Bilde av Bayer, Annette
Photo: Andreas Palmén
Bilde av Bayer, Annette
Department of Chemistry annette.bayer@uit.no +4777644069 +47 95884203

Annette Bayer


Professor, Chemical Synthesis and Analysis


  • Alexandra Kondratieva, Katarzyna Palica, Christopher Frøhlich, Rebekka Rolfsnes Hovd, Hanna-Kirsti S. Leiros, Máté Erdélyi et al.:
    Fluorinated captopril analogues inhibit metallo-β-lactamases and facilitate structure determination of NDM-1 binding pose
    European Journal of Medicinal Chemistry 2024 ARKIV / DOI
  • Martin Pettersen, Cuong Dat Do, Sai Manoj Gorantla Nagavenkatathrinatha, Marc Obst, Roman Damm, Anggi Eka Putra et al.:
    Asymmetric Boracarboxylation of Styrenes Using Carbon Dioxide
    Advanced Synthesis and Catalysis 2024 DATA / ARKIV / DOI
  • Alexandra Sofia Antunes de Sousa, Vegard Borøy, Agnethe Hansen Bæverud, Kjersti Julin, Annette Bayer, Morten B. Strøm et al.:
    Polymyxin B stabilized DNA micelles for sustained antibacterial and antibiofilm activity against P. aeruginosa
    Journal of materials chemistry. B 2023 ARKIV / DOI
  • Lisa Myrseth Hemmingsen, Barbara Giordani, Marianne Hagensen Paulsen, Zeljka Vanic, Gøril Eide Flaten, Beatrice Vitali et al.:
    Tailored anti-biofilm activity – Liposomal delivery for mimic of small antimicrobial peptide
    Biomaterials Advances 2023 ARKIV / DOI
  • Manuel K Langer, Ataur Rahman, Hymonti Dey, Trude Anderssen, Hans-Matti Blencke, Tor Haug et al.:
    Investigation of tetrasubstituted heterocycles reveals hydantoins as a promising scaffold for development of novel antimicrobials with membranolytic properties
    European Journal of Medicinal Chemistry 2023 ARKIV / DOI
  • Susannah von Hofsten, Manuel K Langer, Katja Korelin, Synnøve Norvoll Magnussen, Dominik Ausbacher, Trude Anderssen et al.:
    Amphipathic barbiturates as marine product mimics with cytolytic and immunogenic effects on head and neck squamous cell carcinoma cell lines
    Frontiers in Pharmacology 30. March 2023 ARKIV / DOI
  • Manuel K Langer, Ataur Rahman, Hymonti Dey, Trude Anderssen, Francesco Zilioli, Tor Haug et al.:
    A concise SAR-analysis of antimicrobial cationic amphipathic barbiturates for an improved activity-toxicity profile
    European Journal of Medicinal Chemistry 2022 ARKIV / FULLTEKST / DATA / DOI
  • Susannah von Hofsten, Marianne Hagensen Paulsen, Synnøve Magnussen, Dominik Ausbacher, Mathias Kranz, Annette Bayer et al.:
    The marine natural product mimic MPM-1 is cytolytic and induces DAMP release from human cancer cell lines
    Scientific Reports 2022 ARKIV / DOI
  • Lianne H. E. Wieske, Jonathan Bogaerts, Albin A. M. Leding, Scott Wilcox, Anna Andersson Rasmussen, Kinga Leszczak et al.:
    NMR Backbone Assignment of VIM-2 and Identification of the Active Enantiomer of a Potential Inhibitor
    ACS Medicinal Chemistry Letters 2022 ARKIV / DOI
  • Marianne Hagensen Paulsen, Magnus Engqvist, Dominik Ausbacher, Trude Anderssen, Manuel K- Langer, Tor Haug et al.:
    Amphipathic Barbiturates as Mimics of Antimicrobial Peptides and the Marine Natural Products Eusynstyelamides with Activity against Multi-resistant Clinical Isolates
    Journal of Medicinal Chemistry 2021 ARKIV / DOI
  • Ashot Gevorgyan, Kathrin Helen Hopmann, Annette Bayer :
    Lipids as Versatile Solvents for Chemical Synthesis
    Green Chemistry 2021 ARKIV / DOI
  • Ashot Gevorgyan, Kathrin Helen Hopmann, Annette Bayer :
    Improved Buchwald-Hartwig Amination by the Use of Lipids and Lipid Impurities
    Organometallics 2021 ARKIV / DOI
  • Ljiljana Pavlovic, Martin Pettersen, Ashot Gevorgyan, Janakiram Vaitla, Annette Bayer, Kathrin Helen Hopmann :
    Computational and experimental insights into asymmetric Rh‐catalyzed hydrocarboxylation with CO2
    European Journal of Organic Chemistry 2020 ARKIV / PROSJEKT / FULLTEKST / DOI
  • Ashot Gevorgyan, Kathrin Helen Hopmann, Annette Bayer :
    Exploration of New Biomass-Derived Solvents: Application to Carboxylation Reactions
    ChemSusChem 2020 ARKIV / DOI
