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Bilde av Leiros, Hanna-Kirsti Schrøder
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Bilde av Leiros, Hanna-Kirsti Schrøder
Department of Chemistry hanna-kirsti.leiros@uit.no +4777645706 +4795966897 Tromsø FPARK G 213

Hanna-Kirsti Schrøder Leiros

Professor, Biomolecular and Structural Chemistry, Norstruct

Job description

Crystallization of proteins, structure determination, structure activity relationships (SAR), drug design, inhibitor.

Supervision of students.  

  • Katarzyna Palica, Manuela Vorácová, Susann Skagseth, Anna Andersson Rasmussen, Lisa Allander, Madlen Hubert et al.:
    Metallo-β-Lactamase Inhibitor Phosphonamidate Monoesters
    ACS Omega 2021 ARKIV / FULLTEKST / DOI
  • Bjarte Aarmo Lund, Ane Molden Thomassen, Trine Josefine Warg Carlsen, Hanna-Kirsti Schrøder Leiros :
    Biochemical and biophysical characterization of the OXA-48-like carbapenemase OXA-436
    Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2021 FULLTEKST / ARKIV / DOI
  • Mitchell Silk, Jason R. Price, Biswaranjan Mohanty, Hanna-Kirsti Schrøder Leiros, Bjarte Aarmo Lund, Phillip E. Thompson et al.:
    Side-Chain Interactions in d/l Peptide Nanotubes: Studies by Crystallography, NMR Spectroscopy and Molecular Dynamics
    Chemistry - A European Journal 2021 ARKIV / DOI
  • Jolyn Pan, Kjersti Lian, Aili Sarre, Hanna-Kirsti Schrøder Leiros, Adele Kim Williamson :
    Bacteriophage origin of some minimal ATP-dependent DNA ligases: a new structure from Burkholderia pseudomallei with striking similarity to Chlorella virus ligase
    Scientific Reports 2021 ARKIV / DOI
  • Christopher Frøhlich, João Alves Gama, Klaus Harms, Viivi H. A. Hirvonen, Bjarte Aarmo Lund, Marc W. van der Kamp et al.:
    Cryptic β-Lactamase Evolution Is Driven by Low β-Lactam Concentrations
    mSphere 2021 ARKIV / DOI
  • Zeeshan Muhammad, Susann Skagseth, Marc Boomgaren, Sundus Akhter, Christopher Frøhlich, Aya Ismael et al.:
    Structural studies of triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-β-lactamases
    Bioorganic & Medicinal Chemistry 01. August 2020 ARKIV / DOI
  • Adele Kim Williamson, Hanna-Kirsti S. Leiros :
    Structural insight into DNA joining: from conserved mechanisms to diverse scaffolds
    Nucleic Acids Research (NAR) 2020 ARKIV / DOI
  • Hanna-Kirsti S. Leiros, Ane Molden Thomassen, Ørjan Samuelsen, Carl-Fredrik Flach, Stathis D. Kotsakis, Joakim Larsson :
    Structural insights into the enhanced carbapenemase efficiency of OXA-655 compared to OXA-10
    FEBS Open Bio 2020 ARKIV / FULLTEKST / DOI
  • Christopher Frøhlich, Vidar Sørum, Sandra Huber, Ørjan Samuelsen, Fanny Berglund, Erik Kristiansson et al.:
    Structural and biochemical characterization of the environmental MBLs MYO-1, ECV-1 and SHD-1
    Journal of Antimicrobial Chemotherapy 2020 ARKIV / DOI
  • Ørjan Samuelsen, Ove Alexander Høgmoen Åstrand, Christopher Frøhlich, Adam Heikal, Susann Skagseth, Trine Josefine Olsen Carlsen et al.:
    ZN148 Is a Modular Synthetic Metallo-beta-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens In Vivo
    Antimicrobial Agents and Chemotherapy 2020 ARKIV / DATA / DOI
  • Christopher Frøhlich, Vidar Sørum, Ane Molden Thomassen, Pål Jarle Johnsen, Hanna-Kirsti S. Leiros, Ørjan Samuelsen :
    OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs
    mSphere 2019 ARKIV / DOI
  • Adele Kim Williamson, Hanna-Kirsti S. Leiros :
    Structural intermediates of a DNA-ligase complex illuminate the role of the catalytic metal ion and mechanism of phosphodiester bond formation
    Nucleic Acids Research (NAR) 2019 DATA / FULLTEKST / ARKIV / DOI
  • Anthony Prandina, Sylvie Radix, Marc Le Borgne, Lars Petter Jordheim, Zineb Bousfiha, Christopher Fröhlich et al.:
    Synthesis and biological evaluation of new dipicolylamine zinc chelators as metallo-β-lactamase inhibitors
    Tetrahedron 2019 ARKIV / DOI
  • Francesca Marcoccia, Hanna-Kirsti S. Leiros, Massimiliano Aschi, Gianfranco Amicosante, Mariagrazia Perilli :
