Moldes-Anaya, Angel

Radio- and Nuclear Chemistry (Use of specific radiotracers for imaging brain function by PET and SPECT technologies)

Neuropharmacology and neurotoxicology

Neuroimaging (SPECT and PET/CT)

Certificate of Advance Studies (CAS) in Radiopharmacy, ETH-Zürich (2020)

Certified Toxicologist (EUROTOX-registered toxicologist) (2013)

PhD in veterinary medicine (neurotoxicology and analytical organic chemistry) (2011)

MSc in neuroscience and behavioural biology (2013)

MSc in Chemistry (analytical organic chemistry) (2003)

Neuroanatomy, Neurophysiology, Neuropsychopharmacology at:

MED-2501, Mental Functions I

MED-2521, Mental Functions II

FARM-2202, CNS anatopatophysiology and psychopharmacology

Fagansvarlig syklotron og radiokjemi

PET-senteret, UNN

Scientific articles and book chapters
Other

Berntsen, Hanne Friis; Moldes-Anaya, Angel; Bjørklund, Cesilie Granum; Ragazzi, Lorenzo; Haug, Trude M; Strandabø, Rønnaug; Verhaegen, Steven; Paulsen, Ragnhild Elisabeth; Ropstad, Erik; Tasker, Andrew. Perfluoroalkyl acids potentiate glutamate excitotoxicity in rat cerebellar granule neurons. Toxicology 2020; Volum 445 (152610). ISSN 0300-483X.s 1 - 10.s doi: 10.1016/j.tox.2020.152610.

Fjellaksel, Richard; Moldes-Anaya, Angel; Vasskog, Terje; Oteiza, Ana; Martin-Armas, Maria Montserrat; Hjelstuen, Ole Kristian; Hansen, Jørn H; Riss, Patrick; Sundset, Rune. Evaluation by metabolic profiling and in vitro autoradiography of two promising GnRH‐receptor ligands for brain SPECT imaging. Journal of labelled compounds & radiopharmaceuticals 2019. ISSN 0362-4803.s 1 - 13.s doi: 10.1002/jlcr.3820.

Berntsen, Hanne Friis; Bjørklund, Cesilie Granum; Strandabø, Rønnaug; Haug, Trude; Moldes-Anaya, Angel; Fuentes-Lazaro, Judit; Verhaegen, Steven; Paulsen, Ragnhild Elisabeth; Tasker, R. Andrew; Ropstad, Erik. PFOS-induced excitotoxicity is dependent on Ca2+ influx via NMDA receptors in rat cerebellar granule neurons. Toxicology and Applied Pharmacology 2018; Volum 357. ISSN 0041-008X.s 19 - 32.s doi: 10.1016/j.taap.2018.08.015.

Moldes-Anaya, Angel; Sæther, Thomas; Uhlig, Silvio; Nebb, Hilde Irene; Larsen, Terje; Eilertsen, Hans Christian; Paulsen, Steinar Martin. Two Isomeric C16 Oxo-Fatty Acids from the Diatom Chaetoceros karianus Show Dual Agonist Activity towards Human Peroxisome Proliferator-Activated Receptors (PPARs) α/γ. (fulltekst) Marine Drugs 2017; Volum 15 (148). ISSN 1660-3397.s doi: 10.3390/md15060148.

Berntsen, Hanne Friis; Bogen, Inger Lise; Wigestrand, Mattis B; Fonnum, Frode; Walaas, S. Ivar; Moldes-Anaya, Angel. The fungal neurotoxin penitrem A induces the production of reactive oxygen species in human neutrophils at submicromolar concentrations. Toxicology 2017; Volum 392. ISSN 0300-483X.s 64 - 70.s doi: 10.1016/j.tox.2017.10.008.

Fæste, Christiane Kruse; Moldes-Anaya, Angel. Biotransformation of the fungal neurotoxin Thomitrem A by primary rat hepatocytes. Toxicon 2016; Volum 124. ISSN 0041-0101.s 36 - 43.s doi: 10.1016/j.toxicon.2016.11.003.

