, Terje; Montessuit, C; Papageorgiou, I; Pedrazzini, T; Lerch, R. Role of angii in metabolic phenotype adaptation during progression from cardiac phenotype to hearts failure. Journal of Molecular and Cellular Cardiology 2005; Volum 38. ISSN 0022-2828.s 1057 - 1057.

  • Von Lueder, Thomas; Vinge, Leif Erik; Aasum, Ellen; How, Ole-Jacob; Bjørnerheim, Reidar; Qvigstad, Eirik; Larsen, Terje; Smiseth, Otto A; Attramadal, Håvard. Cardiac-specific inhibition of G protein-couplet receptor kinase-3 transgenic mice causes preload-intolerant, hyperkinetic myocardium and hypertensive phenotype. Hjerteforum 2005; Volum 2 (178). ISSN 0802-1465.

  • Larsen, Terje; Moe, Kristin. Spennende konferanse. 2005.

  • Larsen, Terje. Metabolic and Functional Alterations of the Diabetic Mouse Heart. Invitert gjesteforeleser 2005-12-06 - 2005-12-06 2005.

  • Larsen, Terje. Reduced Efficiency in Hearts from Diabetic Mice. Invitert gjesteforeleser 2005-09-30 - 2005-09-30 2005.

  • Von Lueder, Thomas; Vinge, Leif Erik; Aasum, Ellen; How, Ole-Jacob; Bjørnerheim, Reidar; Qvigstad, Eirik; Larsen, Terje; Smiseth, Otto A; Attramadal, Håvard. Cardiac-specific inhibition of G protein-couplet receptor kinase-3 transgenic mice causes preload-intolerant, hyperkinetic myocardium and hypertensive phenotype. Kardiologisk vintermøte 2005-01-28 - 2005-01-30 2005.

  • How, Ole-Jacob; Aasum, Ellen; Severson, David Lester; Chan, A; Essop, M Fadiel; Larsen, Terje. Cardiac Efficiency is Reduced in Hearts from Diabetic Mice. 3rd. annual meeting of the Society for Heart and Vascular Metabolism 2005-09-26 - 2005-09-29 2005.

  • Vader, Marit Arianne; Essop, Faadiel; Hafstad, Anne Dragøy; Larsen, Terje; Aasum, Ellen. Acute effects of ppar ligands on cardiac metabolism. European Section of International Society for Heart Research 2005-06-21 - 2005-06-25 2005.

  • Pellieux, Corinne; Aasum, Ellen; Larsen, Terje; Montessuit, C; Papageorgiou, I; Pedrazzini, T; Lerch, R. Role of angii in metabolic phenotype adaption during progression from cardiac hypertrophy to heart failure. European Section of International Society for Heart Research 2005-06-21 - 2005-06-25 2005.

  • How, Ole-Jacob; Aasum, Ellen; Severson, David Lester; Larsen, Terje. Altered pressure-volume relationships in hearts from diabetic mice: a possible mechanism of diabetic cardiomyopathy?. European Section of International Society for Heart Research 2005-06-21 - 2005-06-25 2005.

  • Thalen, P; Egdley, D; Severson, David Lester; Aasum, Ellen; Larsen, Terje; Ljung, B; Oakes, Nick. Cardiac metabolic inflexibility in diabetic (db/db) mice as shown by assessment of free fatty acid and glucose utilization in vivo. Second annual meeting of the Society for Heart and Vascular Metabolism 2004-09-09 - 2004-09-11 2004.

  • How, Ole-Jacob; Aasum, Ellen; Kunnathu, S; Severson, David Lester; Larsen, Terje. Influence of substrate supply on cardiac efficiency, by pressure-volume analysis in ex vivo mouse hearts. Journal of Molecular and Cellular Cardiology 2004; Volum 36. ISSN 0022-2828.s 735 - 735.

  • Bratkovski, Serguei; Larsen, Terje. Altered coronary vascular reactivity in type 2 diabetic (db/db) mice. 2004.

  • Khalid, Ahmed Murtaz; Larsen, Terje. Diet-induced obesity and insulin resistance in mice - therapeutic role of PPARalpha ligands. 2004.

  • Larsen, Terje. Control of energy metabolism in the diabetic heart. Diabetesforskningskongressen 2004-09-30 - 2004-10-01 2004.

  • Larsen, Terje. Control of Cardiac Energy Metabolism by PPARs - Direct of Indirect effects. Society for Heart and Vascular Metabolism 2004-09-09 - 2004.

  • Larsen, Terje. Altered metabolism and cardiomyopathy in the db/db mouse. ESC Congress 2004-08-01 - 2004.

  • Von Leuder, T; Vinge, LE; Aasum, Ellen; Qvigstad, E; Bjørnerheim, R; Larsen, Terje; Smiseth, Otto A; Attramadal, Håvard. Cardiac-specific inhibition of the receptor kinase GRK3 in transgenic mice causes preload-intolerant, hyperkinetic myocardium and hypertensive phenotype. American Heart Associaction 2004-11-07 - 2004.

  • Von Leuder, T; Vinge, LE; Aasum, Ellen; Qvigstad, E; Bjørnerheim, R; Larsen, Terje; Smiseth, Otto A; Attramadal, Håvard. Transgenic mice with cardiac-specific inhibition of GRK3 display phenotype with cardiac hypertrophy and alpha1-adrenergic receptor hyperresponsiveness. ESC Meeting 2004-08-01 - 2004.

  • Aasum, Ellen; Khalid, Ahmed Murtaz; Gudbrandsen, Oddrun Anita; How, Ole-Jacob; Berge, Rolf; Larsen, Terje. Different effects of PPAR ligands on cardiac metabolism in mice fed high fat diet. Second annual meeting of the Society for Heart and Vascular Metabolism 2004-09-09 - 2004-09-11 2004.

  • How, Ole-Jacob; Aasum, Ellen; Kunnathu, Stanley; Severson, David Lester; Larsen, Terje. Influence of substrate supply on cardiac efficiency, as measured by pressure-volume analysis in ex vivo mouse hearts. ISHR 2004-06-05 - 2004.

  • Hafstad, Anne Dragøy; Severson, David Lester; Larsen, Terje; Aasum, Ellen. Hearts from type 2 diabetic (db/db) are highly sensitive to insulin. Heart Failure/ISHR ESC Meeting 2003-06-21 - 2003-06-23 2003.