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Bilde av Sjøttem, Eva
Bilde av Sjøttem, Eva
Professor, Head of Department Department of Medical Biology eva.sjottem@uit.no +4777646425 91556342 You can find me here

Eva Sjøttem

Job description

Job description

Eva Sjøttem is Head of Department, Department of Medical Biology, Faculty of Health Science. She is a professor in molecular cell biology at the Autophagy Research Group. Her research is within basic biomedical research. It involves identification of molecular mechanisms regulating the cellular renovation system autophagy, with main focus on the selectivity in this process. Dysregulation of selectiv autophagy is implicated in major human diseases such as neurodegeneration, cancer, cardiac diseases and inflammation, and contributes also to aging. 

Professor at the https://uit.no/research/autophagy

 

  • Bhaskar Saha, Hallvard Lauritz Olsvik, Geneva L. Williams, Seeun Oh, Gry Evjen, Eva Synnøve Sjøttem et al.:
    TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery
    Cell reports 2024 ARKIV / DOI
  • Juncal Garcia Garcia, Anne Kristin McLaren Berge, Katrine Stange Overå, Kenneth Bowitz Larsen, Zambarlal Babanrao Bhujabal, Andreas Brech et al.:
    TRIM27 is an autophagy substrate facilitating mitochondria clustering and mitophagy via phosphorylated TBK1
    The FEBS Journal 2022 ARKIV / DOI
  • Martina Wirth, Stephane Mouilleron, Wenxin Zhang, Eva Sjøttem, Yakubu Princely Abudu, Ashish Jain et al.:
    Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity
    Journal of Molecular Biology (JMB) 2021 ARKIV / DOI
  • Juncal Garcia Garcia, Katrine Stange Overå, Waqas Khan, Eva Sjøttem :
    Generation of the short TRIM32 isoform is regulated by Lys 247 acetylation and a PEST sequence
    PLOS ONE 2021 ARKIV / DOI
  • Thaddaeus Mutugi Nthiga, Birendra Kumar Shrestha, Eva Sjøttem, Trond Lamark, Terje Johansen :
    CALCOCO1 acts with VAMP ‐associated proteins to mediate ER ‐phagy
    EMBO Journal 2020 ARKIV / DOI
  • Åsa birna Birgisdottir, Stephane Mouilleron, Zambarlal Bhujabal, Martina Wirth, Eva Sjøttem, Gry Evjen et al.:
    Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs
    Autophagy 2019 ARKIV / DOI
  • Katrine Stange Overå, Juncal Garcia Garcia, Zambarlal Bhujabal, Ashish Jain, Aud Karin Øvervatn, Kenneth Bowitz Larsen et al.:
    TRIM32, but not its muscular dystrophy-associated mutant, positively regulates and is targeted to autophagic degradation by p62/SQSTM1
    Journal of Cell Science 02. December 2019 ARKIV / DOI
  • Birendra Kumar Shrestha, Mads Skytte Rasmussen, Yakubu Princely Abudu, Jack-Ansgar Bruun, Kenneth Bowitz Larsen, Endalkachew Ashenafi Alemu et al.:
    NIMA-related kinase 9–mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1
    Journal of Biological Chemistry 2019 ARKIV / DOI
  • Gry Hoem, Kenneth Bowitz Larsen, Aud Karin Øvervatn, Andreas Brech, Trond Lamark, Eva Sjøttem et al.:
    The FMRpolyGlycine protein mediates aggregate formation and toxicity independent of the CGG mRNA hairpin in a cellular model for FXTAS
    Frontiers in Genetics 2019 ARKIV / DOI
  • Carmela Fusco, Barbara Mandriani, Martina Di Rienzo, Lucia Micale, Natascia Malerba, Dario Cocciadiferro et al.:
    TRIM50 regulates Beclin 1 proautophagic activity
    BBA - Molecular Cell Research 2018 DOI
  • Beate Hegge, Eva Sjøttem, Ingvild Mikkola :
    Generation of a PAX6 knockout glioblastoma cell line with changes in cell cycle distribution and sensitivity to oxidative stress
    BMC Cancer 2018 ARKIV / DOI
  • Zambarlal Bhujabal, Åsa birna Birgisdottir, Eva Sjøttem, Hanne Britt Brenne, Aud Karin Øvervatn, Sabrina Habisov et al.:
    FKBP8 recruits LC3A to mediate Parkin-independent mitophagy
    EMBO Reports 05. April 2017 DOI
  • Mads Skytte Rasmussen, Stephane Mouilleron, Birendra Kumar Shrestha, Martina Wirth, Rebecca Lee, Kenneth Bowitz Larsen et al.:
    ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8
    Autophagy 2017 DOI
  • Ashish Jain, Tor Erik Rusten, Nadja Sandra Katheder, Julianne Elvenes, Jack-Ansgar Bruun, Eva Sjøttem et al.:
    P62/sequestosome-1, autophagy-related gene 8, and autophagy in Drosophila are regulated by nuclear factor erythroid 2-related factor 2(NRF2), independent of transcription factor TFEB
    Journal of Biological Chemistry 2015 ARKIV / DOI
  • Sagar Darvekar, Julianne Elvenes, Hanne Brenne, Terje Johansen, Eva Sjøttem :
    SPBP is a sulforaphane induced transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62/SQSTM1
    PLOS ONE 09. January 2014 ARKIV / DOI
  • Sagar Darvekar, Cecilie Rekdal, Terje Johansen, Eva Sjøttem :
    A Phylogenetic Study of SPBP and RAI1: Evolutionary Conservation of Chromatin Binding Modules