Berntsen, H F; Wigestrand, Mattis Brænne; Bogen, Inger Lise; Fonnum, Frode; Walaas, S. Ivar; Moldes-Anaya, Angel. Mechanisms of penitrem-induced cerebellar granule neuron death in vitro: Possible involvement of GABA(A) receptors and oxidative processes. Neurotoxicology 2013; Volum 35. ISSN 0161-813X.s 129 - 136.s doi: 10.1016/j.neuro.2013.01.004.

Eriksen, Gunnar Sundstøl; Moldes-Anaya, Angel; Fæste, Christiane Kruse. Penitrem A and analogues: toxicokinetics, toxicodynamics including mechanism of action and clinical significance. World Mycotoxin Journal 2013; Volum 6 (3). ISSN 1875-0710.s 263 - 272.s doi: 10.3920/WMJ2013.1574.

Moldes-Anaya, Angel; Rundberget, Thomas; Fæste, Christiane Kruse; Eriksen, Gunnar Sundstøl; Bernhoft, Aksel. Neurotoxicity of Penicillium crustosum secondary metabolites: Tremorgenic activity of orally administered penitrem A and thomitrem A and E in mice. Toxicon 2012; Volum 60 (8). ISSN 0041-0101.s 1428 - 1435.s doi: 10.1016/j.toxicon.2012.10.007.

Moldes-Anaya, Angel; Rundberget, Thomas; Uhlig, Silvio; Rise, Frode; Wilkins, Alistair Lawrence. Isolation and structure elucidation of secopenitrem D, an indole alkaloid from Penicillium crustosum Thom. Toxicon 2011; Volum 57 (2). ISSN 0041-0101.s 259 - 265.s doi: 10.1016/j.toxicon.2010.11.020.

Moldes-Anaya, Angel S.; Fonnum, Frode; Eriksen, Gunnar Sundstøl; Rundberget, Thomas; Walaas, S. Ivar; Wigestrand, Mattis Brænne. In vitro neuropharmacological evaluation of penitrem-induced tremorgenic syndromes: importance of the GABAergic system. Neurochemistry International 2011; Volum 59 (7). ISSN 0197-0186.s 1074 - 1081.s doi: 10.1016/j.neuint.2011.08.014.

Eriksen, Gunnar Sundstøl; Jæderlund, Karin Hultin; Moldes, Angel; Schonheit, Jurgen; Bernhoft, Aksel; Jæger, Gry; Rundberget, Jan Thomas; Skaar, Hanne Ida. Poisoning of dogs with tremorgenic Penicillium toxins. Medical Mycology 2010; Volum 48 (1). ISSN 1369-3786.s 188 - 196.s doi: 10.3109/13693780903225821.

Bernhoft, Aksel; Moldes, Angel; Rudberget, T; Skaar, Ida. Mykotoksinet penitrem A gir hjerneskader hos hunder. Norsk Veterinærtidsskrift 2010; Volum 122 (3). ISSN 0332-5741.s 168 - .

Moldes-Anaya, Angel S; Asp, Tone Normann; Eriksen, Gunnar Sundstøl; Skaar, Ida; Rundberget, Thomas. Determination of cyclopiazonic acid in food and feeds by liquid chromatography-tandem mass spectrometry. Journal of Chromatography A 2009; Volum 1216 (18). ISSN 0021-9673.s 3812 - 3818.s doi: 10.1016/j.chroma.2009.02.061.

Moldes-Anaya, Angel S.; Wilkins, Alistair L.; Rundberget, Thomas; Fæste, Christiane Kruse. In vitro and in vivo hepatic metabolism of the fungal neurotoxin penitrem A. Drug and chemical toxicology (New York, N.Y. 1978) 2009; Volum 32 (1). ISSN 0148-0545.s 26 - 37.s doi: 10.1080/01480540802416232.

