Angel Salvador Moldes-Anaya
Job description
Unit Manager Cyclotron and Radiochemistry
Cyclotron and Radiochemistry Unit
PET Imaging Center, University Hospital of North Norway (UNN)
Work areas
Isotopes / Chromatorgraphy / MicroCT scanning / MicroPET scanning / Radioactivity / Radiation protection / Teaching
Ursula Søndergaard,
Thomas Kolle Ekaney,
Kristina Søborg Pedersen,
Mathias Kranz,
Rune Sundset,
Angel Moldes-Anaya
et al.:
Production of 67Cu at a biomedical cyclotron via 70Zn(p,α)67Cu reaction and its evaluation in a preclinical study using small animal SPECT/CT
Applied Radiation and Isotopes 2025 DOI
Piyapan Suwattananuruk,
Sukanya Yaset,
Chanisa Chotipanich,
Angel Moldes-Anaya,
Rune Sundset,
Rodrigo Berzaghi
et al.:
Radiosynthesis and preclinical evaluation of a 68Ga-labeled tetrahydroisoquinoline-based ligand for PET imaging of C-X-C chemokine receptor type 4 in an animal model of glioblastoma
Ahmet Oguzhan Bicakci,
Mousumi Sarkar,
Yu-Hsin Chang,
Evelyn Kahl,
Lorenzo Ragazzi,
Angel Moldes-Anaya
et al.:
Anxiolytic-like Effects of the Positive GABA-B Receptor Modulator GS39783 Correlate with Mice's Individual Basal Anxiety and Stress Reactivity
Marcel Lindemann,
Ana Oteiza,
Montserrat Martin-Armas,
Yngve Guttormsen,
Angel Moldes-Anaya,
Rodrigo Berzaghi
et al.:
Glioblastoma PET/MRI: kinetic investigation of [18F]rhPSMA-7.3, [18F]FET and [18F]fluciclovine in an orthotopic mouse model of cancer
Hanne Friis Berntsen,
Angel Moldes-Anaya,
Cesilie Granum Bjørklund,
Lorenzo Ragazzi,
Trude M Haug,
Rønnaug Strandabø
et al.:
Perfluoroalkyl acids potentiate glutamate excitotoxicity in rat cerebellar granule neurons
Richard Fjellaksel,
Angel Moldes-Anaya,
Terje Vasskog,
Ana Oteiza,
Maria Montserrat Martin-Armas,
Ole Kristian Hjelstuen
et al.:
Evaluation by metabolic profiling and in vitro autoradiography of two promising GnRH‐receptor ligands for brain SPECT imaging
Hanne Friis Berntsen,
Cesilie Granum Bjørklund,
Rønnaug Strandabø,
Trude Haug,
Angel Moldes-Anaya,
Judit Fuentes-Lazaro
et al.:
PFOS-induced excitotoxicity is dependent on Ca2+ influx via NMDA receptors in rat cerebellar granule neurons
Hanne Friis Berntsen,
Inger Lise Bogen,
Mattis B Wigestrand,
Frode Fonnum,
S. Ivar Walaas,
Angel Moldes-Anaya
:
The fungal neurotoxin penitrem A induces the production of reactive oxygen species in human neutrophils at submicromolar concentrations
Angel Moldes-Anaya,
Thomas Sæther,
Silvio Uhlig,
Hilde Irene Nebb,
Terje Larsen,
Hans Christian Eilertsen
et al.:
Two Isomeric C16 Oxo-Fatty Acids from the Diatom Chaetoceros karianus Show Dual Agonist Activity towards Human Peroxisome Proliferator-Activated Receptors (PPARs) α/γ
Christiane Kruse Fæste,
Angel Moldes-Anaya
:
Biotransformation of the fungal neurotoxin Thomitrem A by primary rat hepatocytes
Toxicon 2016 DOI
H F Berntsen,
Mattis Brænne Wigestrand,
Inger Lise Bogen,
Frode Fonnum,
S. Ivar Walaas,
Angel Moldes-Anaya
:
Mechanisms of penitrem-induced cerebellar granule neuron death in vitro: Possible involvement of GABA(A) receptors and oxidative processes
Neurotoxicology 2013 DOI
Gunnar Sundstøl Eriksen,
Angel Moldes-Anaya,
Christiane Kruse Fæste
:
Penitrem A and analogues: toxicokinetics, toxicodynamics including mechanism of action and clinical significance
World Mycotoxin Journal 09. August 2013 DOI
Angel Moldes-Anaya,
Thomas Rundberget,
Christiane Kruse Fæste,
Gunnar Sundstøl Eriksen,
Aksel Bernhoft
:
Neurotoxicity of Penicillium crustosum secondary metabolites: Tremorgenic activity of orally administered penitrem A and thomitrem A and E in mice
Toxicon 2012 DOI
Angel S. Moldes-Anaya,
Frode Fonnum,
Gunnar Sundstøl Eriksen,
Thomas Rundberget,
S. Ivar Walaas,
Mattis Brænne Wigestrand
:
In vitro neuropharmacological evaluation of penitrem-induced tremorgenic syndromes: importance of the GABAergic system
Neurochemistry International 2011 DOI
