Olsvik, Hallvard Lauritz

Hallvard Lauritz Olsvik

Job description

I work with teaching and research in molecular cell biology. My research focuses on how specific proteins recognise, recruit and coordinate cellular components for degradation through autophagy, and how these processes intersect with vesicle trafficking systems.

Publications

Scientific articles and book chapters
Other

Hallvard Lauritz Olsvik, Terje Johansen :

Golgiphagy mediated by TM9SF3 acts as quality control for stressed Golgi

Developmental Cell 03. November 2025 DOI / ARKIV

Birendra Kumar Shrestha, Eva Sjøttem, Hallvard Lauritz Olsvik, Isaac Odonkor, Aud Karin Øvervatn, Hanne Britt Brenne et al.:

A C-terminal cytoplasmic retention motif and nuclear localization signal regulates nuclear import of TP53INP2

Journal of Cell Science 19. December 2025 DOI / ARKIV

Bhaskar Saha, Hallvard Lauritz Olsvik, Geneva L. Williams, Seeun Oh, Gry Evjen, Eva Synnøve Sjøttem et al.:

TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery

Cell reports 2024 DOI / ARKIV

Hallvard Lauritz Olsvik, Terje Johansen :

AlphaFold-multimer predicts ATG8 protein binding motifs crucial for autophagy research

PLoS Biology 2023 DOI / ARKIV

Jianwen Zhou, Nikoline Lander Rasmussen, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen et al.:

TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1

Journal of Cell Biology 2023 DOI / ARKIV

Nikoline Lander Rasmussen, Jianwen Zhou, Hallvard Lauritz Olsvik, Stéphanie Kaeser-Pebernard, Trond Lamark, Joern Dengjel et al.:

The inflammation repressor TNIP1/ABIN-1 is degraded by autophagy following TBK1 phosphorylation of its LIR

Autophagy 2023 DOI / ARKIV

Martina Wirth, Stephane Mouilleron, Wenxin Zhang, Eva Sjøttem, Yakubu Princely Abudu, Ashish Jain et al.:

Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity

Journal of Molecular Biology (JMB) 2021 DOI / ARKIV

Jakob Mejlvang, Hallvard Lauritz Olsvik, Steingrim Svenning, Jack-Ansgar Bruun, Yakubu Princely Abudu, Kenneth Bowitz Larsen et al.:

Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy

Journal of Cell Biology 17. July 2018 DOI / ARKIV / ARKIV

Hallvard Lauritz Olsvik, Steingrim Svenning, Yakubu Princely Abudu, Andreas Brech, Harald Stenmark, Terje Johansen et al.:

Endosomal microautophagy is an integrated part of the autophagic response to amino acid starvation

Autophagy 2018 DOI / ARKIV

Camilla Raiborg, Eva Wenzel, Nina Marie Pedersen, Hallvard Lauritz Olsvik, Kay Oliver Schink, Sebastian Schultz et al.:

Repeated ER-endosome contacts promote endosome translocation and neurite outgrowth

Nature 2015 DOI / ARKIV

Hallvard Lauritz Olsvik, Trond Lamark, Kenji Takagi, Kenneth Bowitz Larsen, gry Evjen, Aud Karin Øvervatn et al.:

FYCO1 contains a C-terminally extended, LC3A/B-preferring LC3-interacting region (LIR) motif required for efficient maturation of autophagosomes during basal autophagy

Journal of Biological Chemistry 2015 DOI / ARKIV

Endalkachew Ashenafi Alemu, Trond Lamark, Knut Martin Torgersen, Åsa birna Birgisdottir, Kenneth Bowitz Larsen, Ashish Jain et al.:

ATG8 Family Proteins Act as Scaffolds for Assembly of the ULK Complex SEQUENCE REQUIREMENTS FOR LC3-INTERACTING REGION (LIR) MOTIFS

Journal of Biological Chemistry 2012 DOI / ARKIV / ARKIV

Anne Kristin Mclaren Berge, Kjersti Sellæg, Stine Figenschau, Saikat Das Sajib, Hallvard Lauritz Olsvik, Maria Perander et al.:

TRIM32 in Head and Neck Cancer

2023 ARKIV

Anne Kristin McLaren Berge, Juncal Garcia Garcia, Eva Sjøttem, Hallvard Lauritz Olsvik :

The ubiquitin E3 ligase TRIM27 emerges as a new player in mitophagy

Autophagy Reports 2023 DOI / ARKIV

Nikoline Lander Rasmussen, Jianwen Zhou, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen et al.:

TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1

2021 ARKIV

Nikoline Lander Rasmussen, Jianwen Zhou, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen et al.:

TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1

2021 ARKIV

Nikoline Lander Rasmussen, Jianwen Zhou, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen et al.:

TNIP1 is degraded by selective autophagy upon proinflammatory signalling

2021 ARKIV

Martina Wirth, Stephane Mouilleron, Wenxin Zhang, Eva Sjøttem, Yakubu Princely Abudu, Ashish Jain et al.:

Corrigendum to Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity (Journal of Molecular Biology (2021) 433(13), (S0022283621001881), (10.1016/j.jmb.2021.166987))

Journal of Molecular Biology (JMB) 2021 DOI / ARKIV

Research interests

A central aim of my work is to understand how protein interactions and protein architecture govern the function of selective autophagy pathways. By combining protein-protein interactions studies, protein-structure prediction and advanced microscopy, I try to unravel where and when key proteins act in cells, how they assemble into functional complexes, and how their activity is regulated.

I apply an evolutionary perspective to guide structure-function studies. By analysing the conservation of proteins across species, I aim to identify candidate functional motifs and domains. These are then tested experimentally to reveal how molecular features contribute mainly to autophagy, but also to other cellular membrane trafficking mechanisms.

Through this multidisciplinary approach, I aim to provide insight into the cellular systems that maintain protein and organelle quality control. This has relevance for understanding fundamental cell biology and disease-associated defects in intracellular degradation pathways.

ORCID: https://orcid.org/0000-0003-3489-7461

Research and teaching

Member of research group / centre

Autophagy Research Group English content

Member of project

Autophagy-regulated Signalosomes in Cellular Stress and Disease Pathways (July 2016-July 2021)

MH øst L9.237

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