Terje Larsen
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Publications outside Cristin
Selected publications:
1 Larsen TS, Dani R, Giles WR, Lopaschuk GD, Severson DL, Belke D, Tyberg JV. The isolated working mouse heartmethodological considerations. Pflügers Archiv 437: 979-985, 1999
2 Belke DD, Larsen TS, Gibbs EM Severson DL. Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice. Am J Physiol Endocrinol Metab 279: E1104-E1113, 2000
3 Aasum E, Belke DD, Riemersma RA, Severson DL, Larsen TS. Improved Cardiac Function in Diabetic db/db Mice Treated with the Insulin Sensitizer BM 17.0744. Am J Physiol Heart Circ Physiol 283, H949-H957, 2002
4 Aasum E, Hafstad AD, Severson DL and Larsen TS. Cardiac Age-dependent changes in metabolism, contractile function and ischemic sensitivity in hearts from db/db mice. Diabetes 52:434-44, 2003
5 How OJ, Aasum E, Kunnathu S, Severson DL, Myhre ES, Larsen TS. Influence of substrate supply on cardiac efficiency, as measured by pressure-volume analysis in ex vivo mouse hearts. Am J Physiol Heart Circ Physiol. 2005 ;288(6):H2979-85
6 Hafstad AD, Solevåg GH, Severson DL, Larsen TS, Aasum E. Perfused hearts from type 2 diabetic (db/db) mice show metabolic responsiveness to insulin. Am J Physiol Heart Circ Physiol. 290(5): H1763-9, 2006
7 How OJ, Aasum E, Severson DL, Chan A, Essop F, and Larsen TS. Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice.
Diabetes, 55(2): 466-73, 2006
8 Aasum E, Khalid AM, Gudbrandsen OA, How O-J, Berge RK, Larsen TS. Fenofibrate modulates cardiac and hepatic metabolism and increases ischemic tolerance in diet-induced obese mice. J Mol Cell Cardiol 44, 201–209, 2008
9 Stølen TO, Høydal MA, Kemi OJ, Catalucci D, Ceci M, Aasum E, Larsen TS, Rolim N, Condorelli G, Smith GL, Wisløff U. Interval training normalizes cardiomyocyte function, diastolic Ca2+ control, and SR Ca2+ release synchronicity in a mouse model of diabetic cardiomyopathy. Circ Res. 2009;105(6):527-36.
10 Jansen KM, Moreno S, Garcia-Roves PM, Larsen TS. Dietary Calanus oil recovers metabolic flexibility and rescues post-ischemic cardiac function in obese female mice. Am J Physiol Heart Circ Physiol. 2019 Aug 1;317(2):H290-H299. doi: 10.1152/ajpheart.00191.2019. Epub 2019 May 24.
Research interests
My research activity focuses on alterations in myocardial metabolism during obesity and type 2 diabetes, and how such changes may influence the mechanical function of the heart, using primarily diet-induced obese mice as experimental model. We have demonstrated marked changes in cardiac metabolism in these animals, with a clear over-reliance on fatty acid oxidation for energy production and a corresponding reduction in glucose oxidation. In addition, they show cardiomyopathy and/or reduced cardiac efficiency (the relationship between cardiac work and oxygen consumption), as well as reduced tolerance to ischemia-reperfusion.
We are investigating possible mechanisms of diabetes-induced cardiac dysfunction, hypothesizing that the metabolic disorders accompanying the diabetic state play a central role in the development of cardiac disease. Of particular interest is the transcriptional regulation of myocardial substrate supply and utilization via activation of the nuclear peroxisome proliferator-activated receptors (PPARs) – both in the heart, adipose tissue and liver. The experimental activity includes use of various (lipid-lowering) PPAR agonists, exercise training and diet to determine their impact on the mechanical function of the heart. Most recently, we have shown that dietary supplementation with a novel marine oil (1) reduces abdominal obesity, (2) suppresses low-grade inflammation in adipose tissue, (3) improves insulin sensitivity, (4) recovers metabolic flexibility and (5) improves recovery of post-ischemic ventricular function in diet-induced obese mice.
Member of research group / centre
Member of project
CV
Name: Terje Steinar Larsen
Present position and address: Professor, Cardiovascular Research Group, Institute of Medical Biology, University of Tromsø, N-9037 Tromsø, Norway.
Born: April 18, 1950, 8432 Alsvåg, Norway.
Status: Married, three children.
Private address: Ryllikveien 47, 9100 Kvaløysletta, Norway
Education:
1972-1976: University of Tromsø, Norway; Bachelor of Science
1976-1978: University of Tromsø, Norway; Master of Science
1978-1985: University of Tromsø, Norway; PhD
Professional experience and research positions:
1978-1980: Research Fellow (Department of Medical Physiology, University of Tromsø)
1980-1985: Research Fellow (Norwegian Research Council for Science and the Humanities), Department of Arctic Biology, University of Tromsø
1985-1986: Postdoctoral Fellow (Alberta Heritage Foundation for Medical Research), Faculty of Medicine, The University of Calgary, Canada
1986-1990: Postdoctoral Fellow (Norwegian Research Council), Department of Medical Physiology, University of Tromsø
1990-1992: Associate professor, Department of Medical Physiology, University of Tromsø
1992-1996: Professor, Chairman, Department of Medical Physiology, University of Tromsø
1996-1997: Sabbatical stay at The Faculty of Medicine, The University of Calgary, Canada
1997-present: Professor, Department of Medical Physiology, University of Tromsø.
1998-2005: Professor, Department of Medical Physiology, University of Tromsø/Chairman, Institute of Medical Biology, University of Tromsø.
1998-present: Professor & Chairman, Department of Medical Physiology, University of Tromsø
2009-present: Professor, Cardiovascular Research Group IMB; Chairman, Institute of Medical Biology, University of Tromsø.