In collaboration with Terje Larsen, Phd students and Post Docs fellows, my research activity has focused on cardiac metabolic remodeling in relation to insulin resistance/obesity and type 2 diabetes. By using mice models and ex vivo assessment of myocardial substrate utilization, oxygen consumption and ventricular mechanical function, we have elucidated the underlaying mechanisms and consequences of obesity/diabetes-induced impairment of cardiac inefficiency. In addition, we have studied how various pharmacological interventions, exercise training and nutritional supplements influences on heart failure development, the metabolic remodeling and mechanoenergetics changes of these hearts, as well as their tolerance to ischemia-reperfusion.