Currently I am focusing on the use of different “omics” to better study the effects of environmental stressors, as a link between exposure and health endpoints. Right now we are in the preparation of a paper on smoking and DNA methylation in two European Cohorts. We are also planning to combine gene expression data and DNA methylation data in order to improve our understanding of the observed effects and the possible biological understanding.
Before this my research focus the last 10 years has been on environmental contaminants and human health. Through my research I have been trying to merge environmental chemistry and epidemiology, where my students have been involved both in the laboratory and the statistical analysis.
Cross sectional and prospective designs have been utilised at both the smaller community based surveys and larger national as well as international populations based investigations.
Through this unique combination of research fields I have considerable insight into the chemistry of molecules and how contaminants potentially influence human health and at the same time keeping the public health perspective as an important and even essential part of the projects.
My major scientific contribution has been the development and combination of environmental chemistry and human epidemiology into new fields of research that more easily integrates the environmental exposure (both short term and long term) component in larger epidemiological studies. When including “omics” in these projects we are more likely to be able to study causality and not only associations in studies of risk factors and human health. Through the close collaboration with colleagues at the department we have also included the nutritional aspect in studies on diet and contaminants. This has been especially important in our projects on benefits and disadvantages with seafood.
Projects and PhD students:
Relevant projects where I am the PI unless stated otherwise:
“Personal Care Products and female health: exploring endocrine effects of parabens on Cancer of breast and endometrium, and genomic pathways”. UiT financed PhD project. 2014-
“Environment and Human Health in The Norwegian-Russian Border area”. UiT financed PhD project. 2014-
“Perfluorinated compounds and type 2 diabetes: gene environment interactions in the Norwegian Women and cancer study (NOWAC)”, project number 204360/H10: Total budget of 5.89 mill nkr. Co- PI. 2011-
”Food and health security in the Norwegian, Finnish and Russian border region: linking local industries, communities and social-economic impacts on food and health security”. Kolarctic funded. 2012 - http://kolarctic.nilu.no/about/
“Hazardous substances- effects on ecosystem and human health” – Topic 1; “Human health and society”. Co-PI. One of 5 flagships at the Fram Centre. Budget as of today 500knok per year. http://www.framsenteret.no/english.150370.no.html
“Assessment of reproductive health effects caused by exposure to high levels of persistent toxic substances followed by improved pregnancy care and pregnancy outcome in Vietnam” – project number SRV 2037 funded by NORAD. 2005 – 2008( 2.7 mill nkr.)
“DDT and “current use pesticides” in mothers and children in a malaria control area in South Africa”. RCN funded project 2008-2010.
“Food from the Sea”. Funded by the Norwegian Research Council (Project no.: 175467/V40, in total 2640 kNOK). Co-PI. 2008-2011.
“Endocrine disrupting chemicals and breast cancer”. Post doc project in Quebec, Canada and CDC, Atlanta. 2003-2005.
“Human exposure to perfluorinated compounds: Concentrations, dietary impact and molecular signatures”. 2010. Charlotta Rylander. PhD. ISM, UiT. (Main supervisor)
“Maternal concentrations, predictors and change in profiles of organochlorines, toxic and essential elements during pregnancy and postpartum. The Vietnamese Mother-and-Child Study and the Northern Norwegian Mother-and-Child Study.” 2011. Solrunn Hansen. PhD. ISM, UiT. (Co-supervisor)
“Nutrients and toxic elements in semi- domesticated reindeer in Norway”.2012. Ammar Eltayeb Ali Hassan. PhD. ISM, UiT. (Co-supervisor)
“Human biomonitoring of perfluoroalkyl substances and cyclic volatile methyisiloxanes . Concentrations in plasma, serum and whole blood from pregnant, delivering or postmenopausal women, and cord blood”. 2013. Linda hanssen. PhD. ISM, UiT. (Co-supervisor)
“Prenatal exposure to DDT and other selected environmental contaminants and their predictors in malaria and non-malaria areas in coastal KwaZulu Natal, South Africa”. 2014. Kalavati Channa. Dr. Philos. ISM, UiT. (Co-supervisor)
Modelling human concentrations of POPs. Therese H Nøst. The aim of this project is to study historical exposure and use the data together with new models to predict future exposure scenarios that will further improve the accurateness of exposure assessments and an individual and population basis. (Co-supervisor.)
POPs and hormones during pregnancy. The aim is to study changes in POPs and hormone concentrations during pregnancy and Vivian Berg. (Co-supervisor.)
Just funded PhD project:
“Personal Care Products and female health: exploring endocrine effects of parabens on Cancer of breast and endometrium, and genomic pathways”. (Main supervisor)
“Environment and Human Health effects in the Norwegian Russian border area.” (Main supervisor)