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Maria Therese Ahlen

Researcher, University Hospital of North Norway Department of Medical Biology
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Platlet immunology
Alloimmune repsonses in pregnancy

 

Publications

2018

 
Zhi H, Ahlen MT, Thinn AMM, Weiler H, Curtis BR, Skogen B, Zhu J, Newman PJ. 

High-resolution mapping of the polyclonal immune response to the human platelet alloantigen HPA-1a (PlA1). Blood Advances 2018; Nov 13;2(21):3001-3011. doi: 10.1182/bloodadvances.2018023341.

 

Orzińska A, Guz K, Uhrynowska M, Dȩbska M, Mikula M, Ostrowski J, Ahlen MT, Husebekk A, Brojer E.Noninvasive prenatal HPA-1 typing in HPA-1a negative pregnancies selected in the Polish PREVFNAIT screening program. Transfusion 2018 s. 1-7

 


 

2017

Dahl, J, Refsum E, Ahlen MT, Egeland T, Jensen T, Viken MK, Stuge TB, Acharya G, Husebekk A, Skogen B, Tiller H. Unraveling the role of maternal anti-HLA class I antibodies in fetal and neonatal thrombocytopenia?Antibody specificity analysis using epitope data. Journal of Reproductive Immunology 2017 ;Volum 122. s. 1-

 

Tiller H, Husebekk A, Ahlen, MT, Stuge, TB, Skogen, B. Current perspectives on fetal and neonatal alloimmune thrombocytopenia - Increasing clinical concerns and new treatment opportunities. International Journal of Women's Health 2017 ;Volum 9. s. 223-234


2016

Ahlen MT, Husebekk A, Killie IL, Skogen B, Stuge, TB. T cell responses to human platelet antigen-1a involve a unique form of indirect allorecognition. JCI Insight 2016 ;Volum Sep 8.(1) Suppl. 14 s. e86558


2013

Heide G, Stuge TB, Skogen B, Husebekk A, Ahlen MT. The DR7-DQ2 haplotype in a native Norwegian population. Scand J Immunol. 2013 May;77(5):429-30 


2012

Husebekk A, El Ekiaby M, Gorgy G, Killie MK, Uhlin-Hansen C, Salma W, Navarrete C, El Afandi M, Skogen B, Ahlen MT. Foetal/neonatal alloimmune thrombocytopenia in Egypt; human platelet antigen genotype frequencies and antibody detection and follow-up in pregnancies. Transfus Apher Sci. 2012 May 26.

Ahlen MT, Husebekk A, Killie MK, Kjeldsen-Kragh J, Olsson ML and Skogen B. The development of severe neonatal alloimmune thrombocytopenia due to anti-HPA-1a antibodies is correlated to maternal ABO genotypes. Clin Dev Immunol. 2012:156867.


2011

Stuge TB, Skogen B, Ahlen MT, Husebekk A, Urbaniak SJ, Bessos H. The cellular immunobiology associated with fetal and neonatal alloimmune thrombocytopenia. Transfus Apher Sci. 2011 Aug;45(1):53-9. Review.


2010

Husebekk A, Ahlen MT; Killie MK, Tiller H, Eksteen M, Killie IL, Heide G, Kjeldsen-Kragh J, Skogen BR, Stuge TB. Blood group antigens and immune responses-detailed knowledge is necessary to prevent immunization and to follow up immunized individuals. ISBT Science Series 2010 ;Volum 5.(1) s. 24-26

Skogen BR, Killie MK, Kjeldsen-Kragh J, Ahlen MT, Tiller H, StugeTB, Husebekk A. Reconsidering fetal and neonatal alloimmune thrombocytopenia with a focus on screening and prevention. Expert Review of Hematology 2010 ;Volum 3.(5) s. 559-566


2009

Ahlen MT, Husebekk A, Killie MK, Skogen BR, Stuge TB. T-cell responses associated with neonatal alloimmune thrombocytopenia: isolation of HPA-1a-specific, HLA-DRB3*0101-restricted CD4+ T cells. Blood 2009 ;Volum 113.(16) s. 3838-3844

 

Researher at Department of Laboratory medicine, UNN and the Norwegian National Unit for Platelet Immunology.

 

  • Rasmussen, Trude Victoria; Ahlen, Maria Therese. Murine models for studying treatment, prevention and pathogenesis of FNAIT. Transfusion and Apheresis Science 2020; Volum 59 (1). ISSN 1473-0502.s doi: 10.1016/j.transci.2019.102706.

