Master of science Rune Finsås Einrem will Friday February 24, 2023, at 12:15 hold his disputas for the PhD degree in Science. The title of his thesis is:
"New Building Blocks for Cancer Phototherapeutics: 5d Metallocorroles"
Corroles are ring-contracted, triprotic analogues of porphyrins. This PhD study expands earlier knowledge in particular on ReO corroles. Early on, it became apparent that ReO corroles exhibit the highest phosphorescence quantum yields among all metallocorroles. They also sensitize singlet oxygen formation and serve as oxygen sensors and as triplet-triplet annihilation upconverters. I accordingly wanted to synthesize new classes of functionalized 5d corroles as well as to examine ReO corroles as photosensitizers in in vitro photodynamic therapy experiments. I found that amphiphilic meta/para-carboxyl-appended ReO triphenylcorroles exhibit high photocytotoxicity against multiple cancer cell lines.
Evaluation Committee
Supervisors
Professor Cordian Riener, Vice Dean at the Faculty of Science and Technology, UiT, will lead the disputas.
Streaming site
The disputas and trial lecture will be streamed from these sites:
Disputas (12:15 - 16:00)
Trial Lecture (10:15 - 11:00)
Thesis
The thesis is available through Munin.