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Bilde av Pedersen, Hege Lynum
Bilde av Pedersen, Hege Lynum
Associate professor Department of Medical Biology hege.lynum.pedersen@uit.no +4777623371 41100363 You can find me here

Hege Lynum Pedersen

Job description

Associate professor at the RNA and Molecular Pathology research group and Academic Programme Director for the Master programme in Biomedicine

  • Susannah von Hofsten, Kristin Andreassen Fenton, Hege Lynum Pedersen :
    Human and Murine Toll-like Receptor-Driven Disease in Systemic Lupus Erythematosus
    International Journal of Molecular Sciences 2024 ARKIV / DOI
  • Aud-Malin Karlsson Hovd, Saba Nayar, Charlotte G Smith, Premasany Kanapathippilai, Valentina Iannizzotto, Francesca Barone et al.:
    Podoplanin expressing macrophages and their involvement in tertiary lymphoid structures in mouse models of Sjögren’s disease
    Frontiers in Immunology 2024 ARKIV / DOI
  • Kristin Andreassen Fenton, Hege Lynum Pedersen :
    Advanced methods and novel biomarkers in autoimmune diseases ‑ a review of the recent years progress in systemic lupus erythematosus
    Frontiers in medicine 2023 ARKIV / DOI
  • Luz P blanco, Eduardo Patino-Martinez, Shuichiro Nakabo, Mingzeng Zhang, Hege Lynum Pedersen, Xinghao Wang et al.:
    Modulation of the itaconate pathway attenuates murine lupus
    Arthritis & Rheumatology 2022 DOI
  • Luz P. Blanco, Hege Lynum Pedersen, Xinghao Wang, Yaima L. Lightfoot, Nickie Seto, Carmelo Carmona-Rivera et al.:
    Improved Mitochondrial Metabolism and Reduced Inflammation Following Attenuation of Murine Lupus With Coenzyme Q10 Analog Idebenone
    Arthritis & Rheumatology 2020 DOI
  • Seyed Esmaeil Dorraji, Premasany Kanapathippillai, Aud-Malin Karlsson Hovd, Mikael Ryan Stenersrød, Kjersti Daae Horvei, anita Ursvik et al.:
    Kidney tertiary lymphoid structures in Lupus Nephritis develop into large interconnected networks and resemble lymph nodes in gene signature
    American Journal of Pathology 2020 ARKIV / DOI
  • Kristel Berg, Hege Lynum Pedersen, Ingar Leiros :
    Biochemical characterization of ferric uptake regulator (Fur) from Aliivibrio salmonicida. Mapping the DNA sequence specificity through binding studies and structural modelling
    Biometals 2020 ARKIV / DOI
  • KA Fortner, Luz P. Blanco, I Buskiewicz, N Huang, PC Gibson, DL Cook et al.:
    Targeting mitochondrial oxidative stress with MitoQ reduces NET formation and kidney disease in lupus-prone MRL-lpr mice.
    Lupus Science and Medicine 2020 ARKIV / DOI
  • X Wang, Luz P. Blanco, Carmelo Carmona-Rivera, S Nakabo, Hege Lynum Pedersen, ZX Yu et al.:
    Gasdermin D modulates murine lupus and its associated organ damage
    Arthritis & Rheumatology 2020 DOI
  • S Gupta, S Nakabo, Luz P. Blanco, LJ O'Neil, G Wigerblad, RR Goel et al.:
    Sex differences in neutrophil biology modulate response to type I interferons and immunometabolism
    Proceedings of the National Academy of Sciences of the United States of America (PNAS) 2020 DOI
  • Hege Lynum Pedersen, Kjersti Daae Horvei, Dhivya Thiyagarajan, Gudrun Norby, Natalya Seredkina, Gabriella Moroni et al.:
    Lupus nephritis: low urinary DNase I levels reflect loss of renal DNase I and may be utilized as a biomarker of disease progression
    The journal of pathology. Clinical research 2018 ARKIV / DOI