Fjellaksel, Richard; Oteiza, Ana; Martin, armas maria montserrat; Hansen, Jørn H; Moldes-Anaya, Angel; Vasskog, Terje; Hjelstuen, Ole Kristian; Riss, Patrick; Sundset, Rune. Development and evaluation of gonadotropin releasing hormone SPECT radioligands. SNMMI (data) 2018-06-23 - 2018-06-26 2018.

Fjellaksel, Richard; Hansen, Jørn H; Moldes-Anaya, Angel; Martin, armas maria montserrat; Oteiza, Ana; Riss, Patrick; Sundset, Rune. Development and evaluation of gonadotropin releasing hormone (GnRH) SPECT radioligands. EANM 17 (data) (fulltekst) 2017-10-23 - 2017-10-23 2017.

Moldes-Anaya, Angel; Ragazzi, Lorenzo; Kuttner, Samuel; Vincenz, Daniel; Goldschmidt, Jürgen; Brun, Vegard; Kjelstrup, Kirsten Brun. Targetting mnemonic pathways of stress by cerebral perfusion using 99mTc-HMPAO SPECT/CT. 1st Tromsø PET seminar 2017-09-21 - 2017-09-22 2017.

Haugland, Kamilla Gjerland; Moldes-Anaya, Angel; Olberg, Anniken; Lande, Andreas; Kjelstrup, Kirsten Brun; Brun, Vegard. Intrahippocampal growth hormone modulates spatial memory. 5th National PhD Conference in Neuroscience 2017-09-20 - 2017-09-22 2017.

Sæther, Thomas; Moldes-Anaya, Angel; Tungen, Jørn Eivind; Vik, Anders; Paulsen, Steinar M; Sylte, Ingebrigt; Hansen, Trond Vidar; Nebb, Hilde Irene. Anti-diabetic activity from marine lipids: new anti-diabetic drugs. Throne Holst Symposium 2016-05-19 - 2016-05-19 2016.

Haugland, Kamilla Gjerland; Moldes-Anaya, Angel; Kjelstrup, Kirsten Brun; Brun, Vegard. Intrahippocampal growth hormone modulates spatial memory. Society for Neuroscience 2016-11-12 - 2016-11-16 2016.

Ragazzi, Lorenzo; Moldes-Anaya, Angel; Brun, Vegard; Kjelstrup, Kirsten Brun. Contextual fear encoded by hippocampal single units. Society for Neuroscience 2016 2016-11-12 - 2016-11-16 2016.

Moldes-Anaya, Angel; Kuttner, Samuel; Vincenz, Daniel; Goldschmidt, Jürgen; Brun, Vegard; Kjelstrup, Kirsten Brun. Targeting mnemonic pathways of stress by cerebral perfusion using 99mTc-HMPAO SPECT/CT. 1st. Nordic Neuroscience Meeting 2015-06-10 - 2015-06-12 2015.

Sæther, Thomas; Moldes-Anaya, Angel; Tungen, Jørn Eivind; Vik, Anders; Paulsen, Steinar Martin; Sylte, Ingebrigt; Hansen, Trond Vidar; Nebb, Hilde Irene. Anti-diabetic activity from marine lipids: new anti-diabetic drugs. EMBO Conference on Nuclear Receptors 2015-09-24 - 2015-09-28 2015.

Haugland, KG; Moldes-Anaya, Angel; Kjelstrup, Kirsten Brun; Brun, Vegard. The role of intrahippocampal Growth hormone in spatial memmory. 3rd National PhD Conference in Neuroscience 2015-09-21 - 2015-09-23 2015.

Haugland, Kamilla Gjerland; Moldes-Anaya, Angel; Kjelstrup, Kirsten Brun; Brun, Vegard. The role of intrahippocampal growth hormone in spatial memory. 1st. Nordic Neuroscience Meeting 2015-06-10 - 2015-06-12 2015.

