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Professor, PhD Clinical bioinformatics ruth.h.paulssen@uit.no +4777645480 +4740479347 +47 40479347 You can find me here

Ruth H Paulssen


Job description

 

Ruth H. Paulssen is a professor of molecular biology and gene technology at the Department of Clinical Medicine, Faculty of Health Sciences. She is the research group leader of the Clinical Bioinformatics Research Group and head of the Genomics Support Centre Tromsø (GSCT). Her major research interest is to increase the fundamental understanding of the molecular events during inflammatory and autoimmune diseases, thereby improving the individualized treatment of patients, and to enable the unbiased prediction of favourable and personalized treatment strategies for patients with inflammatory conditions. This research will be carried out in collaboration with local, national, and international research partners from clinics, molecular biology, bioinformatics, and computer sciences.


  • Wei Meng, Christopher Graham Fenton, Kay-Martin Johnsen, Hagar Taman, Jon Florholmen, Ruth Erika Hildegard Hracky Paulssen :
    DNA methylation fine-tunes pro-and anti-inflammatory signalling pathways in inactive ulcerative colitis tissue biopsies
    Scientific Reports 2024 ARKIV / DOI
  • Christopher Graham Fenton, Mithlesh Kumar Ray, Ruth Erika Hildegard Hracky Paulssen :
    Challenges in Defining a Reference Set of Differentially Expressed lncRNAs in Ulcerative Colitis by Meta-Analysis
    Current Issues in Molecular Biology 2024 ARKIV / DOI
  • Wei Meng, Kay-Martin Johnsen, Christopher Graham Fenton, Jon Florholmen, Ruth H Paulssen :
    Anti-apoptotic genes and non-coding RNAs are potential outcome predictors for ulcerative colitis
    Functional & Integrative Genomics 2023 ARKIV / DOI
  • Alicia Villatoro, Vincent Cuminetti, Aurora Bernal Mera, Carlos Torroja, Itziar Cossío, Alberto Benguría et al.:
    Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation
    Nature Communications 2023 ARKIV / DOI
  • Christopher Graham Fenton, Mithlesh Kumar Ray, Wei Meng, Ruth H Paulssen :
    Methylation-Regulated Long Non-Coding RNA Expression in Ulcerative Colitis
    International Journal of Molecular Sciences 2023 ARKIV / DOI
  • Sanda Krum-Hansen, Karina Standahl Olsen, Endre Anderssen, Jan Ole Frantzen, Eiliv Lund, Ruth H Paulssen :
    Associations of breast cancer related exposures and gene expression profiles in normal breast tissue - The Norwegian Women and Cancer normal breast tissue study
    Cancer Reports 2023 ARKIV / DOI
  • Mithlesh Kumar Ray, Christopher Graham Fenton, Ruth H Paulssen :
    Novel long non-coding RNAs of relevance for ulcerative colitis pathogenesis
    Non-coding RNA Research 2022 ARKIV / DOI
  • Amrinder Singh, Christopher Graham Fenton, Endre Anderssen, Ruth H Paulssen :
    Identifying predictive signalling networks for Vedolizumab response in ulcerative colitis
    International Journal of Colorectal Disease 11. May 2022 ARKIV / DOI
  • Amrinder Singh, Endre Anderssen, Christopher Graham Fenton, Ruth H Paulssen :
    Identifying anti-TNF response biomarkers in ulcerative colitis using a diffusion-based signalling model
    Bioinformatics Advances 2021 ARKIV / DOI
  • Eva-Stina Isabella Edholm, Christopher Graham Fenton, Stanislas Mondot, Ruth H Paulssen, Marie-Paule Lefranc, Pierre Boudinot et al.:
    Profiling the T Cell Receptor Alpha/Delta Locus in Salmonids
    Frontiers in Immunology 28. October 2021 ARKIV / DOI
  • Hagar Taman, Christopher Graham Fenton, Endre Anderssen, Jon Florholmen, Ruth H Paulssen :
    DNA hypo-methylation facilitates anti-inflammatory responses in severe ulcerative colitis
    PLOS ONE 2021 ARKIV / DOI
  • Christopher Graham Fenton, Hagar Taman, Jon Florholmen, Sveinung Sørbye, Ruth H Paulssen :
    Transcriptional signatures that define ulcerative colitis in remission
    Inflammatory Bowel Diseases 2020 ARKIV / DOI
  • Mona Dixon Gundersen, Rasmus Goll, Christopher Graham Fenton, Endre Anderssen, Sveinung Wergeland Sørbye, Jon Florholmen et al.:
    Fibrosis Mediators in the Colonic Mucosa of Acute and Healed Ulcerative Colitis
    Clinical and Translational Gastroenterology 2019 ARKIV / DOI
  • Hagar Taman, Christopher Graham Fenton, Inga Viktoria Hensel, Endre Anderssen, Jon Florholmen, Ruth H Paulssen :
