The alarming increase in multidrug resistant bacterial pathogens challenge efficient treatment of common infections. A fundamental understanding of the molecular interactions driving bacterial adhesion to host, and bacterial escape from host immunity, is a key step toward the development of novel antimicrobial therapies.
1. S. aureus virulence factors and their role in adhesion and immune evasion.
We use various approaches to evaluate the adhesive properties of bacterial virulence factors, and have previously shown that S. aureus SdrD specifically with Desmogle...
Studies on the genesis of antibodies to dsDNA and to chromatin
Basic and clinical science on SLE and lupus nephritis
Transcriptomics in lupus nephritis
To understand the role of autoimmunity to chromatin in lupus nephritis