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Professor

Mikkola, Ingvild

Professor
Department of Pharmacy

Job description:

Research and teaching.

Lecturer in biochemistry for first year students in pharmacy, medicine and biology. Supervising master and PhD students.




Research interests

The transcriptionfactor Pax6 and its target genes.

CML, Bcr-Abl and resistance.

Zebrafish as a modelsystem.

Publications in CRIStin


  • Sarah Andrea, Roth; Hald, Øyvind Holsbø; Fuchs, Steffen; Løkke, Cecilie; Mikkola, Ingvild; Flægstad, Trond; Schulte, Johannes; Einvik, Christer. MicroRNA-193b-3p represses neuroblastoma cell growth via downregulation of Cyclin D1, MCL-1 and MYCN. OncoTarget 2018; Volum 9 (26). ISSN 1949-2553.s 18160 - 18179.s doi: 10.18632/oncotarget.24793.

  • Lellahi, Seyed Mohammad; Rosenlund, Ingrid Arctander; Hedberg, Annica; Kiær, Liv Torill; Mikkola, Ingvild; Knutsen, Erik; Perander, Maria. The long noncoding RNA NEAT1 and nuclear paraspeckles are up-regulated by the transcription factor HSF1 in the heat shock response. Journal of Biological Chemistry 2018; Volum 293 (49). ISSN 0021-9258.s 18965 - 18976.s doi: 10.1074/jbc.RA118.004473.

  • Hegge, Beate; Sjøttem, Eva; Mikkola, Ingvild. Generation of a PAX6 knockout glioblastoma cell line with changes in cell cycle distribution and sensitivity to oxidative stress. BMC Cancer 2018; Volum 18 (1). ISSN 1471-2407.s doi: 10.1186/s12885-018-4394-6.

  • Austdal, Lars Peter Engeset; Bjørnstad, Sigrid; Mathisen, Gro Haarklou; Aden, Petra; Mikkola, Ingvild; Paulsen, Ragnhild Elisabeth; Rakkestad, Kirsten Eline. Glucocorticoid effects on cerebellar development in a chicken embryo model: exploring changes in PAX6 and Metalloproteinase-9 after exposure to dexamethasone. Journal of neuroendocrinology 2016; Volum 28 (12). ISSN 0953-8194.s doi: 10.1111/jne.12438.

  • Forsdahl, Siri; Kiselev, Yury; Hogseth, Rune; Mjelle, Janne erikke; Mikkola, Ingvild. Pax6 regulates the expression of Dkk3 in murine and human cell lines, and altered responses to Wnt signaling are shown in Flpln-3T3 cells stably expressing either the Pax6 or the Pax6(5a) Isoform. PLoS ONE 2014; Volum 9 (7). ISSN 1932-6203.s doi: 10.1371/journal.pone.0102559.

  • Gruber, Franz; Lundan, Tuija; Goll, Rasmus; Silye, Aleksandra; Mikkola, Ingvild; Rekvig, Ole Petter; Knuutila, S.; Remes, Kari; Gedde-Dahl, Thobias; Porkka, Kimmo; Hjorth-Hansen, Henrik. BCR-ABL isoforms associated with intrinsic or acquired resistance to imatinib: more heterogeneous than just ABL kinase domain point mutations?. Medical Oncology 2012; Volum 29 (1). ISSN 1357-0560.s 219 - 226.s doi: 10.1007/s12032-010-9781-z.

  • Kiselev, Yury; Eriksen, Tonje Engevik; Forsdahl, Siri; Nguyen, Lan; Mikkola, ingvild. 3T3 cell lines stably expressing Pax6 or Pax6(5a)--a new tool used for identification of common and isoform specific target genes. PLoS ONE 2012; Volum 7 (2). ISSN 1932-6203.s doi: 10.1371/journal.pone.0031915.

  • Gruber, Franz; Ernst, Thomas; Kiselev, Yury; Hochhaus, A; Mikkola, ingvild. Detection of Drug-Resistant Clones in Chronic Myelogenous Leukemia Patients during Dasatinib and Nilotinib Treatment. Clinical Chemistry 2010; Volum 56 (3). ISSN 0009-9147.s 469 - 473.s doi: 10.1373/clinchem.2009.133843.

  • Ernst, Thomas; Gruber, Franz; Pelz-Ackermann, Oliver; Maier, J; Pfirrmann, M; Muller, MC; Mikkola, ingvild; Porkka, Kimmo; Niederwieser, D; Hochhaus, A; Lange, T. A co-operative evaluation of different methods of detecting BCR-ABL kinase domain mutations in patients with chronic myeloid leukemia on second-line dasatinib or nilotinib therapy after failure of imatinib. Haematologica 2009; Volum 94 (9). ISSN 0390-6078.s 1227 - 1235.s doi: 10.3324/haematol.2009.006981.