  • Dhivya Thiyagarajan, Hege Lynum Pedersen, Natalya Seredkina, Kjersti Daae Horvei, Lorena Arranz, Ramon Sonneveld et al.:
    IL-1β Promotes a New Function of DNase I as a Transcription Factor for the Fas Receptor Gene
    Frontiers in Cell and Developmental Biology 2018 ARKIV / DOI
  • Kjersti Daae Horvei, Hege Lynum Pedersen, Silje Fismen, Dhivya Thiyagarajan, Andrea Schneider, Ole Petter Rekvig et al.:
    Lupus nephritis progression in FcγRIIB-/-yaa mice is associated with early development of glomerular electron dense deposits and loss of renal DNase I in severe disease.
    PLOS ONE 2017 ARKIV / DOI
  • Ole Petter Rekvig, Dhivya Thiyagarajan, Hege Lynum Pedersen, Kjersti Daae Horvei, Natalya Seredkina :
    Future perspectives on pathogenesis of Lupus Nephritis: facts, problems, and potential causal therapy modalities
    American Journal of Pathology 2016 DOI
  • Hege Lynum Pedersen, Kjersti Daae Horvei, Dhivya Thiyagarajan, Natalya Seredkina, Ole Petter Rekvig :
    Murine and human lupus nephritis: pathogenic mechanisms and theoretical strategies for therapy
    Seminars in Nephrology 2015 DOI
  • Hege Lynum Pedersen, Kenneth Johnson, Colin McVey, Ingar Leiros, Elin Moe :
    Structure determination of uracil-DNA N-glycosylase from Deinococcus radiodurans in complex with DNA
    Acta Crystallographica Section D: Biological Crystallography 2015 ARKIV / DOI
  • Adele Kim Williamson, Hege Lynum Pedersen :
    Recombinant expression and purification of an ATP-dependent DNA ligase from Aliivibrio salmonicida
    Protein Expression and Purification 2014 DOI
  • Rafi Ahmad, Geir Åsmund Hansen, Hilde Hansen, Erik Hjerde, hege lynum Pedersen, steinar Paulsen et al.:
    Prediction, microarray and northern blot analyses identify new intergenic small RNAs in aliivibrio salmonicida
    Journal of Molecular Microbiology and Biotechnology 28. December 2012 DOI
  • hege lynum Pedersen, Rafi Ahmad, EK Riise, Hanna-Kirsti S. Leiros, Stefan Hauglid, S Espelid et al.:
    Experimental and computational characterization of the ferric uptake regulator from Aliivibrio salmonicida (Vibrio salmonicida)
    Journal of Microbiology 2010 DOI
  • hege lynum Pedersen, erik Hjerde, steinar Paulsen, Hilde Hansen, Lotte Olsen, Sunniva Katharina Thode et al.:
    Global responses of Aliivibrio salmonicida to hydrogen peroxide as revealed by microarray analysis
    Marine Genomics 2010 DOI
  • hege lynum Pedersen, Nils Peder Willassen, Ingar Leiros :
    The first structure of a cold-adapted superoxide dismutase (SOD): biochemical and structural characterization of iron SOD from Aliivibrio salmonicida
    Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2009 DOI
  • Kristin Andreassen Fenton, Hege Lynum Pedersen :
    Characterising tertiary lymphoid structures in lupus-prone mice
    Research Features Magazine 05. May 2021 DOI
  • Hege Lynum Pedersen, Luz P. Blanco, Xinghao Wang, Vance Holt, Mariana J. Kaplan :
    White blood cell metabolism in human SLE
    2019
  • Luz P. Blanco, Hege Lynum Pedersen, Yaima L. Lightfoot, Nickie Seto, Carmelo Carmona-Rivera, Yudong Liu et al.:
    The coenzyme Q10 analog idebenone ameliorates murine lupus
    2019
  • Hege Lynum Pedersen, Kjersti Daae Horvei, Dhivya Thiyagarajan, Gudrun Norby, Natalya Seredkina, Gabriella Moroni et al.:
    LUPUS NEPHRITIS: SEVERELY REDUCED URINARY DNASE I LEVELS REFLECT LOSS OF RENAL DNASE I, DISEASE PROGRESSION AND MAY REDUCE THE NEED FOR RENAL BIOPSIES
    2018
  • Hege Lynum Pedersen :
    Lupus nefritt i mus og mennesker - hva har vi lært, og er det muligheter for terapi?
    Revmatologi BestPractice 2016
  • Hege Lynum Pedersen :
    MARZymes - Marine enzymes from the Arctic region
    2013
  • Adele Kim Williamson, Bjørn Altermark, hege lynum Pedersen, Gro Elin Kjæreng Bjerga, Marcin Miroslaw Pierechod, Nils Peder Willassen et al.:
    Discovery of Cold-active Enzymes from the Marine Arctic Environment
    2013
  • hege lynum Pedersen, Bjørn Altermark, Erik Hjerde, Adele Kim Williamson, Marcin Miroslaw Pierechod, Gro Elin Kjæreng Bjerga et al.:
    Genome Sequencing of Bacteria Isolated from the Arctic Marine Environment
    2013
  • Adele Kim Williamson, Bjørn Altermark, Marcin Miroslaw Pierechod, Gro Elin Kjæreng Bjerga, hege lynum Pedersen, Concetta De Santi et al.:
    Hot Investigations into Cold-Sourced Enzymes
    2013
  • Hege Lynum Pedersen :
    Stress responses in Aliivibrio salmonicida
    2010
  • Hege Lynum Pedersen, Laila Niiranen, Kjersti Lian, Aili Sarre, Joanna Timmins, Sean McSweeney et al.:
    Protein interaction studies of BER proteins from the extreme radiation resistant bacterium Deinococcus radiodurans
    2010
  • Laila Niiranen, Hege Lynum Pedersen, Kjersti Lien, Aili Sarre, Joanna Timmins, S McSweeney et al.:
    Identification of novel interaction partners for DNA glycosylases in the extreme radiation resistant bacterium Deinococcus radiodurans
    2009
  • Hege Lynum Pedersen :
    Oxidative stress and iron limitation in Aliivibrio salmonicida Expression profiling, and molecular characterisation of FeSOD and Fur
    UiT Norges arktiske universitet 2009
  • Hege Lynum Pedersen, Ellen Kristin Riise, Arne O. Smalås, Nils Peder Willassen :
    Oxidative stress in Vibrio salmonicida
    2006
  • Inger Liv Uttakleiv Ræder, hege lynum Pedersen, steinar Paulsen, Trond Jørgensen, Nils Peder Willassen, Arne Oskar Smalås :
    Proteomic studies of Vibrio Salmonicida
    2005

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    Research interests

    Read more about the research projects at the home page of RAMP research group

    I work as an Assoociate Professor. My research interests are in immunology and protein research. I work with the autoimmune disease Systemic Lupus Erythematosus (SLE), and my focus has been mainly related to new biomarkers and treatment of this disease. 

    We aim to develop new therapeutic tools and ways to monitor the disease based on novel and precise knowledge of the disease initiation and development. Since the expression of both DNase I and neutrophil extracellular traps (NETs) are abnormal in SLE, we hypothesize that they can be utilized in therapy and as biomarkers. To explore this, we will investigate the expression pattern and regulation of DNase I and NETs.

    Teaching

    MBI-1105, basic biochemistry

    • Lectures and seminars in enzymology

    ODO-2008

    • Lectures, seminars and case in immunology

    MBI-3911

    • Course responsible

    Member of research group

    RNA and molecular pathology research group (RAMP)   Norsk innhold

    Member of project

    Lupus Nephritis-disease mechanisms, detection and therapy Human Lupus Nephritis