  • Kjeldsen-Kragh, Jens; Ahlen, Maria Therese. Foetal and neonatal alloimmune thrombocytopenia - The role of the HLA-DRB3*01:01 allele for HPA-1a-immunisation and foetal/neonatal outcome. Transfusion and Apheresis Science 2020; Volum 59:102707. ISSN 1473-0502.s 1 - 5.s doi: 10.1016/j.transci.2019.102707.

  • Tiller, Heidi; Ahlen, Maria Therese; Akkøk, Cigdem Ahaein; Husebekk, Anne. Fetal and neonatal alloimmune thrombocytopenia - The Norwegian management model. Transfusion and Apheresis Science 2019. ISSN 1473-0502.s doi: 10.1016/j.transci.2019.102711.

  • Orzińska, Agnieszka; Guz, Katarzyna; Uhrynowska, Małgorzata; Dȩbska, Marzena; Mikula, Michal; Ostrowski, Jerzy; Ahlen, Maria Therese; Husebekk, Anne; Brojer, Ewa. Noninvasive prenatal HPA-1 typing in HPA-1a negative pregnancies selected in the Polish PREVFNAIT screening program. Transfusion 2018. ISSN 0041-1132.s 1 - 7.s doi: 10.1111/trf.14963.

  • Zhi, Huiying; Ahlen, Maria Therese; Thinn, Aye Myat Myat; Weiler, Hartmut; Curtis, Brian R.; Skogen, Bjørn; Zhu, Jieqing; Newman, Peter J.. High-resolutionmappingofthepolyclonalimmuneresponsetothehuman platelet alloantigen HPA-1a (PlA1). Blood Advances 2018; Volum 2 (21). ISSN 2473-9529.s 3001 - 3011.

  • Tiller, Heidi; Husebekk, Anne; Ahlen, Maria Therese; Stuge, Tor Brynjar; Skogen, Bjørn Ragnar. Current perspectives on fetal and neonatal alloimmune thrombocytopenia - Increasing clinical concerns and new treatment opportunities. International Journal of Women's Health 2017; Volum 9. ISSN 1179-1411.s 223 - 234.s doi: 10.2147/IJWH.S90753.

  • Dahl, Jesper; Refsum, Erle; Ahlen, Maria Therese; Egeland, Torstein; Jensen, Tore; Viken, Marte K; Stuge, Tor Brynjar; Acharya, Ganesh; Husebekk, Anne; Skogen, Bjørn Ragnar; Tiller, Heidi. Unraveling the role of maternal anti-HLA class I antibodies in fetal and neonatal thrombocytopenia?Antibody specificity analysis using epitope data. Journal of Reproductive Immunology 2017; Volum 122. ISSN 0165-0378.s 1 - 9.s doi: 10.1016/j.jri.2017.06.003.

  • Ahlen, Maria Therese; Husebekk, Anne; Killie, Ida Løken; Skogen, Bjørn Ragnar; Stuge, Tor Brynjar. T cell responses to human platelet antigen-1a involve a unique form of indirect allorecognition. JCI Insight 2016; Volum Sep 8 (1). ISSN 2379-3708.s e86558 - .s doi: 10.1172/jci.insight.86558.

  • Ahlen, Maria Therese; Husebekk, Anne; Killie, Mette Kjær; Kjeldsen-Kragh, Jens; Olsson, Martin L.; Skogen, Bjørn Ragnar. The Development of Severe Neonatal Alloimmune Thrombocytopenia due to Anti-HPA-1a Antibodies Is Correlated to Maternal ABO Genotypes. (fulltekst) Clinical & Developmental Immunology 2012. ISSN 1740-2522.s doi: 10.1155/2012/156867.

  • Husebekk, Anne; El Ekiaby, M; Gorgy, G; Killie, Mette Kjær; Hansen, Camilla Uhlin; Salma, Wahida; Navarrete, C.; El Afandi, M; Skogen, Bjørn Ragnar; Ahlen, Maria Therese. Foetal/neonatal alloimmune thrombocytopenia in Egypt; human platelet antigen genotype frequencies and antibody detection and follow-up in pregnancies. Transfusion and Apheresis Science 2012; Volum 47 (3). ISSN 1473-0502.s 277 - 282.s doi: 10.1016/j.transci.2012.04.001.

  • Stuge, Tor Brynjar; Skogen, Bjørn Ragnar; Ahlen, Maria Therese; Husebekk, Anne; Urbaniak, SJ; Bessos, H. The Cellular immunobiology associated with fetal and neonatal alloimmune thrombocytopenia. Transfusion and Apheresis Science 2011; Volum 45 (1). ISSN 1473-0502.s 53 - 59.s doi: 10.1016/j.transci.2011.06.003.

