Protein Kinase Biophysics

  • Enzyme-ligand interactions

  • Drug design

  • Cheminformatics

Protein kinase overview

Protein kinases transfer phosphate groups from ATP to proteins. The human genome encodes for over 500 structurally similar protein kinases that transfer the gamma-phosphate of ATP to serine, threonine, or tyrosine residues of proteins.

From Åberg, E. et al., "Structural origins of AGC protein kinase inhibitor selectivities: PKA as a drug discovery tool", Biol. Chem. (2012) 393, 1121-1129. PMID: 23092797.

Protein Crystal

Diffraction Pattern

Professor Richard A. Engh
The Norwegian Structural Biology Centre
Forskningsparken 3, Sykehusvegen 23
Fakultet for Naturvitenskap og Teknologi
Universitetet i Tromsø
9037 Tromsø, Norge


Dr. Ulli Rothweiler
The Norwegian Structural Biology Centre
Department of Chemistry
Faculty of Science and Technology
University of Tromsø
9037 Tromsø, Norway


Department of
Chemistry