Photo: Christian Halvorsen
Terje Johansen
Job description
Professor in Biochemistry and Cell Biology.
Leader and PI of the Autophagy Research Group with selective autophagy as main research interest.
Basic research into the cellular- and molecular mechanisms of selective autophagy involving selective autophagy receptors, ATG8 family proteins, other components of the autophagy machinery.
Scientific leader of Proteomics and Metabolomics Core Facility (PRiME).
Biography
Terje has all his academic education from the University of Tromsø, now UiT The Arctic University of Norway. He obtained a Cand. scient. degree (equivalent to Masters degree) in 1985 on studies of "Vector construction and DNA transformation of Physarum polycephalum" in the Cell Biology group, Department of Medical Biology, Faculty of Health Sciences, with professor Finn Haugli as supervisor. His Dr. scient. degree (equivalent to PhD) was obtained in 1988 in the same group also with FInn Haugli as supervisor. From 1988 to 1991 he was a postdoc on grant from the Research Council of Norway working in the Virology group, Department of Medical Biology, before serving as an associate professor 1990-1991 in the Biotehcnology Group. From 1991 onwards Terje Johansen has been Professor and PI leading his own research group at Department of Medical Biology. His research is highly cited with a total of almost 55.000 citations and an h-index of 88.
Athanasios Kournoutis,
Trond Lamark,
Terje Johansen,
Yakubu Princely Abudu
:
WDR83/MORG1 inhibits RRAG GTPase-MTORC1 signaling to facilitate basal autophagy
Yakubu Princely Abudu,
Athanasios Kournoutis,
Hanne Britt Brenne,
Trond Lamark,
Terje Johansen
:
MORG1 limits mTORC1 signaling by inhibiting Rag GTPases
Nikoline Lander Rasmussen,
Jianwen Zhou,
Hallvard Lauritz Olsvik,
Stéphanie Kaeser-Pebernard,
Trond Lamark,
Joern Dengjel
et al.:
The inflammation repressor TNIP1/ABIN-1 is degraded by autophagy following TBK1 phosphorylation of its LIR
Hallvard Lauritz Olsvik,
Terje Johansen
:
AlphaFold-multimer predicts ATG8 protein binding motifs crucial for autophagy research
Athanasios Kournoutis,
Terje Johansen
:
LC3B is a cofactor for LMX1B-mediated transcription of autophagy genes in dopaminergic neurons
Viola Nahse-Kumpf,
Camilla Raiborg,
Kia Wee Tan,
Sissel Mørk,
Maria Lyngaas Torgersen,
Eva Wenzel
et al.:
ATPase activity of DFCP1 controls selective autophagy
Jianwen Zhou,
Nikoline Lander Rasmussen,
Hallvard Lauritz Olsvik,
Vyacheslav Akimov,
Zehan Hu,
Gry Evjen
et al.:
TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1
Vladimir V. Rogov,
Ioannis P. Nezis,
P Tsapras,
Hong Zhang,
Yasin Dagdas,
Nobuo N Noda
et al.:
Atg8 family proteins, LIR/AIM motifs and other interaction modes
Jingyue Jia,
Fulong Wang,
Zambarlal Babanrao Bhujabal,