  • Ørjan Samuelsen, Ove Alexander Høgmoen Åstrand, Christopher Frøhlich, Adam Heikal, Susann Skagseth, Trine Josefine Olsen Carlsen et al.:
    ZN148 Is a Modular Synthetic Metallo-beta-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens In Vivo
    Antimicrobial Agents and Chemotherapy 2020 ARKIV / DATA / DOI
  • Aya Ismael, Troels Skrydstrup, Annette Bayer :
    Carbonylative Suzuki-Miyaura couplings of sterically hindered aryl halides: Synthesis of 2-aroylbenzoate derivatives
    Organic and biomolecular chemistry 2020 ARKIV / DOI
  • Zeeshan Muhammad, Susann Skagseth, Marc Boomgaren, Sundus Akhter, Christopher Frøhlich, Aya Ismael et al.:
    Structural studies of triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-β-lactamases
    Bioorganic & Medicinal Chemistry 01. August 2020 ARKIV / DOI
  • Yngve Guttormsen, Magnus John Espeland Fairhurst, Sunil Kumar Pandey, Johan Isaksson, Bengt Erik Haug, Annette Bayer :
    Total synthesis of phorbazole B
    Molecules 21. October 2020 ARKIV / PROSJEKT / DOI
  • Aya Ismael, Ashot Gevorgyan, Troels Skrydstrup, Annette Bayer :
    Renewable solvents for palladium-catalyzed carbonylation reactions
    Organic Process Research & Development 2020 ARKIV / DOI
  • Ikenna E. Ndukwe, Yu-hong Lam, Sunil Kumar Pandey, Bengt Erik Haug, Annette Bayer, Edward C. Sherer et al.:
    Unequivocal structure confirmation of a breitfussin analog by anisotropic NMR measurements
    Chemical Science 21. September 2020 ARKIV / DOI
  • Marc Obst, Ashot Gevorgyan, Annette Bayer, Kathrin Helen Hopmann :
    Mechanistic Insights into Copper-Catalyzed Carboxylations
    Organometallics 2020 ARKIV / DOI
  • Ashot Gevorgyan, Kathrin Helen Hopmann, Annette Bayer :
    Formal C-H carboxylation of unactivated arenes
    Chemistry - A European Journal 2020 ARKIV / DOI
  • Janakiram Vaitla, Annette Bayer, Kathrin Helen Hopmann :
    Vinyl Sulfoxonium Ylide: A New Vinyl Carbenoid Transfer Reagent for the Synthesis of Heterocycles
    Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry 2019 ARKIV / PROSJEKT / FULLTEKST / DOI
  • Marianne Hagensen Paulsen, Dominik Ausbacher, Annette Bayer, Magnus Engqvist, Terkel Hansen, Tor Haug et al.:
    Antimicrobial activity of amphipathic α,α-disubstituted β-amino amide derivatives against ESBL–CARBA producing multi-resistant bacteria; effect of halogenation, lipophilicity and cationic character
    European Journal of Medicinal Chemistry 2019 ARKIV / DOI
  • Ashot Gevorgyan, Marc Obst, Yngve Guttormsen, Feliu Maseras, Kathrin Helen Hopmann, Annette Bayer :
    Caesium Fluoride-Mediated Hydrocarboxylation of Alkenes and Allenes: Scope and Mechanistic Insights
    Chemical Science 2019 ARKIV / DOI
  • Kine Østnes Hansen, Jeanette hammer Andersen, Annette Bayer, Sunil Kumar Pandey, Marianne Lorentzen, Kåre Bredeli Jørgensen et al.:
    Kinase chemodiversity from the Arctic: the breitfussins
    Journal of Medicinal Chemistry 2019 ARKIV / DOI
  • Janakiram Vaitla, Annette Bayer :
    Sulfoxonium Ylide Derived Metal Carbenoids in Organic Synthesis
    Synthesis (Stuttgart) 2019 ARKIV / DOI
  • Magnus John E. Fairhurst, Zeeshan Muhammad, Bengt Erik Haug, Annette Bayer :
    Aldol condensations on a 3-alkylidene-2,5-diketopiperazine - synthesis of two marine natural products
    Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry 2018 ARKIV / DOI
  • Alexandra Sofia Antunes De Sousa, Mona Susan Johannessen, Annette Bayer, Morten Bøhmer Strøm, Natasa Skalko Basnet, Sybil Akua Okyerewa Obuobi :
    Study of the penetration ability of DNA nanoparticles in biofilms
    2024
  • Annette Bayer, Bengt Erik Haug, Bård Helge Hoff, Magne Olav Sydnes :
    Kjemi og legemiddelberedskap
    Kjemi 2024
  • Annette Bayer, Bengt Erik Haug, Bård Helge Hoff, Magne Olav Sydnes :
    Kjemi og beredskap
    Stavanger Aftenblad 09. March 2024
  • Alexandra Sofia Antunes de Sousa, Kjersti Julin, Annette Bayer, Morten Bøhmer Strøm, Mona Johannessen, Natasa Skalko-Basnet et al.:
    Drug-loaded DNA nanoparticles against bioflms