    Genome-Wide DNA Methylation in Treatment-Naïve Ulcerative Colitis
    Journal - Crohn's and Colitis Foundation of Canada 2018 ARKIV / DOI
  • Hagar Mohamed Taman, Christopher Graham Fenton, Inga Viktoria Hensel, Endre Anderssen, Jon Florholmen, Ruth H Paulssen :
    Transcriptomic Landscape of Treatment-Naïve Ulcerative Colitis
    Journal of Crohn's and Colitis 2018 ARKIV / DOI
  • Armin Schniers, Endre Anderssen, Christopher Graham Fenton, Rasmus Goll, Yvonne Pasing, Ruth H Paulssen et al.:
    The Proteome of Ulcerative Colitis in Colon Biopsies from Adults - Optimized Sample Preparation and Comparison with Healthy Controls
    PROTEOMICS - Clinical Applications 2017 DOI
  • Yvonne Pasing, Christopher Graham Fenton, Rolf Jorde, Ruth H Paulssen :
    Changes in the human transcriptome upon vitamin D supplementation
    Journal of Steroid Biochemistry and Molecular Biology 2017 ARKIV / DOI
  • Åse Florholmen-Kjær, Rasmus Goll, Ole-Martin Fuskevåg, Ingvild Nygård, Ruth H Paulssen, Arthur Revhaug et al.:
    The impact of partial hepatectomy on oxidative state in the liver remnant - An in vivo swine model
    Redox Biology 2016 ARKIV / DOI
  • Kenneth Lønvik, Sveinung Wergeland Sørbye, Marit Nina Nilsen, Ruth H Paulssen :
    Prognostic value of the MicroRNA regulators Dicer and Drosha in non-small-cell lung cancer: Co-expression of Drosha and miR-126 predicts poor survival
    BMC Clinical Pathology 11. December 2014 FULLTEKST / ARKIV / DOI
  • Karina Standahl Olsen, Christopher Graham Fenton, Livar Frøyland, Marit Waaseth, Ruth H Paulssen, Eiliv Lund :
    Plasma Fatty Acid Ratios Affect Blood Gene Expression Profiles - A Cross-Sectional Study of the Norwegian Women and Cancer Post-Genome Cohort
    PLOS ONE 2013 ARKIV / DOI
  • Inigo Zubiavrre Martinez, Christopher Graham Fenton, Hagar Mohamed Taman, ingvild Pettersen, Turid Hellevik, Ruth H Paulssen :
    Tumorigenic responses of Cancer-Associated Fibroblasts after ablative radiotherapy: A transcriptome-profiling study
    Journal of Cancer Therapy 2013 DOI
  • Vasilis Sitras, Christopher Graham Fenton, Ruth H Paulssen, Åse Vårtun, Ganesh Acharya :
    Differences in Gene Expression between First and Third Trimester Human Placenta: A Microarray Study
    PLOS ONE 2012 ARKIV / DOI
  • Turid Hellevik, ingvild Pettersen, Vivian Berg, Jan-Olof Winberg, Bjørn Torvald Greve Moe, Kristian Bartnes et al.:
    Cancer-associated fibroblasts from human NSCLC survive ablative doses of radiation but their invasive capacity is reduced
    Radiation Oncology 2012 ARKIV / DOI
  • vanessa Dumeaux, Karina Standahl Olsen, G Nuel, Ruth H Paulssen, Anne-Lise Børresen-Dale, Eiliv Lund :
    Deciphering Normal Blood Gene Expression Variation-The NOWAC Postgenome Study
    PLoS Genetics 2010 ARKIV / DOI
  • hege lynum Pedersen, erik Hjerde, steinar Paulsen, Hilde Hansen, Lotte Olsen, Sunniva Katharina Thode et al.:
    Global responses of Aliivibrio salmonicida to hydrogen peroxide as revealed by microarray analysis
    Marine Genomics 2010 DOI
  • Kristin Snipstad, Christopher Graham Fenton, Jørn Kjæve, Guanglin Cui, Endre Anderssen, Ruth H Paulssen :
    New specific molecular targets for radio-chemotherapy of rectal cancer
    Molecular Oncology 2010 DOI
  • Vasilis Sitras, Ruth H Paulssen, Jørn Leirvik, Åse VÅrtun, Ganesh Acharya :
    Placental Gene Expression Profile in Intrauterine Growth Restriction Due to Placental Insufficiency
    Reproductive Sciences 2009 DOI
  • Vasilis Sitras, Ruth H Paulssen, Halvor Grønaas, Jørn Leirvik, Tor-Arne Hanssen, Åse VÅrtun et al.:
    Differential Placental Gene Expression in Severe Preeclampsia
    Placenta 2009 DOI
  • Anne Ørbo, Bjørn Torvald Greve Moe, Halvor Grønaas, Ruth H Paulssen :
    Early effects of high concentrations of progesterone and Mifepristone. A gene expression study of endometrial cancer cells (ishikawa)
    Journal of Steroid Biochemistry and Molecular Biology 2009 DOI
  • Vincent Cuminetti, Joanna Konieczny, Aurora Bernal Mera, Marc Ferre Oliver, Manuel José Gomez, Nuria Vilaplana-Lopera et al.:
    Succinate receptor 1 signaling regulates hematopoiesis via S100/a8 and S100/a9 in health and malignancy
    2024
  • Vincent Cuminetti, Joanna Konieczny, Emeline Boet, Aurora Bernal Mera, Marc Ferré Oliver, Manuel José Gomez et al.:
