Master i Farmasi Selenia Ternullo disputerer for ph.d.-graden i helsevitenskap og vil offentlig forsvare avhandlingen:
“Nanocarriers for tailored skin delivery: More than just the carriers?”
Kort sammendrag av avhandlingen:
Localized drug action is expected to improve therapeutic outcome of many diseases, including skin therapy. The optimization of nanocarriers that can carry the drug into the targeted skin layers in a controllable manner leads to improvement in therapy. In this PhD project, different lipid nanoparticles were tested as nanocarriers on the skin model developed to closely mimic the living human skin. Elastic spherical vesicles, deformable liposomes, were found to be the most promising nanocarriers delivering the active compounds in the deeper skin layers while avoiding systemic absorption. By exploring the effect of vesicle surface charge, a sustained dermal delivery of the active substances was achieved and their biological activities, such as anti-inflammatory and anti-bacterial, enhanced. Positively charged deformable liposomes in chitosan hydrogel were proposed as advanced wound dressing able to assure prolonged drug localization at the administration site.
Veiledere
Hovedveileder professor Natasa Skalko-Basnet
Biveileder professor Gøril Eide Flaten
Biveileder førsteamanuensis Ann-Mari Holsæter
Biveileder professor II Louis de Weerd
Bedømmelseskomiteen
Professor Joke Bouwstra, Leiden University, Nederland – 1. opponent
Førsteamanuensis Francesco Cilurzo, The University of Milan, Italia – 2. opponent
Førsteamanuensis Ingvild Mikkola, Institutt for farmasi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet – leder av komité
Disputasleder
Instituttleder Guro Forsdahl, Institutt for farmasi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet
Prøveforelesning over oppgitt emne holdes kl. 10.15, samme sted: “Liposomes as a drug delivery system for inhalation”