    2023
  • Ataur Rahman, Manuel K Langer, Hans-Matti Blencke, Tor Haug, Johanna U Ericson, Morten B. Strøm et al.:
    Development of novel antimicrobial peptides: two classes with improved antimicrobial and antibiofilm activity
    2023 PROSJEKT
  • Guillaume Petit, Kine Østnes Hansen, Jeanette Hammer Andersen, Espen Holst Hansen, Annette Bayer, Bengt Erik Haug et al.:
    A fragment to bind them all: Characterising phorbazole fragments as pan-kinase inhibitor
    2023
  • Manuel K Langer, Annette Bayer :
    Total synthesis of Aspergilone A in batch and flow - A comparison
    2023
  • Manuel K Langer, Ataur Rahman, Hymonti Dey, Trude Anderssen, Hans-Matti Blencke, Tor Haug et al.:
    Tetrasubstituted hydantoins: Novel membranolytic antimicrobials
    2023
  • Lisa Myrseth Hemmingsen, Barbara Giordani, Marianne Hagensen Paulsen, Zeljka Vanic, Gøril Eide Flaten, Beatrice Vitali et al.:
    Liposomes in topical delivery of mimic of small antimicrobial peptide - Improving the anti-biofilm effect
    2023
  • Ainara Nova Flores, Troels Skrydstrup, Kim Daasbjerg, Annette Bayer, Liselotte Karulf :
    Recommendations for Future CO2 Management in the Nordic Countries
  • Jørn Hedløy Hansen, Annette Bayer, Marius Myreng Haugland :
    Enhanced teaching and learning outcomes from restructuring a basic organic chemistry course
    Nordic Journal of STEM Education 2023 ARKIV / FULLTEKST
  • Ataur Rahman, Manuel K Langer, Bartosz Michno, Hans-Matti Blencke, Tor Haug, Johanna U Ericson et al.:
    In vivo toxicity and activity of newly developed novel analogues of short-cationic antimicrobial peptides as novel antibacterial agents
    2023
  • Ataur Rahman, Manuel K Langer, Bartosz Michno, Hans-Matti Blencke, Tor Haug, Johanna U Ericson et al.:
    In vivo toxicity and activity of newly developed novel analogues of short-cationic antimicrobial peptides as novel antibacterial agents
    2023
  • Kjersti Julin, Annette Bayer, Morten Bøhmer Strøm, Mona Johannessen, Natasa Skalko-Basnet, Sybil Akua Okyerewa Obuobi :
    DNA Nanocarriers for improved biofilm penetration
    2022
  • Susannah von Hofsten, Marianne Hagensen Paulsen, Manuel K Langer, Synnøve Norvoll Magnussen, Dominik Ausbacher, Annette Bayer et al.:
    A Compound Inspired by Arctic Marine Animals Kills Cancer Cells in vitro and in vivo
    2022
  • Cuong Dat Do, Martin Pettersen, Marc Obst, Roman Damm, Anggi Eka Putra, Ashot Gevorgyan et al.:
    Cu-Catalyzed Boracarboxylation Of Substituted Styrenes With CO2
    2022
  • Ataur Rahman, Manuel Karl Langer, Hymonti Dey, Jonathan Hira, Ekaterina Mishchenko, Annette Bayer et al.:
    Novel antimicrobial and biofilm-inhibitors from marine resources
    2020
  • Susannah von Hofsten, Synnøve Norvoll Magnussen, Dominik Ausbacher, Marianne Hagensen Paulsen, Annette Bayer, Morten B. Strøm et al.:
    The Marine Natural Product Mimic MHP88 Shows Anticancer Activity and has the Potential to Cause Immunogenic Cell Death
    2020 ARKIV
  • Annette Bayer, Eldrid Borgan :
    Små hjelpestoffer kan få gammel antibiotika til å virke igjen
    13. July 2020
  • Manuel K Langer, Annette Bayer :
    Tetrasubstituted barbiturates and hydantoins as potential antibiotics
    2020
  • Annette Bayer :
    Structure Based Design of Carbapenemase Inhibitors
    2019
  • Annette Bayer :
    Structure-based design of carbapenemase inhibitors
    2019

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    Teaching

    • Introductory Organic Chemistry (KJE-1002); in 2019 i implemented a major change to the pedagogical approach - now focusing on systematic understanding of reaction mechanism rather than a system based on the oxidation state of functional groups - and teaching through a flipped-classroom approach.
    • Practical Organic Chemistry and Spectroscopy(KJE-1003)
    • Intermediate Organic Chemistry (KJE-3301)
    • Organometallic Chemistry(KJE-3308/8308)
    • Nuclear Magnetic Resonance (KJE-3305/8305)

    Member of research group


    Member of project