    Exploring the role of L209 residue in the active site of NDM-1 a metallo-β-lactamase
    PLOS ONE 2018 ARKIV / DOI
  • Sundus Ahkter, Bjarte Aarmo Lund, Aya Ismael, Manuel Langer, Johan Isaksson, Tony Christopeit et al.:
    A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design
    European Journal of Medicinal Chemistry 2018 ARKIV / DOI
  • Adele Kim Williamson, Miriam Grgic, Hanna-Kirsti S. Leiros :
    DNA binding with a minimal scaffold: structure-function analysis of Lig E DNA ligases
    Nucleic Acids Research (NAR) 2018 ARKIV / DOI
  • Ørjan Samuelsen, Frank Hansen, Bettina Aasnæs, Henrik Hasman, Bjarte Aarmo Lund, Hanna-Kirsti S. Leiros et al.:
    Dissemination and Characteristics of a Novel Plasmid-Encoded Carbapenem-Hydrolyzing Class D β-Lactamase, OXA-436, Found in Isolates from Four Patients at Six Different Hospitals in Denmark
    Antimicrobial Agents and Chemotherapy 2018 DOI
  • Bjarte Aarmo Lund, Ane Molden Thomassen, Birgit Helene Berg Nesheim, Trine Josefine Olsen Carlsen, Johan Isaksson, Tony Christopeit et al.:
    The biological assembly of OXA‐48 reveals a dimer interface with high charge complementarity and very high affinity
    The FEBS Journal 2018 DOI
  • Susann Skagseth, Tony Christopeit, Sundus Akhter, Annette Bayer, Ørjan Samuelsen, Hanna-Kirsti S. Leiros :
    Structural insights into TMB-1 and the role of residues 119 and 228 in substrate and inhibitor binding
    Antimicrobial Agents and Chemotherapy 2017 ARKIV / DOI
  • Bjarte Aarmo Lund, Ane Molden Thomassen, Trine Josefine Olsen Carlsen, Hanna-Kirsti S. Leiros :
    Structure, activity and thermostability investigations of OXA-163, OXA-181 and OXA-245 using biochemical analysis, crystal structures and differential scanning calorimetry analysis
    Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2017 ARKIV / DOI
  • Susann Skagseth, Sundus Akhter, Marianne H. Paulsen, Muhammad Zeeshan, Silje Lauksund, Ørjan Samuelsen et al.:
    Metallo-β-lactamase inhibitors by bioisosteric replacement: preparation, activity and binding
    European Journal of Medicinal Chemistry 2017 ARKIV / DOI
  • Tony Christopeit, Ke-Wu Yang, Shao-Kang Yang, Hanna-Kirsti S. Leiros :
    The structure of the metallo-β-lactamase VIM-2 in complex with a triazolylthioacetamide inhibitor
    Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2016 ARKIV / DOI
  • Bjarte Aarmo Lund, Tony Christopeit, Yngve Guttormsen, Annette Bayer, Hanna-Kirsti S. Leiros :
    Screening and Design of Inhibitor Scaffolds for the Antibiotic Resistance Oxacillinase-48 (OXA-48) through Surface Plasmon Resonance Screening
    Journal of Medicinal Chemistry 11. May 2016 ARKIV / DOI
  • Christopher Frøhlich, Hanna-Kirsti S. Leiros :
    Vi må kanskje ta antibiotika hyppigere
    11. August 2022 DATA / PROSJEKT
  • Daniel Salamonsen, Christopher Fröhlich, Hanna-Kirsti S. Leiros :
    Co-selection reduces functional trade-offs in the carbapenemase OXA-48
    2022
  • Christopher Frøhlich, Adrian H. Bunzel, Marc W. Van Der Kamp, Adrian J. Mulholland, Hanna-Kirsti Schrøder Leiros, Pål Jarle Johnsen et al.:
    Positive epistasis drives the molecular evolution of the carbapenemase OXA-48
    2022
  • Hanna-Kirsti S. Leiros :
    Kor ofte skal du ta antibiotika? Kanskje oftare enn vi gjer no, ifølge forskarar
    12. August 2022 PROSJEKT / DATA
  • Klara Stensvåg, Arnfinn Sundsfjord, Pål Jarle Johnsen, Hanna-Kirsti S. Leiros, Lise Nordgård :
    CANS - Centre for New Antibacterial Strategies
    2022 PROSJEKT
  • Mitchell Silk, Jason R. Price, Biswaranjan Mohanty, Hanna-Kirsti Schrøder Leiros, Bjarte Aarmo Lund, Philip E. Thompson et al.:
    Side-Chain Interactions in d/l Peptide Nanotubes: Studies by Crystallography, NMR Spectroscopy and Molecular Dynamics
    Chemistry - A European Journal 2021 DOI
  • Christopher Frøhlich, Hanna-Kirsti S. Leiros, Charlotte Miton, Nobuhiko Tokuriki :
    Ceftazidime drives the evolution of the carbapenemase OXA-48
    2020
  • Hanna-Kirsti S. Leiros :
    På Labben med Forskningsdagene 2020. På Institutt for kjemi, UiT. "Proteiner som gjør at bakterier er resistente mot antibiotika".
