

Klara Stensvåg
Professor/Marine Biotechnology
Job description
Klara Stensvåg (dr. scient) is professor in Marin Biotechnology at The Norwegian College of Fishery Science at the Faculty of Biosciences, Fisheries and Economics. She is the head of the research group in Marine Bioprospecting. Her research concerns antimicrobial compounds and genes of marine origin as source of developing novel antibacterial compounds with new mechanisms of actions against antimicrobial resistant bacteria. Stensvåg is also the leader of an interfaculty collaborations aiming to develop biofilm inhibiting compounds that in the future can be used in within medicine or industrial context.
She is also programe coordinator for the programs in Biotechnology (Bachelor) and Marine Biotechnology (master).
- Hira, Jonathan; Stensvåg, Klara. Evidence for association of Vibrio echinoideorum with tissue necrosis on test of the green sea urchin Strongylocentrotus droebachiensis. Scientific Reports 2022; Volum 12 (1). ISSN 2045-2322.s doi: 10.1038/s41598-022-08772-2.
- Hansen, Ida Kristine Østnes; Isaksson, Johan; Poth, Aaron G.; Østnes Hansen, Kine; Andersen, Aaron John Christian; Richard, Céline Sarah Marine; Blencke, Hans-Matti; Stensvåg, Klara; Craik, David J.; Haug, Tor. Isolation and characterization of antimicrobial peptides with unusual disulfide connectivity from the colonial ascidian Synoicum turgens. Marine Drugs 2020; Volum 18 (1). ISSN 1660-3397.s doi: 10.3390/md18010051.
- Hira, Jonathan; Wolfson, Deanna; Andersen, Aaron John Christian; Haug, Tor; Stensvåg, Klara. Autofluorescence mediated red spherulocyte sorting provides insights into the source of spinochromes in sea urchins. Scientific Reports 2020; Volum 10 (1). ISSN 2045-2322.s 1 - 9.s doi: 10.1038/s41598-019-57387-7.
- Hira, Jonathan; Bentdal, Solveig; Devold, Hege; Stensvåg, Klara; Landfald, Bjarne. Vibrio echinoideorum sp. nov., isolated from an epidermal lesion on the test of a green sea urchin (Strongylocentrotus droebachiensis). International Journal of Systematic and Evolutionary Microbiology 2019; Volum 69 (8). ISSN 1466-5026.s 2277 - 2282.s doi: 10.1099/ijsem.0.003462.
- Solstad, Runar Gjerp; Johansen, Cecilie; Stensvåg, Klara; Strøm, Morten B.; Haug, Tor. Structure‐activity relationship studies of shortened analogues of the antimicrobial peptide EeCentrocin 1 from the sea urchin Echinus esculentus. Journal of Peptide Science 2019; Volum 26 (2). ISSN 1075-2617.s doi: 10.1002/psc.3233.
- Igumnova, Elizaveta; Mishchenko, Ekaterina; Haug, Tor; Blencke, Hans-Matti; Sollid, Johanna U Ericson; Aarag, Elizabeth; Lauksund, Silje; Stensvåg, Klara; Strøm, Morten B.. Amphipathic sulfonamidobenzamides mimicking small antimicrobial marine natural products; investigation of antibacterial and anti-biofilm activity against antibiotic resistant clinical isolates.. Bioorganic & Medicinal Chemistry 2018; Volum 26 (17). ISSN 0968-0896.s 4930 - 4941.s doi: 10.1016/j.bmc.2018.08.032.
- Moe, Morten Kaare; Haug, Tor; Sydnes, Magne Olav; Sperstad, Sigmund; Li, Chun; Vaagsfjord, Lena Christine; de la Vega, Enrique; Stensvåg, Klara. Paralithocins, Antimicrobial Peptides with Unusual Disulfide Connectivity from the Red King Crab, Paralithodes camtschaticus. Journal of natural products 2018; Volum 81 (1). ISSN 0163-3864.s 140 - 150.s doi: 10.1021/acs.jnatprod.7b00780.