Angel Moldes-Anaya,
Thomas Rundberget,
Silvio Uhlig,
Frode Rise,
Alistair Lawrence Wilkins
:
Isolation and structure elucidation of secopenitrem D, an indole alkaloid from Penicillium crustosum Thom
Toxicon 2011 DOI
Aksel Bernhoft,
Angel Moldes,
T Rudberget,
Ida Skaar
:
Mykotoksinet penitrem A gir hjerneskader hos hunder
Norsk veterinærtidsskrift 2010
Gunnar Sundstøl Eriksen,
Karin Hultin Jæderlund,
Angel Moldes,
Jurgen Schonheit,
Aksel Bernhoft,
Gry Jæger
et al.:
Poisoning of dogs with tremorgenic Penicillium toxins
Medical Mycology 2010 DOI
Angel S. Moldes-Anaya,
Alistair L. Wilkins,
Thomas Rundberget,
Christiane Kruse Fæste
:
In vitro and in vivo hepatic metabolism of the fungal neurotoxin penitrem A
Drug and chemical toxicology (New York, N.Y. 1978) 2009 DOI
Angel S Moldes-Anaya,
Tone Normann Asp,
Gunnar Sundstøl Eriksen,
Ida Skaar,
Thomas Rundberget
:
Determination of cyclopiazonic acid in food and feeds by liquid chromatography-tandem mass spectrometry
Journal of Chromatography A 2009 DOI
Karoline Nordli,
Hanna Bähr,
Mathias Kranz,
Angel Moldes-Anaya,
Jørn H Hansen
:
Towards a Novel Radiotracer for PET – Imaging of Glioblastoma
Targeting the Notch Signaling Pathway
2023
Karoline Nordli,
Hanna Bähr,
Angel Moldes-Anaya,
Jørn H Hansen,
Mathias Kranz
:
Towards a novel radiotracer for PET – imaging of glioblastoma
targeting the Notch signaling pathway
2022
Michel Herranz Carnero,
Angel Moldes-Anaya,
Bengt Erik Haug,
Turid Hellevik,
Inigo Zubiavrre Martinez
:
Innovative molecular imaging technique for Granzyme-B characterization as an emerging biomarker for radio-immunotherapy combinations
2022
Yngve Guttormsen,
Angel Moldes-Anaya,
Richard Fjellaksel,
Ana Oteiza,
Montserrat Martin-Armas,
Marcel Lindemann
et al.:
Development of a carbon-11 labeled thienopyrimidine based radioligand for EGFR-tyrosine-kinase-inhibitor (TKI) specific PET imaging of glioblastoma
Journal of Nuclear Medicine 2021
Yngve Guttormsen,
Mathias Kranz,
Richard Fjellaksel,
Montserrat Martin-Armas,
Ana Oteiza,
Julia Bihler
et al.:
SP-015 - Preliminary evaluation of a novel carbon-11 labeled brain-penetrant EGFR-TKI radiotracer for brain cancer imaging
Nuclear Medicine and Biology 2021 DOI
Richard Fjellaksel,
Ana Oteiza,
armas maria montserrat Martin,
Jørn H Hansen,
Angel Moldes-Anaya,
Terje Vasskog
et al.:
Development and evaluation of gonadotropin releasing hormone SPECT radioligands
2018 DATA
Richard Fjellaksel,
Jørn H Hansen,
Angel Moldes-Anaya,
armas maria montserrat Martin,
Ana Oteiza,
Patrick Riss
et al.:
Development and evaluation of gonadotropin releasing hormone (GnRH) SPECT radioligands
Kamilla Gjerland Haugland,
Angel Moldes-Anaya,
Anniken Olberg,
Andreas Lande,
Kirsten Brun Kjelstrup,
Vegard Brun
:
Intrahippocampal growth hormone modulates spatial memory
2017
Angel Moldes-Anaya,
Lorenzo Ragazzi,
Samuel Kuttner,
Daniel Vincenz,
Jürgen Goldschmidt,
Vegard Brun
et al.:
Targetting mnemonic pathways of stress by cerebral perfusion using 99mTc-HMPAO SPECT/CT
2017
Lorenzo Ragazzi,
Angel Moldes-Anaya,
Vegard Brun,
Kirsten Brun Kjelstrup
:
Contextual fear encoded by hippocampal single units
2016
Thomas Sæther,
Angel Moldes-Anaya,
Jørn Eivind Tungen,
Anders Vik,
Steinar M Paulsen,
Ingebrigt Sylte
et al.:
Anti-diabetic activity from marine lipids: new anti-diabetic drugs
2016
Kamilla Gjerland Haugland,
Angel Moldes-Anaya,
Kirsten Brun Kjelstrup,
Vegard Brun
:
Intrahippocampal growth hormone modulates spatial memory
2016
Thomas Sæther,
Angel Moldes-Anaya,
Jørn Eivind Tungen,
Anders Vik,
Steinar Martin Paulsen,
Ingebrigt Sylte
et al.:
Anti-diabetic activity from marine lipids: new anti-diabetic drugs
2015
KG Haugland,
Angel Moldes-Anaya,
Kirsten Brun Kjelstrup,
Vegard Brun
:
The role of intrahippocampal Growth hormone in spatial memmory
2015
Angel Moldes-Anaya,
Samuel Kuttner,
Daniel Vincenz,
Jürgen Goldschmidt,
Vegard Brun,