Ryan Peters,
Michal Mudd,
Thabata Duque
et al.:
Membrane Atg8ylation, stress granule formation, and MTOR regulation during lysosomal damage
Juncal Garcia Garcia,
Anne Kristin McLaren Berge,
Katrine Stange Overå,
Kenneth Bowitz Larsen,
Zambarlal Babanrao Bhujabal,
Andreas Brech
et al.:
TRIM27 is an autophagy substrate facilitating mitochondria clustering and mitophagy via phosphorylated TBK1
Nikoline Lander Rasmussen,
Athanasios Kournoutis,
Trond Lamark,
Terje Johansen
:
NBR1: The archetypal selective autophagy receptor
Jingyue Jia,
Fulong Wang,
Zambarlal Babanrao Bhujabal,
Ryan Peters,
Michal Mudd,
Thabata Duque
et al.:
Stress granules and mTOR are regulated by membrane atg8ylation during lysosomal damage
Martina Wirth,
Stephane Mouilleron,
Wenxin Zhang,
Eva Sjøttem,
Yakubu Princely Abudu,
Ashish Jain
et al.:
Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity
Thaddaeus Mutugi Nthiga,
Birendra Kumar Shrestha,
Jack-Ansgar Bruun,
Kenneth Bowitz Larsen,
Trond Lamark,
Terje Johansen
:
Regulation of Golgi turnover by CALCOCO1-mediated selective autophagy
Daniel J. Klionsky,
Amal Kamal Abdel-Aziz,
Sara Abdelfatah,
Mahmoud Khaled Abdellatif,
Asghar Abdoli,
Yakubu Princely Abudu
et al.:
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Autophagy 2021 DOI
Yakubu Princely Abudu,
Stephane Mouilleron,
Sharon A Tooze,
Trond Lamark,
Terje Johansen
:
SAMM50 is a receptor for basal piecemeal mitophagy and acts with SQSTM1/p62 in OXPHOS-induced mitophagy
Yakubu Princely Abudu,
Birendra Kumar Shrestha,
Wenxin Zhang,
Anthimi Palara,
Hanne Britt Brenne,
Kenneth Bowitz Larsen
et al.:
SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components
Daniel J. Klionsky,
Giulia Petroni,
Ravi K Amaravadi,
Eric H Baehrecke,
Andrea Ballabio,
Patricia Boya
et al.:
Autophagy in major human diseases
Yahyah Aman,
Tomas Schmauck-Medina,
Malene Hansen,
Richard I. Morimoto,
Anna Katharina Simon,
Ivana Bjedov
et al.:
Autophagy in healthy aging and disease
Nature Aging 2021 DOI
Thaddaeus Mutugi Nthiga,
Birendra Kumar Shrestha,
Trond Lamark,
Terje Johansen
:
The soluble reticulophagy receptor CALCOCO1 is also a Golgiphagy receptor.
Aurore Claude-Taupin,
Jingyue Jia,
Zambarlal Bhujabal,
Meriem Garfa-Traore,
Suresh Kumar,
Gustavo Peixoto Duarte da Silva
et al.:
ATG9A protects the plasma membrane from programmed and incidental permeabilization.
Trond Lamark,
Terje Johansen
:
Mechanisms of Selective Autophagy
Arjen J. Jakobi,
Stefan T. Huber,
Simon A. Mortensen,
Sebastian Schultz,
Anthimi Palara,
Tanja Kuhm
et al.:
Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake
S. Petridi,
A.-C. Jacomin,
Zambarlal Bhujabal,
Terje Johansen,
Ioannis P Nezis
:
Exploring selective autophagy in Drosophila: Methods to identify Atg8-interacting proteins.
