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The advanced immunology course will give an overview of mechanisms and signaling pathways involved in inflammatory processes, in topics mainly connected to activities at the Department of Clinical and Molecular Medicine (IKOM). This is inflammation related to infections, but also sterile inflammation (that can be observed during e.g. autoimmune diseases, heart infarction/failure, and obesity).

Although the main focus will be on innate immunity, both innate and adaptive immune responses will be discussed. Cell types involved include macrophages, monocytes, dendritic cells, neutrophils, T cells, B cells, osteoblasts, osteoclasts, and epithelial cells on mucosal surfaces.

Recognition- and signaling mechanisms include complement, phagocytosis, Toll-like receptors (TLRs), inflammasomes, RIG-I family and other helicases, cGAS, C-type lectin receptors, responses to different types of bacteria, viruses, protozoan parasites and fungi, sterile inflammation, vaccines/adjuvants, inflammatory cytokines and cell death.

Inflammatory signals will be discussed in relation to cell biology, molecular trafficking, immunometabolism, and immune activation and evasion by microbial pathogens. We will link the events to clinical situations such as infections, immunodeficiencies, inflammation during pregnancy, inflammatory bowel disease, heart failure, cancer, and bone inflammation.

Full course description at ntnu.no