  • Skogen, Bjørn Ragnar; Killie, Mette Kjær; Kjeldsen-Kragh, Jens; Ahlen, Maria Therese; Tiller, Heidi; Stuge, Tor Brynjar; Husebekk, Anne. Reconsidering fetal and neonatal alloimmune thrombocytopenia with a focus on screening and prevention. Expert Review of Hematology 2010; Volum 3 (5). ISSN 1747-4086.s 559 - 566.s doi: 10.1586/EHM.10.49.

  • Husebekk, Anne; Ahlen, Maria Therese; Killie, Mette Kjær; Tiller, Heidi; Eksteen, Mariana; Killie, Ida Løken; Heide, Gøril; Kjeldsen-Kragh, Jens; Skogen, Bjørn Ragnar; Stuge, Tor Brynjar. Blood group antigens and immune responses-detailed knowledge is necessary to prevent immunization and to follow up immunized individuals. ISBT Science Series 2010; Volum 5 (1). ISSN 1751-2816.s 24 - 26.

  • Ahlen, Maria Therese; Husebekk, Anne; Killie, Mette Kjær; Skogen, Bjørn Ragnar; Stuge, Tor Brynjar. T-cell responses associated with neonatal alloimmune thrombocytopenia: isolation of HPA-1a-specific, HLA-DRB3*0101-restricted CD4+ T cells. Blood 2009; Volum 113 (16). ISSN 0006-4971.s 3838 - 3844.s doi: 10.1182/blood-2008-09-178475.

  • Tiller, Heidi; Kjær, Mette; Ahlen, Maria Therese; Kjeldsen-Kragh, Jens. Føtal/neonatal alloimmun trombocytopeni (FNAIT) - hvordan redusere risiko for intrakraniell blødning hos foster/ nyfødt - erfaringer fra Norge. Bestpractice Onkologi/Hematologi 2019. ISSN 2245-0440.

  • Killie, Ida Løken; Ahlen, Maria Therese; Husebekk, Anne; Skogen, Bjørn Ragnar; Stuge, Tor Brynjar. Induction and detection of in vivo immune responses to HPA-1a in a novel murine model of fetal/neonatal alloimmune thrombocytopenia (FNAIT). European symposium on platelet and granulocyte immunology 2014-07-03 - 2014-07-06 2014.

  • Heide, Gøril; Stuge, Tor Brynjar; Skogen, Bjørn Ragnar; Husebekk, Anne; Ahlen, Maria Therese. The DR7-DQ2 Haplotype in a Native Norwegian Population. Scandinavian Journal of Immunology 2013; Volum 77 (5). ISSN 0300-9475.s 429 - 430.s doi: 10.1111/sji.12031.

  • Killie, Ida Løken; Husebekk, Anne; Ahlen, Maria Therese; Roalso, M.; Skogen, Bjørn Ragnar; Stuge, Tor Brynjar. ARE CURRENT MURINE MODELS OF FETAL/NEONATAL ALLOIMMUNE THROMBOCYTOPENIA BRINGING US CLOSER TO A BETTER UNDERSTANDING OF PATHOPHYSIOLOGY AND TREATMENT OF THE DISEASE?. Vox Sanguinis 2013; Volum 105. ISSN 0042-9007.s 252 - 252.

  • Husebekk, Anne; Tiller, Heidi; Killie, Mette Kjær; Eksteen, Mariana; Ahlen, Maria Therese; Stuge, Tor Brynjar; Ni, H; Kjeldsen-Kragh, Jens; Skogen, Bjørn Ragnar. TOWARDS A PROPHYLACTIC TREATMENT OF HPA-1A-RELATED FETAL AND NEONATAL ALLOIMMUNE THROMBOCYTOPENIA (FNAIT). Vox Sanguinis 2012; Volum 103. ISSN 0042-9007.s 48 - 48.

  • Husebekk, Anne; Ahlen, Maria Therese; Killie, Mette Kjær; Tiller, Heidi; Eksteen, Mariana; Killie, Ida Løken; Heide, Gøril; Skogen, Bjørn Ragnar; Kjeldsen-Kragh, Jens; Stuge, Tor Brynjar. MATERNAL ALLOIMMUNE RESPONSE DURING PREGNANCY: BRAKE OF MATERNAL TOLERANCE TO FETAL HUMAN PLATELET ANTIGEN 1A ANTIGEN MAY BE ASSOCIATED WITH REDUCED PLACENTAL FUNCTION. Placenta 2011; Volum 32 (9). ISSN 0143-4004.s A121 - A121.