    PLOS ONE 18. October 2013 ARKIV / DOI
  • Sagar Ramesh Darvekar, Agnete Bratsberg Eriksen, Terje Johansen, Eva Sjøttem :
    Identification of two independent nucleosome-binding domains in the transcriptional co-activator SPBP
    Biochemical Journal 2012 DOI
  • Julianne Elvenes, Ernst Ivan Thomassen, Sylvia Sagen Johnsen, Katrine Kaino, Eva Sjøttem, Terje Johansen :
    Pax6 Represses Androgen Receptor-Mediated Transactivation by Inhibiting Recruitment of the Coactivator SPBP
    PLOS ONE 2011 ARKIV / DOI
  • Endalkachew Alemu, Eva Sjøttem, heidi Outzen, Kenneth Bowitz Larsen, turid Holm, Geir Bjørkøy et al.:
    Transforming growth factor-beta-inducible early response gene 1 is a novel substrate for atypical protein kinase Cs
    Cellular and Molecular Life Sciences (CMLS) 2011 ARKIV / DOI
  • Ashish Jain, Trond Lamark, Eva Sjøttem, Kenneth Bowitz Larsen, Jane Atesoh Awuh, Aud Karin Øvervatn et al.:
    p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription
    Journal of Biological Chemistry 2010 DOI
  • Julianne Elvenes, Eva Sjøttem, Turid Holm, Geir Bjørkøy, Terje Johansen :
    Pax6 localizes to chromatin-rich territories and displays a slow nuclear mobility altered by disease mutations
    Cellular and Molecular Life Sciences (CMLS) 2010 DOI
  • Eva Sjøttem, Cecilie Rekdal, Gunbjørg Svineng, Sylvia sagen Johnsen, Helle Bagterp Klenow, Rebecca dale Uglehus et al.:
    The ePHD protein SPBP interacts with TopBP1 and together they co-operate to stimulate Ets1-mediated transcription
    Nucleic Acids Research (NAR) 2007 DOI
  • Steinar Johansen, Anna Vader, Eva Sjøttem, Henrik Nielsen :
    In vivo expression of a group I intron HEG from the antisense strand of Didymium ribosomal DNA
    RNA Biology 2006
  • Peik Haugen, Odd-Gunnar Wikmark, Anna Vader, Dag H. Coucheron, Eva Sjøttem, Steinar D. Johansen :
    The recent transfer of a homing endonuclease gene
    Nucleic Acids Research (NAR) 2005 OMTALE / ARKIV
  • Peik Haugen, Odd Gunnar Wikmark, A Vader, Dag-Hugo Coucheron, Eva Sjøttem, Steinar Johansen :
    The recent transfer of a homing endonuclease gene
    Nucleic Acids Research (NAR) 2005
  • Steinar Daae Johansen, morten Andreassen, Åsa birna Birgisdottir, Dag-Hugo Coucheron, Christer Einvik, Tonje Fiskaa et al.:
    Group I introns are very common in nuclear SSU rDNA and LSU rDNA of Myxomycetes
    Scripta Botanica Belgica 2002
  • Cecilie Rekdal, Eva Sjøttem, Terje Johansen :
    The nuclear factor SPBP contains different functional domains and stimulates the activity of various transcriptional activators
    Journal of Biological Chemistry 2000
  • Sølvi Anderssen, Eva Sjøttem, Gunbjørg Svineng, Terje Johansen :
    Comparative Analyses of LTRs of the ERV-H Family of Primate-Specific Retrovirus-like ELements Isolated from Marmoset, African Green Monkey, and Man
    Virology 1997
  • Eva Sjøttem, Cecilie Rekdal, Terje Johansen :
    Structural and functional analyses of DNA bending induced by Sp1 family transcription factors
    Journal of Molecular Biology (JMB) 1997
  • Eva Sjøttem, Sølvi Anderssen, Terje Johansen :
    The Promoter Activity of Long Terminal Repeats of the HERV-H Family of Human Retrovirus-Like Elements Is Critcally Dependent on Sp1 Family Proteins Interacting with a GC/GT Box Located Immediately 3´ to the TATA Box
    Journal of Virology 1996
  • Anne Kristin McLaren Berge, Juncal Garcia Garcia, Eva Sjøttem, Hallvard Lauritz Olsvik :
    The ubiquitin E3 ligase TRIM27 emerges as a new player in mitophagy
    Autophagy Reports 2023 ARKIV / DOI
  • Martina Wirth, Stephane Mouilleron, Wenxin Zhang, Eva Sjøttem, Yakubu Princely Abudu, Ashish Jain et al.:
    Corrigendum to Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity (Journal of Molecular Biology (2021) 433(13), (S0022283621001881), (10.1016/j.jmb.2021.166987))
    Journal of Molecular Biology (JMB) 2021 DOI
  • Agnete B. Kristiansen, Terje Johansen, Eva Sjøttem :
    SPBP associates with transcriptionally active chromatin and interacts with RNA polymerase II
    2007
  • Sylvia sagen Johnsen, Eva Sjøttem, Terje Johansen :
    SPBP: a putative co-activator of Androgen Receptor Activity
    2006
  • Helle Bagterp Klenow, Cecilie Rekdal, Gunbjørg Svineng, Eva Sjøttem, Rebecca Dale Uglehus, Terje Johansen :
    SPBP and TopBP1 interact to enhance Ets-mediated activation of the c-myc promoter
    2006
  • Eva Sjøttem, Helle Bagterp Klenow, Cecilie Rekdal, Gunbjørg Svineng, Sylvia Sagen Johnsen, Rebecca Dale Uglehus et al.:
    SPBP and TopBP1: Modulators of Androgen Receptor Activity
    2006
  • Peik Haugen, Odd Gunnar Wikmark, A Vader, eva SjØttem, Steinar Johansen :
    The recent transfer of a homing endonuclease gene
    2005