- Smith, L. Courtney; Arizza, Vincenzo; Barela Hudgel, Megan A.; Barone, Gianpaolo; Bodnar, Andrea G.; Buckley, Katherine M.; Cunsolo, Vincenzo; Dheilly, Nolwenn M.; Franchi, Nicola; Fugmann, Sebastian D.; Furukawa, Ryohei; Garcia- Arraras, Jose; Henson, John H.; Hibino, Taku; Irons, Zoe H.; Li, Chun; Man Lun, Cheng; Majeske, Audrey J.; Oren, Matan; Pagliara, Patrizia; Pinsino, Annalisa; Raftos, David A.; Rast, Jonathan P.; Samasa, Bakary; Schillaci, Domenico; Schrankel, Catherine S. ; Stabili, Loredana; Stensvåg, Klara; Sutton, Elisse. Echinodermata: The Complex Immune System in Echinoderms. Springer 2018 ISBN 978-3-319-76767-3.s 409 - 501.s doi: 10.1007/978-3-319-76768-0_13.
- Logashina, Yulia A.; Mosharova, Irina V.; Korolkova, Yulia V.; Shelukhina, Irina V; Dyachenko, Igor A.; Palikov, Victor A.; Palikova, Yulia A.; Murashev, Arkadii N.; Kozlov, Sergey A.; Stensvåg, Klara; Andreev, Yaroslav A.. Peptide from sea anemone metridium senile affects transient receptor potential ankyrin-repeat 1 (TRPA1) function and produces analgesic effect. Journal of Biological Chemistry 2017; Volum 292 (7). ISSN 0021-9258.s 2992 - 3004.s doi: 10.1074/jbc.M116.757369.
- Logashina, Yulia A.; Solstad, Runar Gjerp; Mineev, Konstantin S.; Korolkova, Yuliya V.; Mosharova, Irina V.; Dyachenko, Igor A.; Palikov, Victor A.; Palikova, Yulia A.; Murashev, Arkadii N.; Arseniev, Alexander S.; Kozlov, Sergey A.; Stensvåg, Klara; Haug, Tor; Andreev, Yaroslav A.. New Disulfide-Stabilized Fold Provides Sea Anemone Peptide to Exhibit Both Antimicrobial and TRPA1 Potentiating Properties. Toxins 2017; Volum 9 (5). ISSN 2072-6651.s 1 - 23.s doi: 10.3390/toxins9050154.
- Igumnova, Elizaveta Mikhailovna; Mishchenko, Ekaterina; Haug, Tor; Blencke, Hans-Matti; Sollid, Johanna U Ericson; Fredheim, Elizabeth G Aarag; Lauksund, Silje; Stensvåg, Klara; Strøm, Morten Bøhmer. Synthesis and antimicrobial activity of small cationic amphipathic aminobenzamide marine natural product mimics and evaluation of relevance against clinical isolates including ESBL–CARBA producing multi-resistant bacteria.. Bioorganic & Medicinal Chemistry 2016. ISSN 0968-0896.s doi: 10.1016/j.bmc.2016.09.046.
- Paulsen, Victoria; Mardirossian, Mario; Blencke, Hans-Matti; Benincasa, Monica; Runti, Giulia; Nepa, Matteo; Haug, Tor; Stensvåg, Klara; Scocchi, Marco. Inner membrane proteins YgdD and SbmA are required for the complete susceptibility of Escherichia coli to the proline rich antimicrobial peptide arasin 1(1–25). Microbiology (Reading) 2016; Volum 162. ISSN 1350-0872.s 601 - 609.s doi: 10.1099/mic.0.000249.
- Solstad, Runar Gjerp; Li, Chun; Isaksson, Johan; Johansen, Jostein a; Svenson, Johan; Stensvåg, Klara; Haug, Tor. Novel antimicrobial peptides EeCentrocins 1, 2 and EeStrongylocin 2 from the Edible sea urchin Echinus esculentus have 6-br-trp post-translational modifications. PLOS ONE 2016; Volum 11 (3). ISSN 1932-6203.s doi: 10.1371/journal.pone.0151820.
