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Bilde av Brandsdal, Bjørn Olav
Bilde av Brandsdal, Bjørn Olav
Professor, Theoretical and Computational Chemistry, Hylleraas Centre for Quantum Molecular Sciences Department of Chemistry bjorn-olav.brandsdal@uit.no +4777644057 You can find me here

Bjørn Olav Brandsdal

  • Ryan Scott Wilkins, Bjarte Aarmo Lund, Geir Villy Isaksen, Johan Lennart Gösta Åqvist, Bjørn Olav Brandsdal :
    Accurate Computation of Thermodynamic Activation Parameters in the Chorismate Mutase Reaction from Empirical Valence Bond Simulations
    Journal of Chemical Theory and Computation 2024 ARKIV / DOI
  • Florian van der Ent, Susann Skagseth, Bjarte Aarmo Lund, Jaka Sočan, Julia J. Griese, Bjørn Olav Brandsdal et al.:
    Computational design of the temperature optimum of an enzyme reaction
    Science Advances 2023 ARKIV / DOI
  • Florian van der Ent, Bjarte Aarmo Lund, Linn Svalberg, Miha Purg, Ghislean Chukwu, Mikael Widersten et al.:
    Structure and Mechanism of a Cold-Adapted Bacterial Lipase
    Biochemistry 2022 ARKIV / DOI
  • Philip Ben Rainsford, Birta R. Sarre, Margherita Falavigna, Bjørn Olav Brandsdal, Gøril Eide Flaten, Martin Jakubec et al.:
    WIND-PVPA: Water/Ion NMR Detected PVPA to assess lipid barrier integrity in vitro through quantification of passive water- and ion transport
    Biochimica et Biophysica Acta - Biomembranes 2022 ARKIV / DOI
  • Bjarte Aarmo Lund, Bjørn Olav Brandsdal :
    ThermoSlope: A Software for Determining Thermodynamic Parameters from Single Steady-State Experiments
    Molecules 2021 ARKIV / DOI
  • Jaka Socan, Geir Villy Isaksen, Bjørn Olav Brandsdal, Johan Lennart Gösta Åqvist :
    Towards Rational Computational Engineering of Psychrophilic Enzymes
    Scientific Reports 2019 ARKIV / DOI
  • Willem Jespers, Geir Villy Isaksen, Tor Arne Heim Andberg, Silvana Vasile, Amber van Veen, Johan Åqvist et al.:
    QresFEP: An Automated Protocol for Free Energy Calculations of Protein Mutations in Q
    Journal of Chemical Theory and Computation 2019 ARKIV / DOI
  • Jaka Socan, Masoud Kazemi, Geir Villy Isaksen, Bjørn Olav Brandsdal, Johan Åqvist :
    Catalytic Adaptation of Psychrophilic Elastase
    Biochemistry 2018 DOI
  • Davide Michetti, Bjørn Olav Brandsdal, Davide Bon, Geir Villy Isaksen, Matteo Tiberti, Elena Papaleo :
    A comparative study of cold-and warmadapted Endonucleases A using sequence analyses and molecular Dynamics simulations
    PLOS ONE 2017 ARKIV / DOI
  • Marthe Måløy, Frode Måløy, Per Jakobsen, Bjørn Olav Brandsdal :
    Dynamic self-organisation of haematopoiesis and (a)symmetric cell division
    Journal of Theoretical Biology 2017 ARKIV / DOI
  • Johan Åqvist, Masoud Kazemi, Geir Villy Isaksen, Bjørn Olav Brandsdal :
    Entropy and Enzyme Catalysis
    Accounts of Chemical Research 2017 ARKIV / DOI
  • Johan Åqvist, Geir Villy Isaksen, Bjørn Olav Brandsdal :
    Computation of enzyme cold adaptation
    Nature Reviews Chemistry 2017 DOI
  • Geir Villy Isaksen, Johan Åqvist, Bjørn Olav Brandsdal :
    Thermodynamics of the Purine Nucleoside Phosphorylase Reaction Revealed by Computer Simulations
    Biochemistry 2017 DOI
  • Ulli Rothweiler, Wenche Stensen, Bjørn Olav Brandsdal, Johan Isaksson, Frederick Alan Leeson, Richard Alan Engh et al.:
    Probing the ATP-Binding Pocket of Protein Kinase DYRK1A with Benzothiazole Fragment Molecules
    Journal of Medicinal Chemistry 2016 DOI
  • Geir Villy Isaksen, Johan Åqvist, Bjørn Olav Brandsdal :
    Enzyme surface rigidity tunes the temperature dependence of catalytic rates
    Proceedings of the National Academy of Sciences of the United States of America (PNAS) 12. July 2016 DOI
