The LacZymes group


Webpage: https://en.uit.no/prosjekter/prosjekt?p_document_id=467132

Group leader: Professor Hanna-Kirsti S. Leiros

 

Email: hanna-kirsti.leiros@uit.no
Phone:  +47 77645706 or +47 95966897
Researcher ID: https://orcid.org/0000-0002-2726-6322 and https://scholar.google.no/citations?user=07E4TNcAAAAJ&hl=en

Main research activities:
The LacZymes group focuses on ß-lactamases, enzymes breaking down ß-lactam antibiotics and deactivating their antibacterial properties. The ß-lactam antibiotics have long been a cornerstone for the treatment of bacterial diseases, but worryingly many bacteria are now resistant to these drugs. The most common resistance mechanism towards ß-lactam antibiotic is the production of ß-lactamases, and transferable ß-lactamases-encoding genes is spreading rapidly dramatically limiting treatment options. ß-lactamases include both metallo-ß-lactamases (MBLs) and serine-ß-lactamases (SBLs), and occur mainly in Gram-negative pathogens including Enterobacterales, Pseudomonas aeruginosa and Acinetobacter baumannii.  Our long-term goal is finding new inhibitors for both ß-lactamase classes, to be used in combination with a ß-lactam to prolong their lifetime. The group of ß-lactam antibiotics includes penicillins, cephalosporins and carbapenems.