Kirsten Brun Kjelstrup
:
Targeting mnemonic pathways of stress by cerebral perfusion using 99mTc-HMPAO SPECT/CT
2015
Kamilla Gjerland Haugland,
Angel Moldes-Anaya,
Kirsten Brun Kjelstrup,
Vegard Brun
:
The role of intrahippocampal growth hormone in spatial memory
2015
Thomas Sæther,
Angel Moldes-Anaya,
Laila Norrheim-Larsen,
Terje Larsen,
Steinar M Paulsen,
Hilde Irene Nebb
:
Two near identical oxylipins from the diatom Chaetoceros karianus show isoform-specific agonist activity towards human peroxisome proliferator-activated receptors (PPARs)
2014
Thomas Sæther,
Angel Moldes-Anaya,
Laila Norrheim-Larsen,
Terje Larsen,
Steinar M Paulsen,
Hilde Irene Nebb
:
Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae
2013
Angel Moldes-Anaya,
Thomas Sæther,
Laila Norrheim-Larsen,
Hilde Irene Nebb,
Terje Larsen,
Steinar Paulsen
:
Identifying natural products with agonist or modulatory activity against human nuclear receptors in extracts from cultured marine microalgae
2013
Thomas Sæther,
Angel Moldes-Anaya,
Laila Norrheim Larsen,
Terje Larsen,
Steinar Paulsen,
Hilde Irene Nebb
:
Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae
2013
Angel Moldes-Anaya,
Thomas Sæther,
Laila Norrheim Larsen,
Terje Larsen,
Hilde Irene Nebb,
Steinar Paulsen
:
Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae
2013
Angel Moldes-Anaya
:
Hunden kan dø av muggsopp i matavfall
Forskning.no 2012
Gunnar Sundstøl Eriksen,
Thomas Rundberget,
Mattis Brænne Wigestrand,
Frode Fonnum,
Aksel Bernhoft,
Angel Moldes-Anaya
:
Poisoning by penicillium toxins-Clinical and brain receptor effects
Toxicology Letters 2012 DOI
Angel S. Moldes-Anaya
:
Undervurdert muggsoppgift
Forskning.no 2012
Angel Moldes-Anaya
:
Neurological disorders caused by fungal toxins: the case of penitrem-induced neuromycotoxicosis in dogs
2012
Angel Moldes-Anaya
:
Toxicokinetics and toxicodinamics of penitrem A, a fungal neuroactive compound causing neurological disease in humans and animals
2012
Angel S. Moldes-Anaya
:
Penitrem-induced neurological disease in Norway : clinical cases in dogs. Neuropharmacology and toxicokinetics of penitrem A. Structural elucidation of a novel penitremanalogue
Unipub forlag 2011
Angel S. Moldes-Anaya,
Frode Fonnum,
Gunnar Sundstøl Eriksen,
Thomas Rundberget,
S. Ivar Walaas,
Mattis Brænne Wigestrand
:
Hepatic metabolism and neuropharmacological evaluation of fungal tremorgenic syndromes: implication of the GABAergic and glutamatergic systems
2009
Angel S. Moldes-Anaya,
Thomas Rundberget,
Christiane Kruse Fæste,
Gunnar Sundstøl Eriksen
:
In vitro metabolism of tremorgenic mycotoxins in rat hepatocytes and microsomes: identification and potential toxic effects of produced metabolites
2007
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Research interests
Radio- and Nuclear Chemistry (Use of specific radiotracers for imaging brain function by PET and SPECT technologies)
C-11 and F-18 Radiochemistry
Radiometals
Neuropharmacology and neurotoxicology
Neuroimaging (SPECT/PET/CT and PET/MR)
PET tracer pharmacokinetics
Teaching
Course Organizer Radiochemistry and Nuclear Chemistry:
KJE-3316 Radiopharmaceutical Chemistry (10 ETCS, offered at the Dpt. of Chemistry, Master degree course)
KJE-8316 Radiopharmaceutical Chemistry (10 ECTS, offered at the Dpt. of Chemistry, PhD degree course)
Responsible for the areas Neuroanatomy/Neurophysiology and Neuropsychopharmacology at:
MED-2501, Mental Functions I
MED-2521, Mental Functions II
FARM-2202, CNS anatopatophysiology and psychopharmacology
Member of research group
CV
Certificate of Advance Studies (CAS) in Radiopharmacy, ETH-Zürich (2020)
Certified Toxicologist (EUROTOX-registered toxicologist) (2013)
PhD in veterinary medicine (neurotoxicology and analytical organic chemistry) (2011)
MSc in neuroscience and behavioural biology (2013)
MSc in Chemistry (analytical organic chemistry) (2003)