  • Ahlen, Maria Therese; Killie, Mette Kjær; Husebekk, Anne; Kjeldsen-Kragh, Jens; Olsson, ML; Skogen, Bjørn Ragnar. The Development of Severe Anti-HPA 1a-Related Neonatal Alloimmune Thrombocytopenia Is Influenced by the Maternal ABO Type. Blood 2007; Volum 110 (11). ISSN 0006-4971.s 623a - 623a.

  • Ahlen, Maria Therese; Killie, Mette Kjær; Skogen, Bjørn Ragnar; Husebekk, Anne; Stuge, Tor Brynjar. Isolation and Characterization of CD4+ T Cells Specific for the HPA 1a Epitope Associated with Neonatal Alloimmune Thrombocytopenia. Blood 2007; Volum 110 (11). ISSN 0006-4971.s 623a - 624a.

  • Tiller, Heidi; Kjær, Mette; Ahlen, Maria Therese; Kjeldsen-Kragh, Jens. Føtal/neonatal alloimmun trombocytopeni (FNAIT) - hvordan redusere risiko for intrakraniell blødning hos foster/ nyfødt - erfaringer fra Norge. Bestpractice Onkologi/Hematologi 2019. ISSN 2245-0440.

  • Killie, Ida Løken; Ahlen, Maria Therese; Husebekk, Anne; Skogen, Bjørn Ragnar; Stuge, Tor Brynjar. Induction and detection of in vivo immune responses to HPA-1a in a novel murine model of fetal/neonatal alloimmune thrombocytopenia (FNAIT). European symposium on platelet and granulocyte immunology 2014-07-03 - 2014-07-06 2014.

  • Heide, Gøril; Stuge, Tor Brynjar; Skogen, Bjørn Ragnar; Husebekk, Anne; Ahlen, Maria Therese. The DR7-DQ2 Haplotype in a Native Norwegian Population. Scandinavian Journal of Immunology 2013; Volum 77 (5). ISSN 0300-9475.s 429 - 430.s doi: 10.1111/sji.12031.

  • Killie, Ida Løken; Husebekk, Anne; Ahlen, Maria Therese; Roalso, M.; Skogen, Bjørn Ragnar; Stuge, Tor Brynjar. ARE CURRENT MURINE MODELS OF FETAL/NEONATAL ALLOIMMUNE THROMBOCYTOPENIA BRINGING US CLOSER TO A BETTER UNDERSTANDING OF PATHOPHYSIOLOGY AND TREATMENT OF THE DISEASE?. Vox Sanguinis 2013; Volum 105. ISSN 0042-9007.s 252 - 252.

  • Husebekk, Anne; Tiller, Heidi; Killie, Mette Kjær; Eksteen, Mariana; Ahlen, Maria Therese; Stuge, Tor Brynjar; Ni, H; Kjeldsen-Kragh, Jens; Skogen, Bjørn Ragnar. TOWARDS A PROPHYLACTIC TREATMENT OF HPA-1A-RELATED FETAL AND NEONATAL ALLOIMMUNE THROMBOCYTOPENIA (FNAIT). Vox Sanguinis 2012; Volum 103. ISSN 0042-9007.s 48 - 48.

  • Husebekk, Anne; Ahlen, Maria Therese; Killie, Mette Kjær; Tiller, Heidi; Eksteen, Mariana; Killie, Ida Løken; Heide, Gøril; Skogen, Bjørn Ragnar; Kjeldsen-Kragh, Jens; Stuge, Tor Brynjar. MATERNAL ALLOIMMUNE RESPONSE DURING PREGNANCY: BRAKE OF MATERNAL TOLERANCE TO FETAL HUMAN PLATELET ANTIGEN 1A ANTIGEN MAY BE ASSOCIATED WITH REDUCED PLACENTAL FUNCTION. Placenta 2011; Volum 32 (9). ISSN 0143-4004.s A121 - A121.

  • Ahlen, Maria Therese; Killie, Mette Kjær; Husebekk, Anne; Kjeldsen-Kragh, Jens; Olsson, ML; Skogen, Bjørn Ragnar. The Development of Severe Anti-HPA 1a-Related Neonatal Alloimmune Thrombocytopenia Is Influenced by the Maternal ABO Type. Blood 2007; Volum 110 (11). ISSN 0006-4971.s 623a - 623a.

  • Ahlen, Maria Therese; Killie, Mette Kjær; Skogen, Bjørn Ragnar; Husebekk, Anne; Stuge, Tor Brynjar. Isolation and Characterization of CD4+ T Cells Specific for the HPA 1a Epitope Associated with Neonatal Alloimmune Thrombocytopenia. Blood 2007; Volum 110 (11). ISSN 0006-4971.s 623a - 624a.

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