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Department of Pharmacy orjan.samuelsen@uit.no Tromsø

Samuelsen, Ørjan



  • Aleksandra Jakovljev, Jan Egil Afset, Kjersti Haugum, Harald Otto Steinum, Torunn Gresdal Rønning, Ørjan Samuelsen et al.:
    Phenotypic and genotypic characterisation of thymine auxotrophy in Escherichia coli isolated from a patient with recurrent bloodstream infection
    PLOS ONE 2022 ARKIV / DOI
  • Kenneth Lindstedt, Dorota Julia Buczek, Torunn Annie Pedersen, Erik Hjerde, Niclas Peter Raffelsberger, Yutaka Suzuki et al.:
    Detection of Klebsiella pneumoniae human gut carriage: a comparison of culture, qPCR, and whole metagenomic sequencing methods
    Gut microbes 31. August 2022 ARKIV / DOI
  • Christopher Frøhlich, Vidar Sørum, Nobuhiko Tokuriki, Pål Jarle Johnsen, Ørjan Samuelsen :
    Evolution of β-lactamase-mediated cefiderocol resistance
    Journal of Antimicrobial Chemotherapy 2022 ARKIV / DOI
  • Vidar Sørum, Emma Lu Øynes, Anna Sollied Møller, Klaus Harms, Ørjan Samuelsen, Nicole L. Podnecky et al.:
    Evolutionary Instability of Collateral Susceptibility Networks in Ciprofloxacin-Resistant Clinical Escherichia coli Strains
    mBio 2022 ARKIV / DOI
  • Tommi Mäklin, Teemu Kallonen, Jarno Alanko, Ørjan Samuelsen, Kristin Hegstad, Veli Mäkinen et al.:
    Bacterial genomic epidemiology with mixed samples
    Microbial Genomics 2021 ARKIV / DOI
  • Jonina Gudmundsdottir, Elizabeth G. Aarag Fredheim, Catharina I.M. Koumans, Joachim Hegstad, Po-Cheng Tang, Dan I. Andersson et al.:
    The chemotherapeutic drug methotrexate selects for antibiotic resistance
    EBioMedicine 2021 ARKIV / DOI
  • Jessin Janice, Nicholas Agyepong, Alex Owusu-Ofori, Usha Govinden, Sabiha Essack, Ørjan Samuelsen et al.:
    Carbapenem resistance determinants acquired through novel chromosomal integrations in extensively drug-resistant pseudomonas aeruginosa
    Antimicrobial Agents and Chemotherapy 2021 ARKIV / DOI
  • Rebecca Ashley Gladstone, Alan McNally, Anna Kaarina Pöntinen, Gerry Tonkin-Hill, John A. Lees, Kusti Onni Skytén et al.:
    Emergence and dissemination of antimicrobial resistance in Escherichia coli causing bloodstream infections in Norway in 2002–17: a nationwide, longitudinal, microbial population genomic study
    Lancet Microbe 29. June 2021 FULLTEKST / ARKIV / DOI
  • Niclas Peter Raffelsberger, Marit Andrea Klokkhammer Hetland, Kristian Svendsen, Lars Småbrekke, Iren Høyland Löhr, Lotte Andreassen et al.:
    Gastrointestinal carriage of Klebsiella pneumoniae in a general adult population: a cross-sectional study of risk factors and bacterial genomic diversity
    Gut microbes 2021 ARKIV / DOI
  • Julia Kloos, João A Gama, Joachim Hegstad, Ørjan Samuelsen, Pål J Johnsen :
    Piggybacking on Niche Adaptation Improves the Maintenance of Multidrug-Resistance Plasmids
    Molecular Biology and Evolution (MBE) 2021 ARKIV / DOI
  • Sergio Arredondo Alonso, Anna Kaarina Pöntinen, Francois Pierre Alexandre Cleon, Rebecca Ashley Gladstone, Anita C. Schürch, Pål Jarle Johnsen et al.:
    A high-throughput multiplexing and selection strategy to complete bacterial genomes
    GigaScience 2021 ARKIV / DOI
  • Supathep Tansirichaiya, Richard N. Goodman, Xinyu Guo, Issra Bulgasim, Ørjan Samuelsen, Mohammed Al-Haroni et al.:
    Intracellular Transposition and Capture of Mobile Genetic Elements following Intercellular Conjugation of Multidrug Resistance Conjugative Plasmids from Clinical Enterobacteriaceae Isolates
    Microbiology spectrum 2021 ARKIV / DOI
  • Aasmund Fostervold, Marit Andrea Klokkhammer Hetland, Ragna-Johanne Bakksjø, Eva Bernhoff, Kathryn E. Holt, Ørjan Samuelsen et al.:
    A nationwide genomic study of clinical Klebsiella pneumoniae in Norway 2001–15: introduction and spread of ESBLs facilitated by clonal groups CG15 and CG307