- Igumnova, Elizaveta Mikhailovna; Mishchenko, Ekaterina; Haug, Tor; Blencke, Hans-Matti; Sollid, Johanna U Ericson; Aarag, Elizabeth; Lauksund, Reidunn Silje; Stensvåg, Klara; Strøm, Morten B.. Synthesis and antimicrobial activity of small cationic amphipathic aminobenzamide marine natural product mimics and evaluation of relevance against clinical isolates including ESBL–CARBA producing multi-resistant bacteria. Bioorganic & Medicinal Chemistry 2016; Volum 24 (22). ISSN 0968-0896.s 5884 - 5894.s doi: 10.1016/j.bmc.2016.09.046.
- Li, Chun; Blencke, Hans-Matti; Haug, Tor; Stensvåg, Klara. Antimicrobial peptides in echinoderm host defense. Developmental and Comparative Immunology 2015; Volum 49 (1). ISSN 0145-305X.s 190 - 197.s doi: 10.1016/j.dci.2014.11.002.
- Li, Chun; Blencke, Hans-Matti; Haug, Tor; Jørgensen, Øyvind; Stensvåg, Klara. Expression of antimicrobial peptides in coelomocytes and embryos of the green sea urchin (Strongylocentrotus droebachiensis). Developmental and Comparative Immunology 2014; Volum 43 (1). ISSN 0145-305X.s 106 - 113.s doi: 10.1016/j.dci.2013.10.013.
- Li, Chun; Blencke, Hans-Matti; Haug, Tor; Jørgensen, Øyvind; Stensvåg, Klara. Expression of antimicrobial peptides in coelomocytes and embryos of the green sea urchin (Strongylocentrotus droebachiensis). Developmental and Comparative Immunology 2014; Volum 43 (1). ISSN 0145-305X.s 106 - 113.s doi: 10.1016/j.dci.2013.10.013.
- Tadesse, Margey; Svenson, Johan; Sepcic, Kristina; Trembleau, Laurent; Engqvist, Stig Olov Magnus; Andersen, Jeanette hammer; Jaspars, Marcel; Stensvåg, Klara; Haug, Tor. Isolation and Synthesis of Pulmonarins A and B, Acetylcholinesterase Inhibitors from the Colonial Ascidian Synoicum pulmonaria. Journal of natural products 2014; Volum 77 (2). ISSN 0163-3864.s 364 - 369.s doi: 10.1021/np401002s.
- Trepos, Rozenn; Cervin, Gunnar; Hellio, Claire; Pavia Henrik, Henrik; Stensen, Wenche; Stensvåg, Klara; Svendsen, John Sigurd; Haug, Tor; Svenson, Johan. Antifouling compounds from the sub-arctic ascidian synoicum pulmonaria: Synoxazolidinones A and C, pulmonarins A and B, and synthetic analogues. Journal of natural products 2014; Volum 77 (9). ISSN 0163-3864.s 2105 - 2113.s doi: 10.1021/np5005032.
- Paulsen, Victoria; Blencke, Hans-Matti; Benincasa, Monica; Haug, Tor; Eksteen, Jacobus Johannes; Styrvold, Olaf B.; Scocchi, Marco; Stensvåg, Klara. Structure-activity relationships of the antimicrobial peptide arasin 1 - and mode of action studies of the N terminal, proline-rich region. (fulltekst) PLOS ONE 2013; Volum 8 (1:e53326). ISSN 1932-6203.s doi: 10.1371/journal.pone.0053326.
- Bjørn, Camilla; Håkansson, Joakim; Myhrman, Emma; Sjøstrand, Veronika; Haug, Tor; Lindgren, Kerstin; Blencke, Hans-Matti; Stensvåg, Klara; Mahlapuu, Margit. Anti-infectious and anti-inflammatory effects of peptide fragments sequentially derived from the antimicrobial peptide centrocin 1 isolated from the green sea urchin, Strongylocentrotus droebachiensis. (data) AMB Express 2012; Volum 2 (1). ISSN 2191-0855.s 67 - .s doi: 10.1186/2191-0855-2-67.