Sæther, Thomas; Moldes-Anaya, Angel; Norrheim-Larsen, Laila; Larsen, Terje; Paulsen, Steinar M; Nebb, Hilde Irene. Two near identical oxylipins from the diatom Chaetoceros karianus show isoform-specific agonist activity towards human peroxisome proliferator-activated receptors (PPARs). Throne Holst Symposium 2014-06-10 - 2014-06-10 2014.

Sæther, Thomas; Moldes-Anaya, Angel; Norrheim-Larsen, Laila; Larsen, Terje; Paulsen, Steinar M; Nebb, Hilde Irene. Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae. Throne Holst Symposium 2013-05-06 - 2013-05-06 2013.

Sæther, Thomas; Moldes-Anaya, Angel; Larsen, Laila Norrheim; Larsen, Terje; Paulsen, Steinar; Nebb, Hilde Irene. Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae. Keystone Symposia - Nuclear Receptors and Friends: Roles in Energy Homeostasis and Metabolic Dysfunction 2013-04-03 - 2013-04-08 2013.

Moldes-Anaya, Angel; Sæther, Thomas; Norrheim-Larsen, Laila; Nebb, Hilde Irene; Larsen, Terje; Paulsen, Steinar. Identifying natural products with agonist or modulatory activity against human nuclear receptors in extracts from cultured marine microalgae. 14th. International Symposium on Marine Natural Products and 8th. European Conference on Marine Natural Products (MANAPRO) 2013-09-15 - 2013.

Moldes-Anaya, Angel; Sæther, Thomas; Larsen, Laila Norrheim; Larsen, Terje; Nebb, Hilde Irene; Paulsen, Steinar. Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae. BIOPROSP_2013 2013-02-20 - 2013-02-22 2013.

Moldes-Anaya, Angel S.. Undervurdert muggsoppgift. Forskning.no 2012. ISSN 1891-635X.

Moldes-Anaya, Angel. Toxicokinetics and toxicodinamics of penitrem A, a fungal neuroactive compound causing neurological disease in humans and animals. 5th. Baltic Forum of Veterinary Medicine 2012-09-22 - 2012-09-23 2012.

Moldes-Anaya, Angel. Neurological disorders caused by fungal toxins: the case of penitrem-induced neuromycotoxicosis in dogs. 5th. Baltic Forum of Veterinary Medicine 2012-09-22 - 2012-09-23 2012.

Eriksen, Gunnar Sundstøl; Rundberget, Thomas; Wigestrand, Mattis Brænne; Fonnum, Frode; Bernhoft, Aksel; Moldes-Anaya, Angel. Poisoning by penicillium toxins-Clinical and brain receptor effects. Toxicology Letters 2012; Volum 211. ISSN 0378-4274.s S58 - S59.s doi: 10.1016/j.toxlet.2012.03.231.

Moldes-Anaya, Angel. Hunden kan dø av muggsopp i matavfall. Forskning.no 2012. ISSN 1891-635X.

Moldes-Anaya, Angel S.. Penitrem-induced neurological disease in Norway : clinical cases in dogs. Neuropharmacology and toxicokinetics of penitrem A. Structural elucidation of a novel penitremanalogue. Unipub forlag 2011 (96) ISBN 978-82-7725-211-7. ISSN 1890-0364.

Moldes-Anaya, Angel S.; Fonnum, Frode; Eriksen, Gunnar Sundstøl; Rundberget, Thomas; Walaas, S. Ivar; Wigestrand, Mattis Brænne. Hepatic metabolism and neuropharmacological evaluation of fungal tremorgenic syndromes: implication of the GABAergic and glutamatergic systems. 7th. annual congress of International Drug Discovery Science and Technology (IDDST) 2009-10-22 - 2009-10-25 2009.

Moldes-Anaya, Angel S.; Rundberget, Thomas; Fæste, Christiane Kruse; Eriksen, Gunnar Sundstøl. In vitro metabolism of tremorgenic mycotoxins in rat hepatocytes and microsomes: identification and potential toxic effects of produced metabolites. 12th International IUPAC Symposium on Mycotoxins and Phycotoxins 2007-05-21 - 2007-05-25 2007.