  • Geir Villy Isaksen, Kathrin Helen Hopmann, Johan Åqvist, Bjørn Olav Brandsdal :
    Computer Simulations Reveal Substrate Specificity of Glycosidic Bond Cleavage in Native and Mutant Human Purine Nucleoside Phosphorylase
    Biochemistry 17. March 2016 DOI
  • Marte Rørvik Høyem, Frode Måløy, Per Jakobsen, Bjørn Olav Brandsdal :
    Stem cell regulation: Implications when differentiated cells regulate symmetric stem cell division
    Journal of Theoretical Biology 2015 ARKIV / DOI
  • Geir Villy Isaksen, Tor Arne Heim Andberg, Johan Åqvist, Bjørn Olav Brandsdal :
    Qgui: A high-throughput interface for automated setup and analysis of free energy calculations and empirical valence bond simulations in biological systems
    Journal of Molecular Graphics and Modelling 2015 DOI
  • Geir Villy Isaksen, Johan Åqvist, Bjørn Olav Brandsdal :
    Protein surface softness is the origin of enzyme cold-adaptation of trypsin
    PLoS Computational Biology 2014 ARKIV / DOI
  • Annfrid Sivertsen, Johan Isaksson, Hanna-Kirsti S. Leiros, Johan Svenson, John Sigurd Svendsen, Bjørn Olav Brandsdal :
    Synthetic cationic antimicrobial peptides bind with their hydrophobic parts to drug site II of human serum albumin
    BMC Structural Biology 2014 ARKIV / DOI
  • Annfrid Sivertsen, Veronika Tørfoss, Johan Isaksson, Dominik Ausbacher, Trude Anderssen, Bjørn Olav Brandsdal et al.:
    Anticancer potency of small linear and cyclic tetrapeptides and pharmacokinetic investigations of peptide binding to human serum albumin
    Journal of Peptide Science 2014 DOI
  • Annfrid Sivertsen, Bjørn Olav Brandsdal, John Sigurd Svendsen, Jeanette hammer Andersen, Johan Svenson :
    Short cationic antimicrobial peptides bind to human alpha-1 acid glycoprotein with no implications for the in vitro bioactivity
    Journal of Molecular Recognition 2013 DOI
  • Rianne Harmsen, Annfrid Sivertsen, Davide Michetti, Bjørn Olav Brandsdal, Leiv K. Sydnes, Bengt Erik Haug :
    Synthesis and docking of novel piperidine renin inhibitors
    Monatshefte für Chemie 2013 DOI
  • Maarten Beerepoot, Arnfinn Hykkerud Steindal, Jacob Kongsted, Bjørn Olav Brandsdal, Luca Frediani, Kenneth Ruud :
    A polarizable embedding DFT study of one-photon absorption in fluorescent proteins
    Physical Chemistry, Chemical Physics - PCCP 2013 DOI
  • Veronika Tørfoss, Dominik Ausbacher, Cristiane de Albuquerque Cavalcanti Jacobsen, Terkel Hansen, Bjørn Olav Brandsdal, Martina Havelkova et al.:
    Synthesis of anticancer heptapeptides containing a unique lipophilic β2,2-amino acid building block
    Journal of Peptide Science 2012 DOI
  • Rasmus Tørnes Karstad, Geir Villy Isaksen, Evelien Wynendaele, Yngve Guttormsen, Bart De Spiegeleer, Bjørn Olav Brandsdal et al.:
    Targeting the S1 and S3 Subsite of Trypsin with Unnatural Cationic Amino Acids Generates Antimicrobial Peptides with Potential for Oral Administration
    Journal of Medicinal Chemistry 2012 DOI
  • Hanna-Kirsti S. Leiros, Naga Pardha Saradhi Borra, Bjørn Olav Brandsdal, Kine Susann Waade Edvardsen, James Spencer, Timothy R. Walsh et al.:
    Crystal Structure of the Mobile Metallo-beta-Lactamase AIM-1 from Pseudomonas aeruginosa: Insights into Antibiotic Binding and the Role of Gln157
    Antimicrobial Agents and Chemotherapy 2012 DOI
  • Veronika Tørfoss, Johan Isaksson, Dominik Ausbacher, Bjørn Olav Brandsdal, Gøril Eide Flaten, Trude Anderssen et al.:
    Improved anticancer potency by head-to-tail cyclization of short cationic anticancer peptides containing a lipophilic b2,2-amino acid
    Journal of Peptide Science 2012 DOI
  • Johan Isaksson, Bjørn Olav Brandsdal, Stig Olov Magnus Engqvist, Gøril Eide Flaten, John Sigurd Svendsen, Wenche Stensen :