- Tadesse, Margey; Svenson, Johan; Jaspars, Marcel; Strøm, Morten B.; Abdelrahman, Mostafa H.; Andersen, Jeanette hammer; Hansen, Espen; Kristiansen, Per Eugen; Stensvåg, Klara; Haug, Tor. Synoxazolidinone C; a bicyclic member of the synoxazolidinone family with antibacterial and anticancer activities. Tetrahedron Letters 2011; Volum 52. ISSN 0040-4039.s 1804 - 1806.s doi: 10.1016/j.tetlet.2011.02.027.
- Sperstad, sigmund; Haug, Tor; Blencke, Hans-Matti; Styrvold, Olaf B.; Li, Chun; Stensvåg, Klara. Antimicrobial peptides from marine invertebrates: Challenges and perspectives in marine antimicrobial peptide discovery. Biotechnology Advances 2011; Volum 29 (5). ISSN 0734-9750.s 519 - 530.s doi: 10.1016/j.biotechadv.2011.05.021.
- Li, Chun; Blencke, Hans-Matti; Smith, L. Courtney; Karp, Matti T.; Stensvåg, Klara. Two recombinant peptides, SpStrongylocins 1 and 2, from Strongylocentrotus purpuratus, show antimicrobial activity against Gram-positive and Gram-negative bacteria. (fulltekst) Developmental and Comparative Immunology 2010; Volum 34 (3). ISSN 0145-305X.s 286 - 292.s doi: 10.1016/j.dci.2009.10.006.
- Sperstad, sigmund; Smith, Valerie J.; Stensvåg, Klara. Expression of antimicrobial peptides from Hyas araneus haemocytes following bacterial challenge in vitro. (data) Developmental and Comparative Immunology 2010; Volum 34 (6). ISSN 0145-305X.s 618 - 624.s doi: 10.1016/j.dci.2010.01.005.
- Li, Chun; Haug, Tor; Moe, Morten Kaare; Styrvold, Olaf B.; Stensvåg, Klara. Centrocins: Isolation and characterization of novel dimeric antimicrobial peptides from the green sea urchin, Strongylocentrotus droebachiensis. Developmental and Comparative Immunology 2010; Volum 34 (9). ISSN 0145-305X.s 959 - 968.s doi: 10.1016/j.dci.2010.04.004.
- Li, Chun; Haug, Tor; Stensvåg, Klara. Antimicrobial Peptides in Echinoderms. (fulltekst) Invertebrate Survival Journal 2010; Volum 7. ISSN 1824-307X.s 132 - 140.
- Tadesse, Margey; Tørfoss, Veronika; Strøm, Morten B.; Hansen, Espen; Andersen, Jeanette hammer; Stensvåg, Klara; Haug, Tor. Isolation and biological activity of (E)-1-(4-hydroxystyryl)guanidine from the sub-Arctic ascidian, Dendrodoa aggregata. Biochemical Systematics and Ecology 2010; Volum 38 (4). ISSN 0305-1978.s 827 - 829.s doi: 10.1016/j.bse.2010.04.002.
- Tadesse, Margey; Strøm, Morten B.; Svenson, Johan; Jaspars, Marcel; Milne, Bruce F.; Tørfoss, Veronika; Andersen, Jeanette hammer; Hansen, Espen; Stensvåg, Klara; Haug, Tor. Synoxazolidinones A and B; novel bioactive alkaloids from the ascidian Synoicum pulmonaria. Organic Letters 2010; Volum 12 (21). ISSN 1523-7060.s 4752 - 4755.s doi: 10.1021/ol101707u.