    Journal of Antimicrobial Chemotherapy 2021 ARKIV / DOI
  • Christopher Frøhlich, João Alves Gama, Klaus Harms, Viivi H. A. Hirvonen, Bjarte Aarmo Lund, Marc W. van der Kamp et al.:
    Cryptic β-Lactamase Evolution Is Driven by Low β-Lactam Concentrations
    mSphere 2021 ARKIV / DOI
  • Catherine Ludden, Felix Lötsch, Erik Alm, Narender Kumar, Karin Johansson, Barbara Albiger et al.:
    Cross-border spread of blaNDM-1- and blaOXA-48-positive Klebsiella pneumoniae: a European collaborative analysis of whole genome sequencing and epidemiological data, 2014 to 2019
    Eurosurveillance 2020 ARKIV / DOI
  • Joao Pedro Alves Gama, Julia Maria Kloos, Pål Jarle Johnsen, Ørjan Samuelsen :
    Host dependent maintenance of a blaNDM-1-encoding plasmid in clinical Escherichia coli isolates
    Scientific Reports 2020 ARKIV / DOI
  • Julia Maria Kloos, Joao Pedro Alves Gama, Pål Jarle Johnsen, Ørjan Samuelsen :
    Host dependent maintenance of a blaNDM-1-encoding plasmid in clinical Escherichia coli isolates
    Scientific Reports 2020 DOI
  • Torunn Annie Pedersen, Marit Gjerde Tellevik, Øyvind Kommedal, Paul Christoffer Lindemann, Sabrina John Moyo, Jessin Janice James Peter et al.:
    Horizontal plasmid transfer among klebsiella pneumoniae isolates is the key factor for dissemination of extended-spectrum β-lactamases among children in Tanzania
    mSphere 15. July 2020 ARKIV / DOI
  • Hanna-Kirsti S. Leiros, Ane Molden Thomassen, Ørjan Samuelsen, Carl-Fredrik Flach, Stathis D. Kotsakis, Joakim Larsson :
    Structural insights into the enhanced carbapenemase efficiency of OXA-655 compared to OXA-10
    FEBS Open Bio 2020 ARKIV / FULLTEKST / DOI
  • Christopher Frøhlich, Vidar Sørum, Sandra Huber, Ørjan Samuelsen, Fanny Berglund, Erik Kristiansson et al.:
    Structural and biochemical characterization of the environmental MBLs MYO-1, ECV-1 and SHD-1
    Journal of Antimicrobial Chemotherapy 2020 ARKIV / DOI
  • Ørjan Samuelsen, Ove Alexander Høgmoen Åstrand, Christopher Frøhlich, Adam Heikal, Susann Skagseth, Trine Josefine Olsen Carlsen et al.:
    ZN148 Is a Modular Synthetic Metallo-beta-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens In Vivo
    Antimicrobial Agents and Chemotherapy 2020 ARKIV / DATA / DOI
  • Christopher Frøhlich, Vidar Sørum, Ane Molden Thomassen, Pål Jarle Johnsen, Hanna-Kirsti S. Leiros, Ørjan Samuelsen :
    OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs
    mSphere 2019 ARKIV / DOI
  • Petter Elstrøm, Elisabeth Astrup, Kristin Hegstad, Ørjan Samuelsen, Hege Enger, Oliver Kacelnik :
    The fight to keep resistance at bay, epidemiology of carbapenemase producing organisms (CPOs), vancomycin resistant enterococci (VRE) and methicillin resistant Staphylococcus aureus (MRSA) in Norway, 2006-2017
    PLOS ONE 2019 ARKIV / DOI
  • Anthony Prandina, Sylvie Radix, Marc Le Borgne, Lars Petter Jordheim, Zineb Bousfiha, Christopher Fröhlich et al.:
    Synthesis and biological evaluation of new dipicolylamine zinc chelators as metallo-β-lactamase inhibitors
    Tetrahedron 2019 ARKIV / DOI
  • Geir Kildahl-Andersen, Christian Schnaars, Anthony Prandina, Sylvie Radix, Marc Le Borgne, Lars Petter Jordheim et al.:
    Synthesis and biological evaluation of zinc chelating compounds as metallo-β-lactamase inhibitors
    MedChemComm 2019 DOI
  • Ilya Nikolaevich Zykov, Niels Frimodt-Møller, Lars Småbrekke, Arnfinn Sundsfjord, Ørjan Samuelsen :
    Efficacy of mecillinam against clinical multidrug-resistant Escherichia coli in a murine urinary tract infection model
    International Journal of Antimicrobial Agents 02. November 2019 ARKIV / DOI
  • Nicole L. Podnecky, Elizabeth Aarag, Julia Maria Kloos, Vidar Sørum, Raul Primicerio, Adam Paul Roberts et al.:
    Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli.