  • Bruun, Jack-Ansgar; Thomassen, Ernst I.s.; Kristiansen, Kurt; Tylden, Garth Daryl; Holm, Turid; Mikkola, Ingvild; Bjørkøy, Geir; Johansen, Terje. The third helix of the homeodomain of paired class homeodomain proteins acts as a recognition helix both for DNA and protein interactions. Nucleic Acids Research 2005; Volum 33. ISSN 0305-1048.

  • Mikkola, Ingvild; Heavey, Barry; Horcher, Markus; Busslinger, Meinrad. Reversion of B Cell Commitment upon Loss of Pax5 Expression. Science 2002; Volum 297 (5578). ISSN 0036-8075.s 110 - 113.s doi: 10.1126/science.1067518.

  • Nornes, Svanhild; Clarkson, Michael; Mikkola, Ingvild; Delghandi, Marit Pedersen; Bardsley, Anne; Martinez, Juan Pedro; Krauss, Stefan; Johansen, Terje. Zebrafish contains two Pax6 genes involved in eye development. Mechanisms of Development 1998; Volum 77. ISSN 0925-4773.s 185 - 196.

  • Nornes, Svanhild; Mikkola, Ingvild; Krauss, Stefan; Delghandi, Madjid; Perander, maria; Johansen, Terje. Zebrafish Pax9 Encodes Two Proteins with Distinct C-terminal Transactivating Domains of Different Potency Negatively Regulated by Adjacent N-terminal Sequences. Journal of Biological Chemistry 1996; Volum 271 (43). ISSN 0021-9258.s 26914 - 26923.

  • Macdonald, Rachel; Barth, K. Anukampa; Holder, Nigel; Mikkola, Ingvild; Wilson, Stephen W.. Midline signalling is required for Pax gene regulation and patterning of the eyes. Development 1995; Volum 121. ISSN 0950-1991.s 3267 - 3278.

  • Macdonald, R.; Xu, Q.; Barth, A.; Mikkola, Ingvild; Holder, N.; Fjose, Anders; Krauss, Stefan; Wilson, S. W.. Regulatory gene expression boundaries demarcate sites of neuronal differentiation in the embryonic zebrafish forebrain. Neuron 1994; Volum 13. ISSN 0896-6273.s 1039 - 1053.

  • Mikkola, Ingvild; Fjose, Anders; Kuwada, John Y.; Wilson, Stephen; Guddal, Per Henrik; Krauss, Stefan. The Paired Domain-Containing Nuclear Factor pax[b] Is Expressed in Specific Commissural lnterneurons in Zebrafish Embryos. Journal of Neurobiology 1992; Volum 23 (8). ISSN 0022-3034.s 933 - 946.

  • Kiselev, Yury; Valkov, Andrey Yurjevich; Busund, Lill-Tove; Bremnes, Roy M.; Snapkov, Igor; Mikkola, Ingvild; Kilvær, Thomas Karsten; Sorbye, SW; Smeland, Eivind; Dønnem, Tom. Transcription factor PAX6 is expressed in human soft tissue sarcomas and confers negative impact on patients' survival. American Association of Cancer Research Annual Conference 2014-04-06 - 2014-04-07 2014.

  • Gruber, Franz; Ernst, Thomas; Porkka, Kimmo; Engh, Richard Alan; Mikkola, ingvild; Maier, Jacqueline; Lange, Thoralf; Hochhaus, Andreas. Dynamics of the emergence of dasatinib and nilotinib resistance in imatinib-resistant CML patients. Leukemia 2012; Volum 26 (1). ISSN 0887-6924.s 172 - 177.s doi: 10.1038/leu.2011.187.

  • Gruber, Franz; Hjorth-Hansen, H; Mikkola, ingvild; Stenke, L; Johansen, Terje. A novel Bcr-Abl splice isoform is associated with the L248V mutation in CML patients with acquired resistance to imatinib. Leukemia 2006; Volum 20 (11). ISSN 0887-6924.s 2057 - 2060.

  • Mikkola, ingvild. The quest for new target genes for the transcription factor Pax6. Foredrag ved NTNU 2005-01-01 - 2005.

  • Mikkola, ingvild; Hogseth, Rune; Johansen, Terje. Chromatin Immunoprecipitation (ChIP) as a method for identification of new target genes for Pax6. The 6th EMBL Transcription meeting 2004-01-01 - 2004.

  • Mikkola, Ingvild. Regulation of two members of of the Pax family of transcription factors; Involvement of alternative splicing, phosphorylation and protein-protein interactions. 1999.

  • Member of research group