- Courtney Smith, Louise; Ghosh, Julie; Buckley, Katherine M; Clow, Lori A; Dheilly, Nolwenn M; Haug, Tor; Henson, John H; Li, Chun; Man Lun, Cheng; Majeske, Audrey J; Matranga, Valeria; Nair, Sham V; Rast, Jonathan P; Raftos, David A; Roth, Mattias; Sacchi, Sandro; Schrankel, Catherine S; Stensvåg, Klara. Echinoderm immunity. Springer Science+Business Media B.V. 2010 ISBN 978-1-4419-8058-8.s 260 - 301.
- Smith, L. Courtney; Ghosh, Julie; Buckley, Katherine M; Clow, Lori A; Dheilly, Nolwenn M; Haug, Tor; Henson, John H; Li, Chun; Lun, Cheng Man; Majeske, Audrey J; Matranga, Valeria; Nair, Sham V; Rast, Jonathan P; Raftos, David A; Roth, Mattias; Sacchi, Sandro; Schrankel, Catherine S; Stensvåg, Klara. Echinoderm Immunity. Advances in Experimental Medicine and Biology 2010; Volum 708. ISSN 0065-2598.s 260 - 301.s doi: 10.1007/978-1-4419-8059-5_14..
- Sperstad, Sigmund; Haug, Tor; Paulsen, Victoria; Rode, Tone Mari; Strandskog, Guro; Solem, Stein Tore; Styrvold, Olaf B.; Stensvåg, Klara. Characterization of crustins from the hemocytes of the spider crab, Hyas araneus, and the red king crab, Paralithodes camtschaticus. Developmental and Comparative Immunology 2009; Volum 33 (4). ISSN 0145-305X.s 583 - 591.s doi: 10.1016/j.dci.2008.10.010.
- Sperstad, sigmund; Haug, Tor; Vasskog, Terje; Stensvåg, Klara. Hyastatin, a glycine-rich multi-domain antimicrobial peptide isolated from the spider crab (Hyas araneus) hemocytes. Molecular Immunology 2009; Volum 46 (13). ISSN 0161-5890.s 2604 - 2612.s doi: 10.1016/j.molimm.2009.05.002.
- Stensvåg, Klara; Haug, Tor; Sperstad, sigmund; Rekdal, Øystein; Indrevoll, Bård; Styrvold, Olaf B.. Arasin 1, a proline-arginine-rich antimicrobial peptide isolated from the spider crab, Hyas araneus. Developmental and Comparative Immunology 2008; Volum 32. ISSN 0145-305X.s 275 - 285.s doi: 10.1016/j.dci.2007.06.002.
- Li, Chun; Haug, Tor; Styrvold, Olaf B.; Jørgensen, Trond Ø.; Stensvåg, Klara. Strongylocins, novel antimicrobial peptides from the green sea urchin, Stronglyocentrotus droebachiensis. Developmental and Comparative Immunology 2008; Volum 32 (12). ISSN 0145-305X.s 1430 - 1440.s doi: 10.1016/j.dci.2008.06.013.
- Haug, Tor; Stensvåg, Klara; Olsen, Ørjan M.; Sandsdalen, Erling; Styrvold, Olaf B.. Antibacterial activities in various tissues of the horse mussel, Modiolus modiolus. Journal of Invertebrate Pathology 2004; Volum 85. ISSN 0022-2011.s 112 - 119.s doi: 10.1016/jip.2004.02.006.
- Abelseth, Torill; Stensvåg, Klara; Espelid, sigrun; Nygaard, Randi; Ellingsen, Terje; Bøgwald, Jarl; Dalmo, Roy Ambli. The spotted wolffish (Anarhichas minor Olafsen) complement component C3: isolation, characterisation and tissue distribution. Fish and Shellfish Immunology 2003; Volum 15. ISSN 1050-4648.s 13 - 27.s doi: 10.1016/S1050-4648(02)00135-3.
- Sandsdalen, Erling; Haug, Tor; Stensvåg, Klara; Styrvold, Olaf B.. The antibacterial effect of a polyhydroxylated fucophlorethol from the marine brown alga, Fucus vesiculosus. World Journal of Microbiology & Biotechnology 2003; Volum 19. ISSN 0959-3993.s 777 - 782.s doi: 10.1023/A:1026052715260.