    Nature Communications 10. September 2018 ARKIV / DOI
  • Louise Roer, Søren Overballe-Petersen, Frank Hansen, Kristian Schønning, Mikala Wang, Bent L Røder et al.:
    Escherichia coli Sequence Type 410 Is Causing New International High-Risk Clones
    mSphere 2018 ARKIV / DOI
  • George Taiaroa, Ørjan Samuelsen, Tom Kristensen, Ole Andreas Økstad, Adam Heikal :
    Complete Genome Sequence of Pseudomonas aeruginosa K34-7, a Carbapenem-Resistant Isolate of the High-Risk Sequence Type 233
    Microbiology Resource Announcements (MRA) 2018 ARKIV / DOI
  • Ellionor Rapp, Ørjan Samuelsen, Martin Sundqvist :
    Detection of carbapenemases with a newly developed commercial assay using Matrix Assisted Laser Desorption Ionization-Time of Flight
    Journal of Microbiological Methods 2018 ARKIV / DOI
  • Torunn Annie Pedersen, John Osei Sekyere, Usha Govinden, Krishnee Moodley, Audun Sivertsen, Ørjan Samuelsen et al.:
    Spread of plasmid-encoded NDM-1 and GES-5 carbapenemases among extensively drug-resistant and pandrug-resistant clinical enterobacteriaceae in durban, South Africa
    Antimicrobial Agents and Chemotherapy 2018 DOI
  • Christian Schnaars, Geir kildahl-Andersen, Anthony Prandina, Roya Popal, Sylvie Radix, Marc Le Borgne et al.:
    Synthesis and preclinical evaluation of TPA-based zinc chelators as metallo-β-lactamase inhibitors
    ACS Infectious Diseases 2018 DOI
  • Ørjan Samuelsen, Frank Hansen, Bettina Aasnæs, Henrik Hasman, Bjarte Aarmo Lund, Hanna-Kirsti S. Leiros et al.:
    Dissemination and Characteristics of a Novel Plasmid-Encoded Carbapenem-Hydrolyzing Class D β-Lactamase, OXA-436, Found in Isolates from Four Patients at Six Different Hospitals in Denmark
    Antimicrobial Agents and Chemotherapy 2018 DOI
  • Bjørg Haldorsen, Christian G Giske, Dennis S Hansen, Kristjan Orri Helgason, Gunnar Kahlmeter, Iren Høyland Löhr et al.:
    Performance of the EUCAST disc diffusion method and two MIC methods in detection of Enterobacteriaceae with reduced susceptibility to meropenem: the NordicAST CPE study.
    Journal of Antimicrobial Chemotherapy 2018 ARKIV / DOI
  • Ilya Nikolaevich Zykov, Ørjan Samuelsen, Lotte Jakobsen, Lars Småbrekke, Dan I. Andersson, Arnfinn Sundsfjord et al.:
    Pharmacokinetics and pharmacodynamics of fosfomycin and its activity against extended-spectrum-lactamase-, plasmid-mediated AmpC-, and carbapenemase-producing escherichia coli in a murine urinary tract infection model
    Antimicrobial Agents and Chemotherapy 2018 ARKIV / DOI
  • Julia Maria Kloos, Lea Jänisch, Anna Kaarina Pöntinen, Ørjan Samuelsen, Pål Jarle Johnsen, Jukka Corander et al.:
    Different metabolic proficiency among dominant ExPEC lineages
    2022
  • Christopher Frøhlich, Vidar Sørum, Nobuhiko Tokuriki, Ørjan Samuelsen :
    Evolution of ß-lactamase mediated cefiderocol resistance
    2022
  • Bjørg Haldorsen, Jessin Janice, Ørjan Samuelsen :
    Evaluation of the Amplex eazyplex® SuperBug Acineto test for detection of acquired OXA and NDM carbapenemases in Acinetobacter spp.
