DC2
Establish mathematical models resembling subcellular NAD, FAD, SAM, ATP and CoA dynamics and their linkage
Background: In ongoing studies, we recognized a strong linkage in the biosynthesis of NAD, FAD, CoA and ATP with very similar half-life and similar responses to perturbation. The basis of this linkage is so far not well understood. We also found a parallel evolution of the compartmentalisation of NAD, FAD and CoA and showed that mitochondria play an important role as cellular NAD buffer.
Objectives: (1) To conduct a comprehensive AI supported literature search to compile a searchable database containing available information on mitochondrial transporters and enzymes involved in cofactor biosynthesis; (2) Based on (1) we will extend and compartmentalize existing models of cofactor biosynthesis NAD and SAM and link them to ATP, FAD and CoA synthesis.
Location: UiT The Arctic University of Norway