- Haug, Tor; Kjuul, Anita K.; Styrvold, Olaf B.; Sandsdalen, Erling; Olsen, Ørjan M.; Stensvåg, Klara. Antibacterial activity in Strongylocentrotus droebachiensis (Echinoidea), Cucumaria frondosa (Holothuroidea) and Asterias rubens (Asteroidea). Journal of Invertebrate Pathology 2002; Volum 81. ISSN 0022-2011.s 94 - 102.s doi: 10.1016/S0022-2011(02)00153-2.
- Haug, Tor; Kjuul, Anita K.; Stensvåg, Klara; Sandsdalen, Erling; Styrvold, Olaf B.. Antibacterial activity in four marine crustacean decapods. Fish and Shellfish Immunology 2002; Volum 12. ISSN 1050-4648.s 371 - 385.s doi: 10.1006/fsim.2001.0378.
- Stensvåg, Klara; Bøgwald, Jarl; Smedsrød, Bård; Jørgensen, Trond Ø.. Distribution of lipopolysaccharides (LPS) and A-layer protein from Aeromonas salmonicida in Atlantic salmon, Salmo salar L., after intravenous injection. Fish and Shellfish Immunology 1999; Volum 9. ISSN 1050-4648.s 591 - 607.
- Bøgwald, Jarl; Stensvåg, Klara; Stuge, Tor Brynjar; Jørgensen, Trond Ø.. Tissue localisation and immune responses in Atlantic Salmon, Salmo salar L., after oral administration of Aeromonas salmonicida, Vibrio anguillarum and Vibrio salmonicidia antigens. Fish and Shellfish Immunology 1994; Volum 4 (5). ISSN 1050-4648.s 353 - 368.s doi: 10.1006/fsim.1994.1031.
- Bøgwald, Jarl; Stensvåg, Klara; Hoffman, James; Holm, Kåre Olav. Vaccination of Atlantic salmon, Salmo salar L., with particulate lipopolysaccharide antigens from Vibrio salmonicida and Vibrio anguillarum. Fish and Shellfish Immunology 1992; Volum 2. ISSN 1050-4648.s 251 - 261.
- Bøgwald, Jarl; Stensvåg, Klara; Hoffman, James; Espelid, sigrun; Holm, Kåre Olav; Jørgensen, Trond Ø.. Electrophoretic and immunochemical analysis of surface antigens of the fish pathogens Vibrio salmonicida and Vibrio anguillarum. Journal of Fish Diseases 1990; Volum 13. ISSN 0140-7775.s 293 - 301.
- Jørgensen, Trond Ø.; Midling, Kjell Ø.; Espelid, Sigrun; Nilsen, Ragnhild; Stensvåg, Klara. Vibrio salmonicida, a Pathogen in Salmonids, also causes Mortality in Net-pen captured Cod (Gadus Morhua). Bulletin of The European Association of Fish Pathologists 1989; Volum 9 (2). ISSN 0108-0288.s 42 - 44.
- Holm, Kåre Olav; Strøm, Ellen; Stensvåg, Klara; Raa, Jan; Jørgensen, Trond Ø.. Characteristics of a Vibrio sp. associated with the "Hitra disease" of Atlantic Salmon in Norwegian fish farms. Gyobyo kenkyu - Fish pathology 1985; Volum 20. ISSN 0388-788X.s 125 - 129.
Research interests
Drug Discovery, Marine Natural Products, Antimicrobials, Antimicrobial peptides, Marine Bioactive Peptides, Innate immunitity, immune cells in marine invertebrates
Teaching
- Teaching (responsible for courses)
- Bio-2610 Project thesis in Marine Biotechnology (responsible and teaching)
- Bio-3612 Marine bioprospektering og bioaktive komponenter (responsible and teaching)
- Bio-8604 Marine bioprospecting and bioactive compounds for health - (responsible and teaching)
- Teaching in courses:
- Bio-2606 Generell og marin bioteknologi
- Bio-3610 Industrial biotechology