    Journal of Global Antimicrobial Resistance 2021 DOI
  • João Alves Gama, Julia Maria Kloos, Joachim Hegstad, Ørjan Samuelsen, Pål Jarle Johnsen :
    Plasmid cost alleviation as a consequence of niche-adaptation
    2021
  • Julia Maria Kloos, João Alves Gama, Joachim Hegstad, Ørjan Samuelsen, Pål Jarle Johnsen :
    Plasmid Cost Alleviation By Hitchhiking On Niche-adaptation
    2021
  • Julia Maria Kloos, Joao Pedro Alves Gama, Joachim Hegstad, Ørjan Samuelsen, Pål Jarle Johnsen :
    E. coli Niche Adaptation Improves Plasmid Maintenance
    2021
  • Vidar Sørum, Anna Sollied Møller, Pål Jarle Johnsen, Ørjan Samuelsen, Sören Abel, Nicole L. Podnecky :
    Evolutionary stability of collateral effects in ciprofloxacin resistant clinical Escherichia coli strains
    2019
  • Vidar Sørum, Anna Sollied Møller, Sören Abel, Ørjan Samuelsen, Nicole L. Podnecky, Pål Jarle Johnsen :
    Evolutionary stability of collateral effects in ciprofloxacin resistant clinical Escherichia coli strains
    2019
  • Vidar Sørum, Emma Lu Øynes, Anna Møller, Nicole L. Podnecky, Sören Abel, Ørjan Samuelsen et al.:
    Evolutionary stability of collateral susceptibility networks in clinical Escherichia coli strains
    2019
  • Christopher Frøhlich, Hanna-Kirsti S. Leiros, Pål Jarle Johnsen, Ørjan Samuelsen :
    Sub-inhibitory concentrations of ceftazidime drive evolution of the OXA-48 carbapenemase
    2019
  • Christopher Frøhlich, Pål Jarle Johnsen, Hanna-Kirsti Schrøder Leiros, Ørjan Samuelsen :
    Evolution of OXA-48 under sub-MIC conditions
    2019
  • Christopher Frøhlich, Vidar Sørum, Hanna-Kirsti S. Leiros, Pål Jarle Johnsen, Ørjan Samuelsen :
    Development of OXA-48 mediated ceftazidme-avibactam resistance is associated with an evolutionary trade-off
    2018
  • Aleksandra Jakovljev, Jan Egil Afset, Kjersti Haugum, Torunn Gresdal Rønning, Harald Otto Steinum, Ørjan Samuelsen et al.:
    "Escherichia coli sepsis: casus presentasjon med uvanlig resistensmønster"
    2018
  • Julia Maria Kloos, Joao Pedro Alves Gama, Ørjan Samuelsen, Pål Jarle Johnsen :
    Klebsiella pneumoniae MDR-encoding plasmids in clinical isolates of uropathogenic Escherichia coli: plasmid-host co-evolution and its effect on fitness cost of plasmid-mediated resistance
    2018
  • Julia Maria Kloos, Joao Pedro Alves Gama, Ørjan Samuelsen, Pål Jarle Johnsen :
    Plasmid-host co-evolution of Klebsiella pneumoniae MDR-encoding plasmids in clinical isolates of uropathogenic Escherichia coli: effect on fitness cost of plasmid-mediated resistance
    2018

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    Research interests

    Through my positions as Professor II at the Microbial Pharmacology and Population Biology Research Group and as senior scientist at the Norwegian National Advisory Unit on Detection of Antimicrobial Resistance my research focuses broadly on the following topics molecular epidemiology, evaluation of diagnostic methods, biochemical and structural characterization of β-lactamases, development of β-lactamase inhibitors and the evolutionary aspects and transmission dynamics of resistance plasmids.