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    Research interests

    Research interests:

    Characterisation of molecular mechanisms involved in selectivity and regulation of the intracellular process autophagy. Autophagy is a crucial process for cellular homeostasis. It selectively degrades intracellular  destroyed or dangerous components, infectious agents or excess components. Autophagy is important for cell survival during various cellular stresses like starvation, infection and oxygen deprivation. Disregulated autophagy is implicated in various diseases like neurodegenerative diseases, Cardiac diseases, and cancer. Furthermore, autophagy has impact on iflammation ang ageing. Our Research Group has a specific focus on understanding the functional mechanisms of selective autophagy receptors, and how their expression and biological activities are regulated upon stress.

     

    ORCID: https://orcid.org/0000-0003-2668-1708

    Member of research group

    Autophagy Research Group   English content

    Member of project

    Autophagy-regulated Signalosomes in Cellular Stress and Disease Pathways (July 2016-July 2021)

    CV

     

    EDUCATION

    1997                PhD: Disputation date: 07.03.1997

                            The Medical Faculty, University of Tromsø, Norway

    1992                Civil engineer in Biotechnology

                            The Medical Faculty, University of Tromsø, Norway

    1981                Bachelor in Computer Science

                            The Engineering College of Bergen, Bergen, Norway

                                         

    CURRENT AND PREVIOUS POSITIONS

    2022 -              Head of Department, Department of Medical Biology, Faculty of Health Science,

                            UiT The Arctic University of Norway

    2019 – 2022    Professor, Department of Medical Biology, Faculty of Health Science,

                            UiT The Arctic University of Norway

    2000-2019       Associate Professor, Department of Medical Biology, Faculty of Health Science,

                            UiT The Arctic University of Norway

    2008 – 2014      Head of Tromsø BioImaging Platform,

                              The University Hospital of Northern Norway (20%)

    1998-2000       Postdoc Fellow

                            The Medical Faculty, University of Tromsø, Norway

    1994-1997       PhD Fellow

                            The Medical Faculty, University of Tromsø, Norway

    1993                Scientific Assistant

                            The Medical Faculty, University of Tromsø, Norway

    1981-1989         Software engineer

                              Department of Software Development, Norsk Data A.S., Bergen, Norway.

     

    TEACHING ACTIVITIES

    2008-2022       Course director for the two Nordic PhD courses “Molecular and Clinical and Aspects of Cancer I and II”, Faculty of Health Science, University of Tromsø, Norway.

    2000-2010        Course director and lecturer; Molecular Cell Biology for medical (MED100) and odontology (ODO1001) students, The Medical Faculty, University of Tromsø, Norway

    2010-2014        Establishment, course director and lecturer; “MBI-2003: Molecular Cell Biology and Genetics”, Faculty of Health Science, University of Tromsø.          Norway          

    2015-2022       Establishment, course director and lecturer; “MBI-2011: Molecular Cell Biology I”, Faculty of Health Science, University of Tromsø, Norway

    1997-2022       Bachelor courses in “Biochemistry” and “Molecular Cell Biology”.

                            Master courses on “Eukaryotic transcription factors” and “RNA biology”

                            PhD courses “Molecular and Clinical Aspects of Cancer” and “Frontiers in Molecular and Structural Biology”.

                            Faculty of Health Science, University of Tromsø, Norway