    27. September 2020 DATA
  • Tore Rasmussen Steien, Hanna-Kirsti S. Leiros :
    Kjemikerne prøver å stoppe kjeften på antibiotikadreperne
    Norsk Farmaceutisk Tidsskrift 18. February 2020 DATA
  • Hanna-Kirsti S. Leiros :
    Vil ha 40 prosent kvinner i toppstillingar
    24. September 2020 DATA
  • Christopher Frøhlich, Hanna-Kirsti S. Leiros, Pål Jarle Johnsen, Ørjan Samuelsen :
    Sub-inhibitory concentrations of ceftazidime drive evolution of the OXA-48 carbapenemase
    2019
  • Hanna-Kirsti S. Leiros :
    Inhibitor potential of Serine- and Metallo-beta-lactamase inhibitors, and Biochemical and Biophysical characterization
    2019 DATA
  • Hanna-Kirsti S. Leiros :
    Fighting the antibiotic resistant serine-beta-lactamase OXA-48 - through altered ceftazidime activity or new inhibitors?
    2019
  • Hanna-Kirsti S. Leiros :
    Antibiotika resistens er et globalt problem. Nye inhibitorer og velkjente antibiotika, kan de sammen bli ny behandlings metode?
    2019
  • Adele Kim Williamson, Erik Hjerde, Aili Sarre, Ingar Leiros, Kristel Berg, Hanna-Kirsti S. Leiros :
    Discovery and design of novel DNA ligases for biotechnology
    2018
  • Christopher Frøhlich, Vidar Sørum, Hanna-Kirsti S. Leiros, Pål Jarle Johnsen, Ørjan Samuelsen :
    Development of OXA-48 mediated ceftazidme-avibactam resistance is associated with an evolutionary trade-off
    2018
  • Hanna-Kirsti S. Leiros :
    Aiming for inhibitors towards beta-lactamases involved in antibiotic resistance, but starting with fragment screening. How is the progress?
    2017
  • Hanna-Kirsti S. Leiros :
    Kampen. Den livsfarlige resistensen.
    31. March 2017 FULLTEKST
  • Hanna-Kirsti S. Leiros :
    Enzymer involvert i antibiotika resistens
    NBS-nytt 2017 DATA
  • Adele Kim Williamson, Erik Hjerde, Hanna-Kirsti S. Leiros, Kjersti Lian, Miguel A. Ramirez, Wayne M. Patrick :
    Beyond T4: discovery and design of DNA ligases for use in biotechnological applications
    2017
  • Hanna-Kirsti S. Leiros :
    Inhibitors can help fighting antibiotic resistance bacteria, but how do we find the best inhibitors?
    2017
  • Hanna-Kirsti S. Leiros :
    Fragment screening used successfully for detecting OXA, VIM or NDM inhibitors
    2017
  • Susann Skagseth, Hanna-Kirsti S. Leiros :
    Forskere vil gjenreise effekten av antibiotika. https://forskning.no/kortnytt/forskere-vil-gjenreise-effekten-av-antibiotika
    31. March 2017 DATA
  • Vibeke Os, Susann Skagseth, Hanna-Kirsti S. Leiros :
    "Superbugs" skal ikke lengre få herje i fred, Vil gjenreise effekten av antibiotika.
    30. March 2017 FULLTEKST
  • Bjarte Aarmo Lund, Hanna-Kirsti S. Leiros, Annette Bayer, Ørjan Samuelsen, Tony Christopeit :
    The OXA-class of β-lactamases. A structural view on antibiotic resistance
    2017
  • Annette Bayer, Hanna-Kirsti S. Leiros, Sundus Akhter, Bjarte Aarmo Lund, Tony Christopeit, Aya Ismael :
    Towards Antibiotic Resistance Breakers: Fragment-Based Design of OXA- 48 Inhibitors
    2017
  • Hanna-Kirsti S. Leiros :
    Searching for inhibitors towards beta-lactamases involved in antibiotic resistance, starting with fragment screening. Can we reach into the clinic?
    2016

    • The 50 latest publications is shown on this page. See all publications in Cristin here →

    Publications outside Cristin

     

     

     

    Research interests

    Antibiotic resistance, β-lactams, Metallo-β-lactamases, Serine-β-lactamases, Enzymology, Fragment screening, Surface plasmon resonance (SPR), Biophysical characterization, Enzyme inhibitor design, Drug design, Protein crystallography.

    I am part of the research group "Biomolecular and Structural Chemistry Group".

    I am one group leader in Centre for New Antibacterial Strategies (CANS) at UiT.

    Is groupleader in LacZymes.

     

    Researcher profile in Cristin

    Member of research group

    CANS   English content Biomolecular and Structural Chemistry   English content
    FPARK G 213

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