Methods in Cell Biology 2020 DOI
Lu Wang,
Caiyue Xu,
Terje Johansen,
Shelley L. Berger,
Zhixun Dou
:
SIRT1 - a new mammalian substrate of nuclear autophagy
Anne-Claire Jacomin,
Raksha Gohel,
Zunoon Hussain,
Agnes Varga,
Tamas Maruzs,
Mark Eddison
et al.:
Degradation of arouser by endosomal microautophagy is essential for adaptation to starvation in Drosophila
Caiyue Xu,
Lu Wang,
Parinaz Fozouni,
Gry Evjen,
Vemika Chandra,
Jing Jiang
et al.:
SIRT1 is downregulated by autophagy in senescence and ageing
Åsa birna Birgisdottir,
Terje Johansen
:
Autophagy and endocytosis – interconnections and interdependencies
Anne-Claire Jacomin,
Stavroula Petridi,
Marisa Di Monaco,
Zambarlal Bhujabal,
Ashish Jain,
Nitha C. Mulakkal
et al.:
Regulation of Expression of Autophagy Genes by Atg8a-Interacting Partners Sequoia, YL-1, and Sir2 in Drosophila
Thaddaeu Mutugi Nthiga,
Birendra Kumar Shrestha,
Trond Lamark,
Terje Johansen
:
CALCOCO1 is a soluble reticulophagy receptor
Thaddaeus Mutugi Nthiga,
Birendra Kumar Shrestha,
Eva Sjøttem,
Trond Lamark,
Terje Johansen
:
CALCOCO1 acts with VAMP ‐associated proteins to mediate ER ‐phagy
Rocío de la Riva-Carrasco,
Sebastián Perez-Pandolfo,
Sofía Suárez Freire,
Nuria M. Romero,
Zambarlal Bhujabal,
Terje Johansen
et al.:
The immunophilin Zonda controls regulated exocytosis in endocrine and exocrine tissues
Suresh Kumar,
Yuexi Gu,
Yakubu Princely Abudu,
Jack-Ansgar Bruun,
Ashish Jain,
Farzin Farzam
et al.:
Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation
Yakubu Princely Abudu,
Serhiy Pankiv,
Benan John Mathai,
Alf Håkon Lystad,
Christian Bindesbøll,
Hanne Britt Brenne
et al.:
NIPSNAP1 and NIPSNAP2 act as “eat-me signal” for mitophagy
Martina Wirth,
Wenxin Zhang,
Minoo Razi,
Lynet Nyoni,
Dhira Joshi,
Nicola O'Reilly
et al.:
Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins
Åsa birna Birgisdottir,
Stephane Mouilleron,
Zambarlal Bhujabal,
Martina Wirth,
Eva Sjøttem,
Gry Evjen
et al.:
Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs
Katrine Stange Overå,
Juncal Garcia Garcia,
Zambarlal Bhujabal,
Ashish Jain,
Aud Karin Øvervatn,
Kenneth Bowitz Larsen
et al.:
TRIM32, but not its muscular dystrophy-associated mutant, positively regulates and is targeted to autophagic degradation by p62/SQSTM1
Birendra Kumar Shrestha,
Mads Skytte Rasmussen,
Yakubu Princely Abudu,
Jack-Ansgar Bruun,
Kenneth Bowitz Larsen,
Endalkachew Ashenafi Alemu
et al.:
NIMA-related kinase 9–mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1
Terje Johansen
:
Selective Autophagy: RNA Comes from the Vault to Regulate p62/SQSTM1
Yakubu Princely Abudu,
Serhiy Pankiv,
Benan John Mathai,
Trond Lamark,
Terje Johansen,
Anne Simonsen
:
NIPSNAP1 and NIPSNAP2 act as “eat me” signals
to allow sustained recruitment of autophagy
receptors during mitophagy
Autophagy 2019 DOI
Gry Hoem,
Kenneth Bowitz Larsen,
Aud Karin Øvervatn,
Andreas Brech,
Trond Lamark,
Eva Sjøttem
et al.:
The FMRpolyGlycine protein mediates aggregate formation and toxicity independent of the CGG mRNA hairpin in a cellular model for FXTAS
Terje Johansen,
Trond Lamark
:
Selective autophagy: ATG8 family proteins, LIR motifs and cargo receptors
Mads Skytte Rasmussen,
Åsa birna Birgisdottir,
Terje Johansen
:
Use of Peptide Arrays for Identification and Characterization of LIR Motifs
Stephanie R Kehl,
Brandy-Lee A Soos,
Bhaskar Saha,
Seong Won Choi,
Anthony W Herren,
Terje Johansen
et al.:
TAK1 converts Sequestosome 1/p62 from an autophagy receptor to a signaling platform
Terje Johansen
:
Selektiv autofagi: Kildesortering i cellene våre gir sunn aldring