    Succinate receptor 1 restricts hematopoiesis and prevents acute myeloid leukemia progression
    2024
  • Alicia Elena Villatoro Gonzalez, Vincent Cuminetti, Aurora Bernal Mera, Carlos Torroja, Itziar Cossío, Alberto Benguría et al.:
    Author Correction: Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation (Nature Communications, (2023), 14, 1, (12), 10.1038/s41467-022-35700-9)
    Nature Communications 2023 DOI
  • Mithlesh Kumar Ray, Christopher Graham Fenton, Ruth H Paulssen :
    Novel long-coding RNAs of relevance for ulcerative colitis pathogenesis
    2022 ARKIV
  • Wei Meng, Mithlesh Kumar Ray, Christopher Graham Fenton, Endre Anderssen, Ruth H Paulssen :
    Analysis of methylation data with imputation with blocks (MethylBlocks)
    2022 ARKIV
  • Karina Standahl Olsen, Sanda Krum-Hansen, Endre Anderssen, Frantzen Jan-Ole, Eiliv Lund, Ruth H Paulssen :
    Associations of breast cancer related exposures and gene expression profiles in normal breast tissue
    2021
  • Christopher Graham Fenton, Hagar Taman, Jon Florholmen, Ruth H Paulssen :
    Transcriptional profiling of ulcerative colitis in remission
    Journal of Crohn's and Colitis 25. January 2019 ARKIV / DOI
  • Christopher Graham Fenton, Hagar Taman, Jon Florholmen, Ruth H Paulssen :
    Transcriptional profiling of ulcerative colitis in remission
    2019
  • Ruth H Paulssen, Hagar Mohamed Taman, Christopher Graham Fenton, Inga Viktoria Hensel, Endre Anderssen, Jon Florholmen :
    Novel regulatory DNA methylation features of relevance for ulcerative colitis
    American Journal of Gastroenterology 2018 DOI
  • Ruth H Paulssen, Hagar Mohamed Taman, Christopher Graham Fenton, Inga Viktoria Hensel, Endre Anderssen, Jon Florholmen :
    Novel regulatory DNA methylation features of relevance for ulcerative colitis
    2017
  • Mona Dixon Gundersen, Rasmus Goll, Jon Florholmen, Ruth H Paulssen :
    Mucosal healing in active ulcerative colitis treated with infliximab to disease remission
    Inflammatory Bowel Diseases 2016
  • Ruth H Paulssen, Rasmus Goll, Jon Florholmen :
    PROFILE: As inflammatory bowel disease grows in global incidence, Dr Jon Florholmen outlines what could help to create a cure
    PAN european networks science and technology 2014
  • Turid Hellevik, Inger Pettersen, Jan-Olof Winberg, Vivian Berg, Ruth H Paulssen, Kristian Bartnes et al.:
    The Impact of Ionizing Radiation on the Motility and Matrix Remodelling Properties of Carcinoma-associated Fibroblasts
    European Journal of Cancer 2011
  • Vasilis Sitras, Christopher Graham Fenton, Ruth H Paulssen, Åse VÅrtun, Ganesh Acharya :
    Global gene expression profiling in the first and third trimesters of normal human pregnancy
    Placenta 2011
  • Vasilis Sitras, Christopher Graham Fenton, Ruth H Paulssen, Åse VÅrtun, Ganesh Acharya :
    GLOBAL PLACENTAL GENE EXPRESSION PROFILING IN THE FIRST AND THIRD TRIMESTERS OF NORMAL HUMAN PREGNANCY
    Placenta 2011
  • Karina Standahl Olsen, CG Fenton, Endre Anderssen, Livar Frøyland, RH Paulssen, E Lund :
    Associations between serum linolenic acid/alpha-linolenic acid ratio and blood gene expression profiles
    The FEBS Journal 2009
  • Kristin Snipstad, Christopher Graham Fenton, J Kjaeve, Jørn Kjæve, Endre Anderssen, Ruth H Paulssen :
    New specific molecular targets for radiochemotherapy in colorectal cancer
    The FEBS Journal 2009
  • trine Lund, Margareth Bergesen Hals, Ruth H Paulssen, Kirsti Ytrehus :
    Increased gene expression diversity between female and male hearts after transverse aortic constriction (TAC)
    European Journal of Heart Failure. Supplements 2009
  • trine Lund, Margareth Bergesen Hals, Ruth H Paulssen, Kirsti Ytrehus :
    Increased gene expression diversity between female and male mice hearts after transverse aortic constriction (TAC)
    2009
  • trine Lund, Margareth Bergesen Hals, Ruth H Paulssen, Kirsti Ytrehus :
    Increased gene expression diversity between female and male hearts after transverse aortic constriction (TAC)
    2009
  • vanessa Dumeaux, Karina Standahl Olsen, Jørn Leirvik, Ruth H Paulssen, AL Borresen-Dale, Eiliv Lund :
    Variation of gene expression profiles in whole blood from a large representative sample of postmenopausal Norwegian women
    European Journal of Cancer 2008

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