General pharmacology and toxicology

Det helsevitenskapelige fakultet

Spring course

This course can be taken as a singular course.

BIO-1001 Cell and molecular biology, KJE-1001 Introduction to chemistry and the chemistry of biology

The course will describe how drugs and toxic substances are handled by the body (pharmacokinetics and toxicokinetics and how they affect the organism (pharmacodynamics and toxicodynamics). Also included are how drugs and toxic substances are transported to their sites of action (absorption and distribution), how they work, how they are detoxified (bio-transformed) and removed (eliminated) from the body. Toxic reactions and effects and drug side-affects are discussed. The course also describes the development and evaluation of new drugs, as well as of drugs with an addiction potential . Herbal medicines and Sámi folk medicines are also touched upon.

The course should give the student a general introduction to pharmacology and toxicology.

English

Lectures and a compulsory semester assignment which will need to be approved prior to final exam.

Written exam (4 hours). Alphabetical grades (A-F).

Coursework requirements
Semester assignment.

Re-sit eksamination
For students who did not pass their exam, or were unable to sit their exam due to medical reasons etc., we offer a re-sit examination early in the following semester.

Previously used exam papers

Skriftlig eksamen: 10.06.2010

The date for the exam can be changed. The final date will be announced at your faculty early in May and early in November.

Skriftlig eksamen

BIO-262 General and human toxicology 10

Text book: Levine´s Pharmacology, Drug Actions and Reactions, Seventh edition, Carol T. Walsh, Rochelle D. Schwartz-Bloom, Taylor & Francis. Chapters 1-16, p. 1-454

Topic: How drugs act on the living organism, chapters 1-3. p. 1-54
Topic: General principles of passage of drugs across biologic barriers, chapter 4. p. 55-78
Topic: Absorption, chapter 5. p. 79-111
Topic: Distribution, chapter 6. p. 113-128
Topic: Excretion, chapter 7. p. 129-152
Topic: Biotransformation, chapter 8. p. 153-183
Topic: Dose-response relationships, chapter 9. p. 185-220
Topic: Time- response relationships, chapter 10. p. 221-258
Topic: Variability in response attributable to the biologic system, chapter 11. p. 259-286
Topic: Variability in response attributable to the conditions of administration, chapter 12. p. 287-323
Topic: Drug toxicity/toxicology, chapter 13. p. 325-366
Topic: How drugs alter physiologic function, chapter 14. p. 367-389
Topic: The pharmacological aspects of drug abuse and drug dependence, chapter 15. p. 391-426
Topic: The development and evaluation of new drugs, chapter 16. p. 425-454