2022 DATA
Nikoline Lander Rasmussen,
Jianwen Zhou,
Hallvard Lauritz Olsvik,
Vyacheslav Akimov,
Zehan Hu,
Gry Evjen
et al.:
TNIP1 is degraded by selective autophagy upon proinflammatory signalling
2021
Nikoline Lander Rasmussen,
Jianwen Zhou,
Hallvard Lauritz Olsvik,
Vyacheslav Akimov,
Zehan Hu,
Gry Evjen
et al.:
TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1
2021
Nikoline Lander Rasmussen,
Jianwen Zhou,
Hallvard Lauritz Olsvik,
Vyacheslav Akimov,
Zehan Hu,
Gry Evjen
et al.:
TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1
2021
Martina Wirth,
Stephane Mouilleron,
Wenxin Zhang,
Eva Sjøttem,
Yakubu Princely Abudu,
Ashish Jain
et al.:
Corrigendum to Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity (Journal of Molecular Biology (2021) 433(13), (S0022283621001881), (10.1016/j.jmb.2021.166987))
Journal of Molecular Biology (JMB) 2021 DOI
Andres Maldonado,
Ida Sundvor Opstad,
Luis Hernández,
Mona Nystad,
Milton Aguilera,
Merete Storflor
et al.:
Fluorescence Nanoscopy Using Multiple Signal Classification Algorithm (MUSICAL): From Electromagnetics Inverse Scattering Problem to Optics Inverse Source Problem.
2019
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Research interests
Basic research into the cellular- and molecular mechanisms of selective autophagy and cell signaling relevant for cancer, neurodegenerative diseases, aging, inflammation and host defense against intracellular pathogens. Terje and his group made a major breakthrough in our understanding of selective autophagy by discovering the first selective autophagy receptor p62/SQSTM1 and elucidated how specificity in cargo selection (waste disposal) could be achieved and how autophagy receptors could connect the cargo (waste) to the forming autophagosome. Some main discoveries by Terje and co-workers in the Autophagy Research Group are:
- Discovered the first selective autophagy receptors p62/SQSTM1 and NBR1
- Showed that the selective autophagy receptors bound to cargo and to Atg8 family proteins
- Identified the LIR (LC3 Interacting Region) motif mediating the interaction in the majority of Atg8 interacting proteins
- Discovered p62 formed protein bodies inside cells that are degraded by autophagy
- Developed a novel tandem tag fluorescent protein assay to monitor autophagic flux
- Described the positive feedback loop regulation between p62 and NRF2
- Found NBR1 as the selective autophagy receptor in plants
- Discovered NBR1 acting as a pexophagy receptor
- Discovered the first Golgiphagy receptor, CALCOCO1, also acting in ERphagy
- Showed Atg8 family proteins to act as membrane-bound scaffolds for autophagy core machinery proteins including the ULK1/2 complexes, the PI3K class III complex and ATG4 proteins.
- Showed NIPSNAP1 and NIPSNAP2 to act as "Eat Me" signals for Mitophagy
- Discovered that FKBP8 can act as a mitophagy receptor and that SAMM50 is involved in basal and OXPHOS-induced mitophagy
- Found the inflammation repressor TNIP1/ABIN-1 to be degraded by autophagy following TBK1 activation.
- Discovered MORG1 as a new negative regulator of mTORC1 allowing basal selective autophagy in nutrient rich conditions.
Keywords: Selective autophagy receptors, ATG8 family proteins, LIR motifs, aggrephagy, mitophagy, ER-phagy, Golgiphagy
Teaching
Lecturing on courses:
MBI-2001 Biochemistry - 10 ECTS
MBI-2012 Molecular Cell Biology - Cell structure - 10 ECTS
MBI-3004 The Biology of Cancer - 10 ECTS
MBI-3012 Advanced methods in experimental biomedicine - 30 ECTS
MBI-8007 Molecular and Clinical Aspects of Cancer - Block I - 10 ECTS
