1) Design, synthesis and development of antimicrobial and anticancer peptides and peptidomimetics as lead-compounds for drug-development and investigation of pharmacophore models.
2) Design and synthesis of peptidomimetics and bioactive scaffolds for optimization of potency and pharmacokinetic properties.
3) Isolation and structural elucidation of marine bioactive compounds from Arctic and sub-Arctic marine invertebrates and synthesis of marine natural product mimics (marine bio-prospecting).
PhD student supervision
2000 – 2004: Assistant supervisor for Dr. Morten K. Moe - PhD thesis: ESI low-energy tandem MS characterisation of lipids modified by a novel derivatisation method. Financed by the Norwegian Research Council.
2007 – 2010: Assistant supervisor for Dr. Margey Tadesse - PhD thesis: Antimicrobial natural products from Arctic and sub-Arctic marine invertebrates. Financed by UoT.
2007 – 2011: Primary supervisor for Dr. Terkel Hansen (cand. pharm.) - PhD thesis: Antimicrobial and anticancer beta-peptidomimetics – synthesis and biological evaluation of a new class of small and highly potent compounds. Financed by UoT.
2008 – 2012: Primary supervisor for Dominik A. Ausbacher (cand. pharm.) - PhD Thesis: Biological activity of β2,2-amino acid derivatives derived from antimicrobial peptides - Investigations of antimicrobial and anticancer activity and the mechanisms of action. Financed by UoT.
2008 – 2013: Primary supervisor for Veronika Tørfoss (cand. pharm.) - PhD thesis: Short anticancer peptides containing a lipophilic β2,2-amino acid - Synthesis and biological evaluation of linear and cyclic hepta-, hexa-, penta-, and tetrapeptides. Financed by the Norwegian Research Council (KOSK-II program).
2011 – 2015 Assistant supervisor for Elisabeth Klungerbo Olsen (cand. pharm.) - PhD thesis: Bioprospecting of Arctic marine organisms. Financed by MabCent – SFI.
2011 – in progress: Primary supervisor for Elizaveta Mikhailovna Igumnova - Working title: Chemical synthesis, isolation, and structural characterization of marine bioactive hit compounds. Financed by MabCent – SFI.
2012 - 2016: Assistant supervisor for Runar Gjerp Solstad - PhD thesis: Discovery of antimicrobial peptides in two invertebrates, the sea anemone Urticina eques and the sea urchin chinus esculentus - Isolation, characterization and structure-activity relationship studies. Financed by UoT.
2012 - 2017: Primary supervisor for Marianne Hagensen Paulsen - PhD thesis: Synthetic mimics of antimicrobial peptides. Synthesis and biological studies of novel synthetic mimics of antimicrobial peptides. Financed by the Norwegian Research Council (NFR) and UoT - "Fellesløftet".
2014 - 2017: Assistant supervisor for Thomas Aleksander Bakka (NTNU - Trondheim - Norway) - PhD thesis: Synthesis and antimicrobial evaluation of small molecule amphiphiles derived from amphiphilic antimicrobial natural products. Financed by NTNU.
2018 - in progress: Assistant supervisor for Manuel Karl Langer (Department of chemistry – UiT) – Working title: Synthesis of new antimicrobial, antibiofilm and antifouling agents. Financed by UiT – The Arctic University of Norway – "Thematic emphasis programme" - AntifoMar.
2018 - in progress: Primary supervisor for Danijela Simonovic (Department of Pharmacy – UiT) – Working title: Synthesis of antimicrobial amphipathic scaffolds targeting multi-resistant bacteria. Financed by UiT – The Arctic University of Norway – "Thematic emphasis programme" – LEADScAMR.
2018 - in progress: Assistant supervisor for Christoffer Ågnes Sivertsen (Faculty of Bioscience, fisheries, and economics – UiT) – Working title: Antibacterial and antibiofilm compounds in Arctic and sub-Arctic invertebrates. Financed by UiT – The Arctic University of Norway – "Thematic emphasis programme" – AntifoMar.
2019 - in progress: Assistant supervisor for Susannah von Hofsten (Department of medical biology – UiT) – Working title: Identification and development of anticancer peptides and peptidomimetics for targeted therapy of cancer. Financed by UiT – The Arctic University of Norway.
Supervision of master students
I have since 2003 been supervisor for 28 master students in pharmacy / medicinal chemistry / organic chemistry.
1994: Bachelor of Science (Norwegian Cand. Mag.) in chemistry, UoT.
1996: Master of Science (Norwegian Cand. Scient.) in organic chemistry, UoT. Title of thesis: “Synthesis of substrate-analogs for collagenase by peptide synthesis in solution.”
1996: Scientific Researcher at the University Hospital of Northern-Norway (UNN).
1997: PhD student in organic chemistry, UoT.
2001: Philosophiae Doctor (PhD) in organic chemistry. Title of PhD thesis: “Lactoferricin as a model system for preparing highly active antimicrobial peptides”.
2001: Post doc.
2002 – 2012: Associate professor at the Department of Pharmacy (UoT).
2006: University Pedagogical Seminar (UPS) completed.
2012: Professor at the Department of Pharmacy (UoT).
FAR-2301: Medicinal chemistry and natural products chemistry
FAR-3301: Advanced pharmaceutical chemistry