    A Synthetic Antimicrobial Peptidomimetic (LTX 109): Stereochemical Impact on Membrane Disruption
    Journal of Medicinal Chemistry 2011 DOI
  • Peter Kyomuhendo, Bjørnar Myrnes, Bjørn Olav Brandsdal, Arne Smalås, Inge Waller Nilsen, Ronny Helland :
    Thermodynamics and structure of a salmon cold active goose-type lysozyme
    Comparative Biochemistry and Physiology - Part B: Biochemistry & Molecular Biology 2010 DOI
  • Bjørn Olav Brandsdal :
    Kuledetilpassninger - livet under og rundt vannets frysepunkt
    2019
  • Bjørn Olav Brandsdal :
    Multiphase system
    2019
  • Bjørn Olav Brandsdal :
    Computation of enzyme cold-adaptation
    2019
  • Karolina Solheimslid Eikås, Kenneth Ruud, Maarten Beerepoot, Bjørn Olav Brandsdal :
    Towards a computational protocol for VCD spectra of cyclic peptides
    2019
  • Karolina Solheimslid Eikås, Kenneth Ruud, Maarten Beerepoot, Bjørn Olav Brandsdal :
    Towards a computational protocol for VCD spectra of cyclic peptides
    2019
  • Karolina Solheimslid Eikås, Kenneth Ruud, Maarten Beerepoot, Bjørn Olav Brandsdal :
    Towards a computational protocol for VCD spectra of cyclic peptides
    2019
  • Karolina Solheimslid Eikås, Kenneth Ruud, Maarten Beerepoot, Bjørn Olav Brandsdal :
    Towards a computational protocol for VCD spectra of cyclic peptides
    2019
  • Bjørn Olav Brandsdal :
    Computer simulations of cold-adaptation
    2019
  • Bjørn Olav Brandsdal :
    Computation of enzyme cold-adaptation II
    2019
  • Geir Villy Isaksen, Bjørn Olav Brandsdal :
    Tromsø VR lab (forskningsdagene 2019)
    Forskningsdagene 2019 2019
  • Geir Villy Isaksen, Johan Åqvist, Bjørn Olav Brandsdal :
    Computation of Enzyme Temperature Adaptation - Protein Surface Softness Regulates the Enthalpy-Entropy Balance.
    2018
  • Laura Liikanen, Bjørn Olav Brandsdal :
    DigiBiotics
    2018
  • Marc Boomgaren, Birta Ravdna Sarre, Tor Arne Heim Andberg, Bjørn Olav Brandsdal, Johan Isaksson, Jørn H Hansen :
    Synthesis and exploration of a novel molecular scaffold for dUTPase inhibition: Aiming for new anticancer agents
    2017
  • B Sorensen, MA Sommerfelt, G Stjernholm, PL Smith, M Okvist, Bjørn Olav Brandsdal et al.:
    The HIV-1 gp120 C5 Region Shows HLA-like Properties for Immune Activation that May Be Masked by Antibodies
    AIDS Research and Human Retroviruses 2013
  • Bjørn Olav Brandsdal, Kenneth Ruud, Maarten Beerepoot, Arnfinn Hykkerud Steindal :
    Datamodellering i kjemi og biologi, en selvmotsigelse?
    Nordlys 09. December 2013
  • Maarten Beerepoot, Bjørn Olav Brandsdal, Kenneth Ruud, Arnfinn Hykkerud Steindal :
    Nobelprisen i kjemi 2013
    Kjemi 2013
  • Rianne Harmsen, Annfrid Sivertsen, Davide Michetti, Bjørn Olav Brandsdal, Leiv K. Sydnes, Bengt Erik Haug :
    Synthesis and docking of 4-triazolyl substituted piperidine derivatives as novel renin inhibitors
    2012
  • Rianne Harmsen, A Sivertsen, Davide Michetti, Bjørn Olav Brandsdal, Leiv Kristen Sydnes, Bengt Erik Haug :
    Synthesis and docking of 4-triazolyl substituted piperidine derivatives as novel renin inhibitors
    Journal of Peptide Science 2012
  • Geir Villy Isaksen, Johan Isaksson, John Sigurd Svendsen, Bjørn Olav Brandsdal :
    Structural studies of small cationic antimicrobial peptides by NMR and computer simulations have facilitated a refined pharmacophore model able to predict activity versus Staphylococcus aureus
    2011
  • Geir Villy Isaksen, Rasmus Tørnes Karstad, Johan Mattias Isaksson, Johan Svenson, John Sigurd Svendsen, Bjørn Olav Brandsdal :
    Structure of short cationic antimicrobial peptides and their interactions with membranes as